Sodium L-Ascorbyl-2-Phosphate

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  • Identifiers

    CAS number
    66170-10-3

    Molecular formula
    C6H9Na3O9P

    SMILES
    C([C@@H]([C@@H]1C(=C(C(=O)O1)OP(=O)(O)O)O)O)O.[Na].[Na].[Na]

  • Odor profile

    Fragrance
    Odorless 76.4%
    Clean 21.15%
    Savory 18.72%
    Sour 17.69%
    Sweet 16.1%
    Caramellic 15.97%
    Sharp 15.45%
    Burnt 14.92%
    Milky 14.77%
    Buttery 13.57%

     

    Flavor
    Odorless 63.06%
    Very mild 38.67%
    Mild 26.98%
    Sour 26.61%
    Bland 26.54%
    Sweet-like 22.91%
    Caramellic 22.18%
    Yeast 22.02%
    Cotton candy 19.4%
    Urine 19.37%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.62 (neutral)

    Molecular weight
    325.07 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1447°C

    Flash point

    • 295.01 ˚C est.

  • Synonyms

    • Sodium L-ascorbic acid 2-phosphate
    • Sodium L-Ascorbyl-2-Phosphate
    • 66170-10-3
    • VCP-NA
    • CHEBI:81687
    • L-Ascorbic acid 2-phosphate (trisodium)
    • 2-Phospho-L-ascorbic acid (trisodium)
    • s5115
    • C18341

  • Applications

    Sodium L-Ascorbyl-2-Phosphate (CAS 66170-10-3) is a water-soluble derivative of vitamin C used primarily in cosmetics and personal care as an antioxidant and vitamin C source; in skincare formulations it provides antioxidant protection, helps maintain stable delivery of ascorbate in serums and creams, and can contribute to brightening and even skin tone; beyond cosmetics, it is evaluated for antioxidant use in food processing to retard oxidation and color degradation; in pharmaceutical formulations it may serve as an antioxidant stabilizer and vitamin C source, and in nutraceutical/dietary supplement contexts it can be considered as a stable vitamin C derivative.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 49.79
    methanol 130.19
    isopropanol 26.59
    water 498.78
    ethyl acetate 2.96
    n-propanol 21.23
    acetone 29.24
    n-butanol 13.53
    acetonitrile 6.83
    DMF 255.16
    toluene 1.96
    isobutanol 7.75
    1,4-dioxane 22.65
    methyl acetate 5.33
    THF 41.72
    2-butanone 7.25
    n-pentanol 6.73
    sec-butanol 11.51
    n-hexane 0.8
    ethylene glycol 174.87
    NMP 112.86
    cyclohexane 3.02
    DMSO 741.73
    n-butyl acetate 2.83
    n-octanol 5.32
    chloroform 1.01
    n-propyl acetate 2.19
    acetic acid 22.54
    dichloromethane 2.35
    cyclohexanone 9.4
    propylene glycol 59.95
    isopropyl acetate 2.21
    DMAc 126.04
    2-ethoxyethanol 64.33
    isopentanol 7.76
    n-heptane 2.19
    ethyl formate 9.01
    1,2-dichloroethane 4.19
    n-hexanol 7.83
    2-methoxyethanol 192.79
    isobutyl acetate 0.47
    tetrachloromethane 1.13
    n-pentyl acetate 2.18
    transcutol 26.02
    n-heptanol 6.34
    ethylbenzene 1.09
    MIBK 3.1
    2-propoxyethanol 38.86
    tert-butanol 32.61
    MTBE 4.57
    2-butoxyethanol 20.26
    propionic acid 8.07
    o-xylene 2.64
    formic acid 221.13
    diethyl ether 7.36
    m-xylene 1.7
    p-xylene 1.06
    chlorobenzene 0.52
    dimethyl carbonate 11.26
    n-octane 0.96
    formamide 309.51
    cyclopentanone 18.38
    2-pentanone 6.71
    anisole 2.98
    cyclopentyl methyl ether 11.04
    gamma-butyrolactone 21.63
    1-methoxy-2-propanol 83.47
    pyridine 8.61
    3-pentanone 4.29
    furfural 23.46
    n-dodecane 0.53
    diethylene glycol 96.75
    diisopropyl ether 1.77
    tert-amyl alcohol 14.28
    acetylacetone 9.47
    n-hexadecane 0.57
    acetophenone 3.62
    methyl propionate 6.52
    isopentyl acetate 1.65
    trichloroethylene 2.24
    n-nonanol 4.86
    cyclohexanol 10.2
    benzyl alcohol 6.16
    2-ethylhexanol 3.16
    isooctanol 3.25
    dipropyl ether 5.68
    1,2-dichlorobenzene 0.67
    ethyl lactate 6.77
    propylene carbonate 5.27
    n-methylformamide 116.84
    2-pentanol 7.24
    n-pentane 1.62
    1-propoxy-2-propanol 19.24
    1-methoxy-2-propyl acetate 5.53
    2-(2-methoxypropoxy) propanol 12.52
    mesitylene 1.56
    ε-caprolactone 6.87
    p-cymene 1.61
    epichlorohydrin 15.8
    1,1,1-trichloroethane 0.83
    2-aminoethanol 113.37
    morpholine-4-carbaldehyde 79.52
    sulfolane 62.32
    2,2,4-trimethylpentane 0.31
    2-methyltetrahydrofuran 11.44
    n-hexyl acetate 2.62
    isooctane 0.22
    2-(2-butoxyethoxy)ethanol 19.4
    sec-butyl acetate 0.95
    tert-butyl acetate 3.27
    decalin 0.48
    glycerin 143.05
    diglyme 36.5
    acrylic acid 12.14
    isopropyl myristate 1.29
    n-butyric acid 6.03
    acetyl acetate 1.74
    di(2-ethylhexyl) phthalate 1.57
    ethyl propionate 2.36
    nitromethane 46.33
    1,2-diethoxyethane 4.92
    benzonitrile 2.11
    trioctyl phosphate 2.12
    1-bromopropane 1.54
    gamma-valerolactone 32.36
    n-decanol 3.77
    triethyl phosphate 2.49
    4-methyl-2-pentanol 3.07
    propionitrile 3.88
    vinylene carbonate 4.6
    1,1,2-trichlorotrifluoroethane 27.65
    DMS 2.16
    cumene 0.77
    2-octanol 3.44
    2-hexanone 2.62
    octyl acetate 2.1
    limonene 2.3
    1,2-dimethoxyethane 54.36
    ethyl orthosilicate 2.3
    tributyl phosphate 1.5
    diacetone alcohol 16.22
    N,N-dimethylaniline 4.8
    acrylonitrile 6.98
    aniline 5.23
    1,3-propanediol 83.24
    bromobenzene 0.41
    dibromomethane 1.55
    1,1,2,2-tetrachloroethane 3.2
    2-methyl-cyclohexyl acetate 1.86
    tetrabutyl urea 4.46
    diisobutyl methanol 2.38
    2-phenylethanol 5.88
    styrene 0.95
    dioctyl adipate 1.7
    dimethyl sulfate 29.68
    ethyl butyrate 2.54
    methyl lactate 22.19
    butyl lactate 4.07
    diethyl carbonate 1.97
    propanediol butyl ether 16.11
    triethyl orthoformate 2.88
    p-tert-butyltoluene 1.78
    methyl 4-tert-butylbenzoate 6.49
    morpholine 35.12
    tert-butylamine 12.46
    n-dodecanol 2.89
    dimethoxymethane 80.71
    ethylene carbonate 3.92
    cyrene 18.36
    2-ethoxyethyl acetate 3.23
    2-ethylhexyl acetate 1.19
    1,2,4-trichlorobenzene 0.85
    4-methylpyridine 5.76
    dibutyl ether 2.29
    2,6-dimethyl-4-heptanol 2.38
    DEF 20.58
    dimethyl isosorbide 16.98
    tetrachloroethylene 3.77
    eugenol 8.11
    triacetin 2.64
    span 80 8.14
    1,4-butanediol 36.48
    1,1-dichloroethane 1.06
    2-methyl-1-pentanol 3.22
    methyl formate 65.95
    2-methyl-1-butanol 6.44
    n-decane 0.87
    butyronitrile 3.12
    3,7-dimethyl-1-octanol 2.47
    1-chlorooctane 1.33
    1-chlorotetradecane 0.69
    n-nonane 0.91
    undecane 0.67
    tert-butylcyclohexane 0.24
    cyclooctane 1.68
    cyclopentanol 15.75
    tetrahydropyran 8.8
    tert-amyl methyl ether 4.66
    2,5,8-trioxanonane 29.17
    1-hexene 1.04
    2-isopropoxyethanol 20.01
    2,2,2-trifluoroethanol 28.13
    methyl butyrate 3.59

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction