Sodium (hydroxymethyl)glycinate

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  • Identifiers

    CAS number
    70161-44-3

    Molecular formula
    C3H6NNaO3

    SMILES
    C(C(=O)[O-])NCO.[Na+]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 72.59%
    Fishy 26.79%
    Savory 26.4%
    Sweet 26.06%
    Meaty 19.42%
    Alcoholic 17.61%
    Cheesy 13.71%
    Cooked 13.7%
    Cooling 13.08%
    Bitter 13.03%

     

    Flavor
    Odorless 71.63%
    Mild 28.09%
    Very mild 26.6%
    Sweet-like 23.58%
    Bland 23.41%
    Sour 22.75%
    Faint 22.07%
    Yeast 21.63%
    Acidic 19.72%
    Very slight 19.67%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.92 (weak acid)

    Molecular weight
    127.07 g/mol

    Flash point

    • 116.48 ˚C est.

  • Synonyms

    • 70161-44-3
    • sodium hydroxymethylglycinate
    • Suttocide A
    • Integra 44
    • Glycine, N-(hydroxymethyl)-, monosodium salt
    • DIG6BWZ9XT
    • Sodium (hydroxymethyl)glycinate
    • NIPAGUARD SMG
    • GRAMCIDE III
    • RefChem:887614
    • 805-021-6
    • Sodium 2-((hydroxymethyl)amino)acetate
    • Sodium hydroxymethyl glycinate
    • Sodium N-(hydroxymethyl)glycinate
    • sodium;2-(hydroxymethylamino)acetate
    • N-(Hydroxymethyl)glycine monosodium salt
    • MFCD04307769
    • Sodium hydroxymethylamino acetate
    • C3H6NNaO3
    • Glycine, N-(hydroxymethyl)-, sodium salt (1:1)
    • SODIUM 2-[(HYDROXYMETHYL)AMINO]ACETATE
    • UNII-DIG6BWZ9XT
    • EINECS 274-357-8
    • Hydroxymethylaminoacetic acid, sodium salt
    • Hydroxymethylglycine, sodium salt
    • Sodium [(hydroxymethyl)amino]acetate
    • N-(Hydroxymethyl)glycine, monosodium salt
    • SCHEMBL112322
    • DTXSID5035799
    • AKOS006294419
    • CP01006
    • CS-W019206
    • FG14189
    • HY-W018420
    • PD197017
    • SY112921
    • Sodium hydroxymethyl glycinate, AldrichCPR
    • NS00019396
    • F20522
    • F791582
    • GLYCINE, N-(HYDROXYMETHYL)-, SODIUM SALT
    • N-(Hydroxymethyl)-glycine sodium - 50%, in water
    • Q27276411
    • Sodium 2-((hydroxymethyl)amino)acetate50% aqueous solution
    • 70161-44-3

  • Applications

    Sodium (hydroxymethyl)glycinate, CAS 70161-44-3, is commonly used as a formaldehyde-releasing preservative in cosmetics and personal care products to inhibit microbial growth; it is also employed in some household cleaning formulations where preservation and formulation stability are required. In industrial settings, it can serve as an intermediate for preparing glycine derivatives and may function as a stabilizer or buffering component in polymer, coatings/ inks, and adhesive formulations, subject to applicable regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 34.69
    methanol 117.65
    isopropanol 14.03
    water 715.92
    ethyl acetate 3.2
    n-propanol 17.66
    acetone 13.33
    n-butanol 12.12
    acetonitrile 6.32
    DMF 503.34
    toluene 0.92
    isobutanol 7.73
    1,4-dioxane 18.12
    methyl acetate 5.98
    THF 16.03
    2-butanone 4.76
    n-pentanol 4.75
    sec-butanol 7.84
    n-hexane 0.34
    ethylene glycol 171.03
    NMP 177.13
    cyclohexane 0.75
    DMSO 344.64
    n-butyl acetate 2.43
    n-octanol 3.0
    chloroform 1.97
    n-propyl acetate 2.0
    acetic acid 55.4
    dichloromethane 4.02
    cyclohexanone 11.63
    propylene glycol 64.64
    isopropyl acetate 1.71
    DMAc 193.59
    2-ethoxyethanol 36.45
    isopentanol 7.14
    n-heptane 0.61
    ethyl formate 27.91
    1,2-dichloroethane 4.7
    n-hexanol 4.43
    2-methoxyethanol 151.23
    isobutyl acetate 0.8
    tetrachloromethane 0.99
    n-pentyl acetate 1.81
    transcutol 36.39
    n-heptanol 3.3
    ethylbenzene 0.89
    MIBK 1.99
    2-propoxyethanol 20.81
    tert-butanol 14.64
    MTBE 2.54
    2-butoxyethanol 13.64
    propionic acid 24.54
    o-xylene 2.05
    formic acid 351.85
    diethyl ether 2.3
    m-xylene 1.12
    p-xylene 1.08
    chlorobenzene 1.03
    dimethyl carbonate 8.78
    n-octane 0.25
    formamide 291.02
    cyclopentanone 13.76
    2-pentanone 3.61
    anisole 3.35
    cyclopentyl methyl ether 4.01
    gamma-butyrolactone 28.29
    1-methoxy-2-propanol 45.01
    pyridine 8.74
    3-pentanone 2.63
    furfural 63.41
    n-dodecane 0.21
    diethylene glycol 60.36
    diisopropyl ether 0.61
    tert-amyl alcohol 9.48
    acetylacetone 6.79
    n-hexadecane 0.22
    acetophenone 5.52
    methyl propionate 6.29
    isopentyl acetate 2.07
    trichloroethylene 4.7
    n-nonanol 2.77
    cyclohexanol 8.18
    benzyl alcohol 7.87
    2-ethylhexanol 2.47
    isooctanol 2.28
    dipropyl ether 2.1
    1,2-dichlorobenzene 1.82
    ethyl lactate 7.97
    propylene carbonate 12.85
    n-methylformamide 210.45
    2-pentanol 4.03
    n-pentane 0.48
    1-propoxy-2-propanol 10.33
    1-methoxy-2-propyl acetate 4.91
    2-(2-methoxypropoxy) propanol 16.41
    mesitylene 1.04
    ε-caprolactone 13.79
    p-cymene 1.25
    epichlorohydrin 16.21
    1,1,1-trichloroethane 1.13
    2-aminoethanol 116.84
    morpholine-4-carbaldehyde 130.96
    sulfolane 67.78
    2,2,4-trimethylpentane 0.24
    2-methyltetrahydrofuran 5.89
    n-hexyl acetate 2.59
    isooctane 0.14
    2-(2-butoxyethoxy)ethanol 19.44
    sec-butyl acetate 0.98
    tert-butyl acetate 2.04
    decalin 0.33
    glycerin 180.95
    diglyme 38.03
    acrylic acid 41.77
    isopropyl myristate 1.28
    n-butyric acid 18.06
    acetyl acetate 2.82
    di(2-ethylhexyl) phthalate 3.82
    ethyl propionate 2.4
    nitromethane 80.29
    1,2-diethoxyethane 3.81
    benzonitrile 4.68
    trioctyl phosphate 2.48
    1-bromopropane 1.28
    gamma-valerolactone 50.06
    n-decanol 2.25
    triethyl phosphate 3.55
    4-methyl-2-pentanol 2.07
    propionitrile 5.04
    vinylene carbonate 18.79
    1,1,2-trichlorotrifluoroethane 51.11
    DMS 4.18
    cumene 0.95
    2-octanol 1.6
    2-hexanone 1.81
    octyl acetate 2.09
    limonene 1.64
    1,2-dimethoxyethane 46.14
    ethyl orthosilicate 2.93
    tributyl phosphate 2.63
    diacetone alcohol 10.03
    N,N-dimethylaniline 5.44
    acrylonitrile 13.9
    aniline 4.81
    1,3-propanediol 88.82
    bromobenzene 0.66
    dibromomethane 2.06
    1,1,2,2-tetrachloroethane 5.13
    2-methyl-cyclohexyl acetate 2.69
    tetrabutyl urea 6.73
    diisobutyl methanol 1.7
    2-phenylethanol 5.02
    styrene 0.9
    dioctyl adipate 3.17
    dimethyl sulfate 29.7
    ethyl butyrate 2.92
    methyl lactate 25.15
    butyl lactate 5.64
    diethyl carbonate 2.8
    propanediol butyl ether 17.56
    triethyl orthoformate 3.12
    p-tert-butyltoluene 1.18
    methyl 4-tert-butylbenzoate 7.82
    morpholine 30.14
    tert-butylamine 5.79
    n-dodecanol 1.84
    dimethoxymethane 45.84
    ethylene carbonate 12.53
    cyrene 23.57
    2-ethoxyethyl acetate 3.34
    2-ethylhexyl acetate 1.56
    1,2,4-trichlorobenzene 2.12
    4-methylpyridine 7.67
    dibutyl ether 1.41
    2,6-dimethyl-4-heptanol 1.7
    DEF 27.01
    dimethyl isosorbide 20.1
    tetrachloroethylene 5.15
    eugenol 12.86
    triacetin 5.03
    span 80 12.02
    1,4-butanediol 30.85
    1,1-dichloroethane 1.36
    2-methyl-1-pentanol 3.68
    methyl formate 130.66
    2-methyl-1-butanol 6.99
    n-decane 0.28
    butyronitrile 4.91
    3,7-dimethyl-1-octanol 2.37
    1-chlorooctane 0.72
    1-chlorotetradecane 0.45
    n-nonane 0.26
    undecane 0.24
    tert-butylcyclohexane 0.26
    cyclooctane 0.35
    cyclopentanol 11.36
    tetrahydropyran 5.23
    tert-amyl methyl ether 2.65
    2,5,8-trioxanonane 32.83
    1-hexene 0.66
    2-isopropoxyethanol 10.97
    2,2,2-trifluoroethanol 52.06
    methyl butyrate 5.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction