Sodium Citrate

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  • Identifiers

    CAS number
    68-04-2

    Molecular formula
    C6H5Na3O7

    SMILES
    C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 64.67%
    Sweet 44.28%
    Sour 22.78%
    Caramellic 21.13%
    Buttery 21.05%
    Clean 20.66%
    Fatty 19.49%
    Winey 19.47%
    Creamy 19.3%
    Savory 18.18%

     

    Flavor
    Odorless 64.27%
    Very mild 33.4%
    Mild 29.73%
    Bland 24.21%
    Sour 23.46%
    Nutty 22.49%
    Sweet-like 21.56%
    Yeast 21.52%
    Musty 20.62%
    Caramellic 20.37%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    -1.38 (strong acid)

    Molecular weight
    258.07 g/mol

    Melting point expt.

    • 300 undefined
    • >300 °C

    Boiling point

    • BP: Decomposes at red heat /Dihydrate/

    Flash point

    • 201.83 ˚C est.

    Solubility expt.

    • 29.4g/L
    • White, odorless crystals, granules or powder; cool, saline taste. Stable in air; becomes anhydrous at 150 °C. Sol in 1.3 parts water, 0.6 part boiling water. Insol in alcohol. The aqueous soln is slightly alkaline to litmus; pH about 8; /Dihydrate/
    • Solubility in water, g/100ml at 25 °C: 42.5

  • Synonyms

    • Sodium citrate
    • 68-04-2
    • TRISODIUM CITRATE
    • Sodium citrate anhydrous
    • Citrosodine
    • Natrocitral
    • sodium citrate, anhydrous
    • Citric acid, trisodium salt
    • Trisodium citrate, anhydrous
    • Citric acid trisodium salt
    • anhydrous sodium citrate
    • 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt
    • Trisodium citrate anhydrous
    • FEMA No. 3026
    • CCRIS 3293
    • Sodium 2-hydroxypropane-1,2,3-tricarboxylate
    • Sodium citrate (Na3C6H5O7)
    • Sodium citrate,anhydrous
    • HSDB 5201
    • trisodium-citrate
    • Anhydrous trisodium citrate
    • UNII-RS7A450LGA
    • tri-sodium citrate
    • EINECS 200-675-3
    • Bicitra
    • Pneucid
    • Trisodium 2-hydroxy-1,2,3-propanetricarboxylate
    • trisodium 2-hydroxypropane-1,2,3-tricarboxylate
    • 994-36-5
    • CHEBI:53258
    • trisodium;2-hydroxypropane-1,2,3-tricarboxylate
    • RS7A450LGA
    • INS NO.331(III)
    • INS-331(III)
    • EC 200-675-3
    • E-331(III)
    • MFCD00012462
    • FEMA NO. 3026, ANHYDROUS-
    • CITRIC ACID, SODIUM SALT
    • Citrosodina
    • Citnatin
    • Citreme
    • Citrosodna
    • EINECS 213-618-2
    • Sodium citrate hydrous
    • Natrii citras, dehydrate
    • E 331
    • Sodium 2-hydroxy-1,2,3-propanetricarboxylate
    • UNII-68538UP9SE
    • 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt
    • EINECS 242-734-6
    • C6H5Na3O7
    • EC 242-734-6
    • Oracit
    • Natrii citras
    • sodium citrate salt
    • Albright's Solution
    • 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3)
    • sodium (iii) citrate
    • Sodium citrate (USP)
    • Modified Shohl's Solution
    • Anticoagulant Sodium Citrate
    • 1Q73Q2JULR
    • CHEMBL1355
    • SODIUM CITRATE (II)
    • SODIUM CITRATE [MI]
    • Citrate Concentrated Solution
    • DTXSID2026363
    • SODIUM CITRATE (USP-RS)
    • SODIUM CITRATE [WHO-IP]
    • 2-Hydroxy-1,2,3-propanetricarboxylic acid, trisodium salt
    • Citric acid sodium salt anhydrous
    • Citric acid trisodium salt, 99%
    • SODIUM CITRATE, UNSPECIFIED
    • NATRII CITRAS [WHO-IP LATIN]
    • SODIUM CITRATE (USP IMPURITY)
    • AKOS015915009
    • DB09154
    • FT01206
    • SODIUM CITRATE ANHYDROUS [HSDB]
    • ANHYDROUS TRISODIUM CITRATE [II]
    • SODIUM CITRATE, UNSPECIFIED FORM
    • SODIUM CITRATE,ANHYDROUS [VANDF]
    • 8055-55-8
    • AC-15008
    • E331
    • Sodium citrate dihydrate USP Fine Granular
    • SODIUM CITRATE, ANHYDROUS [WHO-IP]
    • NS00077225
    • EN300-74572
    • D05855
    • D77308
    • ANHYDROUS TRISODIUM CITRATE [USP MONOGRAPH]
    • Q409728
    • Citric acid trisodium salt, anhydrous, >=98% (GC)
    • Citric acid trisodium salt, Vetec(TM) reagent grade, 98%

  • Applications

    Sodium Citrate (CAS 68-04-2) is a versatile buffering and chelating agent used across industries: as a water-softening chelant and stabilizer in household detergents and industrial cleaners; as an acidity regulator and pH buffer in foods and beverages; as an anticoagulant in clinical laboratories for blood sample collection; as a stabilizer and pH-adjusting excipient in pharmaceutical formulations; and in cosmetics and personal care as a buffering and chelating additive to improve formulation stability and performance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1157.3
    methanol 2649.25
    isopropanol 610.39
    water 780.39
    ethyl acetate 249.63
    n-propanol 701.91
    acetone 1108.49
    n-butanol 329.66
    acetonitrile 515.58
    DMF 5437.35
    toluene 138.82
    isobutanol 336.98
    1,4-dioxane 652.42
    methyl acetate 382.57
    THF 1311.96
    2-butanone 533.12
    n-pentanol 269.3
    sec-butanol 388.43
    n-hexane 27.25
    ethylene glycol 841.31
    NMP 2245.4
    cyclohexane 19.71
    DMSO 4380.19
    n-butyl acetate 93.06
    n-octanol 131.94
    chloroform 91.56
    n-propyl acetate 203.22
    acetic acid 399.63
    dichloromethane 244.46
    cyclohexanone 342.77
    propylene glycol 552.93
    isopropyl acetate 138.68
    DMAc 2588.03
    2-ethoxyethanol 994.3
    isopentanol 204.63
    n-heptane 21.17
    ethyl formate 339.91
    1,2-dichloroethane 321.19
    n-hexanol 144.82
    2-methoxyethanol 1568.49
    isobutyl acetate 73.98
    tetrachloromethane 16.33
    n-pentyl acetate 81.99
    transcutol 770.16
    n-heptanol 98.26
    ethylbenzene 68.32
    MIBK 207.82
    2-propoxyethanol 574.78
    tert-butanol 570.44
    MTBE 274.31
    2-butoxyethanol 264.4
    propionic acid 380.03
    o-xylene 115.01
    formic acid 1061.4
    diethyl ether 417.46
    m-xylene 99.59
    p-xylene 65.34
    chlorobenzene 57.6
    dimethyl carbonate 528.58
    n-octane 11.97
    formamide 1891.03
    cyclopentanone 749.63
    2-pentanone 413.71
    anisole 313.12
    cyclopentyl methyl ether 400.9
    gamma-butyrolactone 1025.45
    1-methoxy-2-propanol 1091.4
    pyridine 428.43
    3-pentanone 353.02
    furfural 742.05
    n-dodecane 10.26
    diethylene glycol 625.76
    diisopropyl ether 84.22
    tert-amyl alcohol 358.03
    acetylacetone 372.75
    n-hexadecane 10.53
    acetophenone 272.27
    methyl propionate 497.45
    isopentyl acetate 56.79
    trichloroethylene 248.91
    n-nonanol 122.54
    cyclohexanol 185.49
    benzyl alcohol 273.72
    2-ethylhexanol 64.46
    isooctanol 65.87
    dipropyl ether 181.58
    1,2-dichlorobenzene 54.21
    ethyl lactate 211.23
    propylene carbonate 285.93
    n-methylformamide 2427.23
    2-pentanol 230.67
    n-pentane 41.64
    1-propoxy-2-propanol 320.94
    1-methoxy-2-propyl acetate 175.9
    2-(2-methoxypropoxy) propanol 291.86
    mesitylene 58.39
    ε-caprolactone 307.42
    p-cymene 35.1
    epichlorohydrin 827.92
    1,1,1-trichloroethane 63.22
    2-aminoethanol 979.14
    morpholine-4-carbaldehyde 1576.42
    sulfolane 1316.06
    2,2,4-trimethylpentane 11.11
    2-methyltetrahydrofuran 469.85
    n-hexyl acetate 114.79
    isooctane 7.77
    2-(2-butoxyethoxy)ethanol 363.8
    sec-butyl acetate 91.59
    tert-butyl acetate 139.41
    decalin 10.29
    glycerin 757.0
    diglyme 631.48
    acrylic acid 438.58
    isopropyl myristate 63.43
    n-butyric acid 217.02
    acetyl acetate 102.0
    di(2-ethylhexyl) phthalate 57.94
    ethyl propionate 250.3
    nitromethane 1181.66
    1,2-diethoxyethane 235.6
    benzonitrile 130.28
    trioctyl phosphate 53.64
    1-bromopropane 159.5
    gamma-valerolactone 960.84
    n-decanol 97.57
    triethyl phosphate 69.65
    4-methyl-2-pentanol 103.96
    propionitrile 374.75
    vinylene carbonate 308.89
    1,1,2-trichlorotrifluoroethane 436.29
    DMS 144.35
    cumene 46.68
    2-octanol 68.42
    2-hexanone 247.15
    octyl acetate 86.19
    limonene 46.19
    1,2-dimethoxyethane 1180.97
    ethyl orthosilicate 61.84
    tributyl phosphate 52.62
    diacetone alcohol 297.15
    N,N-dimethylaniline 299.22
    acrylonitrile 574.96
    aniline 258.82
    1,3-propanediol 616.75
    bromobenzene 39.57
    dibromomethane 143.48
    1,1,2,2-tetrachloroethane 198.65
    2-methyl-cyclohexyl acetate 69.97
    tetrabutyl urea 124.81
    diisobutyl methanol 41.26
    2-phenylethanol 136.24
    styrene 86.76
    dioctyl adipate 98.55
    dimethyl sulfate 826.08
    ethyl butyrate 112.67
    methyl lactate 475.55
    butyl lactate 98.8
    diethyl carbonate 78.73
    propanediol butyl ether 253.39
    triethyl orthoformate 89.16
    p-tert-butyltoluene 34.92
    methyl 4-tert-butylbenzoate 177.37
    morpholine 852.93
    tert-butylamine 286.44
    n-dodecanol 72.22
    dimethoxymethane 2130.38
    ethylene carbonate 235.22
    cyrene 400.02
    2-ethoxyethyl acetate 130.63
    2-ethylhexyl acetate 45.66
    1,2,4-trichlorobenzene 66.84
    4-methylpyridine 401.77
    dibutyl ether 100.75
    2,6-dimethyl-4-heptanol 41.26
    DEF 695.88
    dimethyl isosorbide 390.66
    tetrachloroethylene 128.85
    eugenol 204.6
    triacetin 147.17
    span 80 172.42
    1,4-butanediol 376.59
    1,1-dichloroethane 152.78
    2-methyl-1-pentanol 150.99
    methyl formate 1593.43
    2-methyl-1-butanol 217.41
    n-decane 16.99
    butyronitrile 229.05
    3,7-dimethyl-1-octanol 79.15
    1-chlorooctane 50.16
    1-chlorotetradecane 24.08
    n-nonane 16.51
    undecane 13.05
    tert-butylcyclohexane 9.13
    cyclooctane 11.15
    cyclopentanol 300.65
    tetrahydropyran 343.96
    tert-amyl methyl ether 235.03
    2,5,8-trioxanonane 519.33
    1-hexene 88.89
    2-isopropoxyethanol 469.99
    2,2,2-trifluoroethanol 289.85
    methyl butyrate 284.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction