Sarcosine

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  • Identifiers

    CAS number
    107-97-1

    Molecular formula
    C3H7NO2

    SMILES
    CNCC(=O)O

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Odorless 66.3%
    Cheesy 26.71%
    Savory 24.93%
    Meaty 24.44%
    Fishy 21.51%
    Sulfurous 19.38%
    Cooked 16.99%
    Sour 16.98%
    Pungent 15.6%
    Sweet 15.04%

     

    Flavor
    Odorless 68.41%
    Sour 38.43%
    Acidic 34.07%
    Mild 27.15%
    Bland 23.25%
    Sweat 22.91%
    Yeast 22.39%
    Pungent 21.38%
    Cheese 21.35%
    Soy 21.21%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.8

    pKa est.
    7.95 (neutral)

    Molecular weight
    89.09 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    223°C

    Melting point expt.

    • 406 °F (Decomposes) (NTP, 1992)
    • 208 °C

    Flash point

    • 111.68 ˚C est.

    Solubility expt.

    • 5.6 [ug/mL] (The mean of the results at pH 7.4)
    • greater than or equal to 100 mg/mL at 61 °F (NTP, 1992)
    • 300.0 mg/mL

  • Synonyms

    • sarcosine
    • 107-97-1
    • N-methylglycine
    • Sarcosinic acid
    • Methylglycine
    • 2-(methylamino)acetic acid
    • Glycine, N-methyl-
    • N-Methylaminoacetic acid
    • Sarcosin
    • Methylaminoacetic acid
    • (Methylamino)acetic acid
    • (Methylamino)ethanoic acid
    • Sargosine hydrochloride
    • Acetic acid, (methylamino)-
    • N-Methyl glycine
    • N-methyl-Glycine
    • MFCD00004279
    • Methylamino-Acetic Acid
    • L-sarcosine
    • BRN 1699442
    • MeGly
    • AI3-15410
    • EINECS 203-538-6
    • N-Methyl-glycocoll
    • N-Methylaminoacetate
    • (methylamino)acetate
    • UNII-Z711V88R5F
    • (methylamino)-Acetate
    • (Methylamino)ethanoate
    • 25951-24-0
    • SAR
    • CHEBI:15611
    • Methylaminoethanoic acid
    • CH3NHCH2COOH
    • Z711V88R5F
    • SARCOSINE [MI]
    • (methylamino)-Acetic acid
    • 2-Methylaminoethanoic acid
    • SARCOSINE [WHO-DD]
    • CHEMBL304383
    • DTXSID1047025
    • sarcosinate
    • H-Sar-OH
    • N-Methylglycocoll
    • Cocoylsarcosine
    • sarcosine zwitterion
    • Magnesium Sarcosylate
    • (methylammonio)acetate
    • (methylazaniumyl)acetate
    • Cocobetaine
    • Cocoyl sarcosine
    • CHEBI:57433
    • SMR000857358
    • N-Cocoyl-N-methylglycine
    • arcosine
    • NMethylglycine
    • methyl-glycine
    • NMethylglycocoll
    • UNII-820Q60DZ0I
    • N Methylglycine
    • methylaminoacetate
    • NMethyl glycocoll
    • Glycine, Nmethyl
    • N-Cocoyl sarcosine
    • Sarcosine, BioXtra
    • EINECS 270-156-4
    • Sarcosine, 98%
    • Me-Gly-OH
    • MeNHCH2COOH
    • NSC 118114
    • NMethylaminoacetic acid
    • METHYL GLYCOCOLL
    • 2Methylaminoethanoic acid
    • CH3NHCH2CO2H
    • SARCOSINE [INCI]
    • acetic acid, methylamino-
    • N-METHYL GLYCOCOLL
    • N-Cocoyl-N-methyl glycine
    • bmse000160
    • Acetic acid, (methylamino)
    • MLS001335909
    • MLS001335910
    • GTPL4713
    • DTXCID9027025
    • Sarcosine, >=99.0% (NT)
    • 820Q60DZ0I
    • HMS2231J19
    • BCP34413
    • STR01554
    • AC7804
    • BBL009707
    • BDBM50017225
    • NSC118114
    • s4702
    • STL141072
    • AKOS000120139
    • CCG-266018
    • CS-W018511
    • DB12519
    • FS02744
    • NSC-118114
    • BP-12554
    • DA-57664
    • Sarcosine, crystallized, >=98.0% (T)
    • SY001630
    • HY-101037
    • M0332
    • NS00004104
    • EN300-20732
    • N-methylglycine;Methylglycine; Sarcosinic acid
    • C00213
    • Q414157
    • 2-Methylaminoethanoic acid; N-Methylglycine; H-Sar-OH
    • BRD-K51263939-001-08-6
    • F0001-0147
    • Z104480276
    • 484652ED-E55A-4308-8F42-0903E08DBAF4
    • N-Methylglycine;(Methylamino)acetic acid;Sarcosinic acid;N-Methylglycocoll
    • 203-538-6

  • Applications

    Chemical name: Sarcosine; CAS number: 107-97-1. Sarcosine (N-methylglycine) is primarily used as a chemical building block and intermediate in organic synthesis and peptide chemistry, enabling the preparation of N-methyl amino acids and related derivatives. It serves as a precursor for sarcosinate-based surfactants, such as sodium lauroyl sarcosinate, which are widely used as mild surfactants in cosmetics, personal care, and household cleaning products. The compound can be used as a feedstock for specialty polymers and coating formulations, including the synthesis of polymeric surfactants and stabilizers through derivatization. In formulations, sarcosine may act as a buffering or metal-binding component under certain conditions, and in research settings it is used as a simple amino acid derivative and metabolite model in biochemical studies.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 14.86
    methanol 97.61
    isopropanol 2.33
    water 1031.43
    ethyl acetate 1.09
    n-propanol 7.38
    acetone 1.84
    n-butanol 3.56
    acetonitrile 1.71
    DMF 42.51
    toluene 0.12
    isobutanol 3.22
    1,4-dioxane 2.53
    methyl acetate 1.26
    THF 6.03
    2-butanone 1.16
    n-pentanol 1.91
    sec-butanol 2.34
    n-hexane 0.11
    ethylene glycol 184.4
    NMP 122.8
    cyclohexane 0.12
    DMSO 75.12
    n-butyl acetate 1.9
    n-octanol 2.32
    chloroform 0.4
    n-propyl acetate 0.86
    acetic acid 192.11
    dichloromethane 0.7
    cyclohexanone 4.95
    propylene glycol 73.37
    isopropyl acetate 0.63
    DMAc 33.02
    2-ethoxyethanol 17.07
    isopentanol 2.17
    n-heptane 0.29
    ethyl formate 4.34
    1,2-dichloroethane 0.62
    n-hexanol 4.39
    2-methoxyethanol 56.62
    isobutyl acetate 0.61
    tetrachloromethane 0.24
    n-pentyl acetate 1.41
    transcutol 36.59
    n-heptanol 3.16
    ethylbenzene 0.13
    MIBK 0.91
    2-propoxyethanol 20.21
    tert-butanol 3.58
    MTBE 0.42
    2-butoxyethanol 11.19
    propionic acid 36.58
    o-xylene 0.36
    formic acid 614.01
    diethyl ether 0.32
    m-xylene 0.3
    p-xylene 0.2
    chlorobenzene 0.29
    dimethyl carbonate 1.64
    n-octane 0.11
    formamide 254.24
    cyclopentanone 7.52
    2-pentanone 0.96
    anisole 0.66
    cyclopentyl methyl ether 1.72
    gamma-butyrolactone 20.81
    1-methoxy-2-propanol 18.06
    pyridine 1.41
    3-pentanone 0.81
    furfural 27.2
    n-dodecane 0.09
    diethylene glycol 54.97
    diisopropyl ether 0.16
    tert-amyl alcohol 4.1
    acetylacetone 2.52
    n-hexadecane 0.09
    acetophenone 1.91
    methyl propionate 1.84
    isopentyl acetate 1.89
    trichloroethylene 1.05
    n-nonanol 2.17
    cyclohexanol 3.71
    benzyl alcohol 2.38
    2-ethylhexanol 2.45
    isooctanol 2.29
    dipropyl ether 1.01
    1,2-dichlorobenzene 0.69
    ethyl lactate 5.21
    propylene carbonate 9.6
    n-methylformamide 47.75
    2-pentanol 1.2
    n-pentane 0.09
    1-propoxy-2-propanol 11.49
    1-methoxy-2-propyl acetate 4.03
    2-(2-methoxypropoxy) propanol 17.74
    mesitylene 0.33
    ε-caprolactone 8.6
    p-cymene 0.65
    epichlorohydrin 5.03
    1,1,1-trichloroethane 0.25
    2-aminoethanol 117.06
    morpholine-4-carbaldehyde 58.34
    sulfolane 68.19
    2,2,4-trimethylpentane 0.12
    2-methyltetrahydrofuran 2.49
    n-hexyl acetate 2.39
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 20.7
    sec-butyl acetate 0.49
    tert-butyl acetate 1.21
    decalin 0.11
    glycerin 188.88
    diglyme 22.35
    acrylic acid 68.67
    isopropyl myristate 1.15
    n-butyric acid 15.91
    acetyl acetate 1.39
    di(2-ethylhexyl) phthalate 5.12
    ethyl propionate 0.95
    nitromethane 52.37
    1,2-diethoxyethane 1.69
    benzonitrile 1.32
    trioctyl phosphate 3.36
    1-bromopropane 0.2
    gamma-valerolactone 27.68
    n-decanol 1.71
    triethyl phosphate 2.41
    4-methyl-2-pentanol 0.97
    propionitrile 1.17
    vinylene carbonate 10.02
    1,1,2-trichlorotrifluoroethane 32.48
    DMS 2.79
    cumene 0.27
    2-octanol 1.36
    2-hexanone 0.79
    octyl acetate 2.04
    limonene 0.96
    1,2-dimethoxyethane 6.93
    ethyl orthosilicate 2.02
    tributyl phosphate 3.63
    diacetone alcohol 7.26
    N,N-dimethylaniline 1.31
    acrylonitrile 2.97
    aniline 1.15
    1,3-propanediol 52.79
    bromobenzene 0.16
    dibromomethane 0.36
    1,1,2,2-tetrachloroethane 1.01
    2-methyl-cyclohexyl acetate 3.01
    tetrabutyl urea 6.17
    diisobutyl methanol 1.42
    2-phenylethanol 3.54
    styrene 0.12
    dioctyl adipate 3.22
    dimethyl sulfate 8.93
    ethyl butyrate 1.76
    methyl lactate 12.36
    butyl lactate 6.24
    diethyl carbonate 1.37
    propanediol butyl ether 20.25
    triethyl orthoformate 1.97
    p-tert-butyltoluene 0.68
    methyl 4-tert-butylbenzoate 7.14
    morpholine 5.96
    tert-butylamine 1.23
    n-dodecanol 1.3
    dimethoxymethane 4.77
    ethylene carbonate 5.51
    cyrene 28.32
    2-ethoxyethyl acetate 2.6
    2-ethylhexyl acetate 1.44
    1,2,4-trichlorobenzene 1.01
    4-methylpyridine 1.03
    dibutyl ether 0.64
    2,6-dimethyl-4-heptanol 1.42
    DEF 5.06
    dimethyl isosorbide 24.1
    tetrachloroethylene 1.41
    eugenol 12.13
    triacetin 5.77
    span 80 20.35
    1,4-butanediol 19.59
    1,1-dichloroethane 0.17
    2-methyl-1-pentanol 1.61
    methyl formate 23.26
    2-methyl-1-butanol 2.8
    n-decane 0.12
    butyronitrile 0.86
    3,7-dimethyl-1-octanol 2.19
    1-chlorooctane 0.4
    1-chlorotetradecane 0.23
    n-nonane 0.11
    undecane 0.1
    tert-butylcyclohexane 0.13
    cyclooctane 0.07
    cyclopentanol 7.49
    tetrahydropyran 0.97
    tert-amyl methyl ether 0.73
    2,5,8-trioxanonane 24.64
    1-hexene 0.18
    2-isopropoxyethanol 6.24
    2,2,2-trifluoroethanol 78.24
    methyl butyrate 1.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction