Salidroside

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  • Identifiers

    CAS number
    10338-51-9

    Molecular formula
    C14H20O7

    SMILES
    C1=CC(=CC=C1CCO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 56.51%
    Odorless 48.13%
    Vanilla 37.11%
    Bitter 27.01%
    Phenolic 25.36%
    Balsamic 23.99%
    Creamy 21.36%
    Powdery 20.96%
    Almond 20.58%
    Spicy 20.14%

     

    Flavor
    Sweet 59.13%
    Bitter 58.46%
    Odorless 37.99%
    Sweet-like 28.29%
    Mild 24.75%
    Fatty 22.62%
    Very slight 21.7%
    Cauliflower 21.46%
    Naphthalic 21.44%
    Soup 20.81%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.6

    pKa est.
    7.13 (neutral)

    Molecular weight
    300.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1253°C

    Flash point

    • 235.12 ˚C est.

  • Synonyms

    • Salidroside
    • 10338-51-9
    • Rhodioloside
    • Rhodosin
    • sallidroside
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol
    • salidroside, (-)-
    • 2-(4-Hydroxyphenyl)ethyl beta-D-glucopyranoside
    • DTXSID4049034
    • M983H6N1S9
    • NSC-741643
    • DTXCID9028960
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(2-(4-hydroxyphenyl)ethoxy)oxane-3,4,5-triol
    • RefChem:48959
    • beta-D-glucopyranoside, 2-(4-hydroxyphenyl)ethyl-
    • 695-621-2
    • Tyrosol glucoside
    • MFCD00210553
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenethoxy)tetrahydro-2H-pyran-3,4,5-triol
    • CHEMBL465208
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]tetrahydropyran-3,4,5-triol
    • CAS-10338-51-9
    • Glucopyranoside, p-hydroxyphenethyl
    • salidrosidin
    • UNII-M983H6N1S9
    • Salidroside?
    • Salidroside CRS
    • NCGC00169145-02
    • Salidroside (Standard)
    • salidroside (rhodioloside)
    • beta-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl
    • SALIDROSIDE [USP-RS]
    • MLS006010734
    • SCHEMBL148079
    • 8-O-b-D-glucoside of tyrosol
    • CHEBI:9009
    • MEGxp0_000478
    • Salidroside, analytical standard
    • ACon1_000366
    • GTPL13729
    • HY-N0109R
    • ILRCGYURZSFMEG-RKQHYHRCSA-N
    • GLXC-03926
    • HMS3884N15
    • p-hydroxyphenethyl-beta-d-glucoside
    • HY-N0109
    • MSK40052
    • tyrosol 8-O-beta-D-glucopyranoside
    • Tox21_113565
    • BDBM50269651
    • NSC741643
    • s2396
    • 4-hydroxyphenyl-2-ethylglucopyranoside
    • AKOS015895134
    • Tox21_113565_1
    • AC-6071
    • CCG-267467
    • CS-5300
    • EBC-432047
    • MS15592
    • NSC 741643
    • Salidroside, >=95% (LC/MS-ELSD)
    • NCGC00169145-01
    • NCGC00169145-03
    • SMR001294679
    • SY067815
    • SW219124-1
    • 2-(4-Hydroxyphenyl)ethyl-b-D-glucopyranoside
    • C06046
    • p-Hydroxyphenethyl alcohol 1-O-beta-D-glucoside
    • 338S519
    • F223339
    • Q7404463
    • TYROSOL .ALPHA.-(.BETA.-D-GLUCOPYRANOSIDE)
    • BRD-K66030860-001-01-0
    • BRD-K66030860-001-03-6
    • BRD-K66030860-001-04-4
    • Salidroside, primary pharmaceutical reference standard
    • 2-(p-hydroxyphenyl)-ethanol 1-O-beta-D-glucopyranoside
    • 2-(4-HYDROXYPHENYL)ETHYL-.BETA.-D-GLUCOPYRANOSIDE
    • SALIDROSIDE (CONSTITUENT OF RHODIOLA ROSEA) [DSC]
    • .BETA.-D-GLUCOPYRANOSIDE, 2-(4-HYDROXYPHENYL)ETHYL-
    • Salidroside, United States Pharmacopeia (USP) Reference Standard
    • (2R,3R,4S,5S,6R)-2-[2-(4-hydroxyphenyl)ethoxy]-6-methylol-tetrahydropyran-3,4,5-triol
    • 10338-51-9

  • Applications

    Salidroside (CAS 10338-51-9) is a plant glycoside primarily used in product development as a bioactive lead in nutraceuticals and dietary supplements, often as an active component in Rhodiola-based extracts. It is also investigated for cosmetic applications as a botanical active with antioxidant activity and potential anti-inflammatory effects, supporting skincare and personal care formulations featuring plant-derived ingredients. In pharmaceutical and biomedical research, salidroside is studied as a bioactive compound and tool for understanding stress-response pathways and natural product drug discovery. It also serves as a reference standard for analytical quality control of Rhodiola-derived products, supporting methods such as HPLC and LC-MS.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.98
    methanol 59.41
    isopropanol 6.11
    water 43.66
    ethyl acetate 3.31
    n-propanol 6.36
    acetone 7.22
    n-butanol 21.66
    acetonitrile 3.26
    DMF 80.34
    toluene 1.48
    isobutanol 2.7
    1,4-dioxane 16.9
    methyl acetate 1.58
    THF 27.92
    2-butanone 2.51
    n-pentanol 2.7
    sec-butanol 4.62
    n-hexane 0.13
    ethylene glycol 104.76
    NMP 34.33
    cyclohexane 1.23
    DMSO 706.91
    n-butyl acetate 0.51
    n-octanol 2.6
    chloroform 0.32
    n-propyl acetate 0.57
    acetic acid 44.2
    dichloromethane 0.37
    cyclohexanone 7.26
    propylene glycol 43.12
    isopropyl acetate 2.23
    DMAc 78.45
    2-ethoxyethanol 48.88
    isopentanol 8.74
    n-heptane 0.66
    ethyl formate 2.58
    1,2-dichloroethane 0.93
    n-hexanol 2.87
    2-methoxyethanol 185.58
    isobutyl acetate 0.31
    tetrachloromethane 0.29
    n-pentyl acetate 1.14
    transcutol 60.01
    n-heptanol 3.4
    ethylbenzene 0.53
    MIBK 3.4
    2-propoxyethanol 19.68
    tert-butanol 8.33
    MTBE 1.72
    2-butoxyethanol 12.01
    propionic acid 6.58
    o-xylene 1.69
    formic acid 225.23
    diethyl ether 3.28
    m-xylene 1.42
    p-xylene 0.47
    chlorobenzene 0.34
    dimethyl carbonate 6.68
    n-octane 0.41
    formamide 224.07
    cyclopentanone 10.6
    2-pentanone 5.91
    anisole 1.67
    cyclopentyl methyl ether 9.12
    gamma-butyrolactone 11.71
    1-methoxy-2-propanol 86.22
    pyridine 4.52
    3-pentanone 3.01
    furfural 14.13
    n-dodecane 0.24
    diethylene glycol 61.09
    diisopropyl ether 1.02
    tert-amyl alcohol 6.16
    acetylacetone 12.52
    n-hexadecane 0.27
    acetophenone 2.5
    methyl propionate 4.55
    isopentyl acetate 0.67
    trichloroethylene 1.19
    n-nonanol 2.86
    cyclohexanol 12.54
    benzyl alcohol 4.03
    2-ethylhexanol 1.48
    isooctanol 2.53
    dipropyl ether 2.49
    1,2-dichlorobenzene 0.43
    ethyl lactate 4.25
    propylene carbonate 3.54
    n-methylformamide 34.44
    2-pentanol 6.84
    n-pentane 0.34
    1-propoxy-2-propanol 10.59
    1-methoxy-2-propyl acetate 4.28
    2-(2-methoxypropoxy) propanol 13.68
    mesitylene 1.08
    ε-caprolactone 6.18
    p-cymene 0.74
    epichlorohydrin 9.24
    1,1,1-trichloroethane 0.36
    2-aminoethanol 67.09
    morpholine-4-carbaldehyde 54.13
    sulfolane 53.0
    2,2,4-trimethylpentane 0.17
    2-methyltetrahydrofuran 6.22
    n-hexyl acetate 1.74
    isooctane 0.11
    2-(2-butoxyethoxy)ethanol 21.13
    sec-butyl acetate 0.5
    tert-butyl acetate 3.2
    decalin 0.23
    glycerin 167.01
    diglyme 36.11
    acrylic acid 12.87
    isopropyl myristate 1.03
    n-butyric acid 11.32
    acetyl acetate 2.91
    di(2-ethylhexyl) phthalate 1.9
    ethyl propionate 1.02
    nitromethane 43.23
    1,2-diethoxyethane 4.58
    benzonitrile 1.18
    trioctyl phosphate 1.58
    1-bromopropane 0.45
    gamma-valerolactone 26.04
    n-decanol 2.27
    triethyl phosphate 1.51
    4-methyl-2-pentanol 2.8
    propionitrile 1.46
    vinylene carbonate 3.32
    1,1,2-trichlorotrifluoroethane 32.27
    DMS 2.38
    cumene 0.43
    2-octanol 1.78
    2-hexanone 0.97
    octyl acetate 1.51
    limonene 1.27
    1,2-dimethoxyethane 25.58
    ethyl orthosilicate 1.52
    tributyl phosphate 1.28
    diacetone alcohol 17.25
    N,N-dimethylaniline 2.27
    acrylonitrile 2.73
    aniline 3.93
    1,3-propanediol 120.37
    bromobenzene 0.25
    dibromomethane 0.28
    1,1,2,2-tetrachloroethane 1.7
    2-methyl-cyclohexyl acetate 1.28
    tetrabutyl urea 2.77
    diisobutyl methanol 1.61
    2-phenylethanol 3.14
    styrene 0.45
    dioctyl adipate 2.21
    dimethyl sulfate 19.3
    ethyl butyrate 0.97
    methyl lactate 21.29
    butyl lactate 3.05
    diethyl carbonate 0.77
    propanediol butyl ether 14.86
    triethyl orthoformate 1.65
    p-tert-butyltoluene 0.83
    methyl 4-tert-butylbenzoate 6.63
    morpholine 26.45
    tert-butylamine 2.25
    n-dodecanol 1.76
    dimethoxymethane 41.9
    ethylene carbonate 2.71
    cyrene 19.06
    2-ethoxyethyl acetate 2.86
    2-ethylhexyl acetate 0.47
    1,2,4-trichlorobenzene 0.7
    4-methylpyridine 2.63
    dibutyl ether 1.5
    2,6-dimethyl-4-heptanol 1.61
    DEF 16.42
    dimethyl isosorbide 18.63
    tetrachloroethylene 1.85
    eugenol 7.56
    triacetin 4.86
    span 80 10.67
    1,4-butanediol 21.52
    1,1-dichloroethane 0.26
    2-methyl-1-pentanol 2.22
    methyl formate 17.74
    2-methyl-1-butanol 6.28
    n-decane 0.44
    butyronitrile 2.28
    3,7-dimethyl-1-octanol 2.08
    1-chlorooctane 0.81
    1-chlorotetradecane 0.4
    n-nonane 0.4
    undecane 0.31
    tert-butylcyclohexane 0.12
    cyclooctane 0.71
    cyclopentanol 9.09
    tetrahydropyran 7.62
    tert-amyl methyl ether 2.59
    2,5,8-trioxanonane 33.86
    1-hexene 0.25
    2-isopropoxyethanol 14.69
    2,2,2-trifluoroethanol 25.26
    methyl butyrate 1.39

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction