(S)-(+)-1-Aminopropan-2-ol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    2799-17-9

    Molecular formula
    C3H9NO

    SMILES
    C[C@@H](CN)O

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Fishy 65.61%
    Odorless 39.97%
    Cheesy 34.17%
    Ripe 27.54%
    Sweet 20.92%
    Alcoholic 20.01%
    Meaty 19.58%
    Savory 18.86%
    Oily 18.68%
    Pungent 16.21%

     

    Flavor
    Odorless 40.24%
    Fishy 37.09%
    Sulfurous 30.88%
    Onion 26.87%
    Ammoniacal 22.75%
    Mild 22.7%
    Very slight 21.72%
    Meaty 21.34%
    Sulfury 20.95%
    Sweet-like 20.16%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    -1.0

    pKa est.
    7.17 (neutral)

    Molecular weight
    75.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Melting point expt.

    • 24-26 °C

    Boiling point

    • 160 °C

    Flash point

    • 70.93 ˚C est.

    Solubility expt.

    • 1000000 mg/L

  • Synonyms

    • (S)-(+)-1-Amino-2-propanol
    • 2-Propanol, 1-amino-, (2S)-
    • (S)-(+)-1-Aminopropan-2-ol
    • EINECS 220-533-4
    • F-LOOP OF VITAMIN B12
    • RefChem:407584
    • (+)-1-Amino-2-propanol
    • (2S)-2-hydroxypropan-1-aminium
    • 220-533-4
    • 2799-17-9
    • (S)-1-aminopropan-2-ol
    • (S)-1-Amino-2-propanol
    • MFCD00064429
    • (+)-Isopropanolamine
    • (S)-(+)-Isopropanolamine
    • 1-Amino-2-propanol #
    • s-(+)-1-amino-2-propanol
    • (2S)-1-amino-2-propanol
    • 2-Propanol, 1-amino-, (S)-
    • s-1-amino-2-propanol
    • (S)-2-hyroxypropylamine
    • (S)-2-hydroxypropylamine
    • (S)-1-amino 2-propanol
    • (S)-2-hydroxy-propylamine
    • SCHEMBL54903
    • (25)-1-amino-2-propanol
    • (25)-1-aminopropan-2-ol
    • (S)-1-Amino-propan-2-ol
    • (S)-1-amino-propane-2-ol
    • SCHEMBL749824
    • (S)-1-amino- propan-2-ol
    • SCHEMBL6691343
    • SCHEMBL6777789
    • (+)-(S)-1-amino-2-propanol
    • (S)-1-(aminomethyl)ethan-1-ol
    • DTXSID201366435
    • (2S)-(+)-1-Aminopropan-2-ol
    • (S)-1-Amino-2-propanol, 99%
    • STR07322
    • EBC-47534
    • AKOS015854566
    • CS-W019029
    • (S)-(+)-1-Amino-2-propanol, 97%
    • A0975
    • NS00082939
    • EN300-84476
    • 799A179
    • F079460
    • Z1203577967
    • (S)-(+)-1-Amino-2-propanol, purum, >=98.0% (sum of enantiomers, GC)
    • 2799-17-9

  • Applications

    (S)-(+)-1-Aminopropan-2-ol is a chiral amino alcohol widely used as a pharmaceutical synthesis building block and a scaffold for enantioenriched amino-alcohol derivatives. In practice, it is employed to install beta-amino alcohol motifs in drug-like molecules and is often used as a starting material for enantioselective reactions, for example in reductive amination sequences or functional-group transformations. It is also viewed as a precursor for the synthesis of agrochemicals and other bioactive compounds bearing the amino-alcohol moiety. Additionally, it may be used in research and development to prepare more complex chiral molecules, participating in various synthetic routes and transformation steps.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 63.04
    methanol 192.73
    isopropanol 18.77
    water 2500.52
    ethyl acetate 6.07
    n-propanol 37.77
    acetone 9.05
    n-butanol 24.94
    acetonitrile 12.91
    DMF 66.56
    toluene 0.91
    isobutanol 20.72
    1,4-dioxane 9.57
    methyl acetate 7.41
    THF 21.45
    2-butanone 7.16
    n-pentanol 11.24
    sec-butanol 17.85
    n-hexane 0.82
    ethylene glycol 243.46
    NMP 117.46
    cyclohexane 1.2
    DMSO 57.09
    n-butyl acetate 6.16
    n-octanol 4.94
    chloroform 5.93
    n-propyl acetate 4.02
    acetic acid 387.54
    dichloromethane 4.55
    cyclohexanone 16.63
    propylene glycol 161.25
    isopropyl acetate 3.33
    DMAc 55.44
    2-ethoxyethanol 39.77
    isopentanol 13.42
    n-heptane 1.43
    ethyl formate 21.35
    1,2-dichloroethane 2.29
    n-hexanol 14.67
    2-methoxyethanol 101.99
    isobutyl acetate 2.48
    tetrachloromethane 4.56
    n-pentyl acetate 4.46
    transcutol 40.51
    n-heptanol 9.97
    ethylbenzene 0.57
    MIBK 2.97
    2-propoxyethanol 41.56
    tert-butanol 14.88
    MTBE 3.08
    2-butoxyethanol 31.28
    propionic acid 106.21
    o-xylene 1.39
    formic acid 927.6
    diethyl ether 2.65
    m-xylene 1.1
    p-xylene 1.06
    chlorobenzene 1.94
    dimethyl carbonate 4.97
    n-octane 0.46
    formamide 362.65
    cyclopentanone 30.58
    2-pentanone 5.44
    anisole 2.01
    cyclopentyl methyl ether 8.66
    gamma-butyrolactone 48.62
    1-methoxy-2-propanol 41.56
    pyridine 9.11
    3-pentanone 4.33
    furfural 58.03
    n-dodecane 0.27
    diethylene glycol 82.23
    diisopropyl ether 0.97
    tert-amyl alcohol 17.39
    acetylacetone 6.57
    n-hexadecane 0.26
    acetophenone 3.8
    methyl propionate 7.92
    isopentyl acetate 4.6
    trichloroethylene 5.63
    n-nonanol 4.35
    cyclohexanol 19.59
    benzyl alcohol 7.92
    2-ethylhexanol 6.81
    isooctanol 6.98
    dipropyl ether 3.41
    1,2-dichlorobenzene 2.0
    ethyl lactate 10.72
    propylene carbonate 23.12
    n-methylformamide 103.56
    2-pentanol 8.42
    n-pentane 0.88
    1-propoxy-2-propanol 23.84
    1-methoxy-2-propyl acetate 7.48
    2-(2-methoxypropoxy) propanol 16.35
    mesitylene 0.88
    ε-caprolactone 21.14
    p-cymene 1.43
    epichlorohydrin 14.15
    1,1,1-trichloroethane 2.19
    2-aminoethanol 239.39
    morpholine-4-carbaldehyde 65.49
    sulfolane 71.09
    2,2,4-trimethylpentane 0.71
    2-methyltetrahydrofuran 13.05
    n-hexyl acetate 4.54
    isooctane 0.33
    2-(2-butoxyethoxy)ethanol 25.14
    sec-butyl acetate 2.22
    tert-butyl acetate 3.21
    decalin 0.51
    glycerin 307.47
    diglyme 28.95
    acrylic acid 142.92
    isopropyl myristate 1.52
    n-butyric acid 78.73
    acetyl acetate 5.78
    di(2-ethylhexyl) phthalate 4.87
    ethyl propionate 3.45
    nitromethane 106.98
    1,2-diethoxyethane 3.64
    benzonitrile 5.03
    trioctyl phosphate 3.86
    1-bromopropane 1.29
    gamma-valerolactone 52.14
    n-decanol 3.0
    triethyl phosphate 3.9
    4-methyl-2-pentanol 4.33
    propionitrile 8.54
    vinylene carbonate 21.08
    1,1,2-trichlorotrifluoroethane 74.48
    DMS 3.92
    cumene 0.74
    2-octanol 3.9
    2-hexanone 3.2
    octyl acetate 2.91
    limonene 2.25
    1,2-dimethoxyethane 15.58
    ethyl orthosilicate 3.9
    tributyl phosphate 4.02
    diacetone alcohol 13.82
    N,N-dimethylaniline 2.56
    acrylonitrile 15.2
    aniline 8.09
    1,3-propanediol 146.31
    bromobenzene 1.08
    dibromomethane 2.86
    1,1,2,2-tetrachloroethane 4.96
    2-methyl-cyclohexyl acetate 4.77
    tetrabutyl urea 5.41
    diisobutyl methanol 2.79
    2-phenylethanol 7.22
    styrene 0.7
    dioctyl adipate 3.34
    dimethyl sulfate 12.24
    ethyl butyrate 4.91
    methyl lactate 27.43
    butyl lactate 12.06
    diethyl carbonate 2.99
    propanediol butyl ether 32.61
    triethyl orthoformate 4.67
    p-tert-butyltoluene 1.38
    methyl 4-tert-butylbenzoate 8.35
    morpholine 21.34
    tert-butylamine 6.58
    n-dodecanol 2.19
    dimethoxymethane 10.7
    ethylene carbonate 15.25
    cyrene 27.43
    2-ethoxyethyl acetate 5.69
    2-ethylhexyl acetate 3.63
    1,2,4-trichlorobenzene 2.64
    4-methylpyridine 6.31
    dibutyl ether 1.75
    2,6-dimethyl-4-heptanol 2.79
    DEF 15.14
    dimethyl isosorbide 20.06
    tetrachloroethylene 8.79
    eugenol 13.59
    triacetin 7.25
    span 80 22.5
    1,4-butanediol 58.47
    1,1-dichloroethane 1.75
    2-methyl-1-pentanol 8.05
    methyl formate 51.75
    2-methyl-1-butanol 17.58
    n-decane 0.43
    butyronitrile 8.35
    3,7-dimethyl-1-octanol 3.63
    1-chlorooctane 0.9
    1-chlorotetradecane 0.44
    n-nonane 0.43
    undecane 0.32
    tert-butylcyclohexane 0.48
    cyclooctane 0.58
    cyclopentanol 37.28
    tetrahydropyran 6.36
    tert-amyl methyl ether 3.6
    2,5,8-trioxanonane 24.87
    1-hexene 1.35
    2-isopropoxyethanol 17.34
    2,2,2-trifluoroethanol 191.09
    methyl butyrate 6.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction