Rhamnetin

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  • Identifiers

    CAS number
    90-19-7

    Molecular formula
    C16H12O7

    SMILES
    COC1=CC(=C2C(=C1)OC(=C(C2=O)O)C3=CC(=C(C=C3)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 59.32%
    Odorless 55.08%
    Burnt 40.54%
    Smoky 30.25%
    Vanilla 26.93%
    Spicy 26.71%
    Medicinal 25.24%
    Balsamic 23.73%
    Savory 20.24%
    Dry 19.71%

     

    Flavor
    Bitter 92.72%
    Odorless 24.92%
    Bland 22.84%
    Sweet-like 21.94%
    Eugenol 20.68%
    Cedarleaf 20.39%
    Parsley 20.33%
    Very strong 19.84%
    Lovage 19.8%
    Indole 19.63%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    10.18 (weak base)

    Molecular weight
    316.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    971°C

    Flash point

    • 242.51 ˚C est.

  • Synonyms

    • Rhamnetin
    • 90-19-7
    • beta-Rhamnocitrin
    • 7-Methoxyquercetin
    • 7-O-Methylquercetin
    • Quercetin 7-methyl ether
    • 7-Methylquercetin
    • 3,3',4',5-Tetrahydroxy-7-methoxyflavone
    • 3,5,3',4'-Tetrahydroxy-7-methoxyflavone
    • 2-(3,4-Dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1-benzopyran-4-one
    • 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxychromen-4-one
    • 3,5,3',4'-Tetrahydroxy-7-methoxyflaone
    • DTXSID40237979
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-
    • Flavone, 3,3',4',5-tetrahydroxy-7-methoxy-
    • NSC-19802
    • 71803L5F4S
    • FLAVONE, 7-METHOXY-3,3',4',5-TETRAHYDROXY-
    • CHEBI:74992
    • 7-methoxy-quercetin
    • RefChem:882910
    • DTXCID40160470
    • 2-(3,4-Dihydroxy-phenyl)-3,5-dihydroxy-7-methoxy-chromen-4-one
    • 201-974-1
    • 7-O-Methyl Quercetin
    • 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-chromen-4-one
    • .beta.-Rhamnocitrin
    • C.I. 75690
    • NSC19802
    • CHEMBL312163
    • 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-chromen-4-one
    • MFCD00016931
    • 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-y-methoxy-4H-1-benzopyran-4-one
    • NSC 19802
    • CCRIS 3792
    • EINECS 201-974-1
    • BRN 0047741
    • rhamentin
    • UNII-71803L5F4S
    • Rhamnetin (Standard)
    • Spectrum_001185
    • SpecPlus_000463
    • RHAMNETIN [MI]
    • quercetin-7-methyl ether
    • Spectrum2_000642
    • Spectrum3_001343
    • Spectrum4_001872
    • Spectrum5_000464
    • BSPBio_003125
    • KBioGR_002367
    • KBioSS_001665
    • SPECTRUM310031
    • 5-18-05-00495 (Beilstein Handbook Reference)
    • DivK1c_006559
    • Rhamnetin, analytical standard
    • SCHEMBL555118
    • SPBio_000643
    • orb1297453
    • SCHEMBL29453025
    • SCHEMBL29496169
    • BDBM23410
    • HY-N7036R
    • KBio1_001503
    • KBio2_001665
    • KBio2_004233
    • KBio2_006801
    • KBio3_002345
    • Rhamnetin - Tech grade ca 50%
    • HY-N7036
    • CCG-38555
    • LMPK12112624
    • AKOS027320587
    • 3,4',5-Tetrahydroxy-7-methoxyflavone
    • CS-W014522
    • EBC-441046
    • FM25558
    • SDCCGMLS-0066624.P001
    • NCGC00095624-01
    • NCGC00095624-02
    • NCGC00095624-03
    • NCGC00178254-01
    • AS-78315
    • DA-51073
    • NCI60_001648
    • 3',3,4',5-tetrahydroxy-7-methoxyflavone
    • Flavone,3',4',5-tetrahydroxy-7-methoxy-
    • NS00015848
    • ST50331696
    • E87178
    • Q288988
    • SR-05000002269
    • SR-05000002269-2
    • BRD-K37206356-001-01-3
    • 4H-1-Benzopyran-4-one,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-
    • 7-Methoxyquercetin; 7-Methylquercetin; Quercetin 7-methyl ether; |A-Rhamnocitrin; 3,3',4',5-Tetrahydroxy 7-methoxyflavone
    • J8G
    • 90-19-7

  • Applications

    Rhamnetin (CAS 90-19-7) is a natural flavonol of interest primarily as an antioxidant component in plant-derived extracts and as a potential active in cosmetics and personal care formulations to stabilize ingredients and impart a light yellow color. It is often considered as a chemical intermediate or reference standard in pharmaceutical research and the industrial synthesis of flavonoid compounds. In food processing, Rhamnetin may be evaluated as a natural ingredient related to quality stabilization or color from botanical extracts; in coatings and inks, it can serve as a natural antioxidant additive to improve aging stability. Its applications depend on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.4
    methanol 1.42
    isopropanol 1.53
    water 0.0
    ethyl acetate 1.27
    n-propanol 2.85
    acetone 0.33
    n-butanol 2.54
    acetonitrile 0.19
    DMF 12.09
    toluene 0.04
    isobutanol 1.29
    1,4-dioxane 2.12
    methyl acetate 1.24
    THF 22.53
    2-butanone 3.44
    n-pentanol 0.95
    sec-butanol 3.36
    n-hexane 0.01
    ethylene glycol 1.53
    NMP 13.88
    cyclohexane 0.01
    DMSO 72.34
    n-butyl acetate 1.21
    n-octanol 0.79
    chloroform 0.01
    n-propyl acetate 0.81
    acetic acid 1.34
    dichloromethane 0.02
    cyclohexanone 2.98
    propylene glycol 1.78
    isopropyl acetate 0.92
    DMAc 27.43
    2-ethoxyethanol 8.53
    isopentanol 2.02
    n-heptane 0.01
    ethyl formate 0.61
    1,2-dichloroethane 0.08
    n-hexanol 0.87
    2-methoxyethanol 27.99
    isobutyl acetate 0.21
    tetrachloromethane 0.01
    n-pentyl acetate 0.91
    transcutol 11.32
    n-heptanol 0.9
    ethylbenzene 0.04
    MIBK 1.04
    2-propoxyethanol 9.89
    tert-butanol 2.35
    MTBE 1.03
    2-butoxyethanol 4.6
    propionic acid 1.47
    o-xylene 0.07
    formic acid 1.8
    diethyl ether 0.66
    m-xylene 0.04
    p-xylene 0.05
    chlorobenzene 0.02
    dimethyl carbonate 1.12
    n-octane 0.01
    formamide 4.29
    cyclopentanone 7.2
    2-pentanone 1.7
    anisole 0.4
    cyclopentyl methyl ether 2.06
    gamma-butyrolactone 7.57
    1-methoxy-2-propanol 18.55
    pyridine 1.06
    3-pentanone 1.16
    furfural 3.7
    n-dodecane 0.01
    diethylene glycol 9.1
    diisopropyl ether 0.13
    tert-amyl alcohol 4.21
    acetylacetone 1.63
    n-hexadecane 0.01
    acetophenone 0.63
    methyl propionate 2.37
    isopentyl acetate 1.14
    trichloroethylene 0.11
    n-nonanol 0.95
    cyclohexanol 1.39
    benzyl alcohol 0.54
    2-ethylhexanol 0.63
    isooctanol 0.73
    dipropyl ether 0.83
    1,2-dichlorobenzene 0.03
    ethyl lactate 1.44
    propylene carbonate 1.19
    n-methylformamide 4.28
    2-pentanol 1.52
    n-pentane 0.01
    1-propoxy-2-propanol 6.29
    1-methoxy-2-propyl acetate 3.43
    2-(2-methoxypropoxy) propanol 5.24
    mesitylene 0.03
    ε-caprolactone 3.63
    p-cymene 0.11
    epichlorohydrin 6.53
    1,1,1-trichloroethane 0.02
    2-aminoethanol 3.11
    morpholine-4-carbaldehyde 12.55
    sulfolane 25.09
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 5.41
    n-hexyl acetate 1.31
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 6.37
    sec-butyl acetate 0.6
    tert-butyl acetate 1.63
    decalin 0.01
    glycerin 7.84
    diglyme 11.56
    acrylic acid 1.3
    isopropyl myristate 0.54
    n-butyric acid 2.04
    acetyl acetate 0.31
    di(2-ethylhexyl) phthalate 0.58
    ethyl propionate 1.28
    nitromethane 2.84
    1,2-diethoxyethane 2.02
    benzonitrile 0.2
    trioctyl phosphate 0.58
    1-bromopropane 0.08
    gamma-valerolactone 13.34
    n-decanol 0.65
    triethyl phosphate 0.96
    4-methyl-2-pentanol 0.68
    propionitrile 0.62
    vinylene carbonate 0.64
    1,1,2-trichlorotrifluoroethane 6.45
    DMS 1.0
    cumene 0.04
    2-octanol 0.65
    2-hexanone 1.14
    octyl acetate 0.83
    limonene 0.18
    1,2-dimethoxyethane 11.37
    ethyl orthosilicate 0.83
    tributyl phosphate 0.67
    diacetone alcohol 7.24
    N,N-dimethylaniline 0.42
    acrylonitrile 0.92
    aniline 0.38
    1,3-propanediol 7.25
    bromobenzene 0.01
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.2
    2-methyl-cyclohexyl acetate 0.81
    tetrabutyl urea 1.26
    diisobutyl methanol 0.45
    2-phenylethanol 0.78
    styrene 0.03
    dioctyl adipate 0.96
    dimethyl sulfate 4.12
    ethyl butyrate 1.16
    methyl lactate 4.16
    butyl lactate 1.64
    diethyl carbonate 0.64
    propanediol butyl ether 3.18
    triethyl orthoformate 1.29
    p-tert-butyltoluene 0.11
    methyl 4-tert-butylbenzoate 1.69
    morpholine 8.62
    tert-butylamine 0.46
    n-dodecanol 0.42
    dimethoxymethane 7.71
    ethylene carbonate 0.56
    cyrene 4.14
    2-ethoxyethyl acetate 1.74
    2-ethylhexyl acetate 0.74
    1,2,4-trichlorobenzene 0.08
    4-methylpyridine 0.62
    dibutyl ether 0.73
    2,6-dimethyl-4-heptanol 0.45
    DEF 5.34
    dimethyl isosorbide 7.07
    tetrachloroethylene 0.12
    eugenol 2.05
    triacetin 1.36
    span 80 2.6
    1,4-butanediol 0.96
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 1.06
    methyl formate 1.52
    2-methyl-1-butanol 2.37
    n-decane 0.02
    butyronitrile 0.53
    3,7-dimethyl-1-octanol 0.66
    1-chlorooctane 0.14
    1-chlorotetradecane 0.05
    n-nonane 0.01
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 2.32
    tetrahydropyran 1.59
    tert-amyl methyl ether 1.89
    2,5,8-trioxanonane 8.1
    1-hexene 0.04
    2-isopropoxyethanol 3.51
    2,2,2-trifluoroethanol 0.62
    methyl butyrate 1.76

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction