Retinyl oleate

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  • Identifiers

    CAS number
    631-88-9

    Molecular formula
    C38H62O2

    SMILES
    CCCCCCCC/C=C\CCCCCCCC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(CCCC1(C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Floral 53.72%
    Woody 51.1%
    Waxy 47.95%
    Oily 46.47%
    Balsamic 45.58%
    Sweet 41.23%
    Green 38.12%
    Fruity 36.72%
    Fatty 33.47%
    Rose 30.62%

     

    Flavor
    Herbal 34.28%
    Balsam 31.77%
    Woody 28.1%
    Balsamic 24.39%
    Wood 24.17%
    Diterpene 22.28%
    Spicy 22.26%
    Low 22.2%
    Waxy 22.11%
    Oriental 21.77%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    13.7

    pKa est.
    -164.68 (strong acid)

    Molecular weight
    550.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    578°C

    Flash point

    • -611.22 ˚C est.

  • Synonyms

    • Retinol oleate
    • all-trans-retinyl oleate
    • Retinyl oleate
    • 631-88-9
    • O-oleoyl-all-trans-retinol
    • Retinol, (Z)-9-octadecenoate
    • 8HU01DH65P
    • Retinol, 9-octadecenoate, (Z)-
    • O(15)-[(9Z)-octadec-9-enoyl]retinol
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl (9Z)-octadec-9-enoate
    • CHEBI:70760
    • DTXSID601021962
    • O(15)-((9Z)-octadec-9-enoyl)retinol
    • RefChem:930684
    • DTXCID301506866
    • Vitamin A Oleate
    • [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] (Z)-octadec-9-enoate
    • Retinol 15-[(9Z)-9-Octadecenoate
    • UNII-8HU01DH65P
    • SCHEMBL15375758
    • all-trans-retinyl 9Z-octadecenoate
    • VAE 18:1
    • LMFA07011033
    • OLEIC ACID, ESTER WITH RETINOL
    • RETINOL, (9Z)-9-OCTADECENOATE
    • RETINOL, 15-((9Z)-9-OCTADECENOATE)
    • Q27139070
    • 631-88-9

  • Applications

    Retinyl oleate, CAS 631-88-9, is commonly used in cosmetics and personal care as a skin-conditioning emollient and a source of vitamin A in products such as creams, serums, and lip balms. As an oil-soluble carrier, it helps deliver lipophilic actives and can improve texture, spreadability, and the overall sensory feel of formulations. In topical pharmaceutical preparations, it may be used as a vitamin A ester to provide retinyl activity within lipid-based vehicles. It can also serve in hair care and color cosmetic formulations to deliver conditioning benefits and support desirable aesthetics.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 12.97
    methanol 13.16
    isopropanol 5.23
    water 0.01
    ethyl acetate 59.9
    n-propanol 18.97
    acetone 23.63
    n-butanol 22.11
    acetonitrile 5.0
    DMF 31.18
    toluene 57.59
    isobutanol 13.11
    1,4-dioxane 67.98
    methyl acetate 26.82
    THF 177.64
    2-butanone 59.27
    n-pentanol 24.0
    sec-butanol 16.33
    n-hexane 12.36
    ethylene glycol 0.23
    NMP 133.53
    cyclohexane 19.33
    DMSO 23.44
    n-butyl acetate 64.24
    n-octanol 17.48
    chloroform 225.87
    n-propyl acetate 62.03
    acetic acid 15.13
    dichloromethane 239.09
    cyclohexanone 159.66
    propylene glycol 0.94
    isopropyl acetate 50.52
    DMAc 124.39
    2-ethoxyethanol 31.41
    isopentanol 23.1
    n-heptane 8.13
    ethyl formate 19.88
    1,2-dichloroethane 117.65
    n-hexanol 20.36
    2-methoxyethanol 21.33
    isobutyl acetate 48.33
    tetrachloromethane 33.76
    n-pentyl acetate 95.58
    transcutol 194.66
    n-heptanol 22.99
    ethylbenzene 42.58
    MIBK 51.53
    2-propoxyethanol 41.22
    tert-butanol 7.9
    MTBE 41.67
    2-butoxyethanol 57.46
    propionic acid 14.13
    o-xylene 37.0
    formic acid 3.4
    diethyl ether 54.96
    m-xylene 37.81
    p-xylene 44.38
    chlorobenzene 77.06
    dimethyl carbonate 13.74
    n-octane 3.32
    formamide 5.17
    cyclopentanone 119.91
    2-pentanone 62.28
    anisole 75.24
    cyclopentyl methyl ether 101.51
    gamma-butyrolactone 102.49
    1-methoxy-2-propanol 23.15
    pyridine 91.92
    3-pentanone 64.13
    furfural 70.64
    n-dodecane 1.66
    diethylene glycol 7.46
    diisopropyl ether 17.98
    tert-amyl alcohol 23.19
    acetylacetone 59.63
    n-hexadecane 1.99
    acetophenone 77.84
    methyl propionate 44.84
    isopentyl acetate 73.54
    trichloroethylene 218.08
    n-nonanol 21.51
    cyclohexanol 30.91
    benzyl alcohol 30.69
    2-ethylhexanol 27.38
    isooctanol 25.82
    dipropyl ether 55.6
    1,2-dichlorobenzene 89.9
    ethyl lactate 17.47
    propylene carbonate 56.99
    n-methylformamide 11.16
    2-pentanol 13.8
    n-pentane 6.96
    1-propoxy-2-propanol 40.58
    1-methoxy-2-propyl acetate 72.08
    2-(2-methoxypropoxy) propanol 59.35
    mesitylene 23.06
    ε-caprolactone 166.85
    p-cymene 24.26
    epichlorohydrin 160.08
    1,1,1-trichloroethane 100.39
    2-aminoethanol 2.04
    morpholine-4-carbaldehyde 82.01
    sulfolane 129.99
    2,2,4-trimethylpentane 7.83
    2-methyltetrahydrofuran 145.07
    n-hexyl acetate 86.47
    isooctane 3.29
    2-(2-butoxyethoxy)ethanol 73.7
    sec-butyl acetate 65.36
    tert-butyl acetate 70.36
    decalin 12.95
    glycerin 1.79
    diglyme 173.99
    acrylic acid 8.7
    isopropyl myristate 29.02
    n-butyric acid 43.0
    acetyl acetate 32.82
    di(2-ethylhexyl) phthalate 29.63
    ethyl propionate 63.94
    nitromethane 24.66
    1,2-diethoxyethane 97.52
    benzonitrile 25.4
    trioctyl phosphate 17.75
    1-bromopropane 94.24
    gamma-valerolactone 175.24
    n-decanol 12.81
    triethyl phosphate 39.8
    4-methyl-2-pentanol 12.6
    propionitrile 12.0
    vinylene carbonate 49.43
    1,1,2-trichlorotrifluoroethane 63.87
    DMS 32.94
    cumene 29.51
    2-octanol 15.48
    2-hexanone 74.1
    octyl acetate 36.61
    limonene 38.45
    1,2-dimethoxyethane 88.39
    ethyl orthosilicate 50.77
    tributyl phosphate 22.19
    diacetone alcohol 45.75
    N,N-dimethylaniline 58.26
    acrylonitrile 10.42
    aniline 34.05
    1,3-propanediol 6.01
    bromobenzene 100.89
    dibromomethane 143.49
    1,1,2,2-tetrachloroethane 191.9
    2-methyl-cyclohexyl acetate 83.06
    tetrabutyl urea 35.56
    diisobutyl methanol 17.22
    2-phenylethanol 35.74
    styrene 44.7
    dioctyl adipate 52.84
    dimethyl sulfate 26.78
    ethyl butyrate 78.47
    methyl lactate 11.04
    butyl lactate 43.97
    diethyl carbonate 37.61
    propanediol butyl ether 21.94
    triethyl orthoformate 72.02
    p-tert-butyltoluene 22.33
    methyl 4-tert-butylbenzoate 84.62
    morpholine 88.97
    tert-butylamine 6.96
    n-dodecanol 8.27
    dimethoxymethane 44.25
    ethylene carbonate 44.69
    cyrene 60.91
    2-ethoxyethyl acetate 113.39
    2-ethylhexyl acetate 72.75
    1,2,4-trichlorobenzene 105.85
    4-methylpyridine 86.93
    dibutyl ether 47.86
    2,6-dimethyl-4-heptanol 17.22
    DEF 81.27
    dimethyl isosorbide 136.1
    tetrachloroethylene 115.21
    eugenol 56.97
    triacetin 79.23
    span 80 53.06
    1,4-butanediol 2.54
    1,1-dichloroethane 76.17
    2-methyl-1-pentanol 37.14
    methyl formate 8.58
    2-methyl-1-butanol 27.07
    n-decane 4.45
    butyronitrile 18.03
    3,7-dimethyl-1-octanol 22.04
    1-chlorooctane 23.33
    1-chlorotetradecane 6.53
    n-nonane 3.91
    undecane 2.49
    tert-butylcyclohexane 10.58
    cyclooctane 7.15
    cyclopentanol 19.81
    tetrahydropyran 138.7
    tert-amyl methyl ether 59.34
    2,5,8-trioxanonane 94.29
    1-hexene 35.6
    2-isopropoxyethanol 29.6
    2,2,2-trifluoroethanol 4.74
    methyl butyrate 82.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction