Retinol

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  • Identifiers

    CAS number
    68-26-8

    Molecular formula
    C20H30O

    SMILES
    CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Woody 67.79%
    Floral 66.69%
    Sweet 61.47%
    Balsamic 50.57%
    Fruity 49.71%
    Powdery 43.77%
    Tropical 43.67%
    Berry 42.75%
    Violet 35.38%
    Waxy 34.53%

     

    Flavor
    Balsam 42.74%
    Sweet 39.1%
    Balsamic 31.99%
    Spicy 31.6%
    Woody 31.08%
    Herbal 28.62%
    Citrus 28.07%
    Wood 27.73%
    Oriental 24.59%
    Floral 23.41%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    5.7

    pKa est.
    8.59 (weak base)

    Molecular weight
    286.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 144 to 147 °F (NTP, 1992)
    • 63.5 °C
    • 62-64 °C
    • Pale yellow prismatic crystals from methanol; mp: 57-58 °C; UV max (ethanol): 326 nm (E=1,550, 1%, 1 cm) /Retinol acetate/
    • Amorphous or crystalline; mp: 28-29 °C; UV max (ethanol); 325-328 nm (E=975, 1%, 1 cm) /Retinol palmitate/
    • 61 - 63 °C

    Boiling point

    • 279 to 280 °F at 1e-06 mmHg (NTP, 1992)
    • 137-138 °C at 1X10-6 mm Hg

    Flash point

    • 179.66 ˚C est.

    Solubility expt.

    • Practically insoluble (NTP, 1992)
    • 0.671 mg/L
    • Practically insoluble in water or glycerol; soluble in absolute alcohol, methanol, chloroform, ether, fats and oils
    • Sol in ethanol and acetone and benzene

  • Synonyms

    • retinol
    • all-trans-Retinol
    • 68-26-8
    • trans-retinol
    • Veroftal
    • Agoncal
    • Bentavit A
    • Homagenets Aoral
    • Sehkraft A
    • Testavol S
    • all-trans-Vitamin A
    • All-trans retinol
    • Super A
    • Axerophtholum
    • Wachstumsvitamin
    • Vitaminum A
    • Vitamine A
    • Retinolo
    • Retinolum
    • Retinol, all trans-
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
    • Ro-a-vit
    • Antixerophthalmisches Vitamin
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
    • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
    • G2SH0XKK91
    • NSC-122759
    • DTXSID3023556
    • DTXCID203556
    • CHEBI:17336
    • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraen-1-ol
    • All Trans Retinol
    • CHEBI:50211
    • Nepalm
    • RerinolCream
    • Recovery Cream
    • Surfree Firming
    • Firming Cream
    • Highy-Stable
    • Neck Firming
    • Pure Retinol
    • Anti-aging cream
    • Bean Moisturizing
    • Vitamin A 1
    • CVC Retinol collagen
    • Ultra Brightening Fade
    • RefChem:6198
    • Anti Wrinkle Eye Cream
    • RETINOL VITAMIN E
    • retinolum densatum oleosum
    • Moisturizing Anti-Aging Cream
    • LANIMPRESS Anti-aging cream
    • A11CA01
    • D10AD02
    • R01AX02
    • S01XA02
    • LANIMPRESS Dark Anti-aging cream
    • 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraen-1-ol
    • Retinol cream for face moisturizer face cream
    • 3,7-Dimethyl-9-(2,6, 6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
    • 200-683-7
    • Vitamin A
    • Vitamin A1
    • Alphalin
    • Chocola A
    • Apostavit
    • Axerophthol
    • Epiteliol
    • Prepalin
    • Testavol
    • Agiolan
    • Apexol
    • Avibon
    • Avitol
    • Axerol
    • Vaflol
    • Vitpex
    • Aoral
    • Vogan
    • Vitamin A alcohol
    • Anatola A
    • A-Mulsal
    • Alphasterol
    • Aquasynth
    • Biosterol
    • Ophthalamin
    • Vi-Alpha
    • 11103-57-4
    • Anatola
    • Myvpack
    • Dofsol
    • Disatabs Tabs
    • Oleovitamin A
    • Lard Factor
    • all-trans-Retinyl alcohol
    • Dohyfral A
    • Vitamin A1 alcohol
    • A-Sol
    • Alcovit A
    • Vogan-Neu
    • Plivit A
    • A-Vitan
    • ATAV
    • Atars
    • Vafol
    • all-trans-Vitamin A alcohol
    • Retrovitamin A
    • Hi-A-Vita
    • Nio-A-Let
    • A-Vi-Pel
    • ACON
    • Anti-infective vitamin
    • Solu-A
    • Vio-A
    • Antixerophthalmic vitamin
    • Vitavel A
    • Thalasphere
    • beta-Retinol
    • all-trans-Vitamin A1
    • trans-Vitamin A alcohol
    • Vitamin A alcohol, all-trans-
    • Vitamin A1, all-trans-
    • MFCD00001552
    • .beta.-Retinol
    • Vitamin A1 alcohol, all-trans-
    • C20H30O
    • 68-26-8

  • Applications

    Retinol (CAS 68-26-8) is used across several industries as an essential vitamin A alcohol and a versatile intermediate. In cosmetics and personal care, it is formulated into serums and creams for skin conditioning and anti-aging applications. In pharmaceutical contexts, it serves as a precursor in the synthesis of retinoids and related dermatological actives. In nutrition and food processing, retinol is used as a dietary supplement ingredient and, where permitted, as a vitamin A fortificant. In industrial manufacturing, it functions as an intermediate in the production of retinoid derivatives and related chemical syntheses. In agriculture, retinol derivatives can be included in animal feeds as a vitamin A source. Usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 215.61
    methanol 144.15
    isopropanol 90.08
    water 0.03
    ethyl acetate 157.85
    n-propanol 176.26
    acetone 63.54
    n-butanol 201.23
    acetonitrile 25.51
    DMF 59.88
    toluene 146.8
    isobutanol 85.41
    1,4-dioxane 335.06
    methyl acetate 66.43
    THF 585.7
    2-butanone 122.97
    n-pentanol 124.38
    sec-butanol 110.68
    n-hexane 23.61
    ethylene glycol 2.48
    NMP 53.0
    cyclohexane 40.75
    DMSO 38.59
    n-butyl acetate 168.39
    n-octanol 44.27
    chloroform 244.1
    n-propyl acetate 95.19
    acetic acid 24.04
    dichloromethane 187.15
    cyclohexanone 165.73
    propylene glycol 10.14
    isopropyl acetate 103.17
    DMAc 90.54
    2-ethoxyethanol 123.67
    isopentanol 135.71
    n-heptane 25.95
    ethyl formate 43.98
    1,2-dichloroethane 119.0
    n-hexanol 173.8
    2-methoxyethanol 155.76
    isobutyl acetate 81.26
    tetrachloromethane 29.31
    n-pentyl acetate 85.44
    transcutol 634.34
    n-heptanol 64.72
    ethylbenzene 63.01
    MIBK 99.23
    2-propoxyethanol 217.65
    tert-butanol 100.1
    MTBE 217.74
    2-butoxyethanol 117.99
    propionic acid 23.04
    o-xylene 60.18
    formic acid 7.37
    diethyl ether 398.8
    m-xylene 90.45
    p-xylene 58.75
    chlorobenzene 79.61
    dimethyl carbonate 17.14
    n-octane 6.97
    formamide 12.93
    cyclopentanone 128.01
    2-pentanone 148.25
    anisole 125.29
    cyclopentyl methyl ether 209.49
    gamma-butyrolactone 83.15
    1-methoxy-2-propanol 133.78
    pyridine 177.33
    3-pentanone 96.79
    furfural 74.99
    n-dodecane 3.9
    diethylene glycol 51.02
    diisopropyl ether 76.36
    tert-amyl alcohol 100.84
    acetylacetone 79.57
    n-hexadecane 4.53
    acetophenone 78.45
    methyl propionate 82.45
    isopentyl acetate 157.31
    trichloroethylene 175.25
    n-nonanol 48.61
    cyclohexanol 92.05
    benzyl alcohol 63.74
    2-ethylhexanol 103.66
    isooctanol 57.11
    dipropyl ether 216.25
    1,2-dichlorobenzene 66.52
    ethyl lactate 27.13
    propylene carbonate 50.83
    n-methylformamide 25.99
    2-pentanol 100.86
    n-pentane 25.18
    1-propoxy-2-propanol 166.26
    1-methoxy-2-propyl acetate 164.06
    2-(2-methoxypropoxy) propanol 123.61
    mesitylene 52.94
    ε-caprolactone 137.92
    p-cymene 48.53
    epichlorohydrin 183.08
    1,1,1-trichloroethane 91.18
    2-aminoethanol 18.39
    morpholine-4-carbaldehyde 117.28
    sulfolane 65.24
    2,2,4-trimethylpentane 12.97
    2-methyltetrahydrofuran 327.74
    n-hexyl acetate 107.47
    isooctane 11.52
    2-(2-butoxyethoxy)ethanol 186.56
    sec-butyl acetate 91.25
    tert-butyl acetate 125.62
    decalin 16.25
    glycerin 12.95
    diglyme 328.21
    acrylic acid 10.69
    isopropyl myristate 47.29
    n-butyric acid 90.82
    acetyl acetate 50.73
    di(2-ethylhexyl) phthalate 44.06
    ethyl propionate 85.01
    nitromethane 31.99
    1,2-diethoxyethane 302.89
    benzonitrile 51.37
    trioctyl phosphate 27.01
    1-bromopropane 147.47
    gamma-valerolactone 194.44
    n-decanol 34.52
    triethyl phosphate 49.7
    4-methyl-2-pentanol 59.3
    propionitrile 51.16
    vinylene carbonate 43.81
    1,1,2-trichlorotrifluoroethane 57.04
    DMS 47.92
    cumene 43.62
    2-octanol 35.11
    2-hexanone 108.07
    octyl acetate 55.52
    limonene 71.17
    1,2-dimethoxyethane 290.19
    ethyl orthosilicate 63.44
    tributyl phosphate 33.31
    diacetone alcohol 94.06
    N,N-dimethylaniline 86.04
    acrylonitrile 33.14
    aniline 84.44
    1,3-propanediol 54.32
    bromobenzene 87.64
    dibromomethane 144.06
    1,1,2,2-tetrachloroethane 148.69
    2-methyl-cyclohexyl acetate 111.21
    tetrabutyl urea 44.43
    diisobutyl methanol 53.7
    2-phenylethanol 104.68
    styrene 66.22
    dioctyl adipate 69.09
    dimethyl sulfate 17.71
    ethyl butyrate 141.33
    methyl lactate 19.21
    butyl lactate 51.69
    diethyl carbonate 64.45
    propanediol butyl ether 60.96
    triethyl orthoformate 109.56
    p-tert-butyltoluene 50.22
    methyl 4-tert-butylbenzoate 90.25
    morpholine 462.99
    tert-butylamine 81.78
    n-dodecanol 24.66
    dimethoxymethane 156.71
    ethylene carbonate 41.01
    cyrene 72.1
    2-ethoxyethyl acetate 132.48
    2-ethylhexyl acetate 133.75
    1,2,4-trichlorobenzene 74.85
    4-methylpyridine 160.64
    dibutyl ether 96.04
    2,6-dimethyl-4-heptanol 53.7
    DEF 123.75
    dimethyl isosorbide 195.45
    tetrachloroethylene 87.13
    eugenol 82.06
    triacetin 82.12
    span 80 101.28
    1,4-butanediol 14.32
    1,1-dichloroethane 93.75
    2-methyl-1-pentanol 109.05
    methyl formate 13.98
    2-methyl-1-butanol 126.74
    n-decane 9.14
    butyronitrile 102.79
    3,7-dimethyl-1-octanol 54.51
    1-chlorooctane 38.65
    1-chlorotetradecane 12.83
    n-nonane 8.25
    undecane 5.62
    tert-butylcyclohexane 17.87
    cyclooctane 13.7
    cyclopentanol 54.12
    tetrahydropyran 515.31
    tert-amyl methyl ether 148.44
    2,5,8-trioxanonane 203.86
    1-hexene 97.07
    2-isopropoxyethanol 93.51
    2,2,2-trifluoroethanol 4.65
    methyl butyrate 99.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction