Resorcinol

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  • Identifiers

    CAS number
    108-46-3

    Molecular formula
    C6H6O2

    SMILES
    C1=CC(=CC(=C1)O)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 85.9%
    Medicinal 56.91%
    Nutty 46.47%
    Burnt 42.56%
    Smoky 40.62%
    Musty 37.59%
    Animal 30.1%
    Woody 29.98%
    Odorless 27.68%
    Leathery 27.64%

     

    Flavor
    Phenolic 71.88%
    Nutty 53.34%
    Musty 43.19%
    Medicinal 36.97%
    Medical 35.92%
    Creamy 33.43%
    Bitter 32.95%
    Smoke 32.81%
    Phenol 32.16%
    Leather 30.4%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor threshold concentration (detection): 6.0 mg/L

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    10.8 (weak base)

    Molecular weight
    110.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 228 to 232 °F (NTP, 1992)
    • 109.8 °C
    • Heat of fusion at mp: 21.0 kJ/mol; Heat of vaporization (kJ/mol): 78.2 at 110 °C, 75.2 at 150 °C, 72.0 at 190 °C
    • 111 °C
    • 110 °C
    • 228-232 °F
    • 228 °F

    Boiling point

    • 531 to 536 °F at 760 mmHg (NTP, 1992)
    • 280 °C, but volatilizes at lower temperature and is slightly volatile with steam
    • 178.00 °C. @ 16.00 mm Hg
    • 280 °C
    • 531 °F

    Flash point

    • 125.84 ˚C est.
    • 261 °F (NTP, 1992)
    • 261 °F
    • 261 °F (Closed cup)
    • 127 °C (261 °F) (Closed cup)
    • 261 °F (127 °C) (Closed cup)
    • 127 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 65.3 °F (NTP, 1992)
    • In water, 7.17X10+5 mg/L at 25 °C
    • 1 g dissolves in 0.9 mL water at room temperature, 0.2 mL water at 80 °C
    • 1 g dissolves in 0.9 mL alcohol; freely soluble in ether, glycerol; slightly soluble in chloroform
    • Very soluble in carbon tetrachloride; soluble in ethanol, ethyl ether; slightly soluble in benzene, chloroform
    • Soluble in DMSO /dimethyl sulfoxide/, acetone at greater than or equal to 100 mg/mL at 18 °C
    • 717 mg/mL at 25 °C
    • Solubility in water, g/100ml: 140
    • soluble in water
    • moderately soluble (in ethanol)
    • 110%

  • Synonyms

    • resorcinol
    • 108-46-3
    • benzene-1,3-diol
    • 1,3-Benzenediol
    • 1,3-Dihydroxybenzene
    • Resorcin
    • m-Hydroquinone
    • m-Hydroxyphenol
    • m-Dihydroxybenzene
    • 3-Hydroxyphenol
    • Resorcine
    • m-Benzenediol
    • m-Dioxybenzene
    • Dihydroxybenzol
    • Resorzin
    • Developer O
    • Developer R
    • Developer RS
    • Fouramine RS
    • Fourrine EW
    • Pelagol RS
    • Pelagol Grey RS
    • Resorcinolum
    • Fourrine 79
    • Nako TGG
    • Durafur developer G
    • C.I. Oxidation Base 31
    • Phenol, m-hydroxy-
    • C.I. Developer 4
    • Benzene, m-dihydroxy-
    • Rcra waste number U201
    • Benzene, 1,3-dihydroxy-
    • 3-Hydroxycyclohexadien-1-one
    • FEMA No. 3589
    • Acnomel
    • Resorcinum
    • Rezamid
    • Sulforcin
    • Resorcinol (USP)
    • NCI-C05970
    • NSC 1571
    • C.I. 76505
    • CCRIS 4052
    • HSDB 722
    • UNII-YUL4LO94HK
    • YUL4LO94HK
    • RCRA waste no. U201
    • NSC-1571
    • EINECS 203-585-2
    • .alpha.-Resorcinol
    • Resorcin (JAN)
    • Resorcin (TN)
    • Resorcinol [USP]
    • EPA Pesticide Chemical Code 071401
    • BRN 0906905
    • 1,3-Dihydroxybenzol
    • DTXSID2021238
    • CHEBI:27810
    • AI3-03996
    • MFCD00002269
    • CHEMBL24147
    • DTXCID601238
    • C.I.-76505
    • EC 203-585-2
    • 4-06-00-05658 (Beilstein Handbook Reference)
    • Resorcinol [UN2876] [Poison]
    • NCGC00091501-01
    • RESORCIN [JAN]
    • BENZENE,1,3-DIHYDROXY RESORCINOL
    • RESORCINOL (IARC)
    • RESORCINOL [IARC]
    • RESORCINOL (MART.)
    • RESORCINOL [MART.]
    • RESORCINOL (USP-RS)
    • RESORCINOL [USP-RS]
    • RCO
    • Caswell No. 723
    • RESORCINOL (EP MONOGRAPH)
    • RESORCINOL [EP MONOGRAPH]
    • RESORCINOL (USP MONOGRAPH)
    • RESORCINOL [USP MONOGRAPH]
    • Rezorsine
    • m-phenylenediol
    • Reso
    • Rodol RS
    • 203-585-2
    • CAS-108-46-3
    • FLUORESCEIN IMPURITY A (EP IMPURITY)
    • FLUORESCEIN IMPURITY A [EP IMPURITY]
    • HEXYLRESORCINOL IMPURITY B (EP IMPURITY)
    • HEXYLRESORCINOL IMPURITY B [EP IMPURITY]
    • UN2876
    • Remazol
    • RS 11H
    • RS 11L
    • m-hydroxy-phenol
    • 3-hydroxy-phenol
    • Resorcinol, ACS
    • 3aqt
    • 3-Hydroxy phenol
    • Resorcinol, 8CI
    • benzen-1,3-diol
    • Resorcinol, Reagent
    • 1,3-benzene diol
    • Resorcine, technical
    • 1,3-dihyroxybenzene
    • Acnomel (Salt/Mix)
    • Eskamel (Salt/Mix)
    • Rezamid (Salt/Mix)
    • phenol derivative, 3
    • Benzene,3-dihydroxy-
    • NAKO-TGG
    • Sulforcin (Salt/Mix)
    • 1,3-dihydroxy-benzene
    • Spectrum_000173
    • RESORCINOL [MI]
    • Spectrum2_001310
    • Spectrum3_000895
    • Spectrum4_000990
    • Spectrum5_001152
    • RESORCINOL [FHFI]
    • RESORCINOL [HSDB]
    • RESORCINUM [HPUS]
    • WLN: QR CQ
    • DURAFOR DEVELOPER G
    • RESORCINOL [VANDF]
    • bmse000415
    • 1,3-Dihydroxybenzene, XII

  • Applications

    Resorcinol (CAS 108-46-3) is a versatile dihydroxybenzene used as a chemical intermediate in the production of phenolic resins and resorcinol-formaldehyde adhesives for wood panels and laminates; it serves as a precursor for epoxy resin crosslinkers (for example, resorcinol diglycidyl ether) used in coatings, varnishes, and specialty plastics; in cosmetics and personal care it is employed as a colorant precursor in hair dye formulations; it provides intermediates for pharmaceutical synthesis and for dye/pigment manufacture; and in general polymer and coatings applications it acts as a crosslinking or curing component within various resin systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 404.18
    methanol 515.89
    isopropanol 326.4
    water 17.2
    ethyl acetate 112.89
    n-propanol 261.09
    acetone 376.22
    n-butanol 191.61
    acetonitrile 159.84
    DMF 403.44
    toluene 3.37
    isobutanol 168.08
    1,4-dioxane 430.11
    methyl acetate 149.36
    THF 703.73
    2-butanone 152.55
    n-pentanol 156.57
    sec-butanol 184.65
    n-hexane 3.95
    ethylene glycol 225.52
    NMP 189.2
    cyclohexane 1.58
    DMSO 772.67
    n-butyl acetate 54.39
    n-octanol 78.67
    chloroform 3.27
    n-propyl acetate 85.36
    acetic acid 384.69
    dichloromethane 3.37
    cyclohexanone 94.22
    propylene glycol 265.09
    isopropyl acetate 83.29
    DMAc 202.46
    2-ethoxyethanol 342.83
    isopentanol 159.65
    n-heptane 6.18
    ethyl formate 81.91
    1,2-dichloroethane 8.05
    n-hexanol 120.85
    2-methoxyethanol 560.7
    isobutyl acetate 58.24
    tetrachloromethane 2.51
    n-pentyl acetate 48.37
    transcutol 748.63
    n-heptanol 68.72
    ethylbenzene 2.77
    MIBK 112.37
    2-propoxyethanol 312.74
    tert-butanol 408.11
    MTBE 146.15
    2-butoxyethanol 156.61
    propionic acid 209.89
    o-xylene 4.22
    formic acid 221.51
    diethyl ether 132.77
    m-xylene 6.44
    p-xylene 4.28
    chlorobenzene 3.94
    dimethyl carbonate 75.41
    n-octane 2.34
    formamide 311.76
    cyclopentanone 192.19
    2-pentanone 137.54
    anisole 32.78
    cyclopentyl methyl ether 121.26
    gamma-butyrolactone 251.81
    1-methoxy-2-propanol 451.95
    pyridine 29.75
    3-pentanone 64.91
    furfural 118.11
    n-dodecane 3.36
    diethylene glycol 364.74
    diisopropyl ether 45.07
    tert-amyl alcohol 205.3
    acetylacetone 176.47
    n-hexadecane 3.49
    acetophenone 31.16
    methyl propionate 100.76
    isopentyl acetate 51.7
    trichloroethylene 9.96
    n-nonanol 69.6
    cyclohexanol 76.46
    benzyl alcohol 34.24
    2-ethylhexanol 51.74
    isooctanol 55.04
    dipropyl ether 73.57
    1,2-dichlorobenzene 4.55
    ethyl lactate 78.52
    propylene carbonate 114.16
    n-methylformamide 227.28
    2-pentanol 133.5
    n-pentane 4.33
    1-propoxy-2-propanol 211.63
    1-methoxy-2-propyl acetate 110.14
    2-(2-methoxypropoxy) propanol 160.52
    mesitylene 6.0
    ε-caprolactone 96.42
    p-cymene 7.25
    epichlorohydrin 164.42
    1,1,1-trichloroethane 8.86
    2-aminoethanol 321.71
    morpholine-4-carbaldehyde 276.99
    sulfolane 259.55
    2,2,4-trimethylpentane 4.29
    2-methyltetrahydrofuran 231.98
    n-hexyl acetate 85.53
    isooctane 5.65
    2-(2-butoxyethoxy)ethanol 245.09
    sec-butyl acetate 57.15
    tert-butyl acetate 118.59
    decalin 2.01
    glycerin 357.39
    diglyme 355.79
    acrylic acid 156.65
    isopropyl myristate 40.46
    n-butyric acid 177.0
    acetyl acetate 80.6
    di(2-ethylhexyl) phthalate 35.29
    ethyl propionate 69.07
    nitromethane 468.31
    1,2-diethoxyethane 128.19
    benzonitrile 22.35
    trioctyl phosphate 34.08
    1-bromopropane 6.52
    gamma-valerolactone 251.8
    n-decanol 53.22
    triethyl phosphate 33.42
    4-methyl-2-pentanol 93.22
    propionitrile 84.16
    vinylene carbonate 69.04
    1,1,2-trichlorotrifluoroethane 122.39
    DMS 55.11
    cumene 4.56
    2-octanol 45.32
    2-hexanone 101.84
    octyl acetate 53.97
    limonene 12.28
    1,2-dimethoxyethane 373.66
    ethyl orthosilicate 31.41
    tributyl phosphate 37.54
    diacetone alcohol 221.3
    N,N-dimethylaniline 23.53
    acrylonitrile 77.35
    aniline 19.61
    1,3-propanediol 361.08
    bromobenzene 1.97
    dibromomethane 2.42
    1,1,2,2-tetrachloroethane 11.53
    2-methyl-cyclohexyl acetate 45.5
    tetrabutyl urea 47.62
    diisobutyl methanol 43.32
    2-phenylethanol 41.52
    styrene 2.79
    dioctyl adipate 61.51
    dimethyl sulfate 106.2
    ethyl butyrate 51.94
    methyl lactate 128.39
    butyl lactate 58.57
    diethyl carbonate 38.44
    propanediol butyl ether 176.11
    triethyl orthoformate 47.03
    p-tert-butyltoluene 8.75
    methyl 4-tert-butylbenzoate 68.49
    morpholine 403.75
    tert-butylamine 159.56
    n-dodecanol 40.89
    dimethoxymethane 307.2
    ethylene carbonate 69.91
    cyrene 117.54
    2-ethoxyethyl acetate 84.3
    2-ethylhexyl acetate 33.64
    1,2,4-trichlorobenzene 7.59
    4-methylpyridine 26.81
    dibutyl ether 58.25
    2,6-dimethyl-4-heptanol 43.32
    DEF 108.28
    dimethyl isosorbide 192.44
    tetrachloroethylene 7.71
    eugenol 75.0
    triacetin 91.72
    span 80 124.47
    1,4-butanediol 157.69
    1,1-dichloroethane 7.6
    2-methyl-1-pentanol 104.3
    methyl formate 173.15
    2-methyl-1-butanol 124.63
    n-decane 4.96
    butyronitrile 80.19
    3,7-dimethyl-1-octanol 67.49
    1-chlorooctane 19.09
    1-chlorotetradecane 9.05
    n-nonane 4.25
    undecane 3.99
    tert-butylcyclohexane 3.64
    cyclooctane 1.1
    cyclopentanol 145.08
    tetrahydropyran 174.88
    tert-amyl methyl ether 84.81
    2,5,8-trioxanonane 278.27
    1-hexene 13.12
    2-isopropoxyethanol 228.11
    2,2,2-trifluoroethanol 129.82
    methyl butyrate 80.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction