Rebaudioside M

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  • Identifiers

    CAS number
    1220616-44-3

    Molecular formula
    C56H90O33

    SMILES
    C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C(=O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 71.91%
    Sweet 33.56%
    Cooling 22.1%
    Woody 21.0%
    Alcoholic 17.28%
    Clean 17.11%
    Spicy 16.43%
    Milky 16.35%
    Savory 16.26%
    Warm 15.59%

     

    Flavor
    Bitter 54.24%
    Sweet 49.22%
    Odorless 41.46%
    Fatty 34.55%
    Sweet-like 31.32%
    Bland 24.92%
    Cauliflower 21.56%
    Alkaline 20.97%
    Very slight 20.97%
    Cedarleaf 20.35%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -6.0

    pKa est.
    1.94 (strong acid)

    Molecular weight
    1291.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    4217°C

    Flash point

    • 157.02 ˚C est.

  • Synonyms

    • REBAUDIOSIDE M
    • 1220616-44-3
    • rebaudioside X
    • Fema No. 4895
    • Fema No. 4922
    • FQA8XMC4XJ
    • CHEBI:145019
    • KAUR-16-EN-18-oic acid, 13-((o-beta-D-glucopyranosyl-(1->2)-O-(beta-D-glucopyranosyl-(1->3))-beta-D-glucopyranosyl)oxy)-, o-beta-D-glucopyranosyl-(1->2)-O-(beta-D-glucopyranosyl-(1->3))-beta-D-glucopyranosyl ester, (4alpha)-
    • DTXSID701019863
    • RefChem:47853
    • DTXCID201477733
    • ((2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy)oxan-2-yl) (1R,4S,5R,9S,10R,13S)-13-((2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy)oxan-2-yl)oxy-5,9-dimethyl-14-methylidenetetracyclo(11.2.1.01,10.04,9)hexadecane-5-carboxylate
    • Reb M
    • Reb X
    • Reb-M
    • Reb-X
    • REBAUDIOSIDEM
    • UNII-FQA8XMC4XJ
    • E960c
    • orb1301485
    • CHEMBL5095195
    • SCHEMBL29359782
    • HY-N6833
    • C56H90O33
    • MSK162904
    • s3282
    • AKOS040758812
    • EBC-617713
    • OR44885
    • AC-34451
    • DA-77380
    • MS-32094
    • CS-0100251
    • NS00121723
    • E80657
    • Q63393666
    • 13-[(O-b-D-Glucopyranosyl-(1,2)-O-[b-D-glucopyranosyl-(1,3)]-b-D-glucopyranosyl)oxy]-kaur-16-en-18-oic acid (4')-O-b-D-glucopyranosy l-(1,2)-O-[b-D-glucopyranosyl-(1,3)]-b-D-glucopyranosyl ester
    • beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-1-O-(13alpha-{[beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-beta-D-glucopyranosyl]oxy}-18-oxo-5beta,8alpha,9beta,10alpha-kaur-16-en-18-yl)-beta-D-glucopyranose
    • KAUR-16-EN-18-OIC ACID, 13-((O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->3))-.BETA.-D-GLUCOPYRANOSYL)OXY)-, O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->3))-.BETA.-D-GLUCOPYRANOSYL ESTER, (4.ALPHA.)-
    • 1220616-44-3

  • Applications

    Rebaudioside M (CAS 1220616-44-3) is a high-intensity natural sweetener used to replace sugar in food and beverage formulations, enabling lower-calorie products with a clean aftertaste. It is commonly employed in confectionery, dairy products, bakery and general food processing to improve palatability and reduce added sugars, and is also utilized in dietary supplements and nutraceuticals for taste masking and consumer acceptance. In pharmaceutical applications, it is often evaluated for sweetening syrups and oral dosage forms while considering stability and regulatory compliance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.84
    methanol 25.53
    isopropanol 1.04
    water 0.75
    ethyl acetate 3.66
    n-propanol 1.8
    acetone 4.8
    n-butanol 0.88
    acetonitrile 2.46
    DMF 67.96
    toluene 0.78
    isobutanol 0.62
    1,4-dioxane 9.59
    methyl acetate 4.55
    THF 16.82
    2-butanone 3.28
    n-pentanol 0.58
    sec-butanol 0.71
    n-hexane 0.03
    ethylene glycol 9.49
    NMP 75.84
    cyclohexane 0.07
    DMSO 71.48
    n-butyl acetate 1.15
    n-octanol 0.69
    chloroform 3.8
    n-propyl acetate 1.37
    acetic acid 40.43
    dichloromethane 4.55
    cyclohexanone 4.43
    propylene glycol 6.82
    isopropyl acetate 1.84
    DMAc 57.32
    2-ethoxyethanol 9.77
    isopentanol 0.44
    n-heptane 0.07
    ethyl formate 3.95
    1,2-dichloroethane 2.18
    n-hexanol 0.48
    2-methoxyethanol 29.21
    isobutyl acetate 0.54
    tetrachloromethane 0.52
    n-pentyl acetate 1.8
    transcutol 15.26
    n-heptanol 0.85
    ethylbenzene 0.23
    MIBK 0.98
    2-propoxyethanol 8.44
    tert-butanol 0.64
    MTBE 0.57
    2-butoxyethanol 6.41
    propionic acid 5.83
    o-xylene 0.54
    formic acid 78.78
    diethyl ether 1.21
    m-xylene 0.49
    p-xylene 0.26
    chlorobenzene 0.72
    dimethyl carbonate 12.5
    n-octane 0.04
    formamide 57.37
    cyclopentanone 11.93
    2-pentanone 2.31
    anisole 1.21
    cyclopentyl methyl ether 3.19
    gamma-butyrolactone 24.73
    1-methoxy-2-propanol 14.39
    pyridine 6.63
    3-pentanone 2.22
    furfural 28.33
    n-dodecane 0.02
    diethylene glycol 14.48
    diisopropyl ether 0.22
    tert-amyl alcohol 0.56
    acetylacetone 8.68
    n-hexadecane 0.03
    acetophenone 2.19
    methyl propionate 6.22
    isopentyl acetate 0.73
    trichloroethylene 6.85
    n-nonanol 0.73
    cyclohexanol 0.78
    benzyl alcohol 1.73
    2-ethylhexanol 0.25
    isooctanol 0.49
    dipropyl ether 0.87
    1,2-dichlorobenzene 0.86
    ethyl lactate 3.23
    propylene carbonate 9.1
    n-methylformamide 30.74
    2-pentanol 0.44
    n-pentane 0.04
    1-propoxy-2-propanol 4.7
    1-methoxy-2-propyl acetate 5.32
    2-(2-methoxypropoxy) propanol 4.28
    mesitylene 0.26
    ε-caprolactone 6.29
    p-cymene 0.22
    epichlorohydrin 15.0
    1,1,1-trichloroethane 1.05
    2-aminoethanol 8.3
    morpholine-4-carbaldehyde 58.58
    sulfolane 56.51
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 3.21
    n-hexyl acetate 1.66
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 6.39
    sec-butyl acetate 0.71
    tert-butyl acetate 1.61
    decalin 0.03
    glycerin 26.34
    diglyme 15.23
    acrylic acid 14.61
    isopropyl myristate 0.4
    n-butyric acid 4.77
    acetyl acetate 4.9
    di(2-ethylhexyl) phthalate 0.79
    ethyl propionate 1.65
    nitromethane 61.01
    1,2-diethoxyethane 2.36
    benzonitrile 1.29
    trioctyl phosphate 0.6
    1-bromopropane 0.5
    gamma-valerolactone 37.77
    n-decanol 0.43
    triethyl phosphate 1.05
    4-methyl-2-pentanol 0.23
    propionitrile 1.27
    vinylene carbonate 11.26
    1,1,2-trichlorotrifluoroethane 35.44
    DMS 3.72
    cumene 0.14
    2-octanol 0.43
    2-hexanone 1.0
    octyl acetate 0.82
    limonene 0.31
    1,2-dimethoxyethane 9.83
    ethyl orthosilicate 0.86
    tributyl phosphate 0.54
    diacetone alcohol 4.32
    N,N-dimethylaniline 1.1
    acrylonitrile 3.92
    aniline 1.65
    1,3-propanediol 6.98
    bromobenzene 0.63
    dibromomethane 1.61
    1,1,2,2-tetrachloroethane 4.44
    2-methyl-cyclohexyl acetate 0.88
    tetrabutyl urea 1.07
    diisobutyl methanol 0.18
    2-phenylethanol 1.34
    styrene 0.3
    dioctyl adipate 1.02
    dimethyl sulfate 33.45
    ethyl butyrate 1.31
    methyl lactate 16.21
    butyl lactate 2.87
    diethyl carbonate 0.98
    propanediol butyl ether 6.42
    triethyl orthoformate 1.43
    p-tert-butyltoluene 0.23
    methyl 4-tert-butylbenzoate 3.85
    morpholine 11.79
    tert-butylamine 0.19
    n-dodecanol 0.26
    dimethoxymethane 26.73
    ethylene carbonate 6.09
    cyrene 10.5
    2-ethoxyethyl acetate 5.35
    2-ethylhexyl acetate 0.59
    1,2,4-trichlorobenzene 1.39
    4-methylpyridine 3.3
    dibutyl ether 0.42
    2,6-dimethyl-4-heptanol 0.18
    DEF 7.45
    dimethyl isosorbide 9.31
    tetrachloroethylene 3.5
    eugenol 3.82
    triacetin 5.4
    span 80 4.3
    1,4-butanediol 2.39
    1,1-dichloroethane 1.09
    2-methyl-1-pentanol 0.3
    methyl formate 26.16
    2-methyl-1-butanol 0.5
    n-decane 0.06
    butyronitrile 0.76
    3,7-dimethyl-1-octanol 0.35
    1-chlorooctane 0.23
    1-chlorotetradecane 0.07
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.02
    cyclooctane 0.05
    cyclopentanol 1.75
    tetrahydropyran 2.32
    tert-amyl methyl ether 0.68
    2,5,8-trioxanonane 9.2
    1-hexene 0.09
    2-isopropoxyethanol 3.48
    2,2,2-trifluoroethanol 21.4
    methyl butyrate 1.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction