Rebaudioside E

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  • Identifiers

    CAS number
    63279-14-1

    Molecular formula
    C44H70O23

    SMILES
    C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)(C)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 68.37%
    Sweet 31.41%
    Woody 25.39%
    Cooling 23.1%
    Spicy 20.55%
    Clean 17.89%
    Warm 17.16%
    Mint 17.0%
    Balsamic 16.77%
    Milky 16.48%

     

    Flavor
    Bitter 57.86%
    Sweet 41.43%
    Odorless 37.65%
    Fatty 35.48%
    Sweet-like 30.37%
    Bland 25.43%
    Cauliflower 21.42%
    Alkaline 21.11%
    Cedarleaf 21.08%
    Very slight 20.79%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -2.8

    pKa est.
    3.53 (weak acid)

    Molecular weight
    967.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    4421°C

    Flash point

    • 228.25 ˚C est.

  • Synonyms

    • Rebaudioside E
    • 63279-14-1
    • (-)-Rebaudioside E
    • 693TGS3OHR
    • FEMA NO. 4936
    • CHEBI:145018
    • DTXSID301019861
    • KAUR-16-EN-18-oic acid, 13-((2-o-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-, 2-o-beta-D-glucopyranosyl-beta-D-glucopyranosyl ester, (4alpha)-
    • RefChem:46988
    • DTXCID801477731
    • ((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyoxan-2-yl) (1R,4S,5R,9S,10R,13S)-13-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyoxan-2-yl)oxy-5,9-dimethyl-14-methylidenetetracyclo(11.2.1.01,10.04,9)hexadecane-5-carboxylate
    • Rebaudioside E [MI]
    • UNII-693TGS3OHR
    • (4R)-13-[[2-O-(beta-D-Glucopyranosyl)-beta-D-glucopyranosyl]oxy]kaur-16-en-18-oic acid 2-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl ester
    • Reb E
    • Rebaudioside Impurity E
    • orb1684275
    • SCHEMBL29354277
    • HY-N6888
    • MSK162903
    • AKOS040760664
    • OR44886
    • NCGC00483101-01
    • DA-77378
    • CS-0100495
    • NS00125037
    • E87138
    • Q27264309
    • (4R)-13-[[2-O-(|A-D-Glucopyranosyl)-|A-D-glucopyranosyl]oxy]kaur-16-en-18-oic acid 2-O-(|A-D-glucopyranosyl)-|A-D-glucopyranosyl ester
    • 13-[(O-b-D-Glucoopyranosyl-(1,2)-O-[b-D-glucopyranosyl)-oxy]-kaur-16-en-18-oic acid (4')-O-b-D-glucopyranosyl-deoxy-(1,2)-O-[b-D-glu copyranosyl ester
    • 2-O-beta-D-glucopyranosyl-1-O-({(4R,4aS,6aR,9S,11aR,11bS)-9-[(2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalen-4-yl}carbonyl)-beta-D-glucopyranose
    • 2-O-beta-D-Glucopyranosyl-1-O-{13alpha-[(2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-18-oxo-5beta,8alpha,9beta,10alpha-kaur-16-en-18-yl}-beta-D-glucopyranose
    • KAUR-16-EN-18-OIC ACID, 13-((2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-, 2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL ESTER, (4.ALPHA.)-
    • 63279-14-1

  • Applications

    Rebaudioside E (CAS 63279-14-1) is a high-intensity steviol glycoside used primarily as a non-caloric sweetener. In food and beverage applications, it is added to formulations to replace sugar while delivering sweetness; it is commonly found in confectionery, dairy, bakery, and dessert products, and in palatable oral dosage forms to mask bitterness and improve palatability. In cosmetics and personal care, it may serve as a sweetener or taste modifier in edible or oral care products. It is also evaluated for use in flavor formulations and other industrial applications where clean sweetness is desired. Applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.92
    methanol 39.88
    isopropanol 1.44
    water 0.61
    ethyl acetate 5.24
    n-propanol 2.59
    acetone 6.85
    n-butanol 1.33
    acetonitrile 3.05
    DMF 84.61
    toluene 0.92
    isobutanol 0.9
    1,4-dioxane 12.7
    methyl acetate 5.99
    THF 26.47
    2-butanone 4.54
    n-pentanol 0.77
    sec-butanol 0.99
    n-hexane 0.03
    ethylene glycol 12.71
    NMP 105.52
    cyclohexane 0.07
    DMSO 90.31
    n-butyl acetate 1.54
    n-octanol 0.82
    chloroform 6.11
    n-propyl acetate 1.77
    acetic acid 72.85
    dichloromethane 6.92
    cyclohexanone 6.38
    propylene glycol 9.62
    isopropyl acetate 2.56
    DMAc 68.28
    2-ethoxyethanol 13.12
    isopentanol 0.64
    n-heptane 0.06
    ethyl formate 6.0
    1,2-dichloroethane 3.16
    n-hexanol 0.67
    2-methoxyethanol 42.3
    isobutyl acetate 0.71
    tetrachloromethane 0.77
    n-pentyl acetate 2.32
    transcutol 19.38
    n-heptanol 1.06
    ethylbenzene 0.26
    MIBK 1.37
    2-propoxyethanol 11.95
    tert-butanol 0.85
    MTBE 0.73
    2-butoxyethanol 8.31
    propionic acid 8.64
    o-xylene 0.6
    formic acid 118.38
    diethyl ether 1.47
    m-xylene 0.58
    p-xylene 0.28
    chlorobenzene 1.01
    dimethyl carbonate 16.15
    n-octane 0.04
    formamide 79.36
    cyclopentanone 18.33
    2-pentanone 3.33
    anisole 1.52
    cyclopentyl methyl ether 4.13
    gamma-butyrolactone 37.91
    1-methoxy-2-propanol 20.24
    pyridine 8.91
    3-pentanone 2.92
    furfural 41.17
    n-dodecane 0.02
    diethylene glycol 19.14
    diisopropyl ether 0.26
    tert-amyl alcohol 0.73
    acetylacetone 12.61
    n-hexadecane 0.03
    acetophenone 2.76
    methyl propionate 8.46
    isopentyl acetate 1.04
    trichloroethylene 11.08
    n-nonanol 0.88
    cyclohexanol 1.05
    benzyl alcohol 2.37
    2-ethylhexanol 0.33
    isooctanol 0.6
    dipropyl ether 0.96
    1,2-dichlorobenzene 1.2
    ethyl lactate 4.23
    propylene carbonate 14.49
    n-methylformamide 43.99
    2-pentanol 0.59
    n-pentane 0.04
    1-propoxy-2-propanol 5.94
    1-methoxy-2-propyl acetate 6.98
    2-(2-methoxypropoxy) propanol 5.29
    mesitylene 0.3
    ε-caprolactone 9.39
    p-cymene 0.25
    epichlorohydrin 24.05
    1,1,1-trichloroethane 1.65
    2-aminoethanol 12.13
    morpholine-4-carbaldehyde 77.37
    sulfolane 79.88
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 4.83
    n-hexyl acetate 2.18
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 7.95
    sec-butyl acetate 0.92
    tert-butyl acetate 2.2
    decalin 0.03
    glycerin 36.51
    diglyme 19.0
    acrylic acid 21.57
    isopropyl myristate 0.48
    n-butyric acid 7.97
    acetyl acetate 7.51
    di(2-ethylhexyl) phthalate 1.01
    ethyl propionate 2.06
    nitromethane 93.01
    1,2-diethoxyethane 2.73
    benzonitrile 1.72
    trioctyl phosphate 0.76
    1-bromopropane 0.63
    gamma-valerolactone 57.01
    n-decanol 0.5
    triethyl phosphate 1.3
    4-methyl-2-pentanol 0.32
    propionitrile 1.62
    vinylene carbonate 17.37
    1,1,2-trichlorotrifluoroethane 54.57
    DMS 4.64
    cumene 0.16
    2-octanol 0.48
    2-hexanone 1.26
    octyl acetate 1.01
    limonene 0.35
    1,2-dimethoxyethane 12.69
    ethyl orthosilicate 1.04
    tributyl phosphate 0.69
    diacetone alcohol 6.02
    N,N-dimethylaniline 1.28
    acrylonitrile 4.91
    aniline 2.27
    1,3-propanediol 10.76
    bromobenzene 0.85
    dibromomethane 2.34
    1,1,2,2-tetrachloroethane 6.85
    2-methyl-cyclohexyl acetate 1.18
    tetrabutyl urea 1.26
    diisobutyl methanol 0.23
    2-phenylethanol 1.86
    styrene 0.35
    dioctyl adipate 1.26
    dimethyl sulfate 42.18
    ethyl butyrate 1.63
    methyl lactate 22.2
    butyl lactate 3.68
    diethyl carbonate 1.21
    propanediol butyl ether 8.28
    triethyl orthoformate 1.75
    p-tert-butyltoluene 0.26
    methyl 4-tert-butylbenzoate 4.9
    morpholine 16.65
    tert-butylamine 0.23
    n-dodecanol 0.29
    dimethoxymethane 35.85
    ethylene carbonate 9.48
    cyrene 13.4
    2-ethoxyethyl acetate 6.95
    2-ethylhexyl acetate 0.8
    1,2,4-trichlorobenzene 2.05
    4-methylpyridine 4.47
    dibutyl ether 0.45
    2,6-dimethyl-4-heptanol 0.23
    DEF 9.49
    dimethyl isosorbide 11.36
    tetrachloroethylene 5.35
    eugenol 4.75
    triacetin 6.98
    span 80 5.45
    1,4-butanediol 3.11
    1,1-dichloroethane 1.61
    2-methyl-1-pentanol 0.41
    methyl formate 38.58
    2-methyl-1-butanol 0.71
    n-decane 0.05
    butyronitrile 1.02
    3,7-dimethyl-1-octanol 0.43
    1-chlorooctane 0.26
    1-chlorotetradecane 0.07
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.04
    cyclopentanol 2.49
    tetrahydropyran 3.27
    tert-amyl methyl ether 0.84
    2,5,8-trioxanonane 11.16
    1-hexene 0.1
    2-isopropoxyethanol 4.41
    2,2,2-trifluoroethanol 32.68
    methyl butyrate 2.6

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction