Rebaudioside D

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  • Identifiers

    CAS number
    63279-13-0

    Molecular formula
    C50H80O28

    SMILES
    C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C(=O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 70.56%
    Sweet 32.68%
    Woody 22.7%
    Cooling 22.56%
    Spicy 18.1%
    Clean 17.43%
    Milky 16.44%
    Warm 16.25%
    Alcoholic 16.16%
    Mint 16.02%

     

    Flavor
    Bitter 55.75%
    Sweet 45.91%
    Odorless 39.85%
    Fatty 35.11%
    Sweet-like 30.96%
    Bland 25.2%
    Cauliflower 21.52%
    Alkaline 21.05%
    Very slight 20.9%
    Cedarleaf 20.67%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -4.4

    pKa est.
    2.68 (strong acid)

    Molecular weight
    1129.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    4413°C

    Flash point

    • 193.57 ˚C est.

  • Synonyms

    • Rebaudioside D
    • 63279-13-0
    • (-)-Rebaudioside D
    • Rebaudioside D, (-)-
    • 1SU114WXBX
    • FEMA NO. 4921
    • CHEBI:145022
    • DTXSID601019860
    • KAUR-16-EN-18-oic acid, 13-((o-beta-D-glucopyranosyl-(1->2)-O-(beta-D-glucopyranosyl-(1->3))-beta-D-glucopyranosyl)oxy)-, 2-o-beta-D-glucopyranosyl-beta-D-glucopyranosyl ester, (4alpha)-
    • RefChem:46981
    • DTXCID101477730
    • ((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyoxan-2-yl) (1R,4S,5R,9S,10R,13S)-13-((2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy)oxan-2-yl)oxy-5,9-dimethyl-14-methylidenetetracyclo(11.2.1.01,10.04,9)hexadecane-5-carboxylate
    • Rebaudioside-D
    • UNII-1SU114WXBX
    • (4R)-13-[[2-O-(beta-D-Glucopyranosyl)-3-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]oxy]kaur-16-en-18-oic acid 2-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl ester
    • 2-O-beta-D-glucopyranosyl-1-O-(13alpha-{[beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-beta-D-glucopyranosyl]oxy}-18-oxo-5beta,8alpha,9beta,10alpha-kaur-16-en-18-yl)-beta-D-glucopyranose
    • RebD
    • Kaur-16-en-18-oic acid, 13-[(O-ss-D-glucopyranosyl-(1?2)-O-[ss-D-glucopyranosyl-(1?3)]-ss-D-glucopyranosyl)oxy]-, 2-O-ss-D-glucopyranosyl-ss-D-glucopyranosyl ester, (4a)-; Rebaudioside D
    • Reb D
    • Reb-D
    • Rebaudioside D (Standard)
    • REBAUDIOSIDE D [MI]
    • orb1304656
    • CHEMBL3286747
    • SCHEMBL29354590
    • HY-N0468R
    • HY-N0468
    • MSK40344
    • MFCD11113790
    • s3259
    • AKOS040750454
    • EBC-617499
    • OR44882
    • AC-34450
    • DA-77377
    • MS-31994
    • SY231971
    • CS-0008993
    • NS00125093
    • D85011
    • Rebaudioside DRebaudioside D, (-)-; Rebaudioside-D
    • Q27252844
    • (4R)-13-[[2-O-(|A-D-Glucopyranosyl)-3-O-(|A-D-glucopyranosyl)-|A-D-glucopyranosyl]oxy]kaur-16-en-18-oic acid 2-O-(|A-D-glucopyranosyl)-|A-D-glucopyranosyl ester
    • JDO
    • KAUR-16-EN-18-OIC ACID, 13-((O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->3))-.BETA.-D-GLUCOPYRANOSYL)OXY)-, 2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL ESTER, (4.ALPHA.)-
    • 63279-13-0

  • Applications

    Rebaudioside D (CAS 63279-13-0) is a high-intensity, non-caloric sweetener derived from stevia and is used to sweeten products without added sugar. In food processing and flavor formulation, it substitutes for sucrose in beverages, dairy, confectionery and bakery applications, and is often blended with other sweeteners to tailor sweetness and mouthfeel. In pharmaceuticals, it serves as a palatable excipient for syrups, chewables and oral dosage forms, aiding taste masking and consumer acceptability. In nutraceuticals and dietary supplements, it is employed to sweeten powder mixes and ready-to-drink formats while maintaining a low-calorie profile. In cosmetics and personal care, it may be used in flavored lip products or oral-care items where sweetness is desirable. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.22
    methanol 32.12
    isopropanol 1.19
    water 0.66
    ethyl acetate 4.43
    n-propanol 2.14
    acetone 5.61
    n-butanol 1.09
    acetonitrile 2.77
    DMF 78.31
    toluene 0.86
    isobutanol 0.75
    1,4-dioxane 11.02
    methyl acetate 5.34
    THF 20.78
    2-butanone 3.89
    n-pentanol 0.66
    sec-butanol 0.84
    n-hexane 0.03
    ethylene glycol 11.19
    NMP 93.28
    cyclohexane 0.07
    DMSO 77.84
    n-butyl acetate 1.33
    n-octanol 0.75
    chloroform 4.92
    n-propyl acetate 1.57
    acetic acid 54.55
    dichloromethane 5.71
    cyclohexanone 5.29
    propylene glycol 8.26
    isopropyl acetate 2.19
    DMAc 64.86
    2-ethoxyethanol 11.29
    isopentanol 0.54
    n-heptane 0.06
    ethyl formate 4.86
    1,2-dichloroethane 2.67
    n-hexanol 0.56
    2-methoxyethanol 35.5
    isobutyl acetate 0.62
    tetrachloromethane 0.64
    n-pentyl acetate 2.07
    transcutol 17.38
    n-heptanol 0.95
    ethylbenzene 0.25
    MIBK 1.17
    2-propoxyethanol 10.07
    tert-butanol 0.73
    MTBE 0.65
    2-butoxyethanol 7.38
    propionic acid 7.17
    o-xylene 0.58
    formic acid 98.87
    diethyl ether 1.33
    m-xylene 0.54
    p-xylene 0.27
    chlorobenzene 0.87
    dimethyl carbonate 14.62
    n-octane 0.04
    formamide 68.47
    cyclopentanone 14.8
    2-pentanone 2.79
    anisole 1.4
    cyclopentyl methyl ether 3.65
    gamma-butyrolactone 31.06
    1-methoxy-2-propanol 17.17
    pyridine 7.81
    3-pentanone 2.61
    furfural 35.33
    n-dodecane 0.02
    diethylene glycol 16.65
    diisopropyl ether 0.24
    tert-amyl alcohol 0.64
    acetylacetone 10.39
    n-hexadecane 0.03
    acetophenone 2.49
    methyl propionate 7.41
    isopentyl acetate 0.87
    trichloroethylene 8.96
    n-nonanol 0.81
    cyclohexanol 0.92
    benzyl alcohol 2.06
    2-ethylhexanol 0.29
    isooctanol 0.55
    dipropyl ether 0.91
    1,2-dichlorobenzene 1.04
    ethyl lactate 3.81
    propylene carbonate 11.72
    n-methylformamide 37.49
    2-pentanol 0.51
    n-pentane 0.04
    1-propoxy-2-propanol 5.28
    1-methoxy-2-propyl acetate 6.22
    2-(2-methoxypropoxy) propanol 4.87
    mesitylene 0.28
    ε-caprolactone 7.84
    p-cymene 0.24
    epichlorohydrin 19.33
    1,1,1-trichloroethane 1.34
    2-aminoethanol 10.17
    morpholine-4-carbaldehyde 69.98
    sulfolane 68.23
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 3.95
    n-hexyl acetate 1.93
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 7.15
    sec-butyl acetate 0.81
    tert-butyl acetate 1.9
    decalin 0.03
    glycerin 32.08
    diglyme 17.33
    acrylic acid 18.26
    isopropyl myristate 0.44
    n-butyric acid 6.2
    acetyl acetate 6.14
    di(2-ethylhexyl) phthalate 0.91
    ethyl propionate 1.87
    nitromethane 76.75
    1,2-diethoxyethane 2.54
    benzonitrile 1.52
    trioctyl phosphate 0.69
    1-bromopropane 0.57
    gamma-valerolactone 46.73
    n-decanol 0.47
    triethyl phosphate 1.2
    4-methyl-2-pentanol 0.27
    propionitrile 1.47
    vinylene carbonate 14.26
    1,1,2-trichlorotrifluoroethane 45.68
    DMS 4.33
    cumene 0.15
    2-octanol 0.46
    2-hexanone 1.11
    octyl acetate 0.92
    limonene 0.34
    1,2-dimethoxyethane 11.2
    ethyl orthosilicate 0.96
    tributyl phosphate 0.62
    diacetone alcohol 5.15
    N,N-dimethylaniline 1.21
    acrylonitrile 4.5
    aniline 2.0
    1,3-propanediol 8.67
    bromobenzene 0.75
    dibromomethane 1.96
    1,1,2,2-tetrachloroethane 5.71
    2-methyl-cyclohexyl acetate 1.03
    tetrabutyl urea 1.17
    diisobutyl methanol 0.2
    2-phenylethanol 1.59
    styrene 0.33
    dioctyl adipate 1.15
    dimethyl sulfate 38.91
    ethyl butyrate 1.47
    methyl lactate 19.69
    butyl lactate 3.29
    diethyl carbonate 1.11
    propanediol butyl ether 7.42
    triethyl orthoformate 1.61
    p-tert-butyltoluene 0.25
    methyl 4-tert-butylbenzoate 4.48
    morpholine 14.17
    tert-butylamine 0.21
    n-dodecanol 0.27
    dimethoxymethane 31.38
    ethylene carbonate 7.76
    cyrene 12.15
    2-ethoxyethyl acetate 6.23
    2-ethylhexyl acetate 0.69
    1,2,4-trichlorobenzene 1.75
    4-methylpyridine 3.9
    dibutyl ether 0.44
    2,6-dimethyl-4-heptanol 0.2
    DEF 8.6
    dimethyl isosorbide 10.53
    tetrachloroethylene 4.44
    eugenol 4.37
    triacetin 6.4
    span 80 4.96
    1,4-butanediol 2.71
    1,1-dichloroethane 1.34
    2-methyl-1-pentanol 0.35
    methyl formate 32.28
    2-methyl-1-butanol 0.61
    n-decane 0.06
    butyronitrile 0.88
    3,7-dimethyl-1-octanol 0.39
    1-chlorooctane 0.25
    1-chlorotetradecane 0.07
    n-nonane 0.05
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.05
    cyclopentanol 2.1
    tetrahydropyran 2.78
    tert-amyl methyl ether 0.77
    2,5,8-trioxanonane 10.38
    1-hexene 0.09
    2-isopropoxyethanol 3.92
    2,2,2-trifluoroethanol 27.01
    methyl butyrate 2.29

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction