Rebaudioside C

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  • Identifiers

    CAS number
    63550-99-2

    Molecular formula
    C44H70O22

    SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@@]34CC[C@H]5[C@@]6(CCC[C@@]([C@H]6CC[C@]5(C3)CC4=C)(C)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C)CO)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 68.36%
    Sweet 29.47%
    Woody 25.97%
    Cooling 22.83%
    Spicy 21.03%
    Clean 17.19%
    Milky 17.06%
    Warm 17.01%
    Mint 16.82%
    Balsamic 16.19%

     

    Flavor
    Bitter 58.27%
    Sweet 38.72%
    Odorless 35.83%
    Fatty 35.82%
    Sweet-like 29.89%
    Bland 25.25%
    Cauliflower 21.3%
    Cedarleaf 21.26%
    Alkaline 21.07%
    Metallic 20.97%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.3

    pKa est.
    3.02 (weak acid)

    Molecular weight
    951.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    3923°C

    Flash point

    • 214.42 ˚C est.

  • Synonyms

    • Rebaudioside C
    • 63550-99-2
    • FE0M8Z5L2E
    • FEMA NO. 4720
    • DTXSID301019859
    • RefChem:47597
    • DTXCID801477729
    • ((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl) (1R,4S,5R,9S,10R,13S)-13-((2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-3-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxy-5,9-dimethyl-14-methylidenetetracyclo(11.2.1.01,10.04,9)hexadecane-5-carboxylate
    • RebaudiosideC
    • MFCD30188121
    • (-)-Rebaudioside C
    • UNII-FE0M8Z5L2E
    • Rebaudioside-C
    • CCRIS 6120
    • Rebaudioside C?
    • Kaur-16-en-18-oic acid, 13-[(O-6-deoxy-a-L-mannopyranosyl-(1?2)-O-[ss-D-glucopyranosyl-(1?3)]-ss-D-glucopyranosyl)oxy]-, ss-D-glucopyranosyl ester, (4a)-; Dulcoside B; Rebaudioside C
    • REBC
    • REBAUDIOSIDE C [MI]
    • orb1304276
    • REBAUDIOSIDE C, (-)-
    • SCHEMBL29362998
    • HY-N0467
    • MSK40343
    • C44H70O22
    • AKOS027250690
    • EBC-616205
    • OR44881
    • NCGC00390521-01
    • AS-56464
    • Q27277943
    • 1-O-(13alpha-{[6-Deoxy-alpha-L-mannopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-beta-D-glucopyranosyl]oxy}-18-oxo-5beta,8alpha,9beta,10alpha-kaur-16-en-18-yl)-beta-D-glucopyranose
    • KAUR-16-EN-18-OIC ACID, 13-((O-6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->2)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->3))-.BETA.-D-GLUCOPYRANOSYL)OXY)-, .BETA.-D-GLUCOPYRANOSYL ESTER, (4.ALPHA.)-
    • 63550-99-2

  • Applications

    Rebaudioside C (CAS 63550-99-2) is a high-intensity natural sweetener derived from Stevia. In practice it is used as a non-caloric sweetener in food processing and beverage formulations to reduce sugar while preserving sweetness. It can function as a flavor modifier in products by adjusting sweetness profiles and helping mask bitter notes. In cosmetics/personal care, it is used as a sweetener in flavored or scented formulations, including oral care products, to improve palatability. In pharmaceuticals, it may serve as a taste-masking excipient in syrups, suspensions, and solid dosage forms to enhance patient acceptance. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.95
    methanol 51.24
    isopropanol 1.7
    water 0.49
    ethyl acetate 4.92
    n-propanol 3.25
    acetone 6.03
    n-butanol 1.71
    acetonitrile 2.69
    DMF 82.17
    toluene 0.79
    isobutanol 1.13
    1,4-dioxane 13.97
    methyl acetate 5.54
    THF 28.24
    2-butanone 4.6
    n-pentanol 0.94
    sec-butanol 1.21
    n-hexane 0.02
    ethylene glycol 15.08
    NMP 102.46
    cyclohexane 0.06
    DMSO 87.27
    n-butyl acetate 1.5
    n-octanol 0.97
    chloroform 6.28
    n-propyl acetate 1.63
    acetic acid 82.51
    dichloromethane 6.88
    cyclohexanone 6.52
    propylene glycol 12.3
    isopropyl acetate 2.43
    DMAc 64.15
    2-ethoxyethanol 15.55
    isopentanol 0.81
    n-heptane 0.05
    ethyl formate 6.48
    1,2-dichloroethane 3.04
    n-hexanol 0.82
    2-methoxyethanol 53.89
    isobutyl acetate 0.68
    tetrachloromethane 0.72
    n-pentyl acetate 2.45
    transcutol 23.07
    n-heptanol 1.26
    ethylbenzene 0.23
    MIBK 1.39
    2-propoxyethanol 14.41
    tert-butanol 0.93
    MTBE 0.78
    2-butoxyethanol 9.97
    propionic acid 9.52
    o-xylene 0.52
    formic acid 133.49
    diethyl ether 1.5
    m-xylene 0.51
    p-xylene 0.24
    chlorobenzene 0.94
    dimethyl carbonate 14.5
    n-octane 0.03
    formamide 83.45
    cyclopentanone 18.26
    2-pentanone 3.44
    anisole 1.5
    cyclopentyl methyl ether 4.13
    gamma-butyrolactone 36.1
    1-methoxy-2-propanol 23.56
    pyridine 9.06
    3-pentanone 2.72
    furfural 40.65
    n-dodecane 0.02
    diethylene glycol 23.0
    diisopropyl ether 0.25
    tert-amyl alcohol 0.87
    acetylacetone 11.76
    n-hexadecane 0.02
    acetophenone 2.64
    methyl propionate 7.76
    isopentyl acetate 1.11
    trichloroethylene 10.83
    n-nonanol 1.01
    cyclohexanol 1.18
    benzyl alcohol 2.62
    2-ethylhexanol 0.38
    isooctanol 0.7
    dipropyl ether 0.93
    1,2-dichlorobenzene 1.1
    ethyl lactate 4.38
    propylene carbonate 14.17
    n-methylformamide 46.64
    2-pentanol 0.71
    n-pentane 0.04
    1-propoxy-2-propanol 6.65
    1-methoxy-2-propyl acetate 6.94
    2-(2-methoxypropoxy) propanol 6.23
    mesitylene 0.26
    ε-caprolactone 10.18
    p-cymene 0.23
    epichlorohydrin 25.36
    1,1,1-trichloroethane 1.42
    2-aminoethanol 15.86
    morpholine-4-carbaldehyde 81.92
    sulfolane 76.92
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 5.26
    n-hexyl acetate 2.41
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 9.54
    sec-butyl acetate 0.87
    tert-butyl acetate 2.16
    decalin 0.03
    glycerin 46.21
    diglyme 21.63
    acrylic acid 22.52
    isopropyl myristate 0.49
    n-butyric acid 9.24
    acetyl acetate 6.75
    di(2-ethylhexyl) phthalate 1.13
    ethyl propionate 1.9
    nitromethane 90.02
    1,2-diethoxyethane 2.88
    benzonitrile 1.67
    trioctyl phosphate 0.82
    1-bromopropane 0.65
    gamma-valerolactone 63.34
    n-decanol 0.55
    triethyl phosphate 1.26
    4-methyl-2-pentanol 0.37
    propionitrile 1.5
    vinylene carbonate 16.74
    1,1,2-trichlorotrifluoroethane 59.15
    DMS 4.3
    cumene 0.15
    2-octanol 0.56
    2-hexanone 1.24
    octyl acetate 1.06
    limonene 0.34
    1,2-dimethoxyethane 13.99
    ethyl orthosilicate 1.03
    tributyl phosphate 0.71
    diacetone alcohol 6.31
    N,N-dimethylaniline 1.22
    acrylonitrile 4.49
    aniline 2.36
    1,3-propanediol 14.3
    bromobenzene 0.75
    dibromomethane 2.25
    1,1,2,2-tetrachloroethane 6.7
    2-methyl-cyclohexyl acetate 1.19
    tetrabutyl urea 1.25
    diisobutyl methanol 0.24
    2-phenylethanol 2.07
    styrene 0.31
    dioctyl adipate 1.3
    dimethyl sulfate 37.53
    ethyl butyrate 1.53
    methyl lactate 22.35
    butyl lactate 4.05
    diethyl carbonate 1.16
    propanediol butyl ether 10.08
    triethyl orthoformate 1.66
    p-tert-butyltoluene 0.23
    methyl 4-tert-butylbenzoate 5.0
    morpholine 19.45
    tert-butylamine 0.25
    n-dodecanol 0.3
    dimethoxymethane 36.33
    ethylene carbonate 9.38
    cyrene 14.3
    2-ethoxyethyl acetate 7.58
    2-ethylhexyl acetate 0.82
    1,2,4-trichlorobenzene 1.91
    4-methylpyridine 4.58
    dibutyl ether 0.47
    2,6-dimethyl-4-heptanol 0.24
    DEF 9.4
    dimethyl isosorbide 11.73
    tetrachloroethylene 5.34
    eugenol 5.17
    triacetin 7.07
    span 80 6.32
    1,4-butanediol 3.77
    1,1-dichloroethane 1.52
    2-methyl-1-pentanol 0.51
    methyl formate 38.52
    2-methyl-1-butanol 0.91
    n-decane 0.05
    butyronitrile 1.06
    3,7-dimethyl-1-octanol 0.48
    1-chlorooctane 0.26
    1-chlorotetradecane 0.07
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.04
    cyclopentanol 2.76
    tetrahydropyran 3.58
    tert-amyl methyl ether 0.92
    2,5,8-trioxanonane 12.47
    1-hexene 0.09
    2-isopropoxyethanol 5.04
    2,2,2-trifluoroethanol 32.55
    methyl butyrate 2.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction