Rebaudioside B

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  • Identifiers

    CAS number
    58543-17-2

    Molecular formula
    C38H60O18

    SMILES
    C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 67.11%
    Sweet 28.57%
    Woody 25.48%
    Cooling 24.94%
    Spicy 22.84%
    Balsamic 18.35%
    Mint 18.3%
    Clean 18.1%
    Warm 17.67%
    Amber 17.42%

     

    Flavor
    Bitter 58.17%
    Sweet 37.35%
    Odorless 36.87%
    Fatty 35.85%
    Sweet-like 29.54%
    Bland 24.89%
    Cauliflower 21.56%
    Cedarleaf 21.38%
    Alkaline 21.29%
    Naphthalic 20.8%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -1.0

    pKa est.
    3.13 (weak acid)

    Molecular weight
    804.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    3364°C

    Flash point

    • 239.22 ˚C est.

  • Synonyms

    • Rebaudioside B
    • 58543-17-2
    • U2N4XKX7HP
    • DTXSID70974103
    • (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid
    • (1R,4S,5R,9S,10R,13S)-13-((2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy)oxan-2-yl)oxy-5,9-dimethyl-14-methylidenetetracyclo(11.2.1.01,10.04,9)hexadecane-5-carboxylic acid
    • RefChem:45981
    • DTXCID601776139
    • REBAUDIOSIDE B(P)(NEW)
    • Stevioside A4
    • MFCD32854014
    • (8alpha,9beta,10alpha,13alpha)-13-{[beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-beta-D-glucopyranosyl]oxy}kaur-16-en-18-oic acid
    • UNII-U2N4XKX7HP
    • CCRIS 6118
    • AUO
    • Kaur-16-en-18-oic acid, 13-[(O-ss-D-glucopyranosyl-(1?2)-O-[ss-D-glucopyranosyl-(1?3)]-ss-D-glucopyranosyl)oxy]-, (4a)-; (4a)-13-[(O-ss-D-Glucopyranosyl-(1?2)-O-[ss-D-glucopyranosyl-(1?3)]-ss-D-glucopyranosyl)oxy]kaur-16-en-18-oic acid; Rebaudioside B; Stevioside a4
    • Reb B
    • REBB
    • Rebaudioside B (Standard)
    • Rebaudioside BStevioside A4
    • REBAUDIOSIDE B [MI]
    • orb1301514
    • SCHEMBL19770001
    • HY-N6808R
    • CHEBI:229537
    • HY-N6808
    • MSK40342
    • s3257
    • AKOS040758804
    • EBC-617580
    • OR44880
    • 13-O-[b-D-Glucopyranosyl-(1,2)-b-D-glucopyranosyl-(1,3)-b-D-glucopyranoside]-16-kauren-19-oic acid
    • AS-83110
    • CS-0090755
    • R0248
    • Q27290599
    • (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-3,4-bis[[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy]-5-oxidanyl-oxan-2-yl]oxy-5,9-dimethyl-14-methylidene-tetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid
    • (1R,4S,5R,9S,10R,13S)-13-{[(2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxan-2-yl]oxy}-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecane-5-carboxylic acid
    • (4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5R,6R)-5-Hydroxy-6-(hydroxymethyl)-3,4-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
    • 13alpha-{[beta-D-Glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-beta-D-glucopyranosyl]oxy}-5beta,8alpha,9beta,10alpha-kaur-16-en-18-oic acid
    • KAUR-16-EN-18-OIC ACID, 13-((O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->3))-.BETA.-D-GLUCOPYRANOSYL)OXY)-, (4.ALPHA.)-
    • 58543-17-2

  • Applications

    Rebaudioside B (CAS 58543-17-2) is a high-intensity non-nutritive sweetener in the steviol glycoside family, primarily used to sweeten foods and beverages. In commercial formulations, it is commonly incorporated as a sweetening component in flavor systems to provide natural sweetness without added sugars. It may be used as a sugar substitute in dietary supplements and pharmaceutical products (liquid syrups, tablets) to improve palatability, and it is also being explored for applications in cosmetics and personal care as a non-caloric sweetener ingredient. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.53
    methanol 18.4
    isopropanol 0.49
    water 0.29
    ethyl acetate 1.45
    n-propanol 0.88
    acetone 2.64
    n-butanol 0.42
    acetonitrile 1.01
    DMF 34.17
    toluene 0.27
    isobutanol 0.29
    1,4-dioxane 4.83
    methyl acetate 1.67
    THF 8.48
    2-butanone 1.5
    n-pentanol 0.27
    sec-butanol 0.3
    n-hexane 0.01
    ethylene glycol 5.66
    NMP 33.13
    cyclohexane 0.02
    DMSO 42.59
    n-butyl acetate 0.49
    n-octanol 0.35
    chloroform 1.7
    n-propyl acetate 0.55
    acetic acid 24.66
    dichloromethane 1.92
    cyclohexanone 2.02
    propylene glycol 3.65
    isopropyl acetate 0.76
    DMAc 26.23
    2-ethoxyethanol 5.45
    isopentanol 0.21
    n-heptane 0.02
    ethyl formate 1.82
    1,2-dichloroethane 0.91
    n-hexanol 0.23
    2-methoxyethanol 17.43
    isobutyl acetate 0.24
    tetrachloromethane 0.22
    n-pentyl acetate 0.91
    transcutol 9.15
    n-heptanol 0.44
    ethylbenzene 0.09
    MIBK 0.51
    2-propoxyethanol 4.81
    tert-butanol 0.28
    MTBE 0.23
    2-butoxyethanol 3.68
    propionic acid 2.48
    o-xylene 0.19
    formic acid 51.46
    diethyl ether 0.5
    m-xylene 0.19
    p-xylene 0.1
    chlorobenzene 0.3
    dimethyl carbonate 5.12
    n-octane 0.01
    formamide 31.78
    cyclopentanone 5.42
    2-pentanone 1.09
    anisole 0.57
    cyclopentyl methyl ether 1.29
    gamma-butyrolactone 9.98
    1-methoxy-2-propanol 7.52
    pyridine 2.92
    3-pentanone 0.93
    furfural 13.69
    n-dodecane 0.01
    diethylene glycol 9.29
    diisopropyl ether 0.09
    tert-amyl alcohol 0.24
    acetylacetone 4.47
    n-hexadecane 0.01
    acetophenone 1.03
    methyl propionate 2.42
    isopentyl acetate 0.33
    trichloroethylene 3.15
    n-nonanol 0.38
    cyclohexanol 0.31
    benzyl alcohol 0.88
    2-ethylhexanol 0.12
    isooctanol 0.26
    dipropyl ether 0.37
    1,2-dichlorobenzene 0.37
    ethyl lactate 1.56
    propylene carbonate 3.56
    n-methylformamide 15.27
    2-pentanol 0.18
    n-pentane 0.01
    1-propoxy-2-propanol 2.43
    1-methoxy-2-propyl acetate 2.51
    2-(2-methoxypropoxy) propanol 2.49
    mesitylene 0.1
    ε-caprolactone 2.62
    p-cymene 0.09
    epichlorohydrin 7.05
    1,1,1-trichloroethane 0.42
    2-aminoethanol 4.61
    morpholine-4-carbaldehyde 27.87
    sulfolane 26.58
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.29
    n-hexyl acetate 0.84
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 3.96
    sec-butyl acetate 0.29
    tert-butyl acetate 0.73
    decalin 0.01
    glycerin 16.15
    diglyme 8.75
    acrylic acid 6.43
    isopropyl myristate 0.19
    n-butyric acid 2.09
    acetyl acetate 2.09
    di(2-ethylhexyl) phthalate 0.45
    ethyl propionate 0.68
    nitromethane 32.0
    1,2-diethoxyethane 1.16
    benzonitrile 0.57
    trioctyl phosphate 0.32
    1-bromopropane 0.19
    gamma-valerolactone 20.21
    n-decanol 0.22
    triethyl phosphate 0.42
    4-methyl-2-pentanol 0.11
    propionitrile 0.5
    vinylene carbonate 4.63
    1,1,2-trichlorotrifluoroethane 18.69
    DMS 1.53
    cumene 0.06
    2-octanol 0.21
    2-hexanone 0.46
    octyl acetate 0.39
    limonene 0.12
    1,2-dimethoxyethane 5.56
    ethyl orthosilicate 0.36
    tributyl phosphate 0.27
    diacetone alcohol 2.25
    N,N-dimethylaniline 0.48
    acrylonitrile 1.53
    aniline 0.7
    1,3-propanediol 3.86
    bromobenzene 0.24
    dibromomethane 0.65
    1,1,2,2-tetrachloroethane 1.99
    2-methyl-cyclohexyl acetate 0.4
    tetrabutyl urea 0.52
    diisobutyl methanol 0.08
    2-phenylethanol 0.72
    styrene 0.11
    dioctyl adipate 0.5
    dimethyl sulfate 13.98
    ethyl butyrate 0.54
    methyl lactate 7.34
    butyl lactate 1.44
    diethyl carbonate 0.39
    propanediol butyl ether 3.99
    triethyl orthoformate 0.6
    p-tert-butyltoluene 0.1
    methyl 4-tert-butylbenzoate 2.01
    morpholine 5.38
    tert-butylamine 0.07
    n-dodecanol 0.12
    dimethoxymethane 14.81
    ethylene carbonate 2.4
    cyrene 5.88
    2-ethoxyethyl acetate 2.82
    2-ethylhexyl acetate 0.26
    1,2,4-trichlorobenzene 0.6
    4-methylpyridine 1.36
    dibutyl ether 0.19
    2,6-dimethyl-4-heptanol 0.08
    DEF 3.04
    dimethyl isosorbide 4.92
    tetrachloroethylene 1.65
    eugenol 2.23
    triacetin 2.72
    span 80 2.49
    1,4-butanediol 1.24
    1,1-dichloroethane 0.43
    2-methyl-1-pentanol 0.15
    methyl formate 14.01
    2-methyl-1-butanol 0.22
    n-decane 0.02
    butyronitrile 0.32
    3,7-dimethyl-1-octanol 0.17
    1-chlorooctane 0.1
    1-chlorotetradecane 0.03
    n-nonane 0.02
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 0.68
    tetrahydropyran 0.96
    tert-amyl methyl ether 0.26
    2,5,8-trioxanonane 5.35
    1-hexene 0.04
    2-isopropoxyethanol 1.84
    2,2,2-trifluoroethanol 10.14
    methyl butyrate 0.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction