Pyridoxine

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  • Identifiers

    CAS number
    65-23-6

    Molecular formula
    C8H11NO3

    SMILES
    CC1=NC=C(C(=C1O)CO)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 50.39%
    Vanilla 48.14%
    Odorless 43.64%
    Creamy 31.07%
    Phenolic 29.41%
    Milky 28.4%
    Burnt 26.9%
    Powdery 26.3%
    Caramellic 25.53%
    Balsamic 24.86%

     

    Flavor
    Bitter 56.39%
    Odorless 39.33%
    Sweet 36.61%
    Mild 36.11%
    Sweet-like 25.11%
    Musty 22.86%
    Bland 22.22%
    Vanilla 21.69%
    Cooked beef juice 21.56%
    Smoked 21.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.8

    pKa est.
    8.21 (weak base)

    Molecular weight
    169.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    581°C

    Melting point expt.

    • 159-162 °C
    • 159 - 162 °C

    Flash point

    • 186.21 ˚C est.

    Solubility expt.

    • 220000 mg/L
    • 79 mg/mL

  • Synonyms

    • pyridoxine
    • 65-23-6
    • Pyridoxol
    • Pyridoxin
    • 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
    • Adermine
    • Gravidox
    • Hydoxin
    • Pyridoxolum
    • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-
    • 5-Hydroxy-6-methyl-3,4-pyridinedimethanol
    • Piridoxina
    • Pyridoxinum
    • 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
    • Piridossina
    • Piridossina [DCIT]
    • 3-Hydroxy-4,5-dimethylol-alpha-picoline
    • Pyridoxinum [INN-Latin]
    • 12001-77-3
    • Piridoxina [INN-Spanish]
    • Hexabione
    • 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
    • 2-Picoline-4,5-dimethanol, 3-hydroxy-
    • Pyridoxine [INN:BAN]
    • (5-Hydroxy-6-methylpyridine-3,4-diyl)dimethanol
    • 2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine
    • 2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
    • CHEBI:16709
    • EINECS 200-603-0
    • UNII-KV2JZ1BI6Z
    • KV2JZ1BI6Z
    • VitaminB6
    • Vitamin V6
    • Pyridoxin hydrochloride
    • vitamin B-6
    • 2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
    • 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol
    • NSC-759148
    • DTXSID4023541
    • Pyridoxine free base
    • 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]
    • 4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol
    • Prestwick0_000623
    • Prestwick1_000623
    • Prestwick2_000623
    • Prestwick3_000623
    • Adermin hydrochloride
    • 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin
    • TimTec1_000657
    • Oprea1_061614
    • BSPBio_000586
    • CBDivE_015627
    • SPBio_002805
    • DTXCID903541
    • BPBio1_000646
    • Pyridoxine hydrogen chloride
    • Pyridoxine (INN)
    • M.V.I.-12
    • STK177324
    • 65-23-6 (FREE BASE)
    • 2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine
    • 3-hydroxy-2-Picoline-4,5-dimethanol
    • NSC 759148
    • DB00165
    • CAS-58-56-0
    • SMP2_000230
    • NCGC00016261-01
    • NCGC00016261-03
    • PYRIDOXINE [INN]
    • Pyridoxinum (INN-Latin)
    • Piridoxina (INN-Spanish)
    • C00314
    • AC-907/25014218
    • Adermin
    • Bezatin
    • Pirivitol
    • Infuvite Pediatric
    • CAS-65-23-6
    • PN
    • NSC36225
    • Pyridoxine (Vit B6)
    • SR-05000001644
    • NCGC00164317-01
    • M.V.I.-12 Lyophilized
    • pyridoxina
    • Pridoxine
    • vitaminum b6
    • UEG
    • Beesix (Salt/Mix)
    • nchembio.93-comp1
    • Becilan (Salt/Mix)
    • Benadon (Salt/Mix)
    • Hexobion (Salt/Mix)
    • Pyridoxine (Standard)
    • Pyridoxol; Vitamin B6
    • Pyridoxine, >=98%
    • Hexabetalin (Salt/Mix)
    • PYRIDOXINE [MI]
    • Vitamin b6,hydrochloride
    • LS-134393
    • PYRIDOXINE [VANDF]
    • bmse000288
    • SCHEMBL3506
    • CHEMBL1364
    • PYRIDOXINE [WHO-DD]
    • BIDD:PXR0180
    • P5669_SIGMA
    • PYRIDOXINE [ORANGE BOOK]
    • HY-B1328R
    • A11HA02
    • NSC36225 (HCL)
    • Pyridoxol, Vitamin B6, Gravidox
    • AIDS006784
    • HMS2093L07
    • KUC106691N
    • Pharmakon1600-01505453
    • AIDS-006784
    • ALBB-022452
    • BCP27975
    • HY-B1328
    • NCB30231
    • Tox21_113644
    • Tox21_300365
    • BBL005552
    • BDBM50103505
    • c1302
    • MFCD00006335
    • NSC759148

  • Applications

    Pyridoxine (CAS 65-23-6) is applied across several industries as a nutrient ingredient: as a vitamin B6 additive in pharmaceuticals and dietary supplements; as a fortifying ingredient for processed foods and functional products; as a feed additive in animal nutrition; as a component in cosmetics and personal care formulations; and in nutraceuticals and consumer wellness products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.22
    methanol 9.38
    isopropanol 3.64
    water 8.17
    ethyl acetate 1.52
    n-propanol 4.53
    acetone 2.14
    n-butanol 3.95
    acetonitrile 2.37
    DMF 46.39
    toluene 0.66
    isobutanol 3.48
    1,4-dioxane 14.58
    methyl acetate 2.22
    THF 22.83
    2-butanone 2.7
    n-pentanol 4.41
    sec-butanol 3.14
    n-hexane 0.14
    ethylene glycol 19.96
    NMP 38.02
    cyclohexane 0.27
    DMSO 182.06
    n-butyl acetate 2.85
    n-octanol 5.2
    chloroform 2.63
    n-propyl acetate 2.0
    acetic acid 9.84
    dichloromethane 5.6
    cyclohexanone 9.74
    propylene glycol 5.67
    isopropyl acetate 1.44
    DMAc 42.72
    2-ethoxyethanol 23.41
    isopentanol 4.26
    n-heptane 0.67
    ethyl formate 4.2
    1,2-dichloroethane 4.96
    n-hexanol 7.1
    2-methoxyethanol 37.36
    isobutyl acetate 1.39
    tetrachloromethane 1.95
    n-pentyl acetate 3.74
    transcutol 16.75
    n-heptanol 7.77
    ethylbenzene 1.1
    MIBK 2.81
    2-propoxyethanol 22.26
    tert-butanol 8.63
    MTBE 2.21
    2-butoxyethanol 16.2
    propionic acid 4.77
    o-xylene 1.86
    formic acid 31.54
    diethyl ether 1.16
    m-xylene 1.55
    p-xylene 1.53
    chlorobenzene 1.63
    dimethyl carbonate 3.11
    n-octane 0.38
    formamide 40.01
    cyclopentanone 14.19
    2-pentanone 2.2
    anisole 3.48
    cyclopentyl methyl ether 5.59
    gamma-butyrolactone 21.81
    1-methoxy-2-propanol 17.08
    pyridine 5.48
    3-pentanone 1.89
    furfural 26.35
    n-dodecane 0.32
    diethylene glycol 35.63
    diisopropyl ether 0.76
    tert-amyl alcohol 6.48
    acetylacetone 4.3
    n-hexadecane 0.37
    acetophenone 5.87
    methyl propionate 2.66
    isopentyl acetate 3.27
    trichloroethylene 7.44
    n-nonanol 5.09
    cyclohexanol 4.8
    benzyl alcohol 6.72
    2-ethylhexanol 4.96
    isooctanol 6.35
    dipropyl ether 3.0
    1,2-dichlorobenzene 3.52
    ethyl lactate 4.99
    propylene carbonate 8.93
    n-methylformamide 20.55
    2-pentanol 2.24
    n-pentane 0.13
    1-propoxy-2-propanol 12.51
    1-methoxy-2-propyl acetate 6.47
    2-(2-methoxypropoxy) propanol 11.87
    mesitylene 1.63
    ε-caprolactone 10.19
    p-cymene 2.58
    epichlorohydrin 24.17
    1,1,1-trichloroethane 2.9
    2-aminoethanol 17.22
    morpholine-4-carbaldehyde 39.61
    sulfolane 64.65
    2,2,4-trimethylpentane 0.24
    2-methyltetrahydrofuran 7.8
    n-hexyl acetate 4.75
    isooctane 0.21
    2-(2-butoxyethoxy)ethanol 15.8
    sec-butyl acetate 1.34
    tert-butyl acetate 3.04
    decalin 0.38
    glycerin 26.13
    diglyme 28.82
    acrylic acid 6.85
    isopropyl myristate 2.22
    n-butyric acid 5.54
    acetyl acetate 1.85
    di(2-ethylhexyl) phthalate 4.67
    ethyl propionate 2.06
    nitromethane 15.46
    1,2-diethoxyethane 4.34
    benzonitrile 5.34
    trioctyl phosphate 4.25
    1-bromopropane 1.49
    gamma-valerolactone 27.68
    n-decanol 3.88
    triethyl phosphate 4.32
    4-methyl-2-pentanol 2.43
    propionitrile 2.49
    vinylene carbonate 8.8
    1,1,2-trichlorotrifluoroethane 29.91
    DMS 3.8
    cumene 1.58
    2-octanol 4.13
    2-hexanone 2.72
    octyl acetate 3.29
    limonene 3.23
    1,2-dimethoxyethane 22.86
    ethyl orthosilicate 3.88
    tributyl phosphate 3.31
    diacetone alcohol 10.29
    N,N-dimethylaniline 5.14
    acrylonitrile 5.17
    aniline 2.71
    1,3-propanediol 19.1
    bromobenzene 1.37
    dibromomethane 2.94
    1,1,2,2-tetrachloroethane 7.31
    2-methyl-cyclohexyl acetate 4.82
    tetrabutyl urea 6.18
    diisobutyl methanol 3.34
    2-phenylethanol 8.89
    styrene 0.84
    dioctyl adipate 4.03
    dimethyl sulfate 15.1
    ethyl butyrate 3.05
    methyl lactate 7.74
    butyl lactate 5.55
    diethyl carbonate 2.53
    propanediol butyl ether 10.77
    triethyl orthoformate 3.57
    p-tert-butyltoluene 2.49
    methyl 4-tert-butylbenzoate 11.29
    morpholine 16.99
    tert-butylamine 3.33
    n-dodecanol 2.86
    dimethoxymethane 14.03
    ethylene carbonate 6.81
    cyrene 20.37
    2-ethoxyethyl acetate 5.45
    2-ethylhexyl acetate 2.56
    1,2,4-trichlorobenzene 4.64
    4-methylpyridine 4.12
    dibutyl ether 2.13
    2,6-dimethyl-4-heptanol 3.34
    DEF 8.03
    dimethyl isosorbide 21.55
    tetrachloroethylene 6.74
    eugenol 12.27
    triacetin 5.51
    span 80 9.91
    1,4-butanediol 10.54
    1,1-dichloroethane 1.7
    2-methyl-1-pentanol 4.47
    methyl formate 13.55
    2-methyl-1-butanol 3.83
    n-decane 0.49
    butyronitrile 2.72
    3,7-dimethyl-1-octanol 4.13
    1-chlorooctane 1.93
    1-chlorotetradecane 0.9
    n-nonane 0.42
    undecane 0.39
    tert-butylcyclohexane 0.36
    cyclooctane 0.22
    cyclopentanol 7.5
    tetrahydropyran 4.33
    tert-amyl methyl ether 2.54
    2,5,8-trioxanonane 22.92
    1-hexene 0.48
    2-isopropoxyethanol 12.64
    2,2,2-trifluoroethanol 12.19
    methyl butyrate 3.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction