Putrescine Dihydrochloride

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  • Identifiers

    CAS number
    333-93-7

    Molecular formula
    C4H14Cl2N2

    SMILES
    C(CCN)CN.Cl.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 90.48%
    Cheesy 64.2%
    Ripe 53.75%
    Animal 35.19%
    Odorless 31.76%
    Meaty 21.55%
    Savory 15.74%
    Pungent 15.65%
    Musty 13.66%
    Cooked 13.58%

     

    Flavor
    Fishy 47.59%
    Ammoniacal 44.56%
    Meaty 30.14%
    Ammonia 25.99%
    Sulfurous 25.88%
    Sulfury 23.41%
    Skunky 20.49%
    Glue 20.41%
    Bloody 20.4%
    Odorless 19.77%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    6.61 (neutral)

    Molecular weight
    161.07 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    160°C

    Flash point

    • 56.5 ˚C est.

  • Synonyms

    • 1,4-Diaminobutane dihydrochloride
    • 333-93-7
    • Putrescine dihydrochloride
    • 1,4-Butanediamine dihydrochloride
    • Tetramethylenediamine dihydrochloride
    • Putrescine hydrochloride
    • 1,4-BUTANEDIAMINE, DIHYDROCHLORIDE
    • 1,4-Diaminobutane 2HCl
    • butane-1,4-diamine dihydrochloride
    • butane-1,4-diamine;dihydrochloride
    • 1,4-Butanediamine, hydrochloride
    • X45SUR7RHY
    • 1,4-Diaminobutane, dihydrochloride
    • NSC 5861
    • EINECS 206-375-9
    • MFCD00012526
    • AI3-18304
    • Tetramethylenediammonium dichloride
    • 1,4-Butanediamine, hydrochloride (1:2)
    • DTXSID5059824
    • NSC-5861
    • 1,4-Diaminobutane (dihydrochloride)
    • PUTRESCINE DIHYDROCHLORIDE [MI]
    • 1,4-Diaminobutane DiHCl
    • SR-01000076079
    • UNII-X45SUR7RHY
    • 1,4-Butanediamine, hydrochloride (1:2); 1,4-Butanediamine, dihydrochloride (8CI,9CI); 1,4-Diaminobutane dihydrochloride; Putrescine dihydrochloride; Putrescine hydrochloride; Tetramethylenediamine dihydrochloride
    • Putrescindihydrochlorid
    • 1,4-Diaminobutane*2HCl
    • Tetramethylenediamine*2HCl
    • SCHEMBL29458
    • SPECTRUM1503952
    • 1,4Butanediamine, hydrochloride
    • 1,4Diaminobutane dihydrochloride
    • CHEMBL1528028
    • DTXCID1038668
    • 1,4Butanediamine, dihydrochloride
    • 1,4Diaminobutane, dihydrochloride
    • CHEBI:201718
    • HY-Y1781
    • Tox21_500972
    • CCG-39461
    • AKOS015845890
    • AC-4426
    • FD13309
    • LP00972
    • SB75758
    • NCGC00094272-01
    • NCGC00094272-02
    • NCGC00261657-01
    • AS-14367
    • Putrescine dihydrochloride, >=98% (TLC)
    • DB-048395
    • CS-0019391
    • D0081
    • EU-0100972
    • S5344
    • N11902
    • P 7505
    • SR-01000076079-1
    • SR-01000076079-4
    • Q27293545
    • 1,4-Diaminobutane dihydrochloride, purum, >=99.0% (AT)
    • Putrescine dihydrochloride 100 microg/mL in Acetonitrile/Water
    • Putrescine dihydrochloride, Vetec(TM) reagent grade, >=98%
    • Putrescine dihydrochloride, powder, BioReagent, suitable for cell culture
    • Putrescine dihydrochloride, gamma-irradiated, lyophilized powder, BioXtra, suitable for cell culture

  • Applications

    Putrescine Dihydrochloride (CAS 333-93-7) is an aliphatic diamine salt used primarily as a chemical intermediate in industrial manufacturing. It provides the putrescine moiety for the synthesis of polyamides and polyurethanes, typically as a building block or chain extender in polymer formulations. The dihydrochloride form aids handling and storage as a reactive diamine source and is used in coatings, adhesives, and sealants as a curing or crosslinking component for epoxy and related resin systems. In electronics and advanced materials, it is evaluated as a curing agent in epoxy resins and other resin matrices, contributing to network formation and mechanical properties. Additionally, it serves as a precursor for other diamine-derived intermediates and specialty additives in polymer and resin chemistries. Use is formulation- and regulation-dependent.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 53.13
    methanol 163.75
    isopropanol 17.8
    water 64.61
    ethyl acetate 8.33
    n-propanol 36.91
    acetone 9.49
    n-butanol 25.45
    acetonitrile 11.51
    DMF 33.91
    toluene 1.79
    isobutanol 18.01
    1,4-dioxane 13.64
    methyl acetate 11.5
    THF 42.33
    2-butanone 10.18
    n-pentanol 12.13
    sec-butanol 14.63
    n-hexane 0.6
    ethylene glycol 79.39
    NMP 92.36
    cyclohexane 1.05
    DMSO 78.75
    n-butyl acetate 15.47
    n-octanol 5.77
    chloroform 25.14
    n-propyl acetate 6.28
    acetic acid 180.92
    dichloromethane 15.79
    cyclohexanone 26.34
    propylene glycol 56.0
    isopropyl acetate 3.67
    DMAc 29.64
    2-ethoxyethanol 29.66
    isopentanol 11.16
    n-heptane 1.92
    ethyl formate 23.88
    1,2-dichloroethane 7.64
    n-hexanol 22.1
    2-methoxyethanol 76.24
    isobutyl acetate 3.49
    tetrachloromethane 10.8
    n-pentyl acetate 7.22
    transcutol 28.2
    n-heptanol 13.61
    ethylbenzene 0.87
    MIBK 2.61
    2-propoxyethanol 48.88
    tert-butanol 13.0
    MTBE 2.75
    2-butoxyethanol 32.68
    propionic acid 86.08
    o-xylene 1.82
    formic acid 263.15
    diethyl ether 3.08
    m-xylene 1.41
    p-xylene 1.48
    chlorobenzene 6.99
    dimethyl carbonate 4.54
    n-octane 0.62
    formamide 120.87
    cyclopentanone 49.44
    2-pentanone 6.02
    anisole 2.9
    cyclopentyl methyl ether 11.1
    gamma-butyrolactone 86.51
    1-methoxy-2-propanol 30.03
    pyridine 22.92
    3-pentanone 5.16
    furfural 100.74
    n-dodecane 0.35
    diethylene glycol 59.9
    diisopropyl ether 0.73
    tert-amyl alcohol 13.01
    acetylacetone 6.91
    n-hexadecane 0.36
    acetophenone 5.65
    methyl propionate 9.52
    isopentyl acetate 9.18
    trichloroethylene 23.0
    n-nonanol 5.03
    cyclohexanol 17.18
    benzyl alcohol 10.31
    2-ethylhexanol 10.62
    isooctanol 8.04
    dipropyl ether 6.22
    1,2-dichlorobenzene 8.12
    ethyl lactate 10.78
    propylene carbonate 41.88
    n-methylformamide 67.99
    2-pentanol 7.59
    n-pentane 0.68
    1-propoxy-2-propanol 31.26
    1-methoxy-2-propyl acetate 12.51
    2-(2-methoxypropoxy) propanol 11.53
    mesitylene 1.0
    ε-caprolactone 31.3
    p-cymene 2.93
    epichlorohydrin 32.45
    1,1,1-trichloroethane 7.67
    2-aminoethanol 88.2
    morpholine-4-carbaldehyde 52.03
    sulfolane 125.67
    2,2,4-trimethylpentane 0.53
    2-methyltetrahydrofuran 18.81
    n-hexyl acetate 6.34
    isooctane 0.29
    2-(2-butoxyethoxy)ethanol 16.44
    sec-butyl acetate 2.76
    tert-butyl acetate 3.37
    decalin 0.55
    glycerin 114.82
    diglyme 27.38
    acrylic acid 103.11
    isopropyl myristate 2.13
    n-butyric acid 78.31
    acetyl acetate 7.48
    di(2-ethylhexyl) phthalate 6.33
    ethyl propionate 4.59
    nitromethane 80.44
    1,2-diethoxyethane 5.3
    benzonitrile 11.21
    trioctyl phosphate 5.39
    1-bromopropane 3.6
    gamma-valerolactone 64.36
    n-decanol 3.5
    triethyl phosphate 7.19
    4-methyl-2-pentanol 3.11
    propionitrile 11.24
    vinylene carbonate 40.3
    1,1,2-trichlorotrifluoroethane 92.61
    DMS 5.91
    cumene 0.99
    2-octanol 4.95
    2-hexanone 4.39
    octyl acetate 3.96
    limonene 4.39
    1,2-dimethoxyethane 16.32
    ethyl orthosilicate 6.42
    tributyl phosphate 6.07
    diacetone alcohol 10.75
    N,N-dimethylaniline 2.77
    acrylonitrile 21.43
    aniline 12.8
    1,3-propanediol 81.72
    bromobenzene 4.64
    dibromomethane 9.68
    1,1,2,2-tetrachloroethane 19.72
    2-methyl-cyclohexyl acetate 8.94
    tetrabutyl urea 6.86
    diisobutyl methanol 3.94
    2-phenylethanol 14.38
    styrene 1.32
    dioctyl adipate 4.63
    dimethyl sulfate 14.11
    ethyl butyrate 9.29
    methyl lactate 20.76
    butyl lactate 14.03
    diethyl carbonate 6.36
    propanediol butyl ether 20.59
    triethyl orthoformate 8.13
    p-tert-butyltoluene 3.03
    methyl 4-tert-butylbenzoate 9.44
    morpholine 24.76
    tert-butylamine 5.91
    n-dodecanol 2.59
    dimethoxymethane 8.92
    ethylene carbonate 27.37
    cyrene 22.14
    2-ethoxyethyl acetate 8.34
    2-ethylhexyl acetate 7.93
    1,2,4-trichlorobenzene 10.32
    4-methylpyridine 11.7
    dibutyl ether 2.64
    2,6-dimethyl-4-heptanol 3.94
    DEF 12.87
    dimethyl isosorbide 24.93
    tetrachloroethylene 26.41
    eugenol 14.01
    triacetin 8.35
    span 80 19.6
    1,4-butanediol 27.44
    1,1-dichloroethane 5.5
    2-methyl-1-pentanol 7.04
    methyl formate 39.12
    2-methyl-1-butanol 14.12
    n-decane 0.57
    butyronitrile 10.89
    3,7-dimethyl-1-octanol 4.11
    1-chlorooctane 1.92
    1-chlorotetradecane 0.82
    n-nonane 0.56
    undecane 0.42
    tert-butylcyclohexane 0.54
    cyclooctane 0.46
    cyclopentanol 36.9
    tetrahydropyran 10.77
    tert-amyl methyl ether 3.01
    2,5,8-trioxanonane 18.66
    1-hexene 1.47
    2-isopropoxyethanol 12.39
    2,2,2-trifluoroethanol 76.82
    methyl butyrate 8.23

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction