Pterostilbene

Overview IFRA Request a quote

  • Identifiers

    CAS number
    537-42-8

    Molecular formula
    C16H16O3

    SMILES
    COC1=CC(=CC(=C1)/C=C/C2=CC=C(C=C2)O)OC

    Safety labels

    Corrosive
    Corrosive

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 71.28%
    Floral 66.81%
    Spicy 60.55%
    Fruity 50.23%
    Balsamic 45.68%
    Powdery 40.46%
    Phenolic 39.92%
    Woody 37.6%
    Vanilla 31.56%
    Clove 30.15%

     

    Flavor
    Bitter 62.87%
    Balsam 23.98%
    Floral 20.27%
    Parsley 20.05%
    Nitrile 19.69%
    Curry 19.55%
    Heather 19.52%
    Lovage 19.51%
    Ethyl benzoate 19.48%
    Broom 19.38%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.8

    pKa est.
    9.38 (weak base)

    Molecular weight
    256.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    466°C

    Flash point

    • 181.36 ˚C est.

  • Synonyms

    • Pterostilbene
    • 537-42-8
    • trans-pterostilbene
    • 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
    • pterostilbene, (E)-
    • 3',5'-Dimethoxy-4-stilbenol
    • 3,5-Dimethoxy-4'-hydroxystilbene
    • 3,5-Dimethoxy-4'-hydroxy-trans-stilbene
    • Phenol, 4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-
    • 3',5'-dimethoxy-resveratrol
    • trans-3,5-dimethoxy-4'-hydroxystilbene
    • 26R60S6A5I
    • 4-((E)-2-(3,5-dimethoxyphenyl)ethenyl)phenol
    • CHEBI:8630
    • DTXSID9041106
    • phenol, 4-((1E)-2-(3,5-dimethoxyphenyl)ethenyl)-
    • EH-301 COMPONENT PTEROSTILBENE
    • Phenol, 4-(2-(3,5-dimethoxyphenyl)ethenyl)-, (E)-
    • 3',5'-dimethoxy-4E-stilbenol
    • 3',5'-dimethoxy-4trans-stilbenol
    • RefChem:47231
    • 4trans-(2-(3,5-dimethoxyphenyl)ethenyl)phenol
    • DTXCID7021106
    • 611-041-4
    • Trans-3,5-dimethoxy-4-hydroxystilbene
    • 4-(3,5-Dimethoxystyryl)phenol
    • (E)-4-(3,5-dimethoxystyryl)phenol
    • 4-[(E)-2-(3,5-dimethoxyphenyl)vinyl]phenol
    • MFCD00238710
    • 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol
    • CHEMBL83527
    • phenol, 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]-
    • SMR000440694
    • Pterostilbene, Pterocarpus marsupium
    • 4-((1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL)PHENOL
    • pterostilben
    • pTeroPure
    • UNII-26R60S6A5I
    • Tero-STILL-bean
    • Phenol, 4-[2-(3,5-dimethoxyphenyl)ethenyl]-
    • CPD000440694
    • 4-Stilbenol, 3',5'-dimethoxy-, (E)-
    • Pterostilbene (Standard)
    • SCHEMBL20063
    • MLS000759434
    • MLS000863581
    • MLS001424135
    • PTEROSTILBENE [WHO-DD]
    • GTPL2681
    • MEGxp0_000345
    • orb1304886
    • ACon1_000305
    • HY-N0828R
    • Pterostilbene - Bio-X trade mark
    • HMS2051B10
    • HMS2270J16
    • AKOS 236-80
    • ALBB-013778
    • HY-N0828
    • (E)-3',5'-dimethoxy-4-stilbenol
    • BDBM50131688
    • LMPK13090015
    • MSK162922
    • NSC613735
    • s3937
    • 4''-hydroxy-3,5-dimethoxy stilbene
    • AKOS000277651
    • AKOS025310510
    • AC-5283
    • CCG-101015
    • CS-W008773
    • EBC-157141
    • EBC-615504
    • FP15443
    • NC00265
    • NSC-613735
    • (E)-4'-hydroxy-3,5-dimethoxystilbene
    • Pterostilbene, >=97% (HPLC), solid
    • NCGC00180691-01
    • 4'-Hydroxy-3,5-dimethoxy-trans-stilbene
    • AS-13710
    • BP300110
    • LS-14484
    • SY053629
    • 3,5-Dimethoxy-4''-hydroxyl-trans-stilbene
    • NS00032832
    • P1924
    • 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol
    • (E)-1-hydroxy-4-(3,5-dimethoxy)styrylbenzene
    • E 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol
    • 259P159
    • 4-[(E)-2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol
    • EN300-18388389
    • F093412
    • 4-[(E)-2-(3,5-Dimethoxyphenyl)ethen-1-yl]phenol
    • Q2908011
    • BRD-K53097745-001-01-5
    • Z2065715198
    • trans-1-(3,5-Dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene
    • Phenol, 4-?[(1E)?-?2-?(3,?5-?dimethoxyphenyl)?ethenyl]?-
    • 1318852-41-3
    • Pterostilbene4-(3,5-Dimethoxystyryl)phenol; (E)-4-(3,5-dimethoxystyryl)phenol; 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
    • 537-42-8

  • Applications

    Pterostilbene (CAS 537-42-8) is a natural stilbene studied for diverse applications across industries. In cosmetics and personal care, it is commonly evaluated as an antioxidant with potential as a UV-protective and anti-inflammatory ingredient in topical formulations. In nutraceuticals and dietary supplements, it is often considered for inclusion due to its antioxidant properties. In pharmaceuticals and drug discovery, it remains a lead-like compound under investigation for various biological activities, with emphasis on anti-inflammatory and metabolic effects, while avoiding therapeutic claims. In food processing, it is investigated as a functional ingredient or antioxidant additive to help preserve quality. In polymers and coatings, its antioxidant properties are explored as a stabilizing additive to improve longevity of formulations. Regulatory status varies by region and is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 390.6
    methanol 178.99
    isopropanol 276.78
    water 0.03
    ethyl acetate 307.81
    n-propanol 308.99
    acetone 204.73
    n-butanol 147.58
    acetonitrile 212.18
    DMF 91.65
    toluene 55.49
    isobutanol 118.72
    1,4-dioxane 624.21
    methyl acetate 325.62
    THF 1194.98
    2-butanone 321.52
    n-pentanol 95.32
    sec-butanol 211.63
    n-hexane 2.38
    ethylene glycol 99.37
    NMP 30.45
    cyclohexane 6.85
    DMSO 1116.52
    n-butyl acetate 51.75
    n-octanol 21.61
    chloroform 439.9
    n-propyl acetate 81.19
    acetic acid 119.41
    dichloromethane 382.44
    cyclohexanone 119.47
    propylene glycol 623.15
    isopropyl acetate 89.91
    DMAc 214.86
    2-ethoxyethanol 374.18
    isopentanol 69.54
    n-heptane 4.03
    ethyl formate 86.4
    1,2-dichloroethane 265.83
    n-hexanol 63.4
    2-methoxyethanol 645.6
    isobutyl acetate 44.02
    tetrachloromethane 19.8
    n-pentyl acetate 26.42
    transcutol 481.06
    n-heptanol 20.88
    ethylbenzene 25.56
    MIBK 56.99
    2-propoxyethanol 214.02
    tert-butanol 229.2
    MTBE 130.01
    2-butoxyethanol 71.19
    propionic acid 163.55
    o-xylene 23.87
    formic acid 34.46
    diethyl ether 188.28
    m-xylene 23.36
    p-xylene 25.93
    chlorobenzene 52.88
    dimethyl carbonate 72.87
    n-octane 2.32
    formamide 109.09
    cyclopentanone 191.17
    2-pentanone 127.67
    anisole 102.88
    cyclopentyl methyl ether 123.52
    gamma-butyrolactone 202.68
    1-methoxy-2-propanol 434.31
    pyridine 236.45
    3-pentanone 111.96
    furfural 137.37
    n-dodecane 2.72
    diethylene glycol 201.17
    diisopropyl ether 23.02
    tert-amyl alcohol 147.94
    acetylacetone 155.76
    n-hexadecane 3.1
    acetophenone 63.49
    methyl propionate 220.1
    isopentyl acetate 46.06
    trichloroethylene 384.13
    n-nonanol 23.09
    cyclohexanol 85.09
    benzyl alcohol 88.22
    2-ethylhexanol 30.36
    isooctanol 18.16
    dipropyl ether 53.59
    1,2-dichlorobenzene 39.42
    ethyl lactate 58.06
    propylene carbonate 72.5
    n-methylformamide 101.3
    2-pentanol 82.33
    n-pentane 1.95
    1-propoxy-2-propanol 129.97
    1-methoxy-2-propyl acetate 105.91
    2-(2-methoxypropoxy) propanol 79.62
    mesitylene 12.94
    ε-caprolactone 106.35
    p-cymene 14.65
    epichlorohydrin 499.79
    1,1,1-trichloroethane 143.81
    2-aminoethanol 271.07
    morpholine-4-carbaldehyde 150.26
    sulfolane 203.86
    2,2,4-trimethylpentane 2.82
    2-methyltetrahydrofuran 281.76
    n-hexyl acetate 41.02
    isooctane 1.98
    2-(2-butoxyethoxy)ethanol 123.33
    sec-butyl acetate 53.73
    tert-butyl acetate 80.4
    decalin 4.89
    glycerin 330.11
    diglyme 246.68
    acrylic acid 103.18
    isopropyl myristate 22.36
    n-butyric acid 136.88
    acetyl acetate 94.28
    di(2-ethylhexyl) phthalate 21.15
    ethyl propionate 84.69
    nitromethane 275.47
    1,2-diethoxyethane 133.35
    benzonitrile 58.63
    trioctyl phosphate 14.52
    1-bromopropane 111.3
    gamma-valerolactone 221.05
    n-decanol 18.8
    triethyl phosphate 32.76
    4-methyl-2-pentanol 31.47
    propionitrile 152.32
    vinylene carbonate 65.18
    1,1,2-trichlorotrifluoroethane 255.34
    DMS 63.21
    cumene 16.39
    2-octanol 14.54
    2-hexanone 72.43
    octyl acetate 26.96
    limonene 19.39
    1,2-dimethoxyethane 350.18
    ethyl orthosilicate 30.87
    tributyl phosphate 20.29
    diacetone alcohol 120.65
    N,N-dimethylaniline 43.48
    acrylonitrile 161.65
    aniline 97.74
    1,3-propanediol 305.39
    bromobenzene 53.99
    dibromomethane 212.87
    1,1,2,2-tetrachloroethane 323.52
    2-methyl-cyclohexyl acetate 41.83
    tetrabutyl urea 25.14
    diisobutyl methanol 21.31
    2-phenylethanol 62.68
    styrene 33.52
    dioctyl adipate 37.55
    dimethyl sulfate 99.14
    ethyl butyrate 51.12
    methyl lactate 113.14
    butyl lactate 33.69
    diethyl carbonate 44.18
    propanediol butyl ether 69.79
    triethyl orthoformate 43.33
    p-tert-butyltoluene 14.76
    methyl 4-tert-butylbenzoate 48.39
    morpholine 771.62
    tert-butylamine 68.8
    n-dodecanol 15.55
    dimethoxymethane 281.88
    ethylene carbonate 60.15
    cyrene 65.28
    2-ethoxyethyl acetate 70.57
    2-ethylhexyl acetate 33.64
    1,2,4-trichlorobenzene 58.03
    4-methylpyridine 111.35
    dibutyl ether 37.43
    2,6-dimethyl-4-heptanol 21.31
    DEF 83.22
    dimethyl isosorbide 124.07
    tetrachloroethylene 129.07
    eugenol 50.99
    triacetin 63.03
    span 80 54.09
    1,4-butanediol 102.94
    1,1-dichloroethane 211.74
    2-methyl-1-pentanol 55.23
    methyl formate 74.4
    2-methyl-1-butanol 75.89
    n-decane 4.02
    butyronitrile 94.05
    3,7-dimethyl-1-octanol 24.5
    1-chlorooctane 16.32
    1-chlorotetradecane 8.1
    n-nonane 3.52
    undecane 3.23
    tert-butylcyclohexane 4.6
    cyclooctane 2.3
    cyclopentanol 117.19
    tetrahydropyran 408.63
    tert-amyl methyl ether 78.51
    2,5,8-trioxanonane 170.67
    1-hexene 16.01
    2-isopropoxyethanol 176.31
    2,2,2-trifluoroethanol 37.83
    methyl butyrate 83.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction