Propylene glycol dihexanoate

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  • Identifiers

    CAS number
    50343-36-7

    Molecular formula
    C15H28O4

    SMILES
    CCCCCC(=O)OCC(C)OC(=O)CCCCC

  • Odor profile

    Fragrance
    Fruity 93.34%
    Green 58.41%
    Winey 57.16%
    Fatty 52.61%
    Pineapple 47.41%
    Oily 46.97%
    Waxy 43.42%
    Sweet 39.27%
    Tropical 37.38%
    Apple 37.33%

     

    Flavor
    Fruity 85.32%
    Pineapple 53.1%
    Green 52.15%
    Waxy 47.0%
    Apple 46.41%
    Sweet 46.21%
    Tropical 44.73%
    Berry 40.64%
    Fruit 39.13%
    Pear 37.61%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.3

    pKa est.
    7.1 (neutral)

    Molecular weight
    272.38 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    301°C

    Flash point

    • 148.39 ˚C est.

    Solubility expt.

    • Practically insoluble or insoluble in water
    • Soluble (in ethanol)

  • Synonyms

    • Propylene glycol dihexanoate
    • 50343-36-7
    • Sefsol 220
    • PROPYLENE GLYCOL DICAPROATE
    • 1,2-Propanediol dihexanoate
    • 2-hexanoyloxypropyl hexanoate
    • FEMA No. 4470
    • NSC-409891
    • 1,2-Propylene glycol dicaproate
    • UNII-L37F145LOT
    • L37F145LOT
    • (+-)-Propylene glycol dihexanoate
    • Propylene glycol dihexanoate, (+-)-
    • Hexanoic acid, 1-methyl-1,2-ethanediyl ester
    • Hexanoic acid, 1,1'-(1-methyl-1,2-ethanediyl) ester
    • (+/-)-PROPYLENE GLYCOL DIHEXANOATE
    • PROPYLENE GLYCOL DIHEXANOATE, (+/-)-
    • NSC409891
    • 1,2-propanediol dicaproate
    • Propane-1,2-diyl dihexanoate
    • CHEMBL2268845
    • SCHEMBL17466184
    • DTXSID00866148
    • RMZFJNNOMUICLE-UHFFFAOYSA-N
    • PROPYLENE GLYCOL DICAPROATE [INCI]
    • DB-256012
    • NS00125049
    • Q27282650

  • Applications

    Propylene glycol dihexanoate (CAS 50343-36-7) is used in cosmetics and personal care as an emollient and solvent for lipophilic ingredients, providing slip and moisturization in creams, lotions, and makeup. In perfumery, it acts as a solvent and carrier for fragrance oils, helping dissolve and blend aromatic components. In coatings, inks, and adhesives, it serves as a plasticizer and processing aid, improving flexibility and film formation. In industrial manufacturing, it functions as a non-volatile solvent and formulation carrier for specialty systems, with typical use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 926.91
    methanol 1467.59
    isopropanol 729.94
    water 0.57
    ethyl acetate 1700.01
    n-propanol 708.92
    acetone 2297.08
    n-butanol 686.38
    acetonitrile 1416.63
    DMF 2428.49
    toluene 761.62
    isobutanol 606.4
    1,4-dioxane 1509.21
    methyl acetate 1331.87
    THF 2223.97
    2-butanone 1574.98
    n-pentanol 511.23
    sec-butanol 701.41
    n-hexane 79.33
    ethylene glycol 103.1
    NMP 2701.07
    cyclohexane 197.05
    DMSO 2753.5
    n-butyl acetate 1101.44
    n-octanol 204.38
    chloroform 3347.13
    n-propyl acetate 1097.26
    acetic acid 1767.17
    dichloromethane 3648.51
    cyclohexanone 2900.57
    propylene glycol 166.11
    isopropyl acetate 1159.94
    DMAc 2768.49
    2-ethoxyethanol 857.48
    isopentanol 714.44
    n-heptane 26.37
    ethyl formate 895.55
    1,2-dichloroethane 2724.9
    n-hexanol 370.86
    2-methoxyethanol 1250.94
    isobutyl acetate 672.67
    tetrachloromethane 474.85
    n-pentyl acetate 733.05
    transcutol 2366.18
    n-heptanol 185.77
    ethylbenzene 364.52
    MIBK 885.55
    2-propoxyethanol 756.42
    tert-butanol 1000.61
    MTBE 1119.91
    2-butoxyethanol 496.64
    propionic acid 902.26
    o-xylene 490.54
    formic acid 492.37
    diethyl ether 991.18
    m-xylene 444.47
    p-xylene 566.37
    chlorobenzene 1189.49
    dimethyl carbonate 414.13
    n-octane 17.31
    formamide 793.26
    cyclopentanone 2457.03
    2-pentanone 1396.85
    anisole 683.16
    cyclopentyl methyl ether 1256.09
    gamma-butyrolactone 2797.03
    1-methoxy-2-propanol 893.88
    pyridine 1830.84
    3-pentanone 1080.79
    furfural 2093.97
    n-dodecane 14.92
    diethylene glycol 484.5
    diisopropyl ether 289.45
    tert-amyl alcohol 918.45
    acetylacetone 1746.76
    n-hexadecane 17.92
    acetophenone 832.37
    methyl propionate 1072.72
    isopentyl acetate 1019.07
    trichloroethylene 4243.95
    n-nonanol 183.88
    cyclohexanol 987.69
    benzyl alcohol 577.58
    2-ethylhexanol 273.36
    isooctanol 174.43
    dipropyl ether 334.94
    1,2-dichlorobenzene 1087.07
    ethyl lactate 333.11
    propylene carbonate 1461.26
    n-methylformamide 1120.19
    2-pentanol 500.7
    n-pentane 58.13
    1-propoxy-2-propanol 546.84
    1-methoxy-2-propyl acetate 841.6
    2-(2-methoxypropoxy) propanol 491.42
    mesitylene 264.05
    ε-caprolactone 2384.89
    p-cymene 182.1
    epichlorohydrin 2822.97
    1,1,1-trichloroethane 2243.59
    2-aminoethanol 297.44
    morpholine-4-carbaldehyde 1990.7
    sulfolane 2991.69
    2,2,4-trimethylpentane 54.9
    2-methyltetrahydrofuran 1964.66
    n-hexyl acetate 828.69
    isooctane 29.75
    2-(2-butoxyethoxy)ethanol 682.07
    sec-butyl acetate 758.83
    tert-butyl acetate 1076.3
    decalin 109.01
    glycerin 260.22
    diglyme 1431.87
    acrylic acid 710.5
    isopropyl myristate 246.65
    n-butyric acid 1560.88
    acetyl acetate 1223.4
    di(2-ethylhexyl) phthalate 262.78
    ethyl propionate 915.65
    nitromethane 3048.09
    1,2-diethoxyethane 931.81
    benzonitrile 912.65
    trioctyl phosphate 171.68
    1-bromopropane 1318.93
    gamma-valerolactone 3075.45
    n-decanol 121.98
    triethyl phosphate 314.83
    4-methyl-2-pentanol 286.76
    propionitrile 967.42
    vinylene carbonate 1265.02
    1,1,2-trichlorotrifluoroethane 1711.85
    DMS 672.48
    cumene 229.4
    2-octanol 157.01
    2-hexanone 920.76
    octyl acetate 313.52
    limonene 311.33
    1,2-dimethoxyethane 1721.37
    ethyl orthosilicate 295.76
    tributyl phosphate 272.2
    diacetone alcohol 903.36
    N,N-dimethylaniline 469.62
    acrylonitrile 1123.6
    aniline 757.97
    1,3-propanediol 548.64
    bromobenzene 1377.5
    dibromomethane 2333.71
    1,1,2,2-tetrachloroethane 3597.0
    2-methyl-cyclohexyl acetate 534.77
    tetrabutyl urea 329.39
    diisobutyl methanol 163.31
    2-phenylethanol 452.79
    styrene 502.39
    dioctyl adipate 431.6
    dimethyl sulfate 790.73
    ethyl butyrate 681.18
    methyl lactate 401.75
    butyl lactate 490.51
    diethyl carbonate 447.78
    propanediol butyl ether 449.96
    triethyl orthoformate 418.81
    p-tert-butyltoluene 165.1
    methyl 4-tert-butylbenzoate 559.46
    morpholine 1995.47
    tert-butylamine 565.33
    n-dodecanol 89.51
    dimethoxymethane 1089.6
    ethylene carbonate 1171.97
    cyrene 551.76
    2-ethoxyethyl acetate 933.7
    2-ethylhexyl acetate 785.8
    1,2,4-trichlorobenzene 1199.45
    4-methylpyridine 2034.24
    dibutyl ether 397.64
    2,6-dimethyl-4-heptanol 163.31
    DEF 1737.57
    dimethyl isosorbide 904.85
    tetrachloroethylene 2210.02
    eugenol 496.0
    triacetin 747.35
    span 80 440.83
    1,4-butanediol 242.81
    1,1-dichloroethane 2426.93
    2-methyl-1-pentanol 568.73
    methyl formate 780.25
    2-methyl-1-butanol 645.12
    n-decane 27.5
    butyronitrile 1108.34
    3,7-dimethyl-1-octanol 244.4
    1-chlorooctane 189.28
    1-chlorotetradecane 65.06
    n-nonane 25.94
    undecane 19.02
    tert-butylcyclohexane 76.99
    cyclooctane 44.24
    cyclopentanol 935.41
    tetrahydropyran 1835.45
    tert-amyl methyl ether 834.63
    2,5,8-trioxanonane 864.23
    1-hexene 364.01
    2-isopropoxyethanol 598.0
    2,2,2-trifluoroethanol 584.55
    methyl butyrate 1394.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction