Propanolamine

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  • Identifiers

    CAS number
    156-87-6

    Molecular formula
    C3H9NO

    SMILES
    C(CN)CO

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 73.66%
    Cheesy 50.69%
    Odorless 42.14%
    Ripe 41.22%
    Alcoholic 26.21%
    Oily 23.1%
    Meaty 20.78%
    Pungent 20.44%
    Animal 19.31%
    Sweet 18.85%

     

    Flavor
    Odorless 41.63%
    Sweet 38.2%
    Bitter 34.46%
    Alcoholic 33.79%
    Fishy 29.87%
    Sulfurous 28.16%
    Pungent 24.27%
    Very slight 24.08%
    Sweet-like 23.69%
    Soup 23.07%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    -1.1

    pKa est.
    7.23 (neutral)

    Molecular weight
    75.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Melting point expt.

    • 52 °F (USCG, 1999)
    • 12.4 °C

    Boiling point

    • 369.5 °F at 760 mmHg (USCG, 1999)
    • 187-188 °C @ 756 MM HG

    Flash point

    • 79.5 ˚C est.
    • 175 °F (USCG, 1999)
    • 175 °F

    Solubility expt.

    • SOL IN WATER, ALCOHOL & ETHER
    • MISCIBLE WITH ACETONE & CHLOROFORM

  • Synonyms

    • 3-Aminopropan-1-ol
    • 3-Aminopropanol
    • 3-Amino-1-propanol
    • 156-87-6
    • 1-Propanol, 3-amino-
    • PROPANOLAMINE
    • 3-Propanolamine
    • 3-Aminopropyl alcohol
    • 1-Amino-3-propanol
    • 1,3-Propanolamine
    • 3-Hydroxypropylamine
    • 1-Amino-3-hydroxypropane
    • beta-Alaninol
    • n-Propanolamine
    • .beta.-Alaninol
    • gamma-Aminopropanol
    • 3-Hydroxy-1-propylamine
    • .gamma.-Aminopropanol
    • gamma-Hydroxy-1-propylamine
    • NSC 7766
    • 3-hydroxypropan-1-amine
    • HSDB 5161
    • 3-Hydroxy-1-aminopropane
    • YMA7C44XGY
    • EINECS 205-864-4
    • MFCD00008223
    • BRN 0741855
    • AI3-25439
    • NSC-7766
    • n-(3-hydroxypropyl)amine
    • NSC 7766; Propanolamine
    • PROPANOLAMINE [HSDB]
    • PROPANOLAMINE [USP-RS]
    • 3-Aminopropanol (Propanolamine)
    • DTXSID0059746
    • CHEBI:143408
    • EC 205-864-4
    • .GAMMA.-HYDROXY-1-PROPYLAMINE
    • propane, 1-amino-3-hydroxy-
    • PROPANOLAMINE (USP-RS)
    • 3-Aminopropanol; 3-Amino-1-propanol
    • 3-Amino-propan-1-ol
    • 3-Aminopropanol-(1)
    • UNII-YMA7C44XGY
    • betaAlaninol
    • nPropanolamine
    • 3aminopropanol
    • 3Propanolamine
    • 1Amino3propanol
    • 3Amino1propanol
    • 3Aminopropan1ol
    • gammaAminopropanol
    • 3- aminopropanol
    • 3-amino-propanol
    • aminopropan-3-ol
    • 1,3Propanolamine
    • 3hydroxypropylamine
    • 3-hydroxypropyamine
    • 3-amino-1propanol
    • 3amino-1-propanol
    • 1Propanol, 3amino
    • 3-amino-l-propanol
    • 3Aminopropyl alcohol
    • 3Hydroxy1propylamine
    • 1Amino3hydroxypropane
    • 3-Hydroxylpropylamine
    • 3-aminopropane-1-ol
    • 3-hydroxy-propylamine
    • 1-amino-propan-3-ol
    • 1-propanol, 3-amino
    • 3-amino -1-propanol
    • 3-hydroxy-propyl amine
    • gammaHydroxy1propylamine
    • 0D8
    • 1-amino-3-propyl alcohol
    • WLN: Z3Q
    • 3-Amino-1-propanol, 99%
    • H2N(CH2)3OH
    • NH2(CH2)3OH
    • CHEMBL115530
    • DTXCID1035024
    • H2N-(CH2)3-OH
    • CHEBI:35533
    • 3-Amino-1-propanol, >=99%
    • NSC7766
    • JCA72007
    • STR03558
    • YGA54744
    • STL194299
    • AKOS000119899
    • CS-W020089
    • SB83761
    • 3-Amino-1-propanol, analytical standard
    • BP-31041
    • A0438
    • DEXPANTHENOL IMPURITY A [EP IMPURITY]
    • NS00001059
    • EN300-16772
    • D77871
    • Q223042
    • Z56771034
    • F2190-0368
    • Propanolamine, United States Pharmacopeia (USP) Reference Standard
    • 3-Amino-1-propanol, Pharmaceutical Secondary Standard; Certified Reference Material
    • 205-864-4

  • Applications

    Propanolamine (CAS 156-87-6) is used primarily as an intermediate and solvent in chemical synthesis, notably for the production of surfactants and specialty cleaners; it serves as a building block in polymers and coatings, where it can act as a curing agent or crosslinker in epoxy and polyurethane systems; it may be used as a precursor for pharmaceutical and other fine-chemical intermediates; it can be employed in cosmetics and personal-care formulations as a solvent or pH-modifier and as a handle for synthesizing more complex ingredients; and it is also used as a processing aid in industrial manufacturing and ink formulations, including cleaning formulations, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 156.43
    methanol 587.29
    isopropanol 36.28
    water 1649.25
    ethyl acetate 9.65
    n-propanol 83.76
    acetone 25.13
    n-butanol 47.39
    acetonitrile 18.6
    DMF 120.47
    toluene 0.86
    isobutanol 39.41
    1,4-dioxane 20.89
    methyl acetate 12.05
    THF 67.03
    2-butanone 13.12
    n-pentanol 19.47
    sec-butanol 26.38
    n-hexane 0.72
    ethylene glycol 507.63
    NMP 263.43
    cyclohexane 1.4
    DMSO 268.79
    n-butyl acetate 17.35
    n-octanol 7.81
    chloroform 7.95
    n-propyl acetate 8.18
    acetic acid 1015.55
    dichloromethane 7.27
    cyclohexanone 41.0
    propylene glycol 274.94
    isopropyl acetate 4.77
    DMAc 70.91
    2-ethoxyethanol 68.82
    isopentanol 21.3
    n-heptane 2.09
    ethyl formate 26.76
    1,2-dichloroethane 4.73
    n-hexanol 33.18
    2-methoxyethanol 197.44
    isobutyl acetate 5.1
    tetrachloromethane 5.27
    n-pentyl acetate 8.01
    transcutol 102.44
    n-heptanol 16.44
    ethylbenzene 0.42
    MIBK 4.56
    2-propoxyethanol 95.53
    tert-butanol 27.87
    MTBE 3.47
    2-butoxyethanol 50.11
    propionic acid 236.83
    o-xylene 1.2
    formic acid 1724.35
    diethyl ether 3.91
    m-xylene 1.03
    p-xylene 0.88
    chlorobenzene 2.98
    dimethyl carbonate 6.13
    n-octane 0.53
    formamide 779.92
    cyclopentanone 77.46
    2-pentanone 9.44
    anisole 2.32
    cyclopentyl methyl ether 16.62
    gamma-butyrolactone 126.64
    1-methoxy-2-propanol 71.14
    pyridine 15.76
    3-pentanone 6.45
    furfural 124.67
    n-dodecane 0.32
    diethylene glycol 169.83
    diisopropyl ether 1.17
    tert-amyl alcohol 23.01
    acetylacetone 13.86
    n-hexadecane 0.32
    acetophenone 5.18
    methyl propionate 12.68
    isopentyl acetate 11.24
    trichloroethylene 11.2
    n-nonanol 6.57
    cyclohexanol 33.6
    benzyl alcohol 9.28
    2-ethylhexanol 12.24
    isooctanol 10.17
    dipropyl ether 7.53
    1,2-dichlorobenzene 3.56
    ethyl lactate 17.89
    propylene carbonate 48.35
    n-methylformamide 198.7
    2-pentanol 12.88
    n-pentane 0.88
    1-propoxy-2-propanol 58.15
    1-methoxy-2-propyl acetate 15.89
    2-(2-methoxypropoxy) propanol 26.54
    mesitylene 0.96
    ε-caprolactone 45.14
    p-cymene 1.93
    epichlorohydrin 32.9
    1,1,1-trichloroethane 3.34
    2-aminoethanol 462.24
    morpholine-4-carbaldehyde 138.3
    sulfolane 218.98
    2,2,4-trimethylpentane 0.64
    2-methyltetrahydrofuran 27.65
    n-hexyl acetate 8.36
    isooctane 0.4
    2-(2-butoxyethoxy)ethanol 41.01
    sec-butyl acetate 3.42
    tert-butyl acetate 5.85
    decalin 0.48
    glycerin 515.06
    diglyme 58.16
    acrylic acid 318.9
    isopropyl myristate 2.74
    n-butyric acid 159.21
    acetyl acetate 9.93
    di(2-ethylhexyl) phthalate 8.87
    ethyl propionate 5.42
    nitromethane 271.12
    1,2-diethoxyethane 8.03
    benzonitrile 8.39
    trioctyl phosphate 7.17
    1-bromopropane 1.83
    gamma-valerolactone 130.85
    n-decanol 4.34
    triethyl phosphate 7.01
    4-methyl-2-pentanol 5.78
    propionitrile 11.62
    vinylene carbonate 46.28
    1,1,2-trichlorotrifluoroethane 150.31
    DMS 8.0
    cumene 0.62
    2-octanol 5.67
    2-hexanone 6.21
    octyl acetate 5.14
    limonene 3.72
    1,2-dimethoxyethane 26.56
    ethyl orthosilicate 6.54
    tributyl phosphate 8.26
    diacetone alcohol 22.28
    N,N-dimethylaniline 2.57
    acrylonitrile 23.11
    aniline 10.26
    1,3-propanediol 276.89
    bromobenzene 1.49
    dibromomethane 4.0
    1,1,2,2-tetrachloroethane 10.24
    2-methyl-cyclohexyl acetate 9.72
    tetrabutyl urea 11.02
    diisobutyl methanol 4.64
    2-phenylethanol 12.54
    styrene 0.62
    dioctyl adipate 6.95
    dimethyl sulfate 21.86
    ethyl butyrate 10.46
    methyl lactate 40.2
    butyl lactate 22.31
    diethyl carbonate 5.94
    propanediol butyl ether 50.69
    triethyl orthoformate 9.01
    p-tert-butyltoluene 1.88
    methyl 4-tert-butylbenzoate 13.16
    morpholine 46.48
    tert-butylamine 10.19
    n-dodecanol 3.22
    dimethoxymethane 17.77
    ethylene carbonate 32.18
    cyrene 43.78
    2-ethoxyethyl acetate 10.49
    2-ethylhexyl acetate 8.1
    1,2,4-trichlorobenzene 5.2
    4-methylpyridine 8.44
    dibutyl ether 3.03
    2,6-dimethyl-4-heptanol 4.64
    DEF 22.16
    dimethyl isosorbide 39.4
    tetrachloroethylene 15.73
    eugenol 20.9
    triacetin 14.31
    span 80 40.57
    1,4-butanediol 98.98
    1,1-dichloroethane 2.43
    2-methyl-1-pentanol 11.07
    methyl formate 83.9
    2-methyl-1-butanol 27.02
    n-decane 0.49
    butyronitrile 11.33
    3,7-dimethyl-1-octanol 5.99
    1-chlorooctane 1.43
    1-chlorotetradecane 0.66
    n-nonane 0.48
    undecane 0.37
    tert-butylcyclohexane 0.49
    cyclooctane 0.53
    cyclopentanol 83.74
    tetrahydropyran 14.04
    tert-amyl methyl ether 3.58
    2,5,8-trioxanonane 44.35
    1-hexene 1.35
    2-isopropoxyethanol 27.65
    2,2,2-trifluoroethanol 326.91
    methyl butyrate 10.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction