Potassium glycerophosphate trihydrate

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  • Identifiers

    CAS number
    1319-70-6

    Molecular formula
    C8H18K4O12P2

    SMILES
    C(CO)C(CCO)OP(=O)([O-])[O-].C(C(COP(=O)([O-])[O-])O)O.[K+].[K+].[K+].[K+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 60.72%
    Sweet 41.79%
    Alcoholic 25.2%
    Fruity 20.32%
    Fresh 19.59%
    Oily 19.54%
    Cooling 19.1%
    Milky 18.58%
    Savory 18.34%
    Clean 17.55%

     

    Flavor
    Odorless 68.37%
    Mild 28.76%
    Sweet-like 25.66%
    Bland 24.0%
    Sour 22.4%
    Very slight 22.16%
    Very mild 22.15%
    Yeast 21.85%
    Bitter 20.93%
    Soy 20.8%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.17 (weak acid)

    Molecular weight
    524.56 g/mol

    Flash point

    • 198.25 ˚C est.

  • Synonyms

    • Potassium glycerophosphate trihydrate
    • 1319-70-6
    • Dipotassium glycerophosphate trihydrate
    • 13659SD1OI
    • Glycerophosphoric acid, dipotassium salt, trihydrate
    • Dipotassium 1,2,3-propanetriol mono(dihydrogen phosphate) trihydrate
    • 1,2,3-Propanetriol, mono(dihydrogen phosphate), dipotassium salt, trihydrate
    • RefChem:867820
    • tetrapotassium;1,5-dihydroxypentan-3-yl phosphate;2,3-dihydroxypropyl phosphate
    • UNII-13659SD1OI
    • DTXSID40927383
    • Potassium 1,5-dihydroxypentan-3-yl phosphate 2,3-dihydroxypropyl phosphate (4/1/1)
    • tetrapotassium; 3-phosphonatooxypentane-1,5-diol; 3-phosphonatooxypropane-1,2-diol
    • 1319-70-6

  • Applications

    Potassium glycerophosphate trihydrate (CAS number: 1319-70-6) is used as a buffering and pH-control additive in pharmaceutical, cosmetic, and laboratory formulations, leveraging its buffering capacity to stabilize ionic environments. It also serves as a source of potassium and phosphorus in nutritional products and animal feeds. It is employed as a component of cell culture media and biochemical research buffers to maintain stable pH and osmolarity. Additionally, it can function as an intermediate or precursor in the synthesis of phosphorus-containing glycerophosphate esters and related compounds in industrial manufacturing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 26.27
    methanol 74.45
    isopropanol 12.12
    water 153.29
    ethyl acetate 6.73
    n-propanol 13.49
    acetone 15.54
    n-butanol 10.51
    acetonitrile 8.27
    DMF 181.91
    toluene 3.19
    isobutanol 6.04
    1,4-dioxane 17.24
    methyl acetate 6.37
    THF 28.91
    2-butanone 6.54
    n-pentanol 5.9
    sec-butanol 6.6
    n-hexane 0.44
    ethylene glycol 120.6
    NMP 260.25
    cyclohexane 1.16
    DMSO 268.66
    n-butyl acetate 5.96
    n-octanol 5.65
    chloroform 2.61
    n-propyl acetate 3.17
    acetic acid 37.01
    dichloromethane 5.56
    cyclohexanone 16.88
    propylene glycol 70.29
    isopropyl acetate 4.47
    DMAc 121.07
    2-ethoxyethanol 40.28
    isopentanol 6.22
    n-heptane 1.39
    ethyl formate 11.48
    1,2-dichloroethane 7.13
    n-hexanol 9.35
    2-methoxyethanol 121.4
    isobutyl acetate 1.57
    tetrachloromethane 0.85
    n-pentyl acetate 5.99
    transcutol 46.13
    n-heptanol 8.28
    ethylbenzene 1.63
    MIBK 4.7
    2-propoxyethanol 50.32
    tert-butanol 10.88
    MTBE 2.68
    2-butoxyethanol 29.0
    propionic acid 22.02
    o-xylene 4.52
    formic acid 142.59
    diethyl ether 4.04
    m-xylene 3.85
    p-xylene 1.79
    chlorobenzene 3.09
    dimethyl carbonate 14.99
    n-octane 0.6
    formamide 173.3
    cyclopentanone 27.91
    2-pentanone 7.32
    anisole 4.12
    cyclopentyl methyl ether 9.6
    gamma-butyrolactone 54.55
    1-methoxy-2-propanol 66.95
    pyridine 12.9
    3-pentanone 5.93
    furfural 67.66
    n-dodecane 0.45
    diethylene glycol 102.28
    diisopropyl ether 1.67
    tert-amyl alcohol 6.76
    acetylacetone 16.54
    n-hexadecane 0.5
    acetophenone 8.62
    methyl propionate 12.35
    isopentyl acetate 4.42
    trichloroethylene 7.68
    n-nonanol 5.64
    cyclohexanol 9.14
    benzyl alcohol 11.29
    2-ethylhexanol 4.51
    isooctanol 5.19
    dipropyl ether 4.89
    1,2-dichlorobenzene 4.58
    ethyl lactate 13.61
    propylene carbonate 21.92
    n-methylformamide 88.02
    2-pentanol 5.25
    n-pentane 0.81
    1-propoxy-2-propanol 28.12
    1-methoxy-2-propyl acetate 16.24
    2-(2-methoxypropoxy) propanol 25.3
    mesitylene 3.3
    ε-caprolactone 20.43
    p-cymene 3.31
    epichlorohydrin 27.76
    1,1,1-trichloroethane 1.76
    2-aminoethanol 94.45
    morpholine-4-carbaldehyde 134.29
    sulfolane 138.64
    2,2,4-trimethylpentane 0.34
    2-methyltetrahydrofuran 9.31
    n-hexyl acetate 6.51
    isooctane 0.28
    2-(2-butoxyethoxy)ethanol 32.81
    sec-butyl acetate 1.88
    tert-butyl acetate 5.08
    decalin 0.55
    glycerin 175.36
    diglyme 43.8
    acrylic acid 39.23
    isopropyl myristate 3.13
    n-butyric acid 16.53
    acetyl acetate 5.53
    di(2-ethylhexyl) phthalate 7.73
    ethyl propionate 4.21
    nitromethane 50.52
    1,2-diethoxyethane 7.2
    benzonitrile 7.27
    trioctyl phosphate 6.47
    1-bromopropane 2.24
    gamma-valerolactone 69.56
    n-decanol 4.49
    triethyl phosphate 6.02
    4-methyl-2-pentanol 3.11
    propionitrile 5.51
    vinylene carbonate 22.26
    1,1,2-trichlorotrifluoroethane 58.21
    DMS 9.68
    cumene 1.54
    2-octanol 4.23
    2-hexanone 3.11
    octyl acetate 4.93
    limonene 4.06
    1,2-dimethoxyethane 26.31
    ethyl orthosilicate 4.99
    tributyl phosphate 5.4
    diacetone alcohol 18.13
    N,N-dimethylaniline 6.41
    acrylonitrile 13.06
    aniline 8.46
    1,3-propanediol 58.53
    bromobenzene 2.3
    dibromomethane 3.22
    1,1,2,2-tetrachloroethane 8.99
    2-methyl-cyclohexyl acetate 5.78
    tetrabutyl urea 11.0
    diisobutyl methanol 3.61
    2-phenylethanol 12.21
    styrene 1.58
    dioctyl adipate 6.4
    dimethyl sulfate 43.75
    ethyl butyrate 5.45
    methyl lactate 45.45
    butyl lactate 14.32
    diethyl carbonate 4.26
    propanediol butyl ether 28.43
    triethyl orthoformate 5.63
    p-tert-butyltoluene 3.24
    methyl 4-tert-butylbenzoate 18.94
    morpholine 25.26
    tert-butylamine 4.81
    n-dodecanol 3.47
    dimethoxymethane 47.2
    ethylene carbonate 15.67
    cyrene 47.62
    2-ethoxyethyl acetate 9.91
    2-ethylhexyl acetate 3.48
    1,2,4-trichlorobenzene 5.79
    4-methylpyridine 10.63
    dibutyl ether 2.41
    2,6-dimethyl-4-heptanol 3.61
    DEF 25.57
    dimethyl isosorbide 40.79
    tetrachloroethylene 6.66
    eugenol 25.19
    triacetin 12.48
    span 80 27.05
    1,4-butanediol 27.38
    1,1-dichloroethane 2.44
    2-methyl-1-pentanol 3.77
    methyl formate 51.19
    2-methyl-1-butanol 5.54
    n-decane 0.66
    butyronitrile 5.41
    3,7-dimethyl-1-octanol 4.09
    1-chlorooctane 1.86
    1-chlorotetradecane 1.04
    n-nonane 0.61
    undecane 0.53
    tert-butylcyclohexane 0.37
    cyclooctane 0.78
    cyclopentanol 13.96
    tetrahydropyran 5.82
    tert-amyl methyl ether 3.28
    2,5,8-trioxanonane 40.8
    1-hexene 0.83
    2-isopropoxyethanol 16.81
    2,2,2-trifluoroethanol 31.01
    methyl butyrate 5.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction