Platenolide A

Overview IFRA Request a quote

  • Identifiers

    CAS number
    52212-94-9

    Molecular formula
    C20H32O6

    SMILES
    CC[C@H]1C[C@H](C(=O)/C=C/C=C/C[C@H](OC(=O)C[C@H]([C@@H]([C@H]1O)OC)O)C)C

    Safety labels

  • Odor profile

    Fragrance
    Caramellic 41.81%
    Roasted 33.02%
    Spicy 30.72%
    Burnt 30.41%
    Nutty 29.33%
    Mint 27.67%
    Sweet 25.68%
    Coumarinic 25.24%
    Coconut 25.02%
    Lactonic 24.6%

     

    Flavor
    Minty 44.51%
    Bitter 29.79%
    Spice 29.43%
    Herbal 25.96%
    Mint 23.95%
    Caramel 23.53%
    Sweet 22.68%
    Leaves 20.35%
    Spearmint 20.11%
    Fenugreek 20.1%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    10.45 (weak base)

    Molecular weight
    368.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    812°C

    Flash point

    • 170.77 ˚C est.

  • Synonyms

    • Platenolide A
    • GlyTouCan:G04334GD
    • RefChem:1048646
    • G04334GD
    • 52212-94-9
    • C12202
    • AC1NQZGT
    • orb1695649
    • CHEBI:32022
    • Oxacyclohexadeca-11,13-diene-2,10-dione, 7-ethyl-4,6-dihydroxy-5-methoxy-9,16-dimethyl-, (4R,5S,6S,7S,9R,11E,13E,16R)-
    • Q27114750
    • 52212-94-9

  • Applications

    Platenolide A may be used as a scaffold or intermediate in pharmaceutical research, serving as a basis for natural product–inspired libraries. In organic synthesis, it is often used as a building block for macrocyclic lactone chemistry. In polymers/plastics, it may be explored as a specialty additive or precursor for derivatized polymers. In coatings/inks, it can be evaluated as an intermediate for niche coating formulations. In academic settings, it is a useful probe for structure–activity relationships and the mechanisms of macrocyclic lactone reactions. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 179.21
    methanol 476.99
    isopropanol 78.1
    water 2.63
    ethyl acetate 85.4
    n-propanol 127.07
    acetone 186.34
    n-butanol 76.75
    acetonitrile 60.5
    DMF 466.09
    toluene 32.07
    isobutanol 77.34
    1,4-dioxane 164.11
    methyl acetate 74.02
    THF 362.8
    2-butanone 84.55
    n-pentanol 62.04
    sec-butanol 64.92
    n-hexane 1.91
    ethylene glycol 86.76
    NMP 542.17
    cyclohexane 3.31
    DMSO 962.67
    n-butyl acetate 36.51
    n-octanol 23.54
    chloroform 134.46
    n-propyl acetate 38.03
    acetic acid 613.01
    dichloromethane 154.17
    cyclohexanone 183.51
    propylene glycol 123.47
    isopropyl acetate 51.13
    DMAc 465.61
    2-ethoxyethanol 159.69
    isopentanol 58.28
    n-heptane 1.29
    ethyl formate 52.61
    1,2-dichloroethane 99.96
    n-hexanol 42.46
    2-methoxyethanol 307.79
    isobutyl acetate 26.63
    tetrachloromethane 14.66
    n-pentyl acetate 37.66
    transcutol 485.4
    n-heptanol 28.05
    ethylbenzene 17.01
    MIBK 56.09
    2-propoxyethanol 144.19
    tert-butanol 85.61
    MTBE 30.42
    2-butoxyethanol 88.26
    propionic acid 162.61
    o-xylene 26.16
    formic acid 391.75
    diethyl ether 39.31
    m-xylene 28.73
    p-xylene 19.56
    chlorobenzene 42.91
    dimethyl carbonate 82.56
    n-octane 0.88
    formamide 350.32
    cyclopentanone 279.5
    2-pentanone 77.78
    anisole 41.87
    cyclopentyl methyl ether 105.2
    gamma-butyrolactone 385.08
    1-methoxy-2-propanol 218.97
    pyridine 110.46
    3-pentanone 65.25
    furfural 248.85
    n-dodecane 0.83
    diethylene glycol 183.82
    diisopropyl ether 10.25
    tert-amyl alcohol 61.98
    acetylacetone 158.85
    n-hexadecane 0.92
    acetophenone 69.68
    methyl propionate 106.71
    isopentyl acetate 37.93
    trichloroethylene 210.36
    n-nonanol 23.83
    cyclohexanol 85.4
    benzyl alcohol 68.24
    2-ethylhexanol 21.33
    isooctanol 23.52
    dipropyl ether 19.09
    1,2-dichlorobenzene 44.25
    ethyl lactate 54.51
    propylene carbonate 147.63
    n-methylformamide 235.28
    2-pentanol 40.53
    n-pentane 1.81
    1-propoxy-2-propanol 87.7
    1-methoxy-2-propyl acetate 83.75
    2-(2-methoxypropoxy) propanol 95.25
    mesitylene 15.9
    ε-caprolactone 173.36
    p-cymene 12.23
    epichlorohydrin 279.63
    1,1,1-trichloroethane 57.4
    2-aminoethanol 163.29
    morpholine-4-carbaldehyde 350.95
    sulfolane 571.99
    2,2,4-trimethylpentane 2.02
    2-methyltetrahydrofuran 139.82
    n-hexyl acetate 50.69
    isooctane 1.26
    2-(2-butoxyethoxy)ethanol 124.04
    sec-butyl acetate 27.63
    tert-butyl acetate 58.12
    decalin 3.2
    glycerin 220.07
    diglyme 203.91
    acrylic acid 205.17
    isopropyl myristate 18.59
    n-butyric acid 136.28
    acetyl acetate 82.34
    di(2-ethylhexyl) phthalate 37.66
    ethyl propionate 41.96
    nitromethane 502.34
    1,2-diethoxyethane 61.6
    benzonitrile 53.15
    trioctyl phosphate 24.08
    1-bromopropane 33.07
    gamma-valerolactone 378.89
    n-decanol 16.43
    triethyl phosphate 29.19
    4-methyl-2-pentanol 26.48
    propionitrile 42.02
    vinylene carbonate 138.56
    1,1,2-trichlorotrifluoroethane 295.39
    DMS 69.17
    cumene 12.98
    2-octanol 15.95
    2-hexanone 41.73
    octyl acetate 27.4
    limonene 17.25
    1,2-dimethoxyethane 140.93
    ethyl orthosilicate 26.23
    tributyl phosphate 28.03
    diacetone alcohol 110.75
    N,N-dimethylaniline 40.3
    acrylonitrile 74.14
    aniline 66.98
    1,3-propanediol 160.48
    bromobenzene 37.65
    dibromomethane 82.52
    1,1,2,2-tetrachloroethane 142.46
    2-methyl-cyclohexyl acetate 42.27
    tetrabutyl urea 38.75
    diisobutyl methanol 13.68
    2-phenylethanol 56.98
    styrene 18.39
    dioctyl adipate 40.19
    dimethyl sulfate 191.16
    ethyl butyrate 31.66
    methyl lactate 126.73
    butyl lactate 56.53
    diethyl carbonate 26.6
    propanediol butyl ether 106.48
    triethyl orthoformate 29.68
    p-tert-butyltoluene 11.08
    methyl 4-tert-butylbenzoate 74.48
    morpholine 218.48
    tert-butylamine 28.94
    n-dodecanol 11.26
    dimethoxymethane 242.16
    ethylene carbonate 109.56
    cyrene 128.0
    2-ethoxyethyl acetate 77.41
    2-ethylhexyl acetate 27.48
    1,2,4-trichlorobenzene 64.85
    4-methylpyridine 93.94
    dibutyl ether 14.98
    2,6-dimethyl-4-heptanol 13.68
    DEF 122.03
    dimethyl isosorbide 161.9
    tetrachloroethylene 99.36
    eugenol 72.68
    triacetin 93.52
    span 80 87.82
    1,4-butanediol 73.1
    1,1-dichloroethane 62.42
    2-methyl-1-pentanol 51.41
    methyl formate 171.76
    2-methyl-1-butanol 62.85
    n-decane 1.47
    butyronitrile 34.69
    3,7-dimethyl-1-octanol 23.71
    1-chlorooctane 9.18
    1-chlorotetradecane 3.45
    n-nonane 1.3
    undecane 1.06
    tert-butylcyclohexane 2.45
    cyclooctane 1.54
    cyclopentanol 115.15
    tetrahydropyran 97.61
    tert-amyl methyl ether 32.88
    2,5,8-trioxanonane 149.33
    1-hexene 7.92
    2-isopropoxyethanol 93.5
    2,2,2-trifluoroethanol 195.96
    methyl butyrate 50.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction