Picloram

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  • Identifiers

    CAS number
    1918-02-1

    Molecular formula
    C6H3Cl3N2O2

    SMILES
    C1(=C(C(=NC(=C1Cl)Cl)C(=O)O)Cl)N

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 76.17%
    Bitter 19.55%
    Burnt 17.83%
    Savory 16.42%
    Animal 16.29%
    Milky 16.1%
    Dry 15.63%
    Musk 14.87%
    Cooked 14.22%
    Phenolic 14.2%

     

    Flavor
    Bitter 63.12%
    Odorless 54.07%
    Mild 34.04%
    Bland 25.52%
    Sweet-like 21.08%
    Bread crust 20.74%
    Very mild 20.63%
    Nitrile 20.62%
    Scallion 20.41%
    Yeast 20.4%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    5.21 (weak acid)

    Molecular weight
    241.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 392 °F (decomposes) (NTP, 1992)
    • 218.5 °C
    • MP: 218-219 °C, with decomposition starting at 190 °C. Readily sublimes at 190 °C under 12 mm Hg.
    • No melting point; decomposes at 190 °C
    • 392 °F (decomposes)
    • 424 °F (Decomposes)

    Boiling point

    • Decomposes (NIOSH, 2024)
    • decomposes
    • Decomposes

    Flash point

    • 192.38 ˚C est.
    • Tordon 22k: 46 °C toc; tordon 101 mixture--combustible with an toc flash point of 35 °C; Tordon 155 mixture--104 °C coc /Tordon/

    Solubility expt.

    • less than 0.1 mg/mL at 68 °F (NTP, 1992)
    • In water, 430 mg/L at 25 °C
    • Organic solvents g/100 mL at 25 °C: acetone 1.98; acetonitrile 0.16; benzene 0.02; carbon disulfide less than 0.005; diethyl ether 0.12; ethanol 1.05; isopropanol 0.55; kerosene 0.001; methylene chloride 0.06
    • Solubility in water, mg/l at 25 °C: 430 (very poor)
    • 0.04%

  • Synonyms

    • PICLORAM
    • 1918-02-1
    • 4-Amino-3,5,6-trichloropyridine-2-carboxylic acid
    • 4-Amino-3,5,6-trichloropicolinic acid
    • Tordon
    • 2-Pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-
    • Borolin
    • Amdon
    • Grazon
    • K-Pin
    • Tordon 10K
    • Tordon 22K
    • Piclorame
    • Access
    • Amdon grazon
    • MFCD00012101
    • NCI-C00237
    • ATCP
    • 4-Aminotrichloropicolinic acid
    • Caswell No. 039
    • 4-Amino-3,5,6-trichloro-2-pyridinecarboxylic acid
    • Pathway
    • picloram acid
    • Piclorame [ISO-French]
    • Picloram, technical grade
    • Picolinic acid, 4-amino-3,5,6-trichloro-
    • Picloram [ANSI:BSI:ISO]
    • CCRIS 520
    • 3,5,6-Trichloro-4-aminopicolinic acid
    • Chloramp (Salt/Mix)
    • DTXSID1021160
    • CHEBI:34922
    • HSDB 1151
    • 4-Amino-3,5,6-trichloro-2-picolinic acid
    • O7437X49DW
    • PICLORAM [HSDB]
    • PICLORAM [IARC]
    • PICLORAM [ISO]
    • PICLORAM [MI]
    • EINECS 217-636-1
    • EPA Pesticide Chemical Code 005101
    • NSC 233899
    • NSC-233899
    • BRN 0479075
    • UNII-O7437X49DW
    • DTXCID101160
    • 4-Amino-3,5,6-trichlorpicolinsaeure
    • 2-Pyridine carboxylic acid, 4-amino-3,5,6-trichloro-
    • PICLORAM (IARC)
    • Piclorame (ISO-French)
    • Picloram (ANSI:BSI:ISO)
    • 3,5,6-trichloro-4-amino-2-pyridinecarboxylic acid
    • 5-22-13-00585 (Beilstein Handbook Reference)
    • Grazon PC
    • CAS-1918-02-1
    • Tordonae
    • Picloram, acid
    • Picloram (Standard)
    • Picloram (ACGIH:OSHA)
    • 4-Amino-3,5,6-trichlorpicolinsaeure [German]
    • 4Aminotrichloropicolinic acid
    • SCHEMBL13299
    • 4-amino-3,5,6-trichloro-pyridine-2-carboxylic acid
    • CHEMBL461349
    • Picolinic acid,5,6-trichloro-
    • HY-B2034R
    • 4Amino3,5,6trichlorpicolinsaeure
    • Picloram 100 ug/mL in Methanol
    • 4-Amino-3,6-trichlorpicolinsaeure
    • 3,5,6Trichloro4aminopicolinic acid
    • 4Amino3,5,6trichloropicolinic acid
    • ALBB-023448
    • HY-B2034
    • Tox21_200043
    • Tox21_201298
    • Tox21_301048
    • WLN: T6NJ BVQ CG DZ EG FG
    • 3,6-Trichloro-4-aminopicolinic acid
    • 4-Amino-3,6-trichloropicolinic acid
    • 4Amino3,5,6trichloro2picolinic acid
    • AC1880
    • NSC233899
    • Picloram 100 microg/mL in Methanol
    • STK179674
    • AKOS000120784
    • KS-5272
    • USEPA/OPP Pesticide Code: 005101
    • NCGC00091319-01
    • NCGC00091319-02
    • NCGC00091319-03
    • NCGC00091319-04
    • NCGC00091319-05
    • NCGC00091319-06
    • NCGC00091319-07
    • NCGC00254950-01
    • NCGC00257597-01
    • NCGC00258850-01
    • 2-Pyridinecarboxylic acid,5,6-trichloro-
    • 4-Amino-3,6-trichloro-2-picolinic acid
    • AC-19878
    • FA131305
    • SY023140
    • DB-044774
    • DB-262888
    • 4Amino3,5,6trichloro2pyridinecarboxylic acid
    • CS-0014129
    • NS00006515
    • P1864
    • Picloram, PESTANAL(R), analytical standard
    • EN300-17244
    • 2Pyridinecarboxylic acid, 4amino3,5,6trichloro
    • Picloram, plant cell culture tested, BioReagent
    • 2Pyridine carboxylic acid, 4amino3,5,6trichloro
    • AS-871/43306500
    • Q424662
    • 4Amino3,5,6trichloro2pyridinecarboxylic acid (9CI)
    • Picloram 200 microg/mL in Methyl tert-butyl ether
    • Picloram 200 microg/mL in Methyl-tert. butyl ether
    • Z56899173
    • F3055-0927
    • 4-Amino-3,5,6-trichloropyridine-2-carboxylic acid, 4-amino-3,5,6-trichloro-2-pyridinecarboxylic acid
    • WOM

  • Applications

    Picloram is a systemic herbicide in the picolinate family, used primarily in agriculture and land management to control broadleaf weeds. Common applications include selective weed control in pastures, rangelands, alfalfa and certain crops to improve forage or crop quality; brush and woody plant control in forestry, habitat management, and site preparation; vegetation management in non-crop areas such as rights-of-way, roadsides, and rail corridors; and formulation practices with other herbicides to enhance broadleaf weed control. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 20.49
    methanol 19.07
    isopropanol 16.5
    water 1.96
    ethyl acetate 20.26
    n-propanol 17.48
    acetone 37.45
    n-butanol 16.63
    acetonitrile 9.82
    DMF 189.78
    toluene 3.69
    isobutanol 11.91
    1,4-dioxane 17.42
    methyl acetate 17.57
    THF 126.92
    2-butanone 31.56
    n-pentanol 16.06
    sec-butanol 15.93
    n-hexane 0.83
    ethylene glycol 16.95
    NMP 123.38
    cyclohexane 0.53
    DMSO 185.57
    n-butyl acetate 18.53
    n-octanol 9.23
    chloroform 4.88
    n-propyl acetate 15.72
    acetic acid 10.33
    dichloromethane 7.78
    cyclohexanone 27.14
    propylene glycol 8.55
    isopropyl acetate 15.97
    DMAc 174.67
    2-ethoxyethanol 42.33
    isopentanol 15.38
    n-heptane 2.47
    ethyl formate 15.5
    1,2-dichloroethane 10.48
    n-hexanol 19.68
    2-methoxyethanol 69.84
    isobutyl acetate 6.66
    tetrachloromethane 2.43
    n-pentyl acetate 14.82
    transcutol 24.49
    n-heptanol 13.99
    ethylbenzene 3.86
    MIBK 20.45
    2-propoxyethanol 54.37
    tert-butanol 24.91
    MTBE 15.64
    2-butoxyethanol 28.08
    propionic acid 8.97
    o-xylene 4.91
    formic acid 20.45
    diethyl ether 14.0
    m-xylene 4.87
    p-xylene 4.4
    chlorobenzene 2.63
    dimethyl carbonate 23.06
    n-octane 1.13
    formamide 36.91
    cyclopentanone 62.52
    2-pentanone 33.2
    anisole 14.46
    cyclopentyl methyl ether 33.27
    gamma-butyrolactone 55.22
    1-methoxy-2-propanol 55.64
    pyridine 17.79
    3-pentanone 23.22
    furfural 43.17
    n-dodecane 0.82
    diethylene glycol 49.7
    diisopropyl ether 5.58
    tert-amyl alcohol 22.48
    acetylacetone 37.78
    n-hexadecane 0.92
    acetophenone 18.91
    methyl propionate 28.55
    isopentyl acetate 14.58
    trichloroethylene 13.03
    n-nonanol 9.26
    cyclohexanol 9.77
    benzyl alcohol 13.38
    2-ethylhexanol 11.45
    isooctanol 9.97
    dipropyl ether 16.94
    1,2-dichlorobenzene 3.9
    ethyl lactate 13.99
    propylene carbonate 19.71
    n-methylformamide 49.54
    2-pentanol 14.12
    n-pentane 0.96
    1-propoxy-2-propanol 35.73
    1-methoxy-2-propyl acetate 27.94
    2-(2-methoxypropoxy) propanol 20.94
    mesitylene 3.89
    ε-caprolactone 22.67
    p-cymene 6.62
    epichlorohydrin 53.27
    1,1,1-trichloroethane 5.5
    2-aminoethanol 19.11
    morpholine-4-carbaldehyde 68.82
    sulfolane 94.43
    2,2,4-trimethylpentane 0.74
    2-methyltetrahydrofuran 39.83
    n-hexyl acetate 12.98
    isooctane 0.63
    2-(2-butoxyethoxy)ethanol 24.06
    sec-butyl acetate 10.31
    tert-butyl acetate 20.0
    decalin 0.68
    glycerin 21.86
    diglyme 42.28
    acrylic acid 8.66
    isopropyl myristate 7.6
    n-butyric acid 13.95
    acetyl acetate 9.85
    di(2-ethylhexyl) phthalate 7.61
    ethyl propionate 18.72
    nitromethane 32.1
    1,2-diethoxyethane 14.33
    benzonitrile 9.62
    trioctyl phosphate 8.26
    1-bromopropane 6.28
    gamma-valerolactone 55.59
    n-decanol 7.6
    triethyl phosphate 10.76
    4-methyl-2-pentanol 9.53
    propionitrile 11.38
    vinylene carbonate 14.08
    1,1,2-trichlorotrifluoroethane 37.43
    DMS 10.47
    cumene 3.39
    2-octanol 9.33
    2-hexanone 22.25
    octyl acetate 10.06
    limonene 8.1
    1,2-dimethoxyethane 60.04
    ethyl orthosilicate 9.83
    tributyl phosphate 7.12
    diacetone alcohol 37.42
    N,N-dimethylaniline 17.19
    acrylonitrile 16.14
    aniline 8.71
    1,3-propanediol 26.33
    bromobenzene 2.3
    dibromomethane 5.15
    1,1,2,2-tetrachloroethane 13.31
    2-methyl-cyclohexyl acetate 13.25
    tetrabutyl urea 15.8
    diisobutyl methanol 7.92
    2-phenylethanol 18.36
    styrene 3.61
    dioctyl adipate 9.67
    dimethyl sulfate 55.78
    ethyl butyrate 17.57
    methyl lactate 24.85
    butyl lactate 12.77
    diethyl carbonate 10.54
    propanediol butyl ether 15.41
    triethyl orthoformate 12.24
    p-tert-butyltoluene 6.94
    methyl 4-tert-butylbenzoate 21.18
    morpholine 31.56
    tert-butylamine 11.75
    n-dodecanol 5.87
    dimethoxymethane 96.53
    ethylene carbonate 11.86
    cyrene 29.62
    2-ethoxyethyl acetate 16.78
    2-ethylhexyl acetate 11.2
    1,2,4-trichlorobenzene 5.08
    4-methylpyridine 18.85
    dibutyl ether 7.08
    2,6-dimethyl-4-heptanol 7.92
    DEF 51.13
    dimethyl isosorbide 44.85
    tetrachloroethylene 9.99
    eugenol 23.38
    triacetin 10.18
    span 80 14.16
    1,4-butanediol 13.98
    1,1-dichloroethane 5.2
    2-methyl-1-pentanol 12.68
    methyl formate 35.48
    2-methyl-1-butanol 13.87
    n-decane 1.22
    butyronitrile 12.82
    3,7-dimethyl-1-octanol 7.88
    1-chlorooctane 4.24
    1-chlorotetradecane 2.11
    n-nonane 1.08
    undecane 0.99
    tert-butylcyclohexane 0.76
    cyclooctane 0.46
    cyclopentanol 19.78
    tetrahydropyran 13.5
    tert-amyl methyl ether 17.48
    2,5,8-trioxanonane 33.76
    1-hexene 3.55
    2-isopropoxyethanol 25.24
    2,2,2-trifluoroethanol 11.54
    methyl butyrate 22.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction