Phosphatidylserines

Overview IFRA Request a quote

  • Identifiers

    CAS number
    1446756-47-3

    Molecular formula
    C42H82NO10P

    SMILES
    CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OC[C@@H](C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Waxy 53.1%
    Odorless 44.07%
    Fatty 44.0%
    Oily 34.86%
    Milky 19.46%
    Alcoholic 19.04%
    Savory 18.54%
    Sweet 18.2%
    Creamy 17.5%
    Lactonic 17.43%

     

    Flavor
    Bland 43.15%
    Mild 40.37%
    Odorless 40.25%
    Fatty 38.52%
    Waxy 38.28%
    Faint 29.95%
    Oily 28.68%
    Slightly waxy 23.18%
    Bay oil 22.58%
    Beer 21.71%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    12.1

    pKa est.
    8.03 (weak base)

    Molecular weight
    792.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1063°C

    Flash point

    • 316.92 ˚C est.

  • Synonyms

    • Phosphatidylserine
    • Phosphotidylserine
    • Distearoylphosphatidylserine
    • 394XK0IH40
    • 1446756-47-3
    • (2S)-2-amino-3-[[(2R)-2,3-di(octadecanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid
    • Phosphatidyl Serines
    • Serine, Phosphatidyl
    • Serines, Phosphatidyl
    • Serine Phosphoglycerides
    • Phosphoglycerides, Serine
    • (2S)-2-amino-3-(((2R)-2,3-di(octadecanoyloxy)propoxy)-hydroxyphosphoryl)oxypropanoic acid
    • Phospholipid Serine
    • RefChem:861928
    • GlyTouCan:G17352VJ
    • DTXSID401058684
    • G17352VJ
    • 1,2-Diacyl-sn-glycerol 3-phospho-L-serine
    • (2S)-2-azaniumyl-3-(((2R)-2,3-di(octadecanoyloxy)propoxy)-hydroxyphosphoryl)oxypropanoate
    • (2S)-2-amino-3-((((2R)-2-(butanoyloxy)-3-(propanoyloxy)propoxy)(hydroxy)phosphoryl)oxy)propanoic acid
    • (2S)-2-amino-3-(((2R)-2-butanoyloxy-3-propanoyloxypropoxy)-hydroxyphosphoryl)oxypropanoic acid
    • 51446-62-9
    • 1,2-dioctadecanoyl-sn-glycero-3-phosphoserine
    • Distearoyl phosphatidylserine
    • (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoic acid
    • PS(18:0/18:0)
    • L-alpha-Phosphatidyl-L-serine
    • Phosphatidylserine(36:0)
    • Dioctadecanoylphosphatidylserine
    • PSer(36:0)
    • Phosphatidyl serine [WHO-DD]
    • Phosphatidylserine(18:0/18:0)
    • PSer(18:0/18:0)
    • MFCD00135635
    • (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)(hydroxy)phosphoryl)oxy)propanoic acid
    • 1,2-distearoyl-sn-glycero-3-phosphoserine
    • C42H82NO10P
    • 1,2-distearoyl-sn-glycero-3-phospho-l-serine
    • O-{[(2R)-2,3-bis(octadecanoyloxy)propoxy](hydroxy)phosphoryl}-L-serine
    • L-Serine, 2,3-bis[(1-oxooctadecyl)oxy]propyl ester, dihydrogen phosphate (ester), (R)-
    • O-[(R)-{[(2r)-2,3-Bis(Octadecanoyloxy)propyl]oxy}(Hydroxy)phosphoryl]-L-Serine
    • 1,2-Diacyl-sn-glycero-3-phospho-L-serine
    • Phosphatidylserines (bovine)
    • L-a-Cephalin
    • PS (brain, bovine)
    • L-a-Phosphatidyl-L-serine
    • Phosphatidylserine [INCI]
    • SCHEMBL24649
    • UNII-394XK0IH40
    • orb1306362
    • CHEMBL4297669
    • CHEBI:84519
    • DTXSID10866199
    • PHOSPHATIDYLSERINE [VANDF]
    • PHOSPHOTIDYLSERINE [VANDF]
    • LMGP03010036
    • AKOS016011101
    • EBC-617085
    • FP16194
    • FP47183
    • (2S)-2-amino-3-({[(2R)-2,3-bis(octadecanoyloxy)propoxy](hydroxy)phosphoryl}oxy)propanoic acid
    • AC-37602
    • DA-76830
    • DA-76831
    • 1,2-distearoyl-rac-glycero-3-phosphoserine
    • PS(36:00)
    • H12024
    • Q27157825
    • O-(((R)-2,3-bis(stearoyloxy)propoxy)(hydroxy)phosphoryl)-L-serine
    • (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoicacid
    • (2S)-2-amino-3-[[(2R)-2,3-di(octadecanoyloxy)propoxy]-hydroxy-phosphoryl]oxy-propanoic acid
    • (2S,8R)-2-Amino-5-hydroxy-11-oxo-8-[(1-oxooctadecyl)oxy]-4,6,10-trioxa-5-phosphaoctacosanoic acid 5-oxide sodium salt
    • 51446-62-9

  • Applications

    Phosphatidylserines (CAS 1446756-47-3) are used as biocompatible phospholipid excipients in liposome- or vesicle-based drug delivery systems, forming stable bilayers for encapsulation. In cosmetics and personal care, they function as skin-conditioning agents and surfactant-like emulsifiers that stabilize oil–water blends and improve texture. They are also marketed as nutraceutical dietary supplements derived from phospholipids, providing a lipid-based ingredient option. In pharmaceutical research and formulation development, they serve as standard lipid components for model membrane studies and lipid-based formulations. In industrial manufacturing, phosphatidylserines can act as stabilizers for lipid-containing emulsions and coatings, supporting dispersion and compatibility in complex formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.21
    methanol 8.15
    isopropanol 2.13
    water 2.95
    ethyl acetate 7.44
    n-propanol 3.69
    acetone 10.06
    n-butanol 2.58
    acetonitrile 3.54
    DMF 44.99
    toluene 2.52
    isobutanol 2.36
    1,4-dioxane 7.17
    methyl acetate 9.17
    THF 16.32
    2-butanone 9.29
    n-pentanol 2.71
    sec-butanol 2.77
    n-hexane 0.31
    ethylene glycol 3.34
    NMP 116.15
    cyclohexane 0.43
    DMSO 49.15
    n-butyl acetate 4.32
    n-octanol 2.45
    chloroform 15.48
    n-propyl acetate 6.24
    acetic acid 29.21
    dichloromethane 15.26
    cyclohexanone 16.86
    propylene glycol 5.23
    isopropyl acetate 6.14
    DMAc 89.01
    2-ethoxyethanol 11.75
    isopentanol 2.01
    n-heptane 0.31
    ethyl formate 7.42
    1,2-dichloroethane 8.63
    n-hexanol 1.67
    2-methoxyethanol 14.63
    isobutyl acetate 3.47
    tetrachloromethane 4.25
    n-pentyl acetate 8.24
    transcutol 29.16
    n-heptanol 2.83
    ethylbenzene 1.74
    MIBK 4.47
    2-propoxyethanol 8.9
    tert-butanol 2.75
    MTBE 2.72
    2-butoxyethanol 11.38
    propionic acid 13.82
    o-xylene 3.29
    formic acid 23.34
    diethyl ether 2.24
    m-xylene 2.46
    p-xylene 2.51
    chlorobenzene 3.56
    dimethyl carbonate 13.47
    n-octane 0.26
    formamide 29.66
    cyclopentanone 27.82
    2-pentanone 7.13
    anisole 4.23
    cyclopentyl methyl ether 7.97
    gamma-butyrolactone 42.16
    1-methoxy-2-propanol 12.17
    pyridine 8.97
    3-pentanone 8.48
    furfural 34.87
    n-dodecane 0.17
    diethylene glycol 8.06
    diisopropyl ether 1.07
    tert-amyl alcohol 3.79
    acetylacetone 17.92
    n-hexadecane 0.18
    acetophenone 10.23
    methyl propionate 11.75
    isopentyl acetate 3.83
    trichloroethylene 22.45
    n-nonanol 2.56
    cyclohexanol 3.68
    benzyl alcohol 5.61
    2-ethylhexanol 1.36
    isooctanol 2.29
    dipropyl ether 2.29
    1,2-dichlorobenzene 5.76
    ethyl lactate 9.41
    propylene carbonate 23.66
    n-methylformamide 22.26
    2-pentanol 1.82
    n-pentane 0.25
    1-propoxy-2-propanol 7.45
    1-methoxy-2-propyl acetate 10.33
    2-(2-methoxypropoxy) propanol 11.79
    mesitylene 1.73
    ε-caprolactone 20.9
    p-cymene 1.5
    epichlorohydrin 21.52
    1,1,1-trichloroethane 9.8
    2-aminoethanol 6.03
    morpholine-4-carbaldehyde 42.77
    sulfolane 101.33
    2,2,4-trimethylpentane 0.29
    2-methyltetrahydrofuran 8.25
    n-hexyl acetate 7.11
    isooctane 0.13
    2-(2-butoxyethoxy)ethanol 12.59
    sec-butyl acetate 4.55
    tert-butyl acetate 7.64
    decalin 0.41
    glycerin 13.37
    diglyme 25.54
    acrylic acid 18.15
    isopropyl myristate 2.11
    n-butyric acid 12.11
    acetyl acetate 10.74
    di(2-ethylhexyl) phthalate 4.4
    ethyl propionate 6.71
    nitromethane 42.42
    1,2-diethoxyethane 6.19
    benzonitrile 4.59
    trioctyl phosphate 3.11
    1-bromopropane 2.81
    gamma-valerolactone 43.91
    n-decanol 1.63
    triethyl phosphate 6.3
    4-methyl-2-pentanol 1.27
    propionitrile 3.06
    vinylene carbonate 21.69
    1,1,2-trichlorotrifluoroethane 44.69
    DMS 11.92
    cumene 1.52
    2-octanol 1.97
    2-hexanone 5.91
    octyl acetate 3.55
    limonene 1.97
    1,2-dimethoxyethane 12.78
    ethyl orthosilicate 5.25
    tributyl phosphate 3.81
    diacetone alcohol 12.04
    N,N-dimethylaniline 5.39
    acrylonitrile 5.6
    aniline 4.64
    1,3-propanediol 6.02
    bromobenzene 3.52
    dibromomethane 7.5
    1,1,2,2-tetrachloroethane 22.87
    2-methyl-cyclohexyl acetate 5.64
    tetrabutyl urea 6.61
    diisobutyl methanol 0.98
    2-phenylethanol 3.82
    styrene 1.91
    dioctyl adipate 5.04
    dimethyl sulfate 45.46
    ethyl butyrate 4.98
    methyl lactate 16.51
    butyl lactate 12.58
    diethyl carbonate 4.32
    propanediol butyl ether 11.67
    triethyl orthoformate 5.61
    p-tert-butyltoluene 1.56
    methyl 4-tert-butylbenzoate 16.72
    morpholine 9.95
    tert-butylamine 1.32
    n-dodecanol 1.07
    dimethoxymethane 16.53
    ethylene carbonate 15.26
    cyrene 22.01
    2-ethoxyethyl acetate 14.81
    2-ethylhexyl acetate 3.41
    1,2,4-trichlorobenzene 9.37
    4-methylpyridine 7.99
    dibutyl ether 2.09
    2,6-dimethyl-4-heptanol 0.98
    DEF 15.89
    dimethyl isosorbide 21.11
    tetrachloroethylene 16.06
    eugenol 13.33
    triacetin 21.92
    span 80 10.02
    1,4-butanediol 4.07
    1,1-dichloroethane 6.44
    2-methyl-1-pentanol 2.43
    methyl formate 18.36
    2-methyl-1-butanol 2.51
    n-decane 0.34
    butyronitrile 2.31
    3,7-dimethyl-1-octanol 1.7
    1-chlorooctane 1.5
    1-chlorotetradecane 0.52
    n-nonane 0.3
    undecane 0.22
    tert-butylcyclohexane 0.32
    cyclooctane 0.27
    cyclopentanol 5.9
    tetrahydropyran 4.49
    tert-amyl methyl ether 3.42
    2,5,8-trioxanonane 17.08
    1-hexene 0.89
    2-isopropoxyethanol 7.43
    2,2,2-trifluoroethanol 26.27
    methyl butyrate 8.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction