Phloridzinyl glucoside

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  • Identifiers

    CAS number
    1232681-33-2

    Molecular formula
    C27H34O15

    SMILES
    C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO[C@@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 74.51%
    Sweet 35.87%
    Vanilla 28.18%
    Savory 21.1%
    Milky 20.49%
    Bitter 20.42%
    Phenolic 19.96%
    Balsamic 19.22%
    Spicy 18.42%
    Cooling 17.05%

     

    Flavor
    Bitter 69.06%
    Odorless 40.52%
    Bland 34.79%
    Sweet-like 29.09%
    Cedarleaf 20.49%
    Very mild 20.49%
    Very slight 19.66%
    Parsley 19.65%
    Mild 19.6%
    Eugenol 19.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.3

    pKa est.
    7.05 (neutral)

    Molecular weight
    598.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    5278°C

    Flash point

    • 289.1 ˚C est.

  • Synonyms

    • Phloridzinyl glucoside
    • Inoveol phlo
    • Inoveol phloridzin-glucoside
    • Phloridzin-alpha-d-glucoside
    • UNII-66T0X2BM34
    • 66T0X2BM34
    • 1232681-33-2
    • DTXSID40153923
    • PHLORIDZIN-.ALPHA.-D-GLUCOSIDE
    • 1-Propanone, 1-(2-((6-O-alpha-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-
    • 1-PROPANONE, 1-(2-((6-O-.ALPHA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-4,6-DIHYDROXYPHENYL)-3-(4-HYDROXYPHENYL)-
    • RefChem:173195
    • DTXCID5076414
    • PHLORIDZINYL GLUCOSIDE [INCI]
    • Q27264024
    • 3,5-Dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl 6-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside
    • 1232681-33-2

  • Applications

    Phloridzinyl glucoside is a glycosylated dihydrochalcone derivative that is mainly used as an intermediate in the synthesis of phloridzin-related glycosides and other natural-product derivatives. In industry, it is commonly evaluated for cosmetic and personal care applications as an antioxidant and potential skin-conditioning ingredient; in the fragrance and flavor sector it may serve as a fragrance precursor or contribute to aroma through its polyphenolic structure; in coatings, inks, and polymers it can be explored as a natural antioxidant additive or stabilizer to improve formulation durability; in pharmaceutical and biotech research it can function as a starting material for glycoside-containing libraries; and in cleaning/household products it may be used as an antioxidant/conditioning additive. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.94
    methanol 22.22
    isopropanol 0.7
    water 0.37
    ethyl acetate 0.53
    n-propanol 2.52
    acetone 2.12
    n-butanol 1.29
    acetonitrile 0.5
    DMF 38.99
    toluene 0.14
    isobutanol 0.59
    1,4-dioxane 3.85
    methyl acetate 0.97
    THF 6.9
    2-butanone 1.85
    n-pentanol 0.45
    sec-butanol 0.72
    n-hexane 0.01
    ethylene glycol 13.53
    NMP 34.45
    cyclohexane 0.02
    DMSO 74.39
    n-butyl acetate 0.13
    n-octanol 0.44
    chloroform 0.2
    n-propyl acetate 0.16
    acetic acid 11.79
    dichloromethane 0.27
    cyclohexanone 2.57
    propylene glycol 14.85
    isopropyl acetate 0.24
    DMAc 34.03
    2-ethoxyethanol 8.46
    isopentanol 0.46
    n-heptane 0.02
    ethyl formate 1.19
    1,2-dichloroethane 0.27
    n-hexanol 0.25
    2-methoxyethanol 39.03
    isobutyl acetate 0.06
    tetrachloromethane 0.04
    n-pentyl acetate 0.32
    transcutol 13.05
    n-heptanol 0.48
    ethylbenzene 0.03
    MIBK 0.32
    2-propoxyethanol 5.09
    tert-butanol 0.34
    MTBE 0.17
    2-butoxyethanol 3.66
    propionic acid 3.07
    o-xylene 0.1
    formic acid 43.01
    diethyl ether 0.41
    m-xylene 0.07
    p-xylene 0.03
    chlorobenzene 0.05
    dimethyl carbonate 2.06
    n-octane 0.01
    formamide 32.18
    cyclopentanone 5.01
    2-pentanone 1.02
    anisole 0.2
    cyclopentyl methyl ether 0.87
    gamma-butyrolactone 6.1
    1-methoxy-2-propanol 14.32
    pyridine 1.69
    3-pentanone 0.8
    furfural 6.24
    n-dodecane 0.01
    diethylene glycol 11.04
    diisopropyl ether 0.04
    tert-amyl alcohol 0.42
    acetylacetone 1.89
    n-hexadecane 0.01
    acetophenone 0.33
    methyl propionate 1.52
    isopentyl acetate 0.1
    trichloroethylene 0.49
    n-nonanol 0.43
    cyclohexanol 0.62
    benzyl alcohol 0.55
    2-ethylhexanol 0.1
    isooctanol 0.25
    dipropyl ether 0.23
    1,2-dichlorobenzene 0.05
    ethyl lactate 0.99
    propylene carbonate 1.19
    n-methylformamide 18.28
    2-pentanol 0.33
    n-pentane 0.02
    1-propoxy-2-propanol 2.21
    1-methoxy-2-propyl acetate 0.87
    2-(2-methoxypropoxy) propanol 3.19
    mesitylene 0.04
    ε-caprolactone 2.27
    p-cymene 0.03
    epichlorohydrin 3.98
    1,1,1-trichloroethane 0.06
    2-aminoethanol 14.45
    morpholine-4-carbaldehyde 26.4
    sulfolane 22.25
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.23
    n-hexyl acetate 0.41
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 5.24
    sec-butyl acetate 0.08
    tert-butyl acetate 0.25
    decalin 0.0
    glycerin 44.59
    diglyme 8.44
    acrylic acid 5.85
    isopropyl myristate 0.12
    n-butyric acid 2.11
    acetyl acetate 0.34
    di(2-ethylhexyl) phthalate 0.31
    ethyl propionate 0.24
    nitromethane 14.21
    1,2-diethoxyethane 0.74
    benzonitrile 0.17
    trioctyl phosphate 0.25
    1-bromopropane 0.1
    gamma-valerolactone 19.29
    n-decanol 0.27
    triethyl phosphate 0.17
    4-methyl-2-pentanol 0.12
    propionitrile 0.4
    vinylene carbonate 1.38
    1,1,2-trichlorotrifluoroethane 13.29
    DMS 0.5
    cumene 0.02
    2-octanol 0.21
    2-hexanone 0.26
    octyl acetate 0.28
    limonene 0.06
    1,2-dimethoxyethane 4.96
    ethyl orthosilicate 0.16
    tributyl phosphate 0.19
    diacetone alcohol 1.87
    N,N-dimethylaniline 0.18
    acrylonitrile 0.99
    aniline 0.51
    1,3-propanediol 11.73
    bromobenzene 0.03
    dibromomethane 0.12
    1,1,2,2-tetrachloroethane 0.45
    2-methyl-cyclohexyl acetate 0.14
    tetrabutyl urea 0.51
    diisobutyl methanol 0.06
    2-phenylethanol 0.27
    styrene 0.04
    dioctyl adipate 0.36
    dimethyl sulfate 5.71
    ethyl butyrate 0.19
    methyl lactate 7.15
    butyl lactate 1.07
    diethyl carbonate 0.11
    propanediol butyl ether 5.49
    triethyl orthoformate 0.25
    p-tert-butyltoluene 0.03
    methyl 4-tert-butylbenzoate 1.03
    morpholine 7.66
    tert-butylamine 0.08
    n-dodecanol 0.16
    dimethoxymethane 12.4
    ethylene carbonate 0.86
    cyrene 6.02
    2-ethoxyethyl acetate 1.02
    2-ethylhexyl acetate 0.07
    1,2,4-trichlorobenzene 0.09
    4-methylpyridine 0.67
    dibutyl ether 0.17
    2,6-dimethyl-4-heptanol 0.06
    DEF 3.1
    dimethyl isosorbide 3.57
    tetrachloroethylene 0.37
    eugenol 1.35
    triacetin 1.2
    span 80 3.03
    1,4-butanediol 2.74
    1,1-dichloroethane 0.09
    2-methyl-1-pentanol 0.23
    methyl formate 10.45
    2-methyl-1-butanol 0.61
    n-decane 0.02
    butyronitrile 0.28
    3,7-dimethyl-1-octanol 0.17
    1-chlorooctane 0.07
    1-chlorotetradecane 0.02
    n-nonane 0.02
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.01
    cyclopentanol 1.2
    tetrahydropyran 1.11
    tert-amyl methyl ether 0.27
    2,5,8-trioxanonane 6.41
    1-hexene 0.02
    2-isopropoxyethanol 1.99
    2,2,2-trifluoroethanol 5.04
    methyl butyrate 0.37

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction