Phenacetin

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  • Identifiers

    CAS number
    62-44-2

    Molecular formula
    C10H13NO2

    SMILES
    CCOC1=CC=C(C=C1)NC(=O)C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fruity 59.25%
    Grape 45.17%
    Floral 41.79%
    Sweet 37.57%
    Meaty 32.24%
    Roasted 30.56%
    Berry 29.28%
    Burnt 27.58%
    Vanilla 26.53%
    Savory 23.62%

     

    Flavor
    Sweet 68.47%
    Fruity 61.47%
    Floral 49.29%
    Powdery 39.47%
    Grape 31.61%
    Mild 31.58%
    Spicy 31.5%
    Berry 26.23%
    Honey 25.02%
    Flower 24.82%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    7.51 (neutral)

    Molecular weight
    179.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 273 to 280 °F (NTP, 1992)
    • 137.5 °C
    • 134-135 °C

    Boiling point

    • Decomposes (NTP, 1992)
    • 242-245 °C
    • BP: DECOMP

    Flash point

    • 145.36 ˚C est.

    Solubility expt.

    • 26.1 [ug/mL] (The mean of the results at pH 7.4)
    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • 766 mg/L (at 25 °C)
    • 1 g dissolves in 1310 mL cold water, 82 mL boiling water, 15 mL cold alcohol, 2.8 mL boiling alcohol, 14 mL chloroform, 90 mL ether; sol in glycerol.
    • Very sol in pyrimidine; sol in ethanol, acetone; slightly sol in benzene. ethyl ether.
    • In water, 766 mg/L at 25 °C

  • Synonyms

    • phenacetin
    • 62-44-2
    • N-(4-Ethoxyphenyl)acetamide
    • Acetophenetidin
    • Acetphenetidin
    • Acetophenetidine
    • Acetophenetin
    • p-Acetophenetidide
    • Phenacetine
    • 4'-Ethoxyacetanilide
    • Phenazetin
    • Phenacetinum
    • Fenidina
    • Kalmin
    • Achrocidin
    • Codempiral
    • Commotional
    • Contradol
    • Contradouleur
    • Fenacetina
    • 4-Ethoxyacetanilide
    • p-Acetophenetidine
    • Pertonal
    • Phenacet
    • Phenacitin
    • Phenedina
    • Phenidin
    • Pyraphen
    • Fenina
    • Phenin
    • p-Ethoxyacetanilide
    • p-Acetophenetide
    • p-Acetphenetidin
    • Acetamide, N-(4-ethoxyphenyl)-
    • Clistanol
    • Coricidin
    • Coriforte
    • Daprisal
    • Dolostop
    • Emprazil
    • Fortacyl
    • Gelonida
    • Helvagit
    • Hocophen
    • Melaforte
    • Paramette
    • Paratodol
    • Phenazetina
    • Pyrroxate
    • Quadronal
    • Salgydal
    • Sanalgine
    • Stellacyl
    • Synalogos
    • Tetracydin
    • Anapac
    • Dasikon
    • Edrisal
    • Empiral
    • Epragen
    • Gewodin
    • Pamprin
    • Seranex
    • Sinedal
    • Sinubid
    • Sinutab
    • Treupel
    • Acetylphenetidin
    • Fenia
    • Malex
    • Tacol
    • Viden
    • Xaril
    • Kafa
    • para-Phenacetin
    • Phenaphen plus
    • Bromo seltzer
    • Robaxisal-ph
    • Citra-fort
    • Aceto-4-phenetidine
    • Dasin ch
    • Emprazil-C
    • Paracetophenetidin
    • Acet-p-phenalide
    • Coryban-D
    • Hjorton'S powder
    • Acet-p-phenetidin
    • Thephorin A-C
    • Buff-A-Comp
    • Para-acetphenetidin
    • Melabon
    • N-Acetyl-p-phenetidine
    • Phenodyne
    • Saridon
    • Sinutabs
    • Veganine
    • 1-Acetamido-4-ethoxybenzene
    • Aceto-para-phenalide
    • para-Acetophenetidide
    • Super Anahist
    • Acetanilide, 4'-ethoxy-
    • Aceto-para-phenetidide
    • p-Phenetidine, N-acetyl-
    • Fenacetin
    • Fiorinal
    • para-Acetophenetidine
    • Rcra waste number U187
    • para-Ethoxyacetanilide
    • Fenacetin [Czech]
    • Acetamide, N-(4-ethoxyphenol)-
    • N-para-Ethoxyphenylacetamide
    • CCRIS 496
    • 4-(Acetylamino)phenetole
    • N-Acetyl-4-ethoxyaniline
    • N-Acetyl-para-phenetidine
    • Fenacetina [INN-Spanish]
    • HSDB 3152
    • p-Ethoxyanilid kyseliny octove
    • BRN 1869238
    • Acetic acid amide, N-(4-ethoxyphenyl)-
    • Phenacetin Melting Point Standard
    • AI3-00783
    • UNII-ER0CTH01H9
    • NSC 7651
    • NSC-7651
    • EINECS 200-533-0
    • ER0CTH01H9
    • 4-Ethoxy-1-acetylaminobenzene

  • Applications

    Phenacetin (CAS 62-44-2) is primarily encountered as a chemical intermediate in organic synthesis; historically used as an analgesic and antipyretic in pharmaceuticals, and as a precursor in the manufacture of acetanilide-type compounds such as acetaminophen (paracetamol) and related derivatives. In industrial contexts, it is sometimes employed as a starting material for preparing substituted anilide compounds and may serve as a reference standard in reaction studies. Its use as a medicinal agent has largely declined due to safety concerns, and any current applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 57.13
    methanol 86.7
    isopropanol 37.76
    water 1.9
    ethyl acetate 23.06
    n-propanol 42.48
    acetone 91.32
    n-butanol 46.96
    acetonitrile 39.67
    DMF 325.0
    toluene 6.02
    isobutanol 31.56
    1,4-dioxane 48.78
    methyl acetate 46.15
    THF 75.75
    2-butanone 65.39
    n-pentanol 34.48
    sec-butanol 32.53
    n-hexane 2.56
    ethylene glycol 50.07
    NMP 226.54
    cyclohexane 0.79
    DMSO 550.42
    n-butyl acetate 31.27
    n-octanol 17.42
    chloroform 89.23
    n-propyl acetate 18.18
    acetic acid 87.66
    dichloromethane 99.84
    cyclohexanone 60.13
    propylene glycol 55.39
    isopropyl acetate 18.43
    DMAc 507.27
    2-ethoxyethanol 80.47
    isopentanol 39.63
    n-heptane 1.25
    ethyl formate 24.61
    1,2-dichloroethane 56.53
    n-hexanol 27.72
    2-methoxyethanol 139.16
    isobutyl acetate 16.53
    tetrachloromethane 9.68
    n-pentyl acetate 17.6
    transcutol 287.37
    n-heptanol 11.94
    ethylbenzene 8.1
    MIBK 29.93
    2-propoxyethanol 74.34
    tert-butanol 55.87
    MTBE 40.08
    2-butoxyethanol 36.17
    propionic acid 50.99
    o-xylene 9.36
    formic acid 68.88
    diethyl ether 23.16
    m-xylene 7.35
    p-xylene 10.54
    chlorobenzene 21.66
    dimethyl carbonate 27.56
    n-octane 0.7
    formamide 79.36
    cyclopentanone 91.06
    2-pentanone 38.73
    anisole 37.44
    cyclopentyl methyl ether 30.0
    gamma-butyrolactone 93.7
    1-methoxy-2-propanol 89.89
    pyridine 36.44
    3-pentanone 34.92
    furfural 122.54
    n-dodecane 1.04
    diethylene glycol 94.81
    diisopropyl ether 7.22
    tert-amyl alcohol 46.86
    acetylacetone 58.0
    n-hexadecane 1.17
    acetophenone 40.57
    methyl propionate 32.9
    isopentyl acetate 36.85
    trichloroethylene 113.27
    n-nonanol 15.96
    cyclohexanol 23.42
    benzyl alcohol 32.17
    2-ethylhexanol 19.8
    isooctanol 10.98
    dipropyl ether 15.12
    1,2-dichlorobenzene 30.39
    ethyl lactate 27.33
    propylene carbonate 53.17
    n-methylformamide 80.69
    2-pentanol 22.2
    n-pentane 1.24
    1-propoxy-2-propanol 52.98
    1-methoxy-2-propyl acetate 52.49
    2-(2-methoxypropoxy) propanol 78.5
    mesitylene 5.68
    ε-caprolactone 53.23
    p-cymene 9.88
    epichlorohydrin 112.19
    1,1,1-trichloroethane 42.04
    2-aminoethanol 60.13
    morpholine-4-carbaldehyde 168.85
    sulfolane 210.84
    2,2,4-trimethylpentane 2.08
    2-methyltetrahydrofuran 49.67
    n-hexyl acetate 34.82
    isooctane 1.24
    2-(2-butoxyethoxy)ethanol 80.66
    sec-butyl acetate 15.88
    tert-butyl acetate 31.57
    decalin 2.48
    glycerin 107.5
    diglyme 132.07
    acrylic acid 58.67
    isopropyl myristate 15.1
    n-butyric acid 46.16
    acetyl acetate 24.86
    di(2-ethylhexyl) phthalate 26.3
    ethyl propionate 20.42
    nitromethane 145.88
    1,2-diethoxyethane 46.16
    benzonitrile 34.23
    trioctyl phosphate 14.97
    1-bromopropane 25.29
    gamma-valerolactone 118.63
    n-decanol 12.24
    triethyl phosphate 26.52
    4-methyl-2-pentanol 15.89
    propionitrile 29.25
    vinylene carbonate 49.01
    1,1,2-trichlorotrifluoroethane 139.23
    DMS 44.05
    cumene 8.88
    2-octanol 8.95
    2-hexanone 31.94
    octyl acetate 20.25
    limonene 13.54
    1,2-dimethoxyethane 114.97
    ethyl orthosilicate 24.08
    tributyl phosphate 23.27
    diacetone alcohol 57.51
    N,N-dimethylaniline 33.19
    acrylonitrile 42.15
    aniline 23.88
    1,3-propanediol 68.61
    bromobenzene 19.2
    dibromomethane 52.62
    1,1,2,2-tetrachloroethane 94.61
    2-methyl-cyclohexyl acetate 32.55
    tetrabutyl urea 32.46
    diisobutyl methanol 12.7
    2-phenylethanol 30.58
    styrene 10.03
    dioctyl adipate 29.29
    dimethyl sulfate 92.31
    ethyl butyrate 24.42
    methyl lactate 46.44
    butyl lactate 28.67
    diethyl carbonate 23.46
    propanediol butyl ether 57.98
    triethyl orthoformate 24.43
    p-tert-butyltoluene 9.76
    methyl 4-tert-butylbenzoate 45.25
    morpholine 66.14
    tert-butylamine 27.97
    n-dodecanol 9.58
    dimethoxymethane 77.35
    ethylene carbonate 33.73
    cyrene 69.84
    2-ethoxyethyl acetate 35.17
    2-ethylhexyl acetate 27.7
    1,2,4-trichlorobenzene 42.92
    4-methylpyridine 43.48
    dibutyl ether 17.84
    2,6-dimethyl-4-heptanol 12.7
    DEF 66.16
    dimethyl isosorbide 107.37
    tetrachloroethylene 48.31
    eugenol 49.61
    triacetin 49.82
    span 80 49.68
    1,4-butanediol 35.44
    1,1-dichloroethane 41.46
    2-methyl-1-pentanol 34.8
    methyl formate 52.66
    2-methyl-1-butanol 37.98
    n-decane 1.56
    butyronitrile 31.22
    3,7-dimethyl-1-octanol 20.85
    1-chlorooctane 8.9
    1-chlorotetradecane 4.27
    n-nonane 1.36
    undecane 1.23
    tert-butylcyclohexane 3.16
    cyclooctane 0.43
    cyclopentanol 28.28
    tetrahydropyran 27.56
    tert-amyl methyl ether 34.73
    2,5,8-trioxanonane 112.47
    1-hexene 9.82
    2-isopropoxyethanol 48.73
    2,2,2-trifluoroethanol 44.53
    methyl butyrate 27.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction