Perflutren

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  • Identifiers

    CAS number
    76-19-7

    Molecular formula
    C3F8

    SMILES
    C(C(F)(F)F)(C(F)(F)F)(F)F

    Safety labels

    Compressed Gas
    Compressed Gas

  • Odor profile

    Fragrance
    Odorless 54.73%
    Fishy 24.35%
    Sweet 24.03%
    Woody 21.63%
    Cooling 20.69%
    Balsamic 17.83%
    Savory 16.16%
    Animal 15.44%
    Clean 15.35%
    Dry 15.22%

     

    Flavor
    Odorless 31.87%
    Bland 21.76%
    Sulfurous 19.74%
    Bitter 18.64%
    Mild 18.16%
    Sweet-like 17.69%
    Bloody 17.43%
    Glue 17.32%
    Bouillon 17.21%
    Catty 16.92%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.1

    pKa est.
    6.68 (neutral)

    Molecular weight
    188.02 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -147.6 °C

    Boiling point

    • -36.6 °C
    • -36.7 °C

    Flash point

    • -27.2 ˚C est.

    Solubility expt.

    • 5.7 mg/L (at 15 °C)
    • In water, 5.7 mg/L at 15 °C
    • Miscible with water
    • Miscible with alcohol, ether. Soluble in benzene, chloroform
    • 1.46e-01 g/L

  • Synonyms

    • Perfluoropropane
    • Perflutren
    • OCTAFLUOROPROPANE
    • Definity
    • 76-19-7
    • Propane, octafluoro-
    • 1,1,1,2,2,3,3,3-Octafluoropropane
    • Freon 218
    • luminity
    • Oktafluorpropan
    • Optison
    • Genetron 218
    • Octafluorpropan
    • MRX-115
    • FC 218 (refrigerant)
    • FC 218
    • DMP 115
    • C3F8-gas
    • HFC 218
    • PFC 218
    • FS069
    • Perflutren Lipid Microsphere
    • perflutrene
    • Perflutreno
    • UN 2424
    • DMP-115
    • UNII-CK0N3WH0SR
    • CK0N3WH0SR
    • octafluoro-propane
    • R 218
    • EINECS 200-941-9
    • CHEBI:31980
    • HSDB 8074
    • Propane,1,1,1,2,2,3,3,3-octafluoro-
    • FS-069
    • DTXSID9052503
    • EC 200-941-9
    • Perflutren [USAN]
    • PERFLUTREN (II)
    • PERFLUTREN [II]
    • Propane, 1,1,1,2,2,3,3,3-octafluoro-
    • PERFLUTREN (MART.)
    • PERFLUTREN [MART.]
    • Albumin human
    • MFCD00039239
    • UN2424
    • perflutrenum
    • Perflutren lipid microspheres
    • Perflutren [USAN:INN:BAN]
    • C3F8
    • Definity (TN)
    • Optison (Salt/Mix)
    • DEFINITY RT
    • OXTAFLUOROPROPANE
    • R218
    • PERFLUTREN [INN]
    • PERFLUTREN [JAN]
    • PERFLUTREN [VANDF]
    • Perflutren-lipid microsphere
    • Perflutren Protein-Type A Microspheres injection
    • CHEMBL1663
    • PERFLUTREN [WHO-DD]
    • PERFLUOROPROPANE [MI]
    • Octafluoropropane, high purity
    • Perfluoropropane (PFC-218)
    • Perflutren (JAN/USAN/INN)
    • PERFLUTREN [EMA EPAR]
    • DMP115
    • REFRIGERANT GAS R-218
    • DTXCID3031076
    • PERFLUTREN [ORANGE BOOK]
    • OCTAFLUOROPROPANE [VANDF]
    • OXTAFLUOROPROPANE [VANDF]
    • MRX 115
    • octafluoropropane-lipid microsphere
    • YM454
    • Dulbecco's phosphate buffered saline
    • AKOS006228213
    • DB00556
    • FD45394
    • FS-6566
    • Octafluoropropaneor Refrigerant gas R 218
    • DB-056033
    • NS00006776
    • 1,1,1,2,2,3,3,3-octakis(fluoranyl)propane
    • D01738
    • A838638
    • Q412659
    • Octafluoropropaneor Refrigerant gas R 218 [UN2424] [Nonflammable gas]
    • 200-941-9

  • Applications

    Perflutren (CAS 76-19-7) is used primarily as an ultrasound contrast agent in medicine. It is supplied as stabilized lipid-coated gas-filled microbubbles for intravenous injection to enhance ultrasound signals in echocardiography and other diagnostic ultrasound studies, improving delineation of cardiac chambers, organ perfusion, and vascular structures. In clinical practice it plays a key role in cardiology and radiology workflows, and it is also used in clinical trials and research to develop and evaluate ultrasound imaging protocols. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 89.26
    methanol 174.6
    isopropanol 69.17
    water 73.62
    ethyl acetate 26.96
    n-propanol 66.54
    acetone 72.11
    n-butanol 47.03
    acetonitrile 55.46
    DMF 346.35
    toluene 9.62
    isobutanol 47.02
    1,4-dioxane 50.19
    methyl acetate 38.06
    THF 115.99
    2-butanone 52.65
    n-pentanol 34.02
    sec-butanol 52.18
    n-hexane 8.12
    ethylene glycol 85.79
    NMP 294.53
    cyclohexane 12.97
    DMSO 653.49
    n-butyl acetate 19.0
    n-octanol 17.2
    chloroform 21.37
    n-propyl acetate 22.01
    acetic acid 54.15
    dichloromethane 29.25
    cyclohexanone 47.54
    propylene glycol 72.94
    isopropyl acetate 20.35
    DMAc 312.31
    2-ethoxyethanol 86.1
    isopentanol 36.42
    n-heptane 11.77
    ethyl formate 31.78
    1,2-dichloroethane 29.95
    n-hexanol 26.94
    2-methoxyethanol 144.7
    isobutyl acetate 10.46
    tetrachloromethane 7.55
    n-pentyl acetate 12.49
    transcutol 75.24
    n-heptanol 16.19
    ethylbenzene 7.53
    MIBK 25.83
    2-propoxyethanol 70.98
    tert-butanol 68.7
    MTBE 38.45
    2-butoxyethanol 35.29
    propionic acid 46.73
    o-xylene 13.54
    formic acid 90.13
    diethyl ether 46.01
    m-xylene 9.46
    p-xylene 8.38
    chlorobenzene 4.94
    dimethyl carbonate 33.88
    n-octane 4.57
    formamide 159.88
    cyclopentanone 70.23
    2-pentanone 39.61
    anisole 17.18
    cyclopentyl methyl ether 49.77
    gamma-butyrolactone 80.81
    1-methoxy-2-propanol 108.46
    pyridine 39.79
    3-pentanone 41.5
    furfural 57.31
    n-dodecane 2.96
    diethylene glycol 76.27
    diisopropyl ether 15.97
    tert-amyl alcohol 55.72
    acetylacetone 32.21
    n-hexadecane 3.11
    acetophenone 23.67
    methyl propionate 45.35
    isopentyl acetate 13.34
    trichloroethylene 24.96
    n-nonanol 16.84
    cyclohexanol 42.4
    benzyl alcohol 24.02
    2-ethylhexanol 16.44
    isooctanol 12.6
    dipropyl ether 34.01
    1,2-dichlorobenzene 5.49
    ethyl lactate 32.18
    propylene carbonate 31.09
    n-methylformamide 148.82
    2-pentanol 37.76
    n-pentane 14.22
    1-propoxy-2-propanol 51.85
    1-methoxy-2-propyl acetate 29.28
    2-(2-methoxypropoxy) propanol 41.48
    mesitylene 8.26
    ε-caprolactone 42.27
    p-cymene 9.72
    epichlorohydrin 56.96
    1,1,1-trichloroethane 12.4
    2-aminoethanol 97.73
    morpholine-4-carbaldehyde 150.43
    sulfolane 158.53
    2,2,4-trimethylpentane 5.73
    2-methyltetrahydrofuran 58.49
    n-hexyl acetate 15.06
    isooctane 3.77
    2-(2-butoxyethoxy)ethanol 43.08
    sec-butyl acetate 13.8
    tert-butyl acetate 21.16
    decalin 4.37
    glycerin 96.39
    diglyme 72.84
    acrylic acid 47.79
    isopropyl myristate 8.92
    n-butyric acid 35.04
    acetyl acetate 13.92
    di(2-ethylhexyl) phthalate 9.16
    ethyl propionate 24.44
    nitromethane 100.84
    1,2-diethoxyethane 25.91
    benzonitrile 14.89
    trioctyl phosphate 9.44
    1-bromopropane 22.81
    gamma-valerolactone 81.56
    n-decanol 13.75
    triethyl phosphate 16.72
    4-methyl-2-pentanol 21.94
    propionitrile 45.37
    vinylene carbonate 24.64
    1,1,2-trichlorotrifluoroethane 64.26
    DMS 17.22
    cumene 7.37
    2-octanol 11.58
    2-hexanone 26.43
    octyl acetate 11.31
    limonene 15.06
    1,2-dimethoxyethane 94.16
    ethyl orthosilicate 15.77
    tributyl phosphate 10.07
    diacetone alcohol 42.83
    N,N-dimethylaniline 28.54
    acrylonitrile 53.46
    aniline 22.81
    1,3-propanediol 71.54
    bromobenzene 3.61
    dibromomethane 23.62
    1,1,2,2-tetrachloroethane 31.98
    2-methyl-cyclohexyl acetate 16.41
    tetrabutyl urea 22.27
    diisobutyl methanol 14.11
    2-phenylethanol 18.91
    styrene 7.33
    dioctyl adipate 13.93
    dimethyl sulfate 63.12
    ethyl butyrate 22.15
    methyl lactate 56.22
    butyl lactate 20.59
    diethyl carbonate 14.74
    propanediol butyl ether 34.58
    triethyl orthoformate 19.76
    p-tert-butyltoluene 9.81
    methyl 4-tert-butylbenzoate 24.66
    morpholine 90.15
    tert-butylamine 55.31
    n-dodecanol 11.08
    dimethoxymethane 122.36
    ethylene carbonate 23.56
    cyrene 58.59
    2-ethoxyethyl acetate 15.75
    2-ethylhexyl acetate 11.42
    1,2,4-trichlorobenzene 7.72
    4-methylpyridine 31.4
    dibutyl ether 15.31
    2,6-dimethyl-4-heptanol 14.11
    DEF 89.18
    dimethyl isosorbide 59.31
    tetrachloroethylene 21.36
    eugenol 26.77
    triacetin 20.48
    span 80 28.24
    1,4-butanediol 42.99
    1,1-dichloroethane 19.25
    2-methyl-1-pentanol 23.93
    methyl formate 79.04
    2-methyl-1-butanol 38.69
    n-decane 4.57
    butyronitrile 34.37
    3,7-dimethyl-1-octanol 13.75
    1-chlorooctane 7.76
    1-chlorotetradecane 4.36
    n-nonane 4.54
    undecane 3.55
    tert-butylcyclohexane 3.86
    cyclooctane 6.53
    cyclopentanol 58.25
    tetrahydropyran 45.13
    tert-amyl methyl ether 38.57
    2,5,8-trioxanonane 61.37
    1-hexene 13.89
    2-isopropoxyethanol 50.74
    2,2,2-trifluoroethanol 45.46
    methyl butyrate 30.55

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction