Perflexane

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  • Identifiers

    CAS number
    355-42-0

    Molecular formula
    C6F14

    SMILES
    C(C(C(C(F)(F)F)(F)F)(F)F)(C(C(F)(F)F)(F)F)(F)F

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 54.44%
    Fishy 23.48%
    Woody 22.96%
    Sweet 22.45%
    Cooling 19.83%
    Balsamic 17.68%
    Dry 15.22%
    Savory 15.16%
    Clean 14.93%
    Animal 14.79%

     

    Flavor
    Odorless 29.99%
    Bitter 24.45%
    Bland 22.9%
    Sweet-like 17.42%
    Bloody 16.68%
    Sulfurous 16.6%
    Glue 16.54%
    Bouillon 16.5%
    Oriental 16.46%
    Mild 16.44%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    5.1

    pKa est.
    4.13 (weak acid)

    Molecular weight
    338.04 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -86.1 °C

    Boiling point

    • 57.2 °C

    Flash point

    • 0.67 ˚C est.

    Solubility expt.

    • Soluble in ethyl ether, benzene, chloroform

  • Synonyms

    • Perfluorohexane
    • Perflexane
    • 355-42-0
    • Tetradecafluorohexane
    • Hexane, tetradecafluoro-
    • PERFLUORO-N-HEXANE
    • Flutec PP1
    • n-Tetradecafluorohexane
    • perfluorohexanes
    • n-Perfluorohexane
    • Fluorinert FC72
    • 1,1,1,2,2,3,3,4,4,5,5,6,6,6-Tetradecafluorohexane
    • AF0150
    • Perflexane [USAN:INN]
    • Perflexano
    • UNII-FX3WJ41CMX
    • FX3WJ41CMX
    • Perfluoro-compound FC-72
    • perfluorohexane(s)
    • EINECS 206-585-0
    • Perflexane [USAN]
    • DTXSID7046548
    • CHEBI:39427
    • HSDB 7871
    • PERFLEXANE [INN]
    • PERFLEXANE [VANDF]
    • PERFLEXANE [MART.]
    • AF-0150
    • PERFLEXANE [WHO-DD]
    • PERFLUOROHEXANE [MI]
    • DTXCID5026548
    • PERFLEXANE [ORANGE BOOK]
    • Perfluorohexanes (Mixture of Isomers)
    • NCGC00166122-01
    • Hexane, 1,1,1,2,2,3,3,4,4,5,5,6,6,6-tetradecafluoro-
    • PERFLEXANE (MART.)
    • Imavist
    • fluorinert fc-72
    • fluorinertr(fc-72)
    • MFCD00000437
    • perflexanum
    • Perfluoronhexane
    • flutecr pp
    • per-fluorohexane
    • Imagent?
    • Imavist?
    • fluorinert (tm)
    • AFO 150
    • C6F14
    • FC-72
    • nTetradecafluorohexane
    • fluorinert(r) fc-72
    • Hexane, tetradecafluoro
    • PP 1 (Fluorocarbon)
    • n-perfluorohexane emulsion
    • Perflexane (USAN/INN)
    • Tetradecafluorohexane, 99%
    • Perflexane-lipid microspheres
    • SCHEMBL33789
    • PERFLUOROHEXANE [INCI]
    • Perfluorhexane (mixed isomers)
    • fluorinert(tm) (fc-72)(r)
    • AFO145
    • AFO150
    • CHEMBL1200607
    • ZJIJAJXFLBMLCK-UHFFFAOYSA-
    • Tox21_112328
    • AKOS005258316
    • AF 0150
    • DB09531
    • FP35499
    • AS-56640
    • BP-21389
    • CAS-355-42-0
    • HY-109540
    • CS-0031279
    • NS00011373
    • P0839
    • D05437
    • D92023
    • SBI-0654039.0001
    • Q3291714
    • 1,1,1,2,2,3,3,4,4,5,5,6,6,6-Tetradecafluorohexane #
    • 206-585-0
    • InChI=1/C6F14/c7-1(8,3(11,12)5(15,16)17)2(9,10)4(13,14)6(18,19)20

  • Applications

    Perflexane, CAS 355-42-0, is a fluorinated solvent with chemically inert properties, used in industrial applications that require stability and resistance to harsh operating conditions. Common use cases include: as a cleaning solvent for precision parts such as electronic components; as a heat transfer fluid for high-temperature equipment; as an additive or solvent in coating formulations and inks to tailor surface properties and chemistry; as a solvent or intermediate in polymer and plastics production; and may be evaluated as an intermediate in chemical synthesis workflows, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 51.76
    methanol 123.01
    isopropanol 30.28
    water 33.07
    ethyl acetate 75.77
    n-propanol 37.05
    acetone 108.87
    n-butanol 26.8
    acetonitrile 73.14
    DMF 318.41
    toluene 24.69
    isobutanol 24.79
    1,4-dioxane 96.82
    methyl acetate 83.59
    THF 137.13
    2-butanone 87.4
    n-pentanol 22.53
    sec-butanol 32.85
    n-hexane 7.78
    ethylene glycol 48.44
    NMP 383.41
    cyclohexane 21.28
    DMSO 786.31
    n-butyl acetate 50.22
    n-octanol 22.7
    chloroform 36.66
    n-propyl acetate 41.06
    acetic acid 52.24
    dichloromethane 61.7
    cyclohexanone 91.92
    propylene glycol 30.87
    isopropyl acetate 45.37
    DMAc 376.46
    2-ethoxyethanol 78.96
    isopentanol 20.15
    n-heptane 17.31
    ethyl formate 62.02
    1,2-dichloroethane 60.94
    n-hexanol 27.74
    2-methoxyethanol 125.37
    isobutyl acetate 15.68
    tetrachloromethane 13.45
    n-pentyl acetate 31.09
    transcutol 89.52
    n-heptanol 20.5
    ethylbenzene 14.15
    MIBK 33.13
    2-propoxyethanol 80.36
    tert-butanol 32.67
    MTBE 41.22
    2-butoxyethanol 39.76
    propionic acid 54.24
    o-xylene 30.58
    formic acid 79.96
    diethyl ether 68.31
    m-xylene 17.84
    p-xylene 14.88
    chlorobenzene 14.32
    dimethyl carbonate 77.88
    n-octane 8.12
    formamide 157.31
    cyclopentanone 116.44
    2-pentanone 66.22
    anisole 28.51
    cyclopentyl methyl ether 66.6
    gamma-butyrolactone 152.57
    1-methoxy-2-propanol 83.41
    pyridine 73.43
    3-pentanone 84.01
    furfural 102.4
    n-dodecane 5.4
    diethylene glycol 81.83
    diisopropyl ether 23.57
    tert-amyl alcohol 36.81
    acetylacetone 76.15
    n-hexadecane 5.83
    acetophenone 44.69
    methyl propionate 98.09
    isopentyl acetate 28.6
    trichloroethylene 53.15
    n-nonanol 22.38
    cyclohexanol 37.82
    benzyl alcohol 28.3
    2-ethylhexanol 21.43
    isooctanol 14.03
    dipropyl ether 52.07
    1,2-dichlorobenzene 14.29
    ethyl lactate 42.57
    propylene carbonate 65.78
    n-methylformamide 163.53
    2-pentanol 23.79
    n-pentane 12.95
    1-propoxy-2-propanol 60.49
    1-methoxy-2-propyl acetate 66.74
    2-(2-methoxypropoxy) propanol 49.06
    mesitylene 14.47
    ε-caprolactone 86.64
    p-cymene 19.42
    epichlorohydrin 88.8
    1,1,1-trichloroethane 23.65
    2-aminoethanol 46.39
    morpholine-4-carbaldehyde 206.54
    sulfolane 265.0
    2,2,4-trimethylpentane 6.09
    2-methyltetrahydrofuran 76.19
    n-hexyl acetate 33.51
    isooctane 3.09
    2-(2-butoxyethoxy)ethanol 48.26
    sec-butyl acetate 26.91
    tert-butyl acetate 37.4
    decalin 6.35
    glycerin 56.35
    diglyme 98.21
    acrylic acid 56.28
    isopropyl myristate 18.35
    n-butyric acid 40.51
    acetyl acetate 47.3
    di(2-ethylhexyl) phthalate 15.95
    ethyl propionate 51.87
    nitromethane 165.08
    1,2-diethoxyethane 55.1
    benzonitrile 25.98
    trioctyl phosphate 16.8
    1-bromopropane 37.94
    gamma-valerolactone 138.59
    n-decanol 18.2
    triethyl phosphate 38.83
    4-methyl-2-pentanol 14.74
    propionitrile 51.8
    vinylene carbonate 58.57
    1,1,2-trichlorotrifluoroethane 83.3
    DMS 51.29
    cumene 10.32
    2-octanol 16.64
    2-hexanone 37.45
    octyl acetate 24.43
    limonene 32.3
    1,2-dimethoxyethane 117.48
    ethyl orthosilicate 31.26
    tributyl phosphate 19.17
    diacetone alcohol 47.31
    N,N-dimethylaniline 34.33
    acrylonitrile 69.71
    aniline 32.52
    1,3-propanediol 43.29
    bromobenzene 12.18
    dibromomethane 47.2
    1,1,2,2-tetrachloroethane 51.86
    2-methyl-cyclohexyl acetate 29.51
    tetrabutyl urea 38.09
    diisobutyl methanol 16.52
    2-phenylethanol 28.19
    styrene 14.24
    dioctyl adipate 28.02
    dimethyl sulfate 142.87
    ethyl butyrate 52.97
    methyl lactate 79.89
    butyl lactate 30.05
    diethyl carbonate 38.86
    propanediol butyl ether 32.05
    triethyl orthoformate 40.61
    p-tert-butyltoluene 18.23
    methyl 4-tert-butylbenzoate 41.45
    morpholine 108.19
    tert-butylamine 23.62
    n-dodecanol 14.84
    dimethoxymethane 162.11
    ethylene carbonate 56.37
    cyrene 70.51
    2-ethoxyethyl acetate 45.07
    2-ethylhexyl acetate 29.24
    1,2,4-trichlorobenzene 19.58
    4-methylpyridine 55.67
    dibutyl ether 26.05
    2,6-dimethyl-4-heptanol 16.52
    DEF 144.37
    dimethyl isosorbide 84.57
    tetrachloroethylene 43.41
    eugenol 34.91
    triacetin 49.19
    span 80 33.45
    1,4-butanediol 27.6
    1,1-dichloroethane 30.34
    2-methyl-1-pentanol 17.34
    methyl formate 122.22
    2-methyl-1-butanol 23.94
    n-decane 8.82
    butyronitrile 35.29
    3,7-dimethyl-1-octanol 16.31
    1-chlorooctane 15.22
    1-chlorotetradecane 8.33
    n-nonane 8.73
    undecane 6.8
    tert-butylcyclohexane 4.05
    cyclooctane 11.57
    cyclopentanol 43.12
    tetrahydropyran 67.94
    tert-amyl methyl ether 48.81
    2,5,8-trioxanonane 80.31
    1-hexene 13.24
    2-isopropoxyethanol 49.01
    2,2,2-trifluoroethanol 55.3
    methyl butyrate 54.45

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction