Palmitoyl myristyl serinate

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  • Identifiers

    CAS number
    156042-32-9

    Molecular formula
    C33H65NO4

    SMILES
    CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)OCCCCCCCCCCCCCC

    Safety labels

  • Odor profile

    Fragrance
    Waxy 55.24%
    Fatty 44.67%
    Oily 38.12%
    Odorless 35.13%
    Savory 25.25%
    Milky 23.04%
    Meaty 22.04%
    Woody 21.7%
    Fresh 21.4%
    Fishy 20.2%

     

    Flavor
    Bland 42.2%
    Mild 37.29%
    Odorless 33.83%
    Waxy 32.14%
    Fatty 31.58%
    Faint 31.4%
    Oily 24.99%
    Slightly waxy 23.25%
    Bay oil 21.58%
    Delicate 21.14%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    12.8

    pKa est.
    8.58 (weak base)

    Molecular weight
    539.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    763°C

    Flash point

    • 249.48 ˚C est.

  • Synonyms

    • Palmitoyl myristyl serinate
    • Ceramide A2
    • L-Serine, N-(1-oxohexadecyl)-, tetradecyl ester
    • UNII-203U03P988
    • 203U03P988
    • DTXSID00166034
    • RefChem:169741
    • DTXCID2088525
    • PALMITOYL MYRISTYL SERINATE [INCI]
    • 156042-32-9
    • tetradecyl (2S)-2-(hexadecanoylamino)-3-hydroxypropanoate
    • SCHEMBL28518818
    • XSBIBIYYGMXJED-HKBQPEDESA-N
    • Tetradecyl N-hexadecanoyl-L-serinate
    • Q27253410
    • 156042-32-9

  • Applications

    Palmitoyl myristyl serinate (CAS 156042-32-9) is a fatty ester commonly used as a conditioning/emollient ingredient and surfactant in cosmetics and personal care formulations. It provides slip and texture enhancement in creams, lotions, and hair-care products, and can act as a mild emulsifier in formulations. It is sometimes evaluated as a plasticizer or lubricant in polymer and coating applications, helping modify rheology and surface feel. It may serve as a process intermediate in the synthesis of cosmetic actives or fragrance components. In household or cleaning formulations, it can function as a conditioning additive that improves product texture. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.97
    methanol 9.64
    isopropanol 5.85
    water 0.4
    ethyl acetate 58.98
    n-propanol 9.65
    acetone 44.25
    n-butanol 9.66
    acetonitrile 15.5
    DMF 102.34
    toluene 26.29
    isobutanol 9.36
    1,4-dioxane 56.26
    methyl acetate 47.59
    THF 175.06
    2-butanone 60.55
    n-pentanol 11.17
    sec-butanol 12.64
    n-hexane 5.06
    ethylene glycol 1.62
    NMP 445.45
    cyclohexane 20.36
    DMSO 137.59
    n-butyl acetate 53.81
    n-octanol 20.08
    chloroform 191.77
    n-propyl acetate 66.61
    acetic acid 44.03
    dichloromethane 197.52
    cyclohexanone 209.03
    propylene glycol 4.02
    isopropyl acetate 55.16
    DMAc 311.55
    2-ethoxyethanol 32.7
    isopentanol 11.95
    n-heptane 4.76
    ethyl formate 32.71
    1,2-dichloroethane 121.0
    n-hexanol 9.31
    2-methoxyethanol 30.33
    isobutyl acetate 41.2
    tetrachloromethane 52.44
    n-pentyl acetate 114.06
    transcutol 190.91
    n-heptanol 17.29
    ethylbenzene 20.48
    MIBK 47.18
    2-propoxyethanol 30.42
    tert-butanol 13.15
    MTBE 30.04
    2-butoxyethanol 57.69
    propionic acid 33.66
    o-xylene 30.24
    formic acid 13.84
    diethyl ether 20.73
    m-xylene 20.63
    p-xylene 30.79
    chlorobenzene 55.78
    dimethyl carbonate 38.81
    n-octane 3.41
    formamide 26.99
    cyclopentanone 233.84
    2-pentanone 54.43
    anisole 39.78
    cyclopentyl methyl ether 93.51
    gamma-butyrolactone 255.68
    1-methoxy-2-propanol 32.79
    pyridine 86.84
    3-pentanone 64.38
    furfural 177.63
    n-dodecane 1.89
    diethylene glycol 13.96
    diisopropyl ether 13.59
    tert-amyl alcohol 24.47
    acetylacetone 104.44
    n-hexadecane 2.28
    acetophenone 78.1
    methyl propionate 62.21
    isopentyl acetate 59.94
    trichloroethylene 254.92
    n-nonanol 21.7
    cyclohexanol 33.82
    benzyl alcohol 24.45
    2-ethylhexanol 14.3
    isooctanol 19.22
    dipropyl ether 28.28
    1,2-dichlorobenzene 80.73
    ethyl lactate 38.35
    propylene carbonate 157.81
    n-methylformamide 36.16
    2-pentanol 10.1
    n-pentane 3.15
    1-propoxy-2-propanol 37.26
    1-methoxy-2-propyl acetate 70.13
    2-(2-methoxypropoxy) propanol 60.54
    mesitylene 17.51
    ε-caprolactone 215.47
    p-cymene 17.52
    epichlorohydrin 187.56
    1,1,1-trichloroethane 158.64
    2-aminoethanol 5.22
    morpholine-4-carbaldehyde 179.53
    sulfolane 539.42
    2,2,4-trimethylpentane 5.61
    2-methyltetrahydrofuran 124.15
    n-hexyl acetate 104.28
    isooctane 2.08
    2-(2-butoxyethoxy)ethanol 70.42
    sec-butyl acetate 57.26
    tert-butyl acetate 84.49
    decalin 10.42
    glycerin 9.67
    diglyme 181.0
    acrylic acid 29.65
    isopropyl myristate 28.3
    n-butyric acid 58.33
    acetyl acetate 61.38
    di(2-ethylhexyl) phthalate 32.69
    ethyl propionate 67.9
    nitromethane 105.08
    1,2-diethoxyethane 70.08
    benzonitrile 35.61
    trioctyl phosphate 22.72
    1-bromopropane 50.32
    gamma-valerolactone 284.19
    n-decanol 13.0
    triethyl phosphate 54.28
    4-methyl-2-pentanol 9.27
    propionitrile 17.97
    vinylene carbonate 120.12
    1,1,2-trichlorotrifluoroethane 173.86
    DMS 72.42
    cumene 17.0
    2-octanol 17.97
    2-hexanone 58.23
    octyl acetate 38.82
    limonene 30.02
    1,2-dimethoxyethane 83.06
    ethyl orthosilicate 50.03
    tributyl phosphate 33.07
    diacetone alcohol 76.04
    N,N-dimethylaniline 40.47
    acrylonitrile 23.31
    aniline 26.63
    1,3-propanediol 9.02
    bromobenzene 64.81
    dibromomethane 108.69
    1,1,2,2-tetrachloroethane 253.1
    2-methyl-cyclohexyl acetate 67.04
    tetrabutyl urea 54.45
    diisobutyl methanol 11.73
    2-phenylethanol 20.4
    styrene 22.54
    dioctyl adipate 59.73
    dimethyl sulfate 128.46
    ethyl butyrate 65.35
    methyl lactate 38.05
    butyl lactate 85.73
    diethyl carbonate 43.71
    propanediol butyl ether 46.34
    triethyl orthoformate 63.34
    p-tert-butyltoluene 16.62
    methyl 4-tert-butylbenzoate 107.74
    morpholine 76.93
    tert-butylamine 9.41
    n-dodecanol 8.44
    dimethoxymethane 50.71
    ethylene carbonate 101.2
    cyrene 85.82
    2-ethoxyethyl acetate 129.32
    2-ethylhexyl acetate 54.94
    1,2,4-trichlorobenzene 117.6
    4-methylpyridine 76.31
    dibutyl ether 41.07
    2,6-dimethyl-4-heptanol 11.73
    DEF 107.02
    dimethyl isosorbide 150.63
    tetrachloroethylene 167.07
    eugenol 75.93
    triacetin 146.57
    span 80 54.6
    1,4-butanediol 5.74
    1,1-dichloroethane 88.54
    2-methyl-1-pentanol 16.56
    methyl formate 31.58
    2-methyl-1-butanol 14.7
    n-decane 4.63
    butyronitrile 17.96
    3,7-dimethyl-1-octanol 19.85
    1-chlorooctane 24.46
    1-chlorotetradecane 6.85
    n-nonane 4.34
    undecane 2.73
    tert-butylcyclohexane 6.78
    cyclooctane 6.56
    cyclopentanol 38.05
    tetrahydropyran 80.19
    tert-amyl methyl ether 42.1
    2,5,8-trioxanonane 100.32
    1-hexene 12.11
    2-isopropoxyethanol 29.08
    2,2,2-trifluoroethanol 37.36
    methyl butyrate 94.69

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction