Orthoperiodic acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    10450-60-9

    Molecular formula
    H5IO6

    SMILES
    OI(=O)(O)(O)(O)O

    Safety labels

    Oxidizer
    Oxidizer

    Corrosive
    Corrosive

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 55.01%
    Green 17.96%
    Sweet 17.81%
    Fresh 17.56%
    Clean 17.12%
    Sulfurous 16.27%
    Sharp 14.34%
    Sour 14.02%
    Balsamic 14.01%
    Musty 13.73%

     

    Flavor
    Odorless 58.84%
    Bitter 25.72%
    Sweet 24.37%
    Sweet-like 20.6%
    Mild 19.66%
    Bland 19.31%
    Rotten 18.59%
    Pungent 18.22%
    Very slight 18.16%
    Formyl 17.97%

     

  • Properties

    XLogP3-AA
    -2.1

    pKa est.
    3.86 (weak acid)

    Molecular weight
    227.94 g/mol

    Melting point expt.

    • 130 °C

    Flash point

    • 213.27 ˚C est.

  • Synonyms

    • 10450-60-9
    • Orthoperiodic acid
    • Periodic acid (H5IO6)
    • H5IO6
    • hexaoxoiodic(5-) acid
    • pentahydroxidooxidoiodine
    • AK1D44L87G
    • pentahydrogen hexaoxoiodate(5-)
    • pentahydroxy-lambda(7)-iodanone
    • [IO(OH)5]
    • CHEBI:29150
    • (IO(OH)5)
    • RefChem:168606
    • 233-937-0
    • Periodic(VII) acid
    • MFCD00011344
    • pentahydroxy(oxo)-lambda7-iodane
    • pentahydroxy-l5-iodane oxide
    • Paraperiodic acid
    • Iodic Acid; Orthoperiodic Acid; Paraperiodic Acid;
    • PERIODIC ACID, CRYST
    • UNII-AK1D44L87G
    • ortho periodicacid
    • EINECS 233-937-0
    • Periodic acid, ACS
    • PERIODIC ACID [MI]
    • SCHEMBL1315047
    • SCHEMBL29356634
    • DTXSID10883144
    • Pentahydroxy-lambda5-iodane oxide
    • Pentahydroxy(oxo)-lambda~7~-iodane
    • Periodic acid, ACS reagent, 99%
    • SBB080666
    • Periodic acid, BioXtra, >=99.0%
    • AKOS005267114
    • FS-4319
    • Periodic acid, p.a., 99.0-101.0%
    • Periodic acid, for electrophoresis, >=99%
    • Periodic acid, ReagentPlus(R), >=99.0%
    • NS00003696
    • Periodic acid, 99.999% trace metals basis
    • Periodic acid, SAJ special grade, >=98.5%
    • Q411297
    • Periodic acid, puriss. p.a., ACS reagent, for oxidimetric titration, crystallized, >=99.0% (RT)
    • 10450-60-9

  • Applications

    Orthoperiodic acid (CAS 10450-60-9) is a strong oxidant used in organic synthesis and analytical chemistry to perform selective oxidations, notably the oxidation and cleavage of vicinal 1,2-diols in carbohydrates to give aldehyde or ketone products. It opens sugar rings and enables preparation of carbonyl derivatives for structural analysis. In polymer and biomaterial technology, it oxidizes polysaccharides to introduce aldehyde groups for cross-linking with amines, supporting hydrogel formation and functional surface coatings. It also serves as an oxidant in specialty chemical manufacturing for selective oxidation steps in synthetic sequences. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 276.65
    methanol 547.36
    isopropanol 227.0
    water 772.04
    ethyl acetate 39.32
    n-propanol 173.59
    acetone 247.44
    n-butanol 121.16
    acetonitrile 100.47
    DMF 1094.56
    toluene 15.5
    isobutanol 106.82
    1,4-dioxane 128.01
    methyl acetate 56.86
    THF 325.52
    2-butanone 81.81
    n-pentanol 78.18
    sec-butanol 107.9
    n-hexane 14.73
    ethylene glycol 379.89
    NMP 423.09
    cyclohexane 19.55
    DMSO 1167.02
    n-butyl acetate 36.99
    n-octanol 37.85
    chloroform 24.6
    n-propyl acetate 39.45
    acetic acid 152.8
    dichloromethane 37.76
    cyclohexanone 73.61
    propylene glycol 287.55
    isopropyl acetate 32.91
    DMAc 537.81
    2-ethoxyethanol 230.19
    isopentanol 73.15
    n-heptane 18.29
    ethyl formate 77.53
    1,2-dichloroethane 44.09
    n-hexanol 66.72
    2-methoxyethanol 477.49
    isobutyl acetate 22.01
    tetrachloromethane 10.18
    n-pentyl acetate 28.77
    transcutol 157.78
    n-heptanol 45.49
    ethylbenzene 9.18
    MIBK 50.08
    2-propoxyethanol 213.63
    tert-butanol 186.94
    MTBE 52.25
    2-butoxyethanol 117.28
    propionic acid 102.73
    o-xylene 16.72
    formic acid 316.66
    diethyl ether 78.05
    m-xylene 16.12
    p-xylene 10.45
    chlorobenzene 7.97
    dimethyl carbonate 88.83
    n-octane 7.76
    formamide 453.58
    cyclopentanone 157.89
    2-pentanone 77.93
    anisole 28.16
    cyclopentyl methyl ether 94.35
    gamma-butyrolactone 153.24
    1-methoxy-2-propanol 363.2
    pyridine 64.88
    3-pentanone 57.05
    furfural 134.71
    n-dodecane 4.4
    diethylene glycol 265.48
    diisopropyl ether 24.72
    tert-amyl alcohol 89.56
    acetylacetone 80.93
    n-hexadecane 4.54
    acetophenone 35.14
    methyl propionate 72.88
    isopentyl acetate 25.01
    trichloroethylene 31.1
    n-nonanol 34.17
    cyclohexanol 66.1
    benzyl alcohol 44.08
    2-ethylhexanol 27.93
    isooctanol 28.31
    dipropyl ether 57.82
    1,2-dichlorobenzene 8.06
    ethyl lactate 68.12
    propylene carbonate 59.23
    n-methylformamide 439.03
    2-pentanol 76.2
    n-pentane 25.26
    1-propoxy-2-propanol 144.68
    1-methoxy-2-propyl acetate 59.76
    2-(2-methoxypropoxy) propanol 77.44
    mesitylene 14.15
    ε-caprolactone 60.21
    p-cymene 11.85
    epichlorohydrin 111.98
    1,1,1-trichloroethane 15.74
    2-aminoethanol 394.25
    morpholine-4-carbaldehyde 331.6
    sulfolane 273.68
    2,2,4-trimethylpentane 5.14
    2-methyltetrahydrofuran 94.32
    n-hexyl acetate 29.51
    isooctane 5.32
    2-(2-butoxyethoxy)ethanol 105.13
    sec-butyl acetate 20.24
    tert-butyl acetate 36.06
    decalin 4.69
    glycerin 450.43
    diglyme 186.45
    acrylic acid 116.2
    isopropyl myristate 16.55
    n-butyric acid 80.15
    acetyl acetate 23.77
    di(2-ethylhexyl) phthalate 20.83
    ethyl propionate 38.01
    nitromethane 225.25
    1,2-diethoxyethane 51.96
    benzonitrile 22.7
    trioctyl phosphate 21.83
    1-bromopropane 27.27
    gamma-valerolactone 190.36
    n-decanol 27.16
    triethyl phosphate 25.71
    4-methyl-2-pentanol 39.39
    propionitrile 65.48
    vinylene carbonate 50.36
    1,1,2-trichlorotrifluoroethane 131.64
    DMS 30.33
    cumene 8.75
    2-octanol 27.07
    2-hexanone 44.72
    octyl acetate 22.58
    limonene 16.19
    1,2-dimethoxyethane 272.43
    ethyl orthosilicate 25.57
    tributyl phosphate 20.62
    diacetone alcohol 93.81
    N,N-dimethylaniline 45.53
    acrylonitrile 93.99
    aniline 39.59
    1,3-propanediol 260.12
    bromobenzene 5.58
    dibromomethane 27.4
    1,1,2,2-tetrachloroethane 39.83
    2-methyl-cyclohexyl acetate 25.36
    tetrabutyl urea 44.44
    diisobutyl methanol 23.26
    2-phenylethanol 41.39
    styrene 9.56
    dioctyl adipate 25.37
    dimethyl sulfate 165.39
    ethyl butyrate 35.55
    methyl lactate 139.21
    butyl lactate 51.14
    diethyl carbonate 24.66
    propanediol butyl ether 108.69
    triethyl orthoformate 35.21
    p-tert-butyltoluene 13.7
    methyl 4-tert-butylbenzoate 46.97
    morpholine 208.09
    tert-butylamine 114.24
    n-dodecanol 22.06
    dimethoxymethane 458.02
    ethylene carbonate 47.91
    cyrene 99.77
    2-ethoxyethyl acetate 35.25
    2-ethylhexyl acetate 18.76
    1,2,4-trichlorobenzene 9.73
    4-methylpyridine 48.22
    dibutyl ether 23.03
    2,6-dimethyl-4-heptanol 23.26
    DEF 141.22
    dimethyl isosorbide 118.07
    tetrachloroethylene 29.64
    eugenol 71.51
    triacetin 34.31
    span 80 68.48
    1,4-butanediol 147.13
    1,1-dichloroethane 26.6
    2-methyl-1-pentanol 36.81
    methyl formate 274.89
    2-methyl-1-butanol 67.3
    n-decane 6.73
    butyronitrile 57.16
    3,7-dimethyl-1-octanol 23.14
    1-chlorooctane 11.72
    1-chlorotetradecane 6.65
    n-nonane 7.3
    undecane 5.21
    tert-butylcyclohexane 4.11
    cyclooctane 10.58
    cyclopentanol 124.34
    tetrahydropyran 80.88
    tert-amyl methyl ether 44.25
    2,5,8-trioxanonane 145.31
    1-hexene 21.32
    2-isopropoxyethanol 122.79
    2,2,2-trifluoroethanol 124.06
    methyl butyrate 51.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction