Octyl-sepharose CL-4B

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  • Identifiers

    CAS number
    69106-60-1

    Molecular formula
    C11H24O3

    SMILES
    CCCCCCCCOCC(CO)O

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Oily 56.53%
    Fruity 53.48%
    Sweet 47.74%
    Fresh 47.16%
    Waxy 37.79%
    Fatty 36.51%
    Floral 36.05%
    Citrus 36.03%
    Green 34.2%
    Herbal 30.11%

     

    Flavor
    Sweet 42.89%
    Waxy 39.62%
    Fatty 37.59%
    Oily 34.98%
    Green 31.78%
    Mushroom 30.83%
    Mild 30.27%
    Floral 29.3%
    Musty 29.01%
    Earthy 28.46%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    6.91 (neutral)

    Molecular weight
    204.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    295°C

    Flash point

    • 147.6 ˚C est.

  • Synonyms

    • Octyl-sepharose
    • Octylagarose CL-4B
    • Octylsepharose CL-4B
    • Octyl-sepharose CL-4B
    • 69106-60-1
    • RefChem:573787
    • 10438-94-5
    • caprylyl glyceryl ether
    • 3-(octyloxy)propane-1,2-diol
    • 1,2-Propanediol, 3-(octyloxy)-
    • 3-octoxypropane-1,2-diol
    • 1-Glyceryloctyl ether
    • 3-(Octyloxy)-1,2-propanediol
    • octyl glyceryl ether
    • MI97BW74XZ
    • NSC625447
    • 3-OCTYLOXY-PROPANE-1,2-DIOL
    • 3-octyloxypropane-1,2-diol
    • UNII-MI97BW74XZ
    • octadiol
    • 1-octyl glyceryl ether
    • monooctyl glyceryl ether
    • SCHEMBL117825
    • SCHEMBL633100
    • GLYCERIN 1-OCTYL ETHER
    • GLYCEROL 1-OCTYL ETHER
    • SCHEMBL7853984
    • 1-O-OCTYL-RAC-GLYCEROL
    • CHEMBL1974894
    • SCHEMBL27853729
    • DTXSID50874273
    • 1,2-DIHYDROXY-4-OXADODECANE
    • GLYCEROL .ALPHA.-OCTYL ETHER
    • MFCD06252148
    • SBB060187
    • AKOS024390817
    • (+/-)-1-GLYCERYLOCTYL ETHER
    • NSC-625447
    • 3-OCTYLOXY-1,2-PROPYLENE GLYCOL
    • 1-GLYCERYLOCTYL ETHER, (+/-)-
    • NCI60_007851
    • 3-(octyloxy)-1,2-propanediol, AldrichCPR
    • NS00121752
    • ST51046418
    • G72559
    • Q27284049
    • Sepharose CL 4B, 2-hydroxy-3-(octyloxy)propyl ether
    • 10438-94-5

  • Applications

    Octyl-sepharose CL-4B (CAS 69106-60-1) is an agarose-based resin bearing octyl groups used for hydrophobic interaction chromatography (HIC). In industry, it is applied primarily in downstream processing to purify proteins and enzymes with hydrophobic surface regions, including membrane proteins and hydrolases such as lipases/esterases, by binding hydrophobic partners on the resin and eluting under altered solvent strength or salt conditions. It is employed in both research-scale and pilot/industrial manufacturing settings for protein and enzyme purification in bioprocessing, helping to improve purity and process efficiency. Additionally, it can assist in removing hydrophobic impurities during biopharmaceutical workflows, making it a practical tool in bioprocess development and scale-up.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3943.95
    methanol 5817.99
    isopropanol 2842.9
    water 1.15
    ethyl acetate 1512.28
    n-propanol 2715.16
    acetone 1982.93
    n-butanol 2452.77
    acetonitrile 871.6
    DMF 1169.17
    toluene 155.12
    isobutanol 1736.07
    1,4-dioxane 1768.33
    methyl acetate 828.52
    THF 2691.89
    2-butanone 1067.22
    n-pentanol 1280.69
    sec-butanol 1728.26
    n-hexane 107.68
    ethylene glycol 580.88
    NMP 618.57
    cyclohexane 292.22
    DMSO 4782.34
    n-butyl acetate 1042.31
    n-octanol 333.18
    chloroform 1107.45
    n-propyl acetate 1064.53
    acetic acid 2030.23
    dichloromethane 1226.47
    cyclohexanone 1684.78
    propylene glycol 843.05
    isopropyl acetate 868.8
    DMAc 636.26
    2-ethoxyethanol 1993.04
    isopentanol 1718.06
    n-heptane 114.11
    ethyl formate 876.35
    1,2-dichloroethane 1095.97
    n-hexanol 1169.26
    2-methoxyethanol 3574.28
    isobutyl acetate 537.69
    tetrachloromethane 212.17
    n-pentyl acetate 490.92
    transcutol 3360.86
    n-heptanol 423.33
    ethylbenzene 108.89
    MIBK 698.25
    2-propoxyethanol 1561.97
    tert-butanol 2856.82
    MTBE 1172.74
    2-butoxyethanol 851.65
    propionic acid 1187.12
    o-xylene 130.72
    formic acid 651.51
    diethyl ether 1239.43
    m-xylene 141.69
    p-xylene 142.24
    chlorobenzene 262.68
    dimethyl carbonate 169.5
    n-octane 35.35
    formamide 894.6
    cyclopentanone 1374.79
    2-pentanone 1248.56
    anisole 283.88
    cyclopentyl methyl ether 1130.32
    gamma-butyrolactone 1350.72
    1-methoxy-2-propanol 2348.55
    pyridine 782.2
    3-pentanone 559.83
    furfural 996.14
    n-dodecane 19.42
    diethylene glycol 1149.45
    diisopropyl ether 325.79
    tert-amyl alcohol 1582.1
    acetylacetone 1054.98
    n-hexadecane 22.09
    acetophenone 334.39
    methyl propionate 752.21
    isopentyl acetate 793.42
    trichloroethylene 1446.6
    n-nonanol 275.61
    cyclohexanol 1594.21
    benzyl alcohol 377.28
    2-ethylhexanol 591.87
    isooctanol 348.18
    dipropyl ether 748.41
    1,2-dichlorobenzene 266.44
    ethyl lactate 387.44
    propylene carbonate 769.33
    n-methylformamide 1017.33
    2-pentanol 1417.73
    n-pentane 109.42
    1-propoxy-2-propanol 1275.61
    1-methoxy-2-propyl acetate 713.33
    2-(2-methoxypropoxy) propanol 439.64
    mesitylene 112.5
    ε-caprolactone 1330.26
    p-cymene 121.81
    epichlorohydrin 1640.59
    1,1,1-trichloroethane 679.79
    2-aminoethanol 1377.56
    morpholine-4-carbaldehyde 1031.1
    sulfolane 1530.48
    2,2,4-trimethylpentane 59.59
    2-methyltetrahydrofuran 1704.87
    n-hexyl acetate 552.09
    isooctane 49.92
    2-(2-butoxyethoxy)ethanol 778.0
    sec-butyl acetate 568.98
    tert-butyl acetate 867.87
    decalin 70.7
    glycerin 973.0
    diglyme 1599.71
    acrylic acid 670.29
    isopropyl myristate 168.52
    n-butyric acid 2523.4
    acetyl acetate 634.95
    di(2-ethylhexyl) phthalate 149.58
    ethyl propionate 642.07
    nitromethane 2141.26
    1,2-diethoxyethane 1051.61
    benzonitrile 393.99
    trioctyl phosphate 141.57
    1-bromopropane 605.77
    gamma-valerolactone 1876.52
    n-decanol 178.52
    triethyl phosphate 231.87
    4-methyl-2-pentanol 608.07
    propionitrile 813.23
    vinylene carbonate 571.57
    1,1,2-trichlorotrifluoroethane 1338.69
    DMS 274.69
    cumene 94.75
    2-octanol 250.2
    2-hexanone 854.55
    octyl acetate 210.59
    limonene 253.04
    1,2-dimethoxyethane 2289.95
    ethyl orthosilicate 250.53
    tributyl phosphate 183.74
    diacetone alcohol 1053.49
    N,N-dimethylaniline 180.33
    acrylonitrile 761.84
    aniline 372.76
    1,3-propanediol 2293.9
    bromobenzene 234.26
    dibromomethane 846.99
    1,1,2,2-tetrachloroethane 1300.75
    2-methyl-cyclohexyl acetate 407.54
    tetrabutyl urea 212.4
    diisobutyl methanol 330.75
    2-phenylethanol 359.54
    styrene 142.31
    dioctyl adipate 283.95
    dimethyl sulfate 292.81
    ethyl butyrate 735.92
    methyl lactate 417.62
    butyl lactate 459.12
    diethyl carbonate 365.01
    propanediol butyl ether 672.22
    triethyl orthoformate 468.7
    p-tert-butyltoluene 119.55
    methyl 4-tert-butylbenzoate 300.86
    morpholine 2608.41
    tert-butylamine 1431.6
    n-dodecanol 126.95
    dimethoxymethane 1017.65
    ethylene carbonate 618.48
    cyrene 361.99
    2-ethoxyethyl acetate 592.63
    2-ethylhexyl acetate 536.12
    1,2,4-trichlorobenzene 297.31
    4-methylpyridine 598.12
    dibutyl ether 478.16
    2,6-dimethyl-4-heptanol 330.75
    DEF 1005.79
    dimethyl isosorbide 642.98
    tetrachloroethylene 995.41
    eugenol 298.27
    triacetin 465.61
    span 80 472.02
    1,4-butanediol 725.88
    1,1-dichloroethane 816.41
    2-methyl-1-pentanol 872.28
    methyl formate 575.04
    2-methyl-1-butanol 1362.76
    n-decane 40.56
    butyronitrile 1155.73
    3,7-dimethyl-1-octanol 330.13
    1-chlorooctane 171.52
    1-chlorotetradecane 52.3
    n-nonane 43.95
    undecane 26.01
    tert-butylcyclohexane 65.52
    cyclooctane 72.46
    cyclopentanol 1549.41
    tetrahydropyran 2253.42
    tert-amyl methyl ether 659.0
    2,5,8-trioxanonane 855.32
    1-hexene 369.7
    2-isopropoxyethanol 1154.1
    2,2,2-trifluoroethanol 431.87
    methyl butyrate 1082.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction