N,N-Dimethylglycine hydrochloride

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  • Identifiers

    CAS number
    2491-06-7

    Molecular formula
    C4H10ClNO2

    SMILES
    CN(C)CC(=O)O.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 42.73%
    Cheesy 39.9%
    Fruity 38.35%
    Sweet 24.58%
    Sour 24.08%
    Fishy 20.37%
    Buttery 20.32%
    Savory 19.82%
    Milky 19.29%
    Dairy 19.19%

     

    Flavor
    Odorless 42.98%
    Sour 34.48%
    Cheese 34.27%
    Acidic 30.48%
    Fruity 29.68%
    Sweat 25.73%
    Rancid 24.96%
    Mild 24.63%
    Sweaty 23.91%
    Sulfury 23.66%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    8.28 (weak base)

    Molecular weight
    139.58 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    197°C

    Flash point

    • 86.83 ˚C est.

  • Synonyms

    • N,N-Dimethylglycine hydrochloride
    • 2491-06-7
    • N,N-Dimethylglycine HCl
    • Dimethylglycine hydrochloride
    • Glycine, N,N-dimethyl-, hydrochloride
    • MFCD00012610
    • YXK75EAE92
    • Glycine, N,N-dimethyl-, hydrochloride (1:1)
    • 2-(dimethylamino)acetic acid;hydrochloride
    • N,N-Dimethylaminoacetic acid hydrochloride
    • N,N-Dimethylglycine, HCl
    • 2-(dimethylamino)acetic acid hydrochloride
    • N-Methylsarcosine hydrochloride
    • (Dimethylamino)acetic acid hydrochloride
    • N,N-Dimethylglycinium chloride
    • CCRIS 3352
    • N,N-DimethylglycineHydrochloride
    • N,N-Dimethyl glycine hydrochloride
    • dimethylglycine HCl
    • EINECS 219-648-2
    • AI3-62132
    • N,N-dimethyl glycine HCl
    • UNII-YXK75EAE92
    • Me2NCH2CO2H hydrochloride
    • SCHEMBL15442
    • N,N-dimethylglycine HCl salt
    • N,N-dimethylglycin hydrochloride
    • DTXSID1062463
    • N,N-dimethylglycine.hydrochloride
    • N, N-dimethylglycine hydrochloride
    • AKOS015892680
    • dimethylamino acetic acid hydrochloride
    • CS-W001158
    • FD03715
    • HY-W001158
    • AC-30735
    • AS-12213
    • SY005006
    • DB-002822
    • DB-046575
    • D0728
    • N,N-DIMETHYLGLYCINE HYDROCHLORIDE [MI]
    • N,N-DIMETHYLGLYCINE HYDROCHLORIDE [WHO-DD]
    • Q27294772
    • 219-648-2

  • Applications

    N,N-Dimethylglycine hydrochloride (CAS 2491-06-7) is primarily used as a chemical synthesis intermediate and a soluble source of the dimethylglycine moiety in research and pharmaceutical development. In industrial manufacturing, it serves as an organic building block for the preparation of N,N-dimethylglycine derivatives and related compounds. The hydrochloride salt enhances aqueous solubility and ease of handling, enabling its use as a reagent or precursor in laboratory workflows, including coupling and catalytic steps. It can function as a pH-control or buffering component in process media and may be employed in formulation development for polymers and coatings where a tertiary amine functionality is desirable, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 59.5
    methanol 234.64
    isopropanol 8.29
    water 907.61
    ethyl acetate 1.83
    n-propanol 27.01
    acetone 1.76
    n-butanol 9.79
    acetonitrile 4.03
    DMF 16.38
    toluene 0.21
    isobutanol 6.99
    1,4-dioxane 4.22
    methyl acetate 4.0
    THF 6.88
    2-butanone 1.92
    n-pentanol 2.03
    sec-butanol 7.53
    n-hexane 0.15
    ethylene glycol 272.15
    NMP 65.71
    cyclohexane 0.18
    DMSO 11.4
    n-butyl acetate 2.93
    n-octanol 4.07
    chloroform 2.89
    n-propyl acetate 1.2
    acetic acid 421.76
    dichloromethane 2.66
    cyclohexanone 4.49
    propylene glycol 141.22
    isopropyl acetate 0.69
    DMAc 19.22
    2-ethoxyethanol 15.2
    isopentanol 1.89
    n-heptane 0.46
    ethyl formate 7.32
    1,2-dichloroethane 1.23
    n-hexanol 8.12
    2-methoxyethanol 76.88
    isobutyl acetate 0.77
    tetrachloromethane 1.23
    n-pentyl acetate 1.94
    transcutol 32.65
    n-heptanol 5.48
    ethylbenzene 0.21
    MIBK 0.53
    2-propoxyethanol 30.81
    tert-butanol 5.1
    MTBE 0.54
    2-butoxyethanol 15.47
    propionic acid 89.96
    o-xylene 0.48
    formic acid 863.2
    diethyl ether 0.69
    m-xylene 0.38
    p-xylene 0.29
    chlorobenzene 0.62
    dimethyl carbonate 2.32
    n-octane 0.16
    formamide 257.41
    cyclopentanone 6.14
    2-pentanone 0.83
    anisole 0.92
    cyclopentyl methyl ether 1.96
    gamma-butyrolactone 25.13
    1-methoxy-2-propanol 21.23
    pyridine 3.07
    3-pentanone 1.05
    furfural 27.5
    n-dodecane 0.15
    diethylene glycol 67.51
    diisopropyl ether 0.16
    tert-amyl alcohol 5.74
    acetylacetone 1.34
    n-hexadecane 0.15
    acetophenone 1.98
    methyl propionate 3.72
    isopentyl acetate 2.15
    trichloroethylene 3.08
    n-nonanol 3.69
    cyclohexanol 5.52
    benzyl alcohol 2.81
    2-ethylhexanol 3.46
    isooctanol 3.23
    dipropyl ether 1.64
    1,2-dichlorobenzene 1.3
    ethyl lactate 6.67
    propylene carbonate 12.92
    n-methylformamide 52.13
    2-pentanol 2.07
    n-pentane 0.19
    1-propoxy-2-propanol 16.21
    1-methoxy-2-propyl acetate 5.23
    2-(2-methoxypropoxy) propanol 19.65
    mesitylene 0.32
    ε-caprolactone 10.13
    p-cymene 1.05
    epichlorohydrin 6.69
    1,1,1-trichloroethane 0.84
    2-aminoethanol 215.08
    morpholine-4-carbaldehyde 38.1
    sulfolane 37.05
    2,2,4-trimethylpentane 0.18
    2-methyltetrahydrofuran 3.07
    n-hexyl acetate 3.67
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 21.43
    sec-butyl acetate 0.58
    tert-butyl acetate 1.03
    decalin 0.15
    glycerin 253.62
    diglyme 18.28
    acrylic acid 133.48
    isopropyl myristate 1.4
    n-butyric acid 27.72
    acetyl acetate 1.85
    di(2-ethylhexyl) phthalate 6.25
    ethyl propionate 1.36
    nitromethane 74.65
    1,2-diethoxyethane 1.51
    benzonitrile 1.72
    trioctyl phosphate 4.3
    1-bromopropane 0.54
    gamma-valerolactone 21.47
    n-decanol 2.76
    triethyl phosphate 3.42
    4-methyl-2-pentanol 0.83
    propionitrile 2.96
    vinylene carbonate 14.55
    1,1,2-trichlorotrifluoroethane 45.15
    DMS 4.79
    cumene 0.33
    2-octanol 2.23
    2-hexanone 0.69
    octyl acetate 2.93
    limonene 1.4
    1,2-dimethoxyethane 4.64
    ethyl orthosilicate 2.86
    tributyl phosphate 4.78
    diacetone alcohol 4.76
    N,N-dimethylaniline 1.3
    acrylonitrile 6.58
    aniline 2.28
    1,3-propanediol 92.81
    bromobenzene 0.34
    dibromomethane 1.42
    1,1,2,2-tetrachloroethane 2.83
    2-methyl-cyclohexyl acetate 4.31
    tetrabutyl urea 6.22
    diisobutyl methanol 1.46
    2-phenylethanol 5.06
    styrene 0.2
    dioctyl adipate 3.81
    dimethyl sulfate 6.9
    ethyl butyrate 2.44
    methyl lactate 15.67
    butyl lactate 8.13
    diethyl carbonate 2.26
    propanediol butyl ether 22.21
    triethyl orthoformate 2.66
    p-tert-butyltoluene 1.14
    methyl 4-tert-butylbenzoate 8.16
    morpholine 11.03
    tert-butylamine 2.05
    n-dodecanol 2.05
    dimethoxymethane 4.93
    ethylene carbonate 8.17
    cyrene 22.98
    2-ethoxyethyl acetate 3.62
    2-ethylhexyl acetate 1.99
    1,2,4-trichlorobenzene 2.16
    4-methylpyridine 1.48
    dibutyl ether 0.77
    2,6-dimethyl-4-heptanol 1.46
    DEF 3.0
    dimethyl isosorbide 25.62
    tetrachloroethylene 4.17
    eugenol 13.24
    triacetin 8.1
    span 80 22.86
    1,4-butanediol 18.78
    1,1-dichloroethane 0.6
    2-methyl-1-pentanol 1.08
    methyl formate 27.64
    2-methyl-1-butanol 3.89
    n-decane 0.22
    butyronitrile 1.55
    3,7-dimethyl-1-octanol 2.63
    1-chlorooctane 0.76
    1-chlorotetradecane 0.41
    n-nonane 0.2
    undecane 0.18
    tert-butylcyclohexane 0.18
    cyclooctane 0.09
    cyclopentanol 11.36
    tetrahydropyran 1.84
    tert-amyl methyl ether 0.91
    2,5,8-trioxanonane 20.14
    1-hexene 0.28
    2-isopropoxyethanol 4.82
    2,2,2-trifluoroethanol 154.17
    methyl butyrate 1.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction