Nmda

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  • Identifiers

    CAS number
    6384-92-5

    Molecular formula
    C5H9NO4

    SMILES
    CN[C@H](CC(=O)O)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 74.55%
    Savory 35.11%
    Meaty 28.93%
    Sour 20.86%
    Cooked 20.46%
    Sulfurous 20.33%
    Milky 19.6%
    Cheesy 19.03%
    Sweet 18.98%
    Roasted 17.21%

     

    Flavor
    Odorless 75.3%
    Mild 34.83%
    Very mild 31.99%
    Sour 29.29%
    Bland 27.37%
    Yeast 24.58%
    Acidic 22.12%
    Sweet-like 22.06%
    Faint 21.79%
    Stinky 19.78%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.4

    pKa est.
    6.28 (neutral)

    Molecular weight
    147.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    327°C

    Melting point expt.

    • 187 - 192 °C

    Flash point

    • 182.61 ˚C est.

    Solubility expt.

    • >22.1 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • N-methyl-D-aspartic acid
    • NMDA
    • 6384-92-5
    • D-Aspartic acid, N-methyl-
    • (2R)-2-(methylamino)butanedioic acid
    • Methyl aspartic acid
    • N-Methyl aspartic acid
    • 2-Methylamino-succinic acid
    • DTXSID8041082
    • 1903B9Q6PI
    • CHEBI:31882
    • RefChem:1092483
    • DTXCID6021082
    • N-Methyl-D-aspartate
    • N-Methylaspartate
    • (R)-2-(Methylamino)succinic acid
    • n-methyl-d-aspartic acid (nmda)
    • N-Me-D-Asp-OH
    • (R)-2-Ethylbutannedioic acid
    • NMDA (N-Methyl-D-aspartic acid)
    • MFCD00004226
    • CHEMBL291278
    • M03889
    • (R)-2-(Methylamino)succinic acid hydrochloride
    • SMR000326806
    • BRN 1724431
    • UNII-1903B9Q6PI
    • LC-488A
    • OEM
    • N-Methyl-Daspartate
    • N-methyl D-aspartate
    • Me-D-Asp-OH
    • methyl-d-aspartic acid
    • Spectrum_001456
    • Tocris-0114
    • Spectrum2_001580
    • Spectrum3_001601
    • Spectrum4_000318
    • Spectrum5_001209
    • Lopac-M-3262
    • N-methyl D-aspartic acid
    • (NMDA)
    • NMDA [MI]
    • SCHEMBL2220
    • Lopac0_000775
    • BSPBio_003201
    • KBioGR_000936
    • KBioSS_001936
    • 3-04-00-01522 (Beilstein Handbook Reference)
    • MLS000859947
    • MLS001333165
    • MLS001333166
    • DivK1c_000392
    • SPECTRUM1503636
    • SPBio_001520
    • GTPL4268
    • orb1300618
    • HMS501D14
    • KBio1_000392
    • KBio2_001936
    • KBio2_004504
    • KBio2_007072
    • KBio3_002421
    • (R)-2-(Methylamino)succinicacid
    • (R)-2-Methylamino-succinic acid
    • METHYL ASPARTIC ACID, D-
    • NINDS_000392
    • GLXC-06522
    • HMS1922G08
    • HMS2233F23
    • HMS3262K12
    • HMS3886P09
    • (2R)-2-Methylaminobutanedioic acid
    • Tox21_500775
    • AC2467
    • BDBM50013876
    • CCG-39358
    • HB0454
    • MSK170151
    • PDSP1_000779
    • PDSP2_000767
    • s7072
    • AKOS016843186
    • FM12671
    • LP00775
    • SDCCGSBI-0050753.P003
    • IDI1_000392
    • NCGC00015666-01
    • NCGC00024476-01
    • NCGC00024476-02
    • NCGC00024476-03
    • NCGC00024476-04
    • NCGC00024476-05
    • NCGC00024476-06
    • NCGC00024476-14
    • NCGC00261460-01
    • AC-24119
    • AS-15576
    • BM164154
    • HY-17551
    • SY035118
    • EU-0100775
    • M1360
    • SW219059-1
    • N-Methyl-D-aspartic acid - Bio-X trade mark
    • 84M925
    • M 3262
    • N-Methyl-D-aspartic acid, >=98% (TLC), solid
    • Q632856
    • SR-01000075456
    • SR-01000597701
    • SR-01000075456-1
    • SR-01000597701-1
    • BRD-K62414032-001-12-0
    • N-Methyl-D-aspartic Acid, Hydrate - CAS 6384-92-5
    • 6384-92-5

  • Applications

    Nmda (N-methyl-D-aspartic acid), CAS 6384-92-5, is primarily used as a research reagent in neuroscience and pharmacology to activate NMDA receptors in neuronal preparations, enabling studies of synaptic transmission and synaptic plasticity. It is also employed as a synthetic building block or intermediate in the development of NMDA-receptor–modulating compounds in pharmaceutical R&D. In analytical laboratories, Nmda can serve as a reference material for method development and calibration related to amino-acid derivatives. Additionally, it is commonly used in academic settings as a standard substrate for teaching and assay validation of amino acid chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.39
    methanol 10.9
    isopropanol 3.21
    water 55.8
    ethyl acetate 0.94
    n-propanol 3.78
    acetone 5.32
    n-butanol 2.78
    acetonitrile 1.21
    DMF 103.79
    toluene 0.41
    isobutanol 2.28
    1,4-dioxane 8.27
    methyl acetate 1.32
    THF 18.91
    2-butanone 2.13
    n-pentanol 1.91
    sec-butanol 2.61
    n-hexane 0.28
    ethylene glycol 34.12
    NMP 60.25
    cyclohexane 0.19
    DMSO 122.35
    n-butyl acetate 1.05
    n-octanol 1.62
    chloroform 0.81
    n-propyl acetate 0.72
    acetic acid 5.99
    dichloromethane 1.4
    cyclohexanone 5.4
    propylene glycol 15.35
    isopropyl acetate 0.79
    DMAc 67.14
    2-ethoxyethanol 17.63
    isopentanol 3.01
    n-heptane 0.3
    ethyl formate 8.34
    1,2-dichloroethane 1.64
    n-hexanol 2.7
    2-methoxyethanol 49.97
    isobutyl acetate 0.31
    tetrachloromethane 0.8
    n-pentyl acetate 0.88
    transcutol 6.77
    n-heptanol 2.16
    ethylbenzene 0.59
    MIBK 1.7
    2-propoxyethanol 13.16
    tert-butanol 7.15
    MTBE 1.46
    2-butoxyethanol 7.79
    propionic acid 3.23
    o-xylene 1.0
    formic acid 60.01
    diethyl ether 0.87
    m-xylene 0.72
    p-xylene 0.76
    chlorobenzene 0.35
    dimethyl carbonate 2.3
    n-octane 0.16
    formamide 44.04
    cyclopentanone 9.64
    2-pentanone 2.05
    anisole 1.66
    cyclopentyl methyl ether 3.12
    gamma-butyrolactone 12.43
    1-methoxy-2-propanol 18.47
    pyridine 2.26
    3-pentanone 1.34
    furfural 22.3
    n-dodecane 0.11
    diethylene glycol 29.75
    diisopropyl ether 0.36
    tert-amyl alcohol 5.75
    acetylacetone 4.11
    n-hexadecane 0.12
    acetophenone 2.5
    methyl propionate 1.79
    isopentyl acetate 1.15
    trichloroethylene 1.79
    n-nonanol 1.61
    cyclohexanol 2.74
    benzyl alcohol 3.02
    2-ethylhexanol 1.56
    isooctanol 1.59
    dipropyl ether 1.12
    1,2-dichlorobenzene 0.68
    ethyl lactate 2.99
    propylene carbonate 5.05
    n-methylformamide 35.33
    2-pentanol 1.54
    n-pentane 0.16
    1-propoxy-2-propanol 6.1
    1-methoxy-2-propyl acetate 2.5
    2-(2-methoxypropoxy) propanol 7.87
    mesitylene 0.68
    ε-caprolactone 5.46
    p-cymene 0.68
    epichlorohydrin 9.69
    1,1,1-trichloroethane 0.76
    2-aminoethanol 28.6
    morpholine-4-carbaldehyde 43.88
    sulfolane 41.36
    2,2,4-trimethylpentane 0.14
    2-methyltetrahydrofuran 4.69
    n-hexyl acetate 1.31
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 8.24
    sec-butyl acetate 0.44
    tert-butyl acetate 1.43
    decalin 0.18
    glycerin 53.35
    diglyme 16.08
    acrylic acid 4.68
    isopropyl myristate 0.65
    n-butyric acid 3.89
    acetyl acetate 0.83
    di(2-ethylhexyl) phthalate 1.84
    ethyl propionate 0.96
    nitromethane 11.08
    1,2-diethoxyethane 1.36
    benzonitrile 1.53
    trioctyl phosphate 1.48
    1-bromopropane 0.54
    gamma-valerolactone 23.15
    n-decanol 1.26
    triethyl phosphate 1.85
    4-methyl-2-pentanol 1.29
    propionitrile 1.09
    vinylene carbonate 4.85
    1,1,2-trichlorotrifluoroethane 20.4
    DMS 1.27
    cumene 0.63
    2-octanol 1.19
    2-hexanone 1.21
    octyl acetate 0.97
    limonene 0.82
    1,2-dimethoxyethane 24.3
    ethyl orthosilicate 1.68
    tributyl phosphate 1.29
    diacetone alcohol 7.57
    N,N-dimethylaniline 2.88
    acrylonitrile 2.35
    aniline 1.19
    1,3-propanediol 23.76
    bromobenzene 0.28
    dibromomethane 0.83
    1,1,2,2-tetrachloroethane 2.3
    2-methyl-cyclohexyl acetate 1.49
    tetrabutyl urea 3.03
    diisobutyl methanol 1.17
    2-phenylethanol 2.61
    styrene 0.44
    dioctyl adipate 1.23
    dimethyl sulfate 11.28
    ethyl butyrate 1.15
    methyl lactate 7.68
    butyl lactate 2.41
    diethyl carbonate 0.95
    propanediol butyl ether 7.24
    triethyl orthoformate 1.5
    p-tert-butyltoluene 0.7
    methyl 4-tert-butylbenzoate 4.62
    morpholine 10.56
    tert-butylamine 2.29
    n-dodecanol 0.96
    dimethoxymethane 18.69
    ethylene carbonate 3.57
    cyrene 13.71
    2-ethoxyethyl acetate 1.23
    2-ethylhexyl acetate 0.84
    1,2,4-trichlorobenzene 0.78
    4-methylpyridine 2.63
    dibutyl ether 0.71
    2,6-dimethyl-4-heptanol 1.17
    DEF 9.65
    dimethyl isosorbide 12.91
    tetrachloroethylene 2.13
    eugenol 6.18
    triacetin 1.67
    span 80 5.33
    1,4-butanediol 10.17
    1,1-dichloroethane 0.62
    2-methyl-1-pentanol 2.2
    methyl formate 28.03
    2-methyl-1-butanol 2.64
    n-decane 0.17
    butyronitrile 1.42
    3,7-dimethyl-1-octanol 1.33
    1-chlorooctane 0.47
    1-chlorotetradecane 0.24
    n-nonane 0.16
    undecane 0.14
    tert-butylcyclohexane 0.18
    cyclooctane 0.14
    cyclopentanol 5.39
    tetrahydropyran 2.18
    tert-amyl methyl ether 1.8
    2,5,8-trioxanonane 14.31
    1-hexene 0.49
    2-isopropoxyethanol 6.31
    2,2,2-trifluoroethanol 9.0
    methyl butyrate 2.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction