Naproxen Sodium

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  • Identifiers

    CAS number
    26159-34-2

    Molecular formula
    C14H13NaO3

    SMILES
    C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)[O-].[Na+]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Floral 70.32%
    Sweet 63.19%
    Honey 46.53%
    Powdery 46.04%
    Fruity 38.17%
    Grape 38.16%
    Neroli 37.6%
    Vanilla 35.38%
    Animal 32.99%
    Balsamic 32.55%

     

    Flavor
    Bitter 49.46%
    Fruity 31.15%
    Odorless 30.81%
    Mild 24.63%
    Orange flower 20.42%
    Heather 20.18%
    Broom 20.07%
    Ethyl benzoate 19.98%
    Genet 19.88%
    Orange blossom 19.85%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.6 (weak acid)

    Molecular weight
    252.24 g/mol

    Flash point

    • 180.14 ˚C est.

  • Synonyms

    • naproxen sodium
    • 26159-34-2
    • Naprelan
    • Naproxen sodium salt
    • Anaprox
    • (-)-Naproxen sodium
    • Anaprotab
    • Aprowell
    • Floginex
    • Flogogin
    • Floxalin
    • Karoksen
    • Leniartril
    • Naprodil
    • Naprodol
    • Naprovite
    • Natrioxen
    • Anapran
    • Flogen
    • Floneks
    • Gibinap
    • Gibixen
    • Kapnax
    • Monarit
    • Opraks
    • Pactens
    • Sodimax
    • Tandax
    • Aprol
    • Nixal
    • Causalon Pro
    • Naproxen natrium
    • Naprux Gesic
    • Axer Alfa
    • Naproxen (sodium)
    • Dysmenalgit
    • A-Nox
    • Aleve
    • (S)-Naproxen Sodium Salt
    • Sunprox
    • Flanax
    • sodium naproxen
    • ANAPROX DS
    • BAYH6689
    • Naprium
    • Naprux
    • Proxen
    • Apo-Napro-NA
    • Naproxen sodium anhydrous
    • sodium (S)-2-(6-methoxynaphthalen-2-yl)propanoate
    • Topcare all day pain relief
    • EINECS 247-486-2
    • UNII-9TN87S3A3C
    • MFCD00058507
    • RS 3650
    • 9TN87S3A3C
    • CHEBI:7477
    • DTXSID7045576
    • BAY H6689
    • 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (S)-
    • (-)-Sodium (S)-6-methoxy-alpha-methyl-2-naphthaleneacetate
    • BAY117031
    • BAY-117031
    • RS-3650
    • sodium (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
    • Naproxen sodium [USAN:USP]
    • MLS000069555
    • DTXCID5025576
    • Miranax
    • L-(-)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt
    • 2-NAPHTHALENEACETIC ACID, 6-METHOXY-alpha-METHYL-, SODIUM SALT, L-(-)-
    • ALEVE-D COMPONENT NAPROXEN SODIUM
    • NCGC00017097-01
    • Primeral
    • SMR000058746
    • Synflex
    • TREXIMET COMPONENT NAPROXEN SODIUM
    • (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt
    • 2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, sodium salt, (aS)-
    • CAS-26159-34-2
    • sodium (2S)-2-(6-methoxy-2-naphthyl)propanoate
    • Naproxen sodium (USAN:USP)
    • NAPROXEN SODIUM (MART.)
    • NAPROXEN SODIUM [MART.]
    • NAPROXEN SODIUM (USP-RS)
    • NAPROXEN SODIUM [USP-RS]
    • Naproxen sodium [USAN]
    • NAPROXEN SODIUM (EP IMPURITY)
    • NAPROXEN SODIUM [EP IMPURITY]
    • NAPROXEN SODIUM (EP MONOGRAPH)
    • NAPROXEN SODIUM (USP IMPURITY)
    • NAPROXEN SODIUM [EP MONOGRAPH]
    • NAPROXEN SODIUM [USP IMPURITY]
    • NAPROXEN SODIUM (USP MONOGRAPH)
    • NAPROXEN SODIUM [USP MONOGRAPH]
    • UNM-0000306098
    • AleveCaplets
    • AleveGelcaps
    • AnaDent
    • Belmora Flanax
    • Headache Pain
    • Bayer Aleve
    • Careall Naproxen
    • Naproxen Caplets
    • Rapidol Naproxen
    • All Day Relief
    • Sodium, Naproxen
    • sodium;(2S)-2-(6-methoxynaphthalen-2-yl)propanoate
    • Medique Mediproxen
    • Sodium Naproxenate
    • Naproxen (Aleve)
    • Sodium (-)-2-(6-methoxy-2-naphthyl)propionate
    • Naproxen Sodium DS
    • Naproxenate, Sodium
    • Aleve Headache Pain
    • Anaprox (TN)
    • Naproxen Pain Relief
    • All Day Pain Relief
    • Back and Muscle Pain
    • Naproxen SodiumCaplets
    • Naproxen sodium tablet
    • Rugby All Day Relief
    • Calmadol Pain Reliever
    • Equate Naproxen Sodium
    • Naproxen Headache Pain
    • Careone Naproxen Sodium
    • Naproxen Sodium Caplets
    • Sunmark Naproxen Sodium

  • Applications

    Naproxen Sodium (CAS 26159-34-2) is primarily used as an active pharmaceutical ingredient in NSAID formulations, supplied as tablets or capsules in over-the-counter and prescription products. The sodium salt form improves aqueous solubility and dissolution, facilitating oral dosage form development and manufacturing. In pharmaceutical R&D, it is used for solubility and dissolution studies and as a reference material for analytical method development and quality control. It is also widely used as a standard material for assay and impurity profiling in pharmaceutical manufacturing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 31.41
    methanol 44.5
    isopropanol 18.93
    water 0.06
    ethyl acetate 78.21
    n-propanol 24.65
    acetone 21.77
    n-butanol 19.24
    acetonitrile 31.65
    DMF 100.95
    toluene 16.36
    isobutanol 13.09
    1,4-dioxane 201.5
    methyl acetate 81.65
    THF 107.75
    2-butanone 62.98
    n-pentanol 21.93
    sec-butanol 20.43
    n-hexane 0.24
    ethylene glycol 12.26
    NMP 52.69
    cyclohexane 0.37
    DMSO 120.28
    n-butyl acetate 45.82
    n-octanol 6.35
    chloroform 142.18
    n-propyl acetate 54.23
    acetic acid 37.06
    dichloromethane 187.69
    cyclohexanone 58.0
    propylene glycol 11.84
    isopropyl acetate 35.57
    DMAc 135.1
    2-ethoxyethanol 115.93
    isopentanol 20.93
    n-heptane 0.2
    ethyl formate 23.46
    1,2-dichloroethane 148.52
    n-hexanol 20.6
    2-methoxyethanol 113.56
    isobutyl acetate 27.01
    tetrachloromethane 6.57
    n-pentyl acetate 20.9
    transcutol 352.68
    n-heptanol 9.98
    ethylbenzene 17.98
    MIBK 27.83
    2-propoxyethanol 85.41
    tert-butanol 38.99
    MTBE 31.59
    2-butoxyethanol 40.54
    propionic acid 28.2
    o-xylene 16.53
    formic acid 28.35
    diethyl ether 42.11
    m-xylene 10.88
    p-xylene 19.52
    chlorobenzene 30.59
    dimethyl carbonate 37.26
    n-octane 0.27
    formamide 93.71
    cyclopentanone 62.41
    2-pentanone 32.72
    anisole 77.44
    cyclopentyl methyl ether 32.32
    gamma-butyrolactone 91.69
    1-methoxy-2-propanol 70.88
    pyridine 85.79
    3-pentanone 37.4
    furfural 104.27
    n-dodecane 0.36
    diethylene glycol 78.07
    diisopropyl ether 8.66
    tert-amyl alcohol 35.25
    acetylacetone 57.9
    n-hexadecane 0.43
    acetophenone 58.63
    methyl propionate 58.86
    isopentyl acetate 41.92
    trichloroethylene 237.59
    n-nonanol 7.34
    cyclohexanol 14.99
    benzyl alcohol 48.98
    2-ethylhexanol 12.79
    isooctanol 9.5
    dipropyl ether 18.16
    1,2-dichlorobenzene 36.11
    ethyl lactate 25.26
    propylene carbonate 40.91
    n-methylformamide 53.87
    2-pentanol 12.14
    n-pentane 0.11
    1-propoxy-2-propanol 46.3
    1-methoxy-2-propyl acetate 68.9
    2-(2-methoxypropoxy) propanol 58.29
    mesitylene 6.83
    ε-caprolactone 62.05
    p-cymene 9.6
    epichlorohydrin 210.24
    1,1,1-trichloroethane 44.59
    2-aminoethanol 25.59
    morpholine-4-carbaldehyde 144.42
    sulfolane 100.27
    2,2,4-trimethylpentane 0.63
    2-methyltetrahydrofuran 59.07
    n-hexyl acetate 24.98
    isooctane 0.46
    2-(2-butoxyethoxy)ethanol 74.7
    sec-butyl acetate 37.11
    tert-butyl acetate 48.97
    decalin 1.32
    glycerin 30.41
    diglyme 172.85
    acrylic acid 28.27
    isopropyl myristate 11.66
    n-butyric acid 30.72
    acetyl acetate 37.46
    di(2-ethylhexyl) phthalate 15.02
    ethyl propionate 50.15
    nitromethane 113.95
    1,2-diethoxyethane 87.41
    benzonitrile 35.9
    trioctyl phosphate 8.65
    1-bromopropane 31.95
    gamma-valerolactone 130.41
    n-decanol 5.75
    triethyl phosphate 24.64
    4-methyl-2-pentanol 10.37
    propionitrile 29.16
    vinylene carbonate 45.99
    1,1,2-trichlorotrifluoroethane 97.86
    DMS 48.73
    cumene 12.49
    2-octanol 5.95
    2-hexanone 43.32
    octyl acetate 14.12
    limonene 9.53
    1,2-dimethoxyethane 185.0
    ethyl orthosilicate 23.74
    tributyl phosphate 13.41
    diacetone alcohol 60.05
    N,N-dimethylaniline 42.1
    acrylonitrile 49.26
    aniline 37.04
    1,3-propanediol 38.97
    bromobenzene 29.27
    dibromomethane 78.12
    1,1,2,2-tetrachloroethane 160.35
    2-methyl-cyclohexyl acetate 32.02
    tetrabutyl urea 17.27
    diisobutyl methanol 9.9
    2-phenylethanol 42.26
    styrene 22.14
    dioctyl adipate 22.9
    dimethyl sulfate 61.23
    ethyl butyrate 36.35
    methyl lactate 25.91
    butyl lactate 21.26
    diethyl carbonate 32.3
    propanediol butyl ether 28.45
    triethyl orthoformate 29.59
    p-tert-butyltoluene 8.85
    methyl 4-tert-butylbenzoate 39.91
    morpholine 183.54
    tert-butylamine 14.14
    n-dodecanol 4.62
    dimethoxymethane 108.97
    ethylene carbonate 35.71
    cyrene 53.63
    2-ethoxyethyl acetate 57.54
    2-ethylhexyl acetate 31.3
    1,2,4-trichlorobenzene 46.75
    4-methylpyridine 61.04
    dibutyl ether 14.05
    2,6-dimethyl-4-heptanol 9.9
    DEF 53.16
    dimethyl isosorbide 102.87
    tetrachloroethylene 94.85
    eugenol 46.83
    triacetin 44.54
    span 80 31.68
    1,4-butanediol 18.12
    1,1-dichloroethane 54.42
    2-methyl-1-pentanol 24.87
    methyl formate 35.82
    2-methyl-1-butanol 18.36
    n-decane 0.53
    butyronitrile 19.55
    3,7-dimethyl-1-octanol 9.96
    1-chlorooctane 4.46
    1-chlorotetradecane 2.08
    n-nonane 0.38
    undecane 0.43
    tert-butylcyclohexane 1.42
    cyclooctane 0.18
    cyclopentanol 14.18
    tetrahydropyran 68.62
    tert-amyl methyl ether 28.68
    2,5,8-trioxanonane 118.5
    1-hexene 4.04
    2-isopropoxyethanol 72.45
    2,2,2-trifluoroethanol 21.55
    methyl butyrate 54.93

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction