N-Nitrosodimethylamine

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  • Identifiers

    CAS number
    62-75-9

    Molecular formula
    C2H6N2O

    SMILES
    CN(C)N=O

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Cheesy 40.14%
    Fruity 32.79%
    Pungent 32.58%
    Odorless 30.34%
    Fishy 27.99%
    Ripe 21.52%
    Green 20.18%
    Ethereal 19.82%
    Sharp 18.99%
    Cocoa 17.58%

     

    Flavor
    Pungent 33.09%
    Mustard 26.63%
    Fruity 26.56%
    Cheese 26.15%
    Nutty 24.15%
    Oily 23.87%
    Fishy 22.42%
    Roasted 22.34%
    Cooked 21.55%
    Mousy 21.52%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 0.0079 [mmHg]. Odor Threshold High: 0.01 [mmHg]. Odor threshold from AIHA

  • Properties

    XLogP3-AA
    -0.6

    pKa est.
    5.47 (weak acid)

    Molecular weight
    74.08 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • < 25 °C

    Boiling point

    • 304 to 307 °F at 760 mmHg (EPA, 1998)
    • 152 °C
    • 151 °C
    • 306 °F

    Flash point

    • 35.41 ˚C est.
    • 142 °F (NTP, 1992)
    • 142 °F
    • 61 °C

    Solubility expt.

    • greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
    • Infinitely soluble in water at 23-25 °C
    • Soluble in all common organic solvents and in lipids
    • Very soluble in water, alcohol, ether
    • Miscible with methylene chloride, vegetable oils
    • Soluble in ethanol, ethyl ether, and chloroform; soluble in water.
    • 1000 mg/mL at 24 °C
    • Solubility in water: very good
    • Soluble

  • Synonyms

    • N-NITROSODIMETHYLAMINE
    • Dimethylnitrosamine
    • 62-75-9
    • Dimethylnitrosoamine
    • N-Methyl-N-nitrosomethanamine
    • Nitrosodimethylamine
    • N,N-dimethylnitrous amide
    • N,N-Dimethylnitrosamine
    • DMNA
    • Methanamine, N-methyl-N-nitroso-
    • Dimethylnitrosamin
    • N-Nitroso-N,N-dimethylamine
    • Dimethylamine, N-nitroso-
    • N-Nitroaodimethylamine
    • N-Dimethyl-nitrosamine
    • nitrous dimethylamide
    • RCRA waste number P082
    • Nitrosamine, dimethyl-
    • N-methyl-N-nitroso-methanamine
    • NSC 23226
    • DMN
    • dimethyl(nitroso)amine
    • 1,1-Dimethyl-2-oxohydrazine
    • CCRIS 261
    • HSDB 1667
    • Dimethylnitrosamin [German]
    • EINECS 200-549-8
    • UNII-M43H21IO8R
    • BRN 1738979
    • M43H21IO8R
    • N-dimethylnitrosoamine
    • DTXSID7021029
    • CHEBI:35807
    • AI3-25308
    • n-nitroso-dimethylamine
    • NMDA (GENOTOXIC)
    • NSC-23226
    • (CH3)2NNO
    • MLS001065602
    • DTXCID301029
    • NSC23226
    • SMR000568479
    • Dimethylnitrosamin (german)
    • N-NITROSODIMETHYLAMINE (IARC)
    • N-NITROSODIMETHYLAMINE [IARC]
    • N-NITROSODIMETHYLAMINE (USP-RS)
    • N-NITROSODIMETHYLAMINE [USP-RS]
    • CAS-62-75-9
    • N Nitrosodimethylamine
    • N-Nitrosodimethylamine (10 mg/mL in Ethanol)
    • N-Nitrosodimethylamine (100 ?g/mL in Methanol)
    • N-Nitrosodimethylamine (5.0 mg/mL in Methanol)
    • N-nitrosodimethylamine 1000 microg/mL in Methanol
    • NDMA Nitrosodimethylamine
    • Nitrosodimethylamine, NDMA
    • RCRA waste no. P082
    • N-nitrosodimethylamine 1000 microg/mL in Methanol, Second Source
    • Methamine, N-methyl-N-nitroso-
    • dimethyl nitrosamine
    • dimethyl-nitrosamine
    • N-Nitrosodimethanamine
    • N, N-Dimethylnitrosamine
    • N,N-dimethyl nitrous amide
    • N,N-dimethyl-nitrous amide
    • cid_6124
    • N, N-dimethyl nitrous amide
    • N-N-Dimethyl N Nitrosoamine
    • N-Methyl-N-nitroso-Methamine
    • N-Methyl-N-nitrosomethylamine
    • BIDD:ER0584
    • WLN: ONN1&1
    • N-Nitrosodimethylamine (NDMA)
    • CHEMBL117311
    • 1,1-Dimethyl-2-oxohydrazine #
    • BDBM73982
    • N-NITROSODIMETHYLAMINE [MI]
    • N-Methyl-N-nitrosomethanamine, 9CI
    • Tox21_201663
    • Tox21_302873
    • MSK4920-100M
    • N-NITROSODIMETHYLAMINE [HSDB]
    • AKOS016000499
    • MSK4920-1000L
    • MSK4920-1000M
    • AT21751
    • NCGC00091431-01
    • NCGC00091431-02
    • NCGC00091431-03
    • NCGC00256498-01
    • NCGC00259212-01
    • DA-56224
    • N-Nitrosodimethylamine, analytical standard
    • D0761
    • NS00000636
    • N-Nitrosodimethylamine 0.2 mg/ml in Methanol
    • EN300-7438053
    • A833977
    • N-Nitroso-dimethylamine 10 microg/mL in Methanol
    • N-Nitroso-dimethylamine 100 microg/mL in Methanol
    • Q409367
    • N-Nitrosodimethylamine 1000 microg/mL in Dichloromethane
    • N-Nitrosodimethylamine Solution in Methanol, 100_g/mL
    • N-Nitrosodimethylamine Solution in Methanol, 1000_g/mL
    • Z1255485177
    • N-Nitrosodimethylamine (NDMA) 5000 microg/mL in Methanol
    • N-Nitrosodimethylamine Solution in Dichloromethane, 1000ug/mL
    • 200-549-8

  • Applications

    N-Nitrosodimethylamine (CAS 62-75-9) is mainly encountered as an impurity formed during nitrosation or degradation of dimethylamine-containing processes, so its practical applications are largely analytical and regulatory. It is used as a reference standard and calibrant in environmental, pharmaceutical, and food safety testing to detect and quantify nitrosamines; it serves in toxicology and mechanistic research as a model nitrosamine compound; it supports method development and validation for analytical techniques such as LC–MS/MS and GC–MS for nitrosamine analysis; and it is monitored in quality-control programs to support risk assessment and regulatory compliance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 62.91
    methanol 153.31
    isopropanol 28.07
    water 191.62
    ethyl acetate 13.6
    n-propanol 30.33
    acetone 33.04
    n-butanol 19.51
    acetonitrile 53.52
    DMF 92.04
    toluene 5.99
    isobutanol 20.38
    1,4-dioxane 27.74
    methyl acetate 29.27
    THF 27.28
    2-butanone 23.53
    n-pentanol 9.78
    sec-butanol 20.99
    n-hexane 1.79
    ethylene glycol 53.13
    NMP 122.56
    cyclohexane 2.33
    DMSO 56.2
    n-butyl acetate 8.83
    n-octanol 7.89
    chloroform 80.49
    n-propyl acetate 6.54
    acetic acid 169.33
    dichloromethane 69.82
    cyclohexanone 30.62
    propylene glycol 34.04
    isopropyl acetate 6.02
    DMAc 99.68
    2-ethoxyethanol 23.46
    isopentanol 12.85
    n-heptane 1.64
    ethyl formate 27.39
    1,2-dichloroethane 27.57
    n-hexanol 10.25
    2-methoxyethanol 65.91
    isobutyl acetate 4.06
    tetrachloromethane 18.29
    n-pentyl acetate 7.27
    transcutol 54.88
    n-heptanol 6.95
    ethylbenzene 4.3
    MIBK 5.73
    2-propoxyethanol 23.94
    tert-butanol 24.74
    MTBE 9.46
    2-butoxyethanol 16.36
    propionic acid 59.73
    o-xylene 9.05
    formic acid 237.31
    diethyl ether 8.57
    m-xylene 5.1
    p-xylene 7.67
    chlorobenzene 14.42
    dimethyl carbonate 10.18
    n-octane 0.86
    formamide 174.94
    cyclopentanone 37.29
    2-pentanone 10.38
    anisole 10.18
    cyclopentyl methyl ether 10.61
    gamma-butyrolactone 62.09
    1-methoxy-2-propanol 29.7
    pyridine 36.49
    3-pentanone 12.24
    furfural 81.16
    n-dodecane 0.78
    diethylene glycol 31.73
    diisopropyl ether 2.06
    tert-amyl alcohol 22.04
    acetylacetone 14.91
    n-hexadecane 0.81
    acetophenone 15.82
    methyl propionate 17.24
    isopentyl acetate 8.35
    trichloroethylene 68.49
    n-nonanol 7.12
    cyclohexanol 17.36
    benzyl alcohol 15.69
    2-ethylhexanol 6.91
    isooctanol 5.71
    dipropyl ether 4.87
    1,2-dichlorobenzene 18.67
    ethyl lactate 10.28
    propylene carbonate 33.19
    n-methylformamide 78.82
    2-pentanol 9.33
    n-pentane 2.02
    1-propoxy-2-propanol 14.93
    1-methoxy-2-propyl acetate 11.4
    2-(2-methoxypropoxy) propanol 23.12
    mesitylene 3.54
    ε-caprolactone 33.65
    p-cymene 5.11
    epichlorohydrin 39.01
    1,1,1-trichloroethane 24.73
    2-aminoethanol 60.11
    morpholine-4-carbaldehyde 76.3
    sulfolane 66.2
    2,2,4-trimethylpentane 1.75
    2-methyltetrahydrofuran 21.2
    n-hexyl acetate 10.87
    isooctane 0.71
    2-(2-butoxyethoxy)ethanol 23.42
    sec-butyl acetate 3.9
    tert-butyl acetate 6.74
    decalin 1.66
    glycerin 53.48
    diglyme 37.08
    acrylic acid 84.58
    isopropyl myristate 4.4
    n-butyric acid 34.7
    acetyl acetate 13.57
    di(2-ethylhexyl) phthalate 10.26
    ethyl propionate 7.22
    nitromethane 148.67
    1,2-diethoxyethane 9.1
    benzonitrile 21.41
    trioctyl phosphate 5.43
    1-bromopropane 11.75
    gamma-valerolactone 59.77
    n-decanol 5.17
    triethyl phosphate 8.45
    4-methyl-2-pentanol 4.89
    propionitrile 26.41
    vinylene carbonate 39.11
    1,1,2-trichlorotrifluoroethane 71.81
    DMS 15.51
    cumene 4.24
    2-octanol 4.77
    2-hexanone 6.34
    octyl acetate 6.41
    limonene 6.63
    1,2-dimethoxyethane 24.71
    ethyl orthosilicate 7.2
    tributyl phosphate 7.36
    diacetone alcohol 15.66
    N,N-dimethylaniline 12.06
    acrylonitrile 45.49
    aniline 19.42
    1,3-propanediol 42.63
    bromobenzene 10.26
    dibromomethane 38.08
    1,1,2,2-tetrachloroethane 49.5
    2-methyl-cyclohexyl acetate 9.97
    tetrabutyl urea 11.0
    diisobutyl methanol 4.22
    2-phenylethanol 12.86
    styrene 5.04
    dioctyl adipate 9.16
    dimethyl sulfate 23.06
    ethyl butyrate 7.84
    methyl lactate 19.82
    butyl lactate 11.62
    diethyl carbonate 7.71
    propanediol butyl ether 20.06
    triethyl orthoformate 7.29
    p-tert-butyltoluene 4.82
    methyl 4-tert-butylbenzoate 17.95
    morpholine 35.65
    tert-butylamine 15.7
    n-dodecanol 4.04
    dimethoxymethane 22.42
    ethylene carbonate 23.54
    cyrene 28.74
    2-ethoxyethyl acetate 11.78
    2-ethylhexyl acetate 6.9
    1,2,4-trichlorobenzene 26.91
    4-methylpyridine 31.57
    dibutyl ether 5.14
    2,6-dimethyl-4-heptanol 4.22
    DEF 24.53
    dimethyl isosorbide 32.09
    tetrachloroethylene 46.29
    eugenol 21.34
    triacetin 18.43
    span 80 19.42
    1,4-butanediol 17.48
    1,1-dichloroethane 25.42
    2-methyl-1-pentanol 8.2
    methyl formate 57.44
    2-methyl-1-butanol 15.77
    n-decane 1.2
    butyronitrile 17.85
    3,7-dimethyl-1-octanol 7.68
    1-chlorooctane 4.09
    1-chlorotetradecane 1.92
    n-nonane 1.13
    undecane 0.93
    tert-butylcyclohexane 1.66
    cyclooctane 0.9
    cyclopentanol 24.65
    tetrahydropyran 15.37
    tert-amyl methyl ether 9.41
    2,5,8-trioxanonane 30.69
    1-hexene 4.15
    2-isopropoxyethanol 12.11
    2,2,2-trifluoroethanol 103.47
    methyl butyrate 10.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction