N-Methylpyrrolidine

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  • Identifiers

    CAS number
    120-94-5

    Molecular formula
    C5H11N

    SMILES
    CN1CCCC1

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fishy 81.31%
    Cheesy 67.18%
    Ripe 49.66%
    Animal 43.91%
    Nutty 30.08%
    Popcorn 26.44%
    Musty 26.32%
    Roasted 25.87%
    Oily 23.48%
    Solvent 20.8%

     

    Flavor
    Sweet 39.32%
    Bitter 37.4%
    Animal 35.53%
    Floral 33.39%
    Ammoniacal 28.06%
    Alkaline 27.38%
    Amine 27.16%
    Earthy 26.18%
    Spicy 25.6%
    Roasted 25.22%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    8.33 (weak base)

    Molecular weight
    85.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    77°C

    Flash point

    • -10.81 ˚C est.

  • Synonyms

    • 1-METHYLPYRROLIDINE
    • N-Methylpyrrolidine
    • 120-94-5
    • Pyrrolidine, 1-methyl-
    • Methylpyrrolidine
    • N-Methyltetrahydropyrrole
    • N-methyl pyrrolidine
    • PYRROLIDINE, N-METHYL
    • PYRROLIDINE, N-METHYL-
    • EINECS 204-438-5
    • MFCD00003173
    • NSC 65579
    • BRN 0102445
    • DTXSID8042210
    • 06509TZU6C
    • NSC-65579
    • METHYLPYRROLIDINE, 1-
    • NSC-65
    • DTXCID6022210
    • EC 204-438-5
    • 5-20-01-00166 (Beilstein Handbook Reference)
    • CEFEPIME IMPURITY G [EP IMPURITY]
    • CEFEPIME DIHYDROCHLORIDE MONOHYDRATE IMPURITY G [EP IMPURITY]
    • methyl pyrrolidine
    • CEFEPIME IMPURITY G (EP IMPURITY)
    • 1-Methyl-pyrrolidine
    • N-Methylpyrrolidine; N-Methyltetrahydropyrrole; NSC 65579;
    • UNII-06509TZU6C
    • CEFEPIME DIHYDROCHLORIDE MONOHYDRATE IMPURITY G (EP IMPURITY)
    • 1Methylpyrrolidine
    • N-methylpyrolidine
    • N-methylpyrrolidin
    • N-methylpyrollidine
    • 1-methyl-pyrolidine
    • N- methylpyrrolidine
    • N-methy-lpyrrolidine
    • N-methyl pyrollidine
    • N-methyl-pyrrolidine
    • N-methyl-pyrrolodine
    • Pyrrolidine, 1methyl
    • Pyrrolidine,l-methyl-
    • NMethyltetrahydropyrrole
    • CHEMBL665
    • N-Methylpyrrolidine, 97%
    • PYRROLIDINE, NMETHYL
    • NSC65579
    • Tox21_301212
    • s6216
    • AKOS015850845
    • 1-Methylpyrrolidine, >=98.0% (GC)
    • NCGC00255880-01
    • CAS-120-94-5
    • DB-000678
    • HY-128383
    • CS-0099463
    • M0415
    • NS00006447
    • D78045
    • Q22829186
    • F0001-0336
    • 204-438-5

  • Applications

    N-Methylpyrrolidine (CAS 120-94-5) is a tertiary amine in a five-membered pyrrolidine ring with a methyl group attached to nitrogen. In practical applications, it is commonly used as a solvent for chemical reactions and formulations in industries such as pharmaceuticals, agrochemicals, and polymers. It also serves as a building block or synthetic intermediate for pyrrolidine- and piperidine-derived compounds used in drug and agrochemical manufacturing. As a tertiary amine, it can function as a base or processing aid and occasionally as a catalyst in polymerization and coatings formulations. Additionally, it is employed as a solvent in coatings, inks, and adhesive formulations to aid processing and formulation stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 912.78
    methanol 995.92
    isopropanol 528.96
    water 42.94
    ethyl acetate 530.71
    n-propanol 731.56
    acetone 425.73
    n-butanol 619.55
    acetonitrile 526.01
    DMF 427.18
    toluene 169.33
    isobutanol 437.59
    1,4-dioxane 624.72
    methyl acetate 479.52
    THF 688.59
    2-butanone 409.92
    n-pentanol 299.91
    sec-butanol 480.12
    n-hexane 58.72
    ethylene glycol 455.28
    NMP 443.31
    cyclohexane 116.49
    DMSO 388.31
    n-butyl acetate 377.0
    n-octanol 170.92
    chloroform 1889.78
    n-propyl acetate 188.21
    acetic acid 1379.8
    dichloromethane 1205.16
    cyclohexanone 405.32
    propylene glycol 561.23
    isopropyl acetate 234.48
    DMAc 387.19
    2-ethoxyethanol 474.69
    isopentanol 353.98
    n-heptane 105.76
    ethyl formate 387.46
    1,2-dichloroethane 479.08
    n-hexanol 485.34
    2-methoxyethanol 859.55
    isobutyl acetate 108.46
    tetrachloromethane 532.87
    n-pentyl acetate 164.44
    transcutol 951.78
    n-heptanol 219.76
    ethylbenzene 60.88
    MIBK 133.37
    2-propoxyethanol 681.14
    tert-butanol 444.12
    MTBE 262.87
    2-butoxyethanol 369.55
    propionic acid 872.01
    o-xylene 112.58
    formic acid 664.39
    diethyl ether 388.29
    m-xylene 108.04
    p-xylene 80.88
    chlorobenzene 277.64
    dimethyl carbonate 129.33
    n-octane 28.01
    formamide 552.86
    cyclopentanone 469.82
    2-pentanone 291.08
    anisole 143.64
    cyclopentyl methyl ether 346.91
    gamma-butyrolactone 641.26
    1-methoxy-2-propanol 554.64
    pyridine 565.71
    3-pentanone 255.04
    furfural 609.03
    n-dodecane 19.7
    diethylene glycol 597.73
    diisopropyl ether 92.27
    tert-amyl alcohol 383.34
    acetylacetone 263.83
    n-hexadecane 20.33
    acetophenone 127.49
    methyl propionate 352.3
    isopentyl acetate 233.95
    trichloroethylene 1014.48
    n-nonanol 150.87
    cyclohexanol 384.87
    benzyl alcohol 196.15
    2-ethylhexanol 268.69
    isooctanol 143.52
    dipropyl ether 271.32
    1,2-dichlorobenzene 241.9
    ethyl lactate 144.55
    propylene carbonate 378.86
    n-methylformamide 483.53
    2-pentanol 344.36
    n-pentane 100.36
    1-propoxy-2-propanol 517.75
    1-methoxy-2-propyl acetate 298.42
    2-(2-methoxypropoxy) propanol 221.1
    mesitylene 59.88
    ε-caprolactone 406.57
    p-cymene 88.27
    epichlorohydrin 591.87
    1,1,1-trichloroethane 693.93
    2-aminoethanol 714.58
    morpholine-4-carbaldehyde 481.48
    sulfolane 448.61
    2,2,4-trimethylpentane 43.3
    2-methyltetrahydrofuran 576.17
    n-hexyl acetate 194.49
    isooctane 24.05
    2-(2-butoxyethoxy)ethanol 357.67
    sec-butyl acetate 119.81
    tert-butyl acetate 172.14
    decalin 31.09
    glycerin 648.47
    diglyme 510.97
    acrylic acid 807.46
    isopropyl myristate 72.12
    n-butyric acid 914.98
    acetyl acetate 335.8
    di(2-ethylhexyl) phthalate 86.15
    ethyl propionate 188.29
    nitromethane 949.51
    1,2-diethoxyethane 293.87
    benzonitrile 235.8
    trioctyl phosphate 63.5
    1-bromopropane 391.51
    gamma-valerolactone 589.65
    n-decanol 111.08
    triethyl phosphate 100.59
    4-methyl-2-pentanol 153.46
    propionitrile 474.95
    vinylene carbonate 384.33
    1,1,2-trichlorotrifluoroethane 765.03
    DMS 140.04
    cumene 46.5
    2-octanol 113.66
    2-hexanone 146.03
    octyl acetate 113.42
    limonene 145.48
    1,2-dimethoxyethane 344.7
    ethyl orthosilicate 104.36
    tributyl phosphate 78.71
    diacetone alcohol 244.11
    N,N-dimethylaniline 90.12
    acrylonitrile 506.35
    aniline 382.72
    1,3-propanediol 693.06
    bromobenzene 245.79
    dibromomethane 832.12
    1,1,2,2-tetrachloroethane 808.88
    2-methyl-cyclohexyl acetate 136.47
    tetrabutyl urea 87.57
    diisobutyl methanol 115.3
    2-phenylethanol 246.26
    styrene 85.07
    dioctyl adipate 100.78
    dimethyl sulfate 155.38
    ethyl butyrate 234.27
    methyl lactate 257.34
    butyl lactate 166.53
    diethyl carbonate 158.29
    propanediol butyl ether 270.67
    triethyl orthoformate 177.97
    p-tert-butyltoluene 85.46
    methyl 4-tert-butylbenzoate 150.05
    morpholine 769.62
    tert-butylamine 321.19
    n-dodecanol 85.7
    dimethoxymethane 269.32
    ethylene carbonate 318.74
    cyrene 153.97
    2-ethoxyethyl acetate 232.99
    2-ethylhexyl acetate 197.45
    1,2,4-trichlorobenzene 295.26
    4-methylpyridine 387.75
    dibutyl ether 155.79
    2,6-dimethyl-4-heptanol 115.3
    DEF 325.1
    dimethyl isosorbide 245.98
    tetrachloroethylene 666.98
    eugenol 160.86
    triacetin 188.2
    span 80 248.86
    1,4-butanediol 253.49
    1,1-dichloroethane 667.48
    2-methyl-1-pentanol 201.01
    methyl formate 302.74
    2-methyl-1-butanol 376.78
    n-decane 34.48
    butyronitrile 443.97
    3,7-dimethyl-1-octanol 154.15
    1-chlorooctane 98.36
    1-chlorotetradecane 38.95
    n-nonane 34.66
    undecane 25.01
    tert-butylcyclohexane 30.0
    cyclooctane 38.51
    cyclopentanol 457.33
    tetrahydropyran 567.46
    tert-amyl methyl ether 214.29
    2,5,8-trioxanonane 328.6
    1-hexene 137.58
    2-isopropoxyethanol 281.71
    2,2,2-trifluoroethanol 601.86
    methyl butyrate 212.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction