n-Methyl-p-aminophenol

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  • Identifiers

    CAS number
    150-75-4

    Molecular formula
    C7H9NO

    SMILES
    CNC1=CC=C(C=C1)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 58.14%
    Meaty 46.11%
    Smoky 44.36%
    Burnt 40.72%
    Sweet 37.07%
    Animal 36.97%
    Medicinal 32.75%
    Roasted 32.59%
    Cheesy 31.34%
    Fishy 31.34%

     

    Flavor
    Phenolic 63.17%
    Meaty 43.99%
    Medicinal 42.45%
    Mild 40.74%
    Sulfurous 35.07%
    Phenol 29.41%
    Sweet 28.94%
    Fruity 28.04%
    Smoky 26.78%
    Onion 25.48%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    8.04 (weak base)

    Molecular weight
    123.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 87 °C

    Boiling point

    • 209-211 °C at 1.6 kPa

    Flash point

    • 129.52 ˚C est.

    Solubility expt.

    • Soluble in alcohol, ether
    • Slightly soluble in ethanol; insoluble in diethyl ether
    • Solubility in water, g/100ml at 25 °C: 1.17

  • Synonyms

    • 150-75-4
    • 4-Methylaminophenol
    • N-Methyl-4-aminophenol
    • N-METHYL-P-AMINOPHENOL
    • Paramethylaminophenol
    • Phenol, p-(methylamino)-
    • N-methyl-4-hydroxyaniline
    • CHEBI:55416
    • 11W1883EFB
    • DTXSID8043783
    • 4-N-methylaminophenol
    • RefChem:163709
    • DTXCID6023783
    • 205-768-2
    • 4-(Methylamino)phenol
    • p-Methylaminophenol
    • Phenol, 4-(methylamino)-
    • p-(Methylamino)phenol
    • 4-methylamino-phenol
    • MFCD00042043
    • NSC-7311
    • p-(methylamino)-pheno
    • Phenol,4-(methylamino)-
    • HSDB 4320
    • NSC 7311
    • EINECS 205-768-2
    • BRN 1363740
    • UNII-11W1883EFB
    • Enamine_001032
    • p-(N-methylamino)phenol
    • 4-(N-methylamino)phenol
    • Epitope ID:122668
    • WLN: QR DM1
    • SCHEMBL84826
    • 3-13-00-01007 (Beilstein Handbook Reference)
    • aniline, 4-hydroxy-N-methyl-
    • SCHEMBL1488088
    • SCHEMBL2642366
    • SCHEMBL3813879
    • SCHEMBL8227916
    • CHEMBL1741003
    • SCHEMBL23671896
    • N-METHYL-P-HYDROXYANILINE
    • P-HYDROXY-N-METHYLANILINE
    • 4-HYDROXY-N-METHYLANILINE
    • NSC7311
    • HMS1396O20
    • BB_SC-07044
    • STK358775
    • AKOS003397615
    • N-METHYL-4-AMINOPHENOL [HSDB]
    • SB33784
    • NCGC00091383-02
    • NCGC00091383-03
    • BS-13067
    • CS-0446965
    • NS00002705
    • EN300-33922
    • N-Methyl-4-aminophenol sulfuric acid (1:1)
    • D77985
    • F770106
    • Q27124284
    • 150-75-4

  • Applications

    n-Methyl-p-aminophenol (CAS 150-75-4) is primarily used as an intermediate in dye and pigment chemistry, notably as a color-forming component in oxidative hair dye formulations and as a building block for various textile and pigment dye systems in industrial manufacturing. It also serves as a colorant precursor in coatings and inks, enabling solid-color and specialty color formulations, and can function as a color-related intermediate in polymers and plastics formulations. In organic synthesis, it provides a convenient building block for pharmaceutical and other fine-chemical programs in research and production environments. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 244.27
    methanol 190.53
    isopropanol 136.29
    water 6.26
    ethyl acetate 178.31
    n-propanol 176.68
    acetone 209.9
    n-butanol 140.84
    acetonitrile 182.74
    DMF 365.54
    toluene 13.39
    isobutanol 103.52
    1,4-dioxane 334.08
    methyl acetate 167.32
    THF 405.4
    2-butanone 140.81
    n-pentanol 72.44
    sec-butanol 95.32
    n-hexane 1.1
    ethylene glycol 89.65
    NMP 194.98
    cyclohexane 2.88
    DMSO 464.29
    n-butyl acetate 74.01
    n-octanol 37.64
    chloroform 83.85
    n-propyl acetate 58.67
    acetic acid 266.0
    dichloromethane 147.73
    cyclohexanone 144.82
    propylene glycol 91.83
    isopropyl acetate 62.25
    DMAc 260.6
    2-ethoxyethanol 147.62
    isopentanol 92.42
    n-heptane 5.24
    ethyl formate 163.29
    1,2-dichloroethane 77.59
    n-hexanol 90.93
    2-methoxyethanol 361.78
    isobutyl acetate 30.29
    tetrachloromethane 16.15
    n-pentyl acetate 35.56
    transcutol 290.82
    n-heptanol 43.8
    ethylbenzene 7.5
    MIBK 48.99
    2-propoxyethanol 169.18
    tert-butanol 163.04
    MTBE 70.9
    2-butoxyethanol 85.77
    propionic acid 161.23
    o-xylene 14.37
    formic acid 151.03
    diethyl ether 71.51
    m-xylene 14.04
    p-xylene 11.86
    chlorobenzene 28.83
    dimethyl carbonate 58.32
    n-octane 2.13
    formamide 267.21
    cyclopentanone 274.56
    2-pentanone 108.16
    anisole 41.86
    cyclopentyl methyl ether 92.69
    gamma-butyrolactone 346.4
    1-methoxy-2-propanol 191.34
    pyridine 121.04
    3-pentanone 63.75
    furfural 205.62
    n-dodecane 2.37
    diethylene glycol 152.03
    diisopropyl ether 15.01
    tert-amyl alcohol 101.87
    acetylacetone 125.41
    n-hexadecane 2.53
    acetophenone 41.8
    methyl propionate 125.62
    isopentyl acetate 52.99
    trichloroethylene 140.9
    n-nonanol 34.72
    cyclohexanol 64.07
    benzyl alcohol 41.76
    2-ethylhexanol 41.7
    isooctanol 30.8
    dipropyl ether 48.66
    1,2-dichlorobenzene 29.15
    ethyl lactate 35.38
    propylene carbonate 134.76
    n-methylformamide 252.73
    2-pentanol 57.07
    n-pentane 1.79
    1-propoxy-2-propanol 97.26
    1-methoxy-2-propyl acetate 84.54
    2-(2-methoxypropoxy) propanol 72.52
    mesitylene 9.16
    ε-caprolactone 123.85
    p-cymene 13.07
    epichlorohydrin 314.07
    1,1,1-trichloroethane 57.31
    2-aminoethanol 154.02
    morpholine-4-carbaldehyde 258.2
    sulfolane 269.81
    2,2,4-trimethylpentane 2.33
    2-methyltetrahydrofuran 208.15
    n-hexyl acetate 48.7
    isooctane 1.83
    2-(2-butoxyethoxy)ethanol 104.49
    sec-butyl acetate 31.09
    tert-butyl acetate 61.05
    decalin 2.22
    glycerin 133.31
    diglyme 196.68
    acrylic acid 128.65
    isopropyl myristate 22.22
    n-butyric acid 201.12
    acetyl acetate 88.91
    di(2-ethylhexyl) phthalate 26.12
    ethyl propionate 48.91
    nitromethane 446.71
    1,2-diethoxyethane 83.67
    benzonitrile 48.17
    trioctyl phosphate 22.39
    1-bromopropane 27.64
    gamma-valerolactone 286.39
    n-decanol 26.72
    triethyl phosphate 28.64
    4-methyl-2-pentanol 32.16
    propionitrile 111.14
    vinylene carbonate 111.7
    1,1,2-trichlorotrifluoroethane 157.54
    DMS 43.88
    cumene 8.39
    2-octanol 24.36
    2-hexanone 50.17
    octyl acetate 30.46
    limonene 20.27
    1,2-dimethoxyethane 201.92
    ethyl orthosilicate 29.03
    tributyl phosphate 24.8
    diacetone alcohol 90.47
    N,N-dimethylaniline 27.21
    acrylonitrile 139.14
    aniline 47.76
    1,3-propanediol 207.75
    bromobenzene 21.34
    dibromomethane 56.66
    1,1,2,2-tetrachloroethane 89.73
    2-methyl-cyclohexyl acetate 40.85
    tetrabutyl urea 33.81
    diisobutyl methanol 23.29
    2-phenylethanol 49.0
    styrene 9.05
    dioctyl adipate 35.24
    dimethyl sulfate 89.88
    ethyl butyrate 59.05
    methyl lactate 66.23
    butyl lactate 33.61
    diethyl carbonate 41.77
    propanediol butyl ether 68.15
    triethyl orthoformate 41.3
    p-tert-butyltoluene 13.03
    methyl 4-tert-butylbenzoate 50.49
    morpholine 362.17
    tert-butylamine 67.87
    n-dodecanol 20.83
    dimethoxymethane 202.74
    ethylene carbonate 104.27
    cyrene 70.57
    2-ethoxyethyl acetate 61.53
    2-ethylhexyl acetate 37.34
    1,2,4-trichlorobenzene 37.36
    4-methylpyridine 84.48
    dibutyl ether 30.33
    2,6-dimethyl-4-heptanol 23.29
    DEF 131.95
    dimethyl isosorbide 121.63
    tetrachloroethylene 59.16
    eugenol 50.72
    triacetin 54.54
    span 80 61.07
    1,4-butanediol 65.73
    1,1-dichloroethane 64.34
    2-methyl-1-pentanol 52.36
    methyl formate 196.3
    2-methyl-1-butanol 84.83
    n-decane 3.38
    butyronitrile 115.22
    3,7-dimethyl-1-octanol 31.25
    1-chlorooctane 14.03
    1-chlorotetradecane 6.81
    n-nonane 2.88
    undecane 2.76
    tert-butylcyclohexane 2.48
    cyclooctane 1.39
    cyclopentanol 114.16
    tetrahydropyran 169.51
    tert-amyl methyl ether 45.85
    2,5,8-trioxanonane 142.1
    1-hexene 6.14
    2-isopropoxyethanol 80.52
    2,2,2-trifluoroethanol 89.21
    methyl butyrate 71.83

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction