N-Aminoethylpiperazine

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  • Identifiers

    CAS number
    140-31-8

    Molecular formula
    C6H15N3

    SMILES
    C1CN(CCN1)CCN

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 81.98%
    Odorless 46.14%
    Cheesy 37.6%
    Ripe 33.73%
    Animal 32.48%
    Popcorn 20.47%
    Meaty 18.73%
    Nutty 17.76%
    Cooked 14.67%
    Savory 13.92%

     

    Flavor
    Bitter 32.73%
    Roasted 29.34%
    Ammoniacal 27.83%
    Odorless 25.26%
    Alkaline 24.67%
    Fishy 21.84%
    Animal 21.7%
    Shrimp 21.39%
    Sweet-like 21.21%
    Cereal 20.9%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 0.1 [mmHg]. Odor threshold from CHEMINFO

  • Properties

    XLogP3-AA
    -1.3

    pKa est.
    6.31 (neutral)

    Molecular weight
    129.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Melting point expt.

    • -2 °F (USCG, 1999)
    • FP: 17.6 °C

    Boiling point

    • 428 °F at 760 mmHg (USCG, 1999)
    • 220 °C

    Flash point

    • 98.61 ˚C est.
    • 200 °F (USCG, 1999)
    • 93 °C
    • 200 °F (93 °C) open cup

    Solubility expt.

    • Soluble in water

  • Synonyms

    • 140-31-8
    • N-(2-Aminoethyl)piperazine
    • N-Aminoethylpiperazine
    • 1-(2-Aminoethyl)piperazine
    • 1-Piperazineethanamine
    • 2-(piperazin-1-yl)ethanamine
    • Aminoethylpiperazine
    • 2-piperazin-1-ylethanamine
    • 1-Piperazineethylamine
    • Piperazineethanamine
    • 1-AMINOETHYLPIPERAZINE
    • 2-Piperazinylethylamine
    • Piperazine, 1-(2-aminoethyl)-
    • USAF DO-46
    • 2-Piperazin-1-ylethylamine
    • 2-(1-Piperazinyl)ethylamine
    • N-(beta-Aminoethyl)piperazine
    • NSC 38968
    • CCRIS 6678
    • N-(Aminoethyl)piperazine
    • HSDB 5630
    • 4-(2-aminoethyl)piperazine
    • EINECS 205-411-0
    • UN2815
    • BRN 0104363
    • DTXSID2021997
    • AI3-52274
    • n-aminoethyl piperazine
    • 2-(piperazin-1-yl)ethan-1-amine
    • NSC-38968
    • I86052F9F6
    • n-(2-aminoethyl) piperazine
    • MLS000736991
    • DTXCID401997
    • PIPERAZINEETHANAMINE, 1-
    • N-(.beta.-Aminoethyl)piperazine
    • EC 205-411-0
    • N-(2-AMINOETHYL)PYPERAZINE
    • 5-23-01-00257 (Beilstein Handbook Reference)
    • N-(2-AMINOETHYL)PIPERAZINE [HSDB]
    • 1-[2-Aminoethyl]piperazine
    • 28631-79-0
    • Ancamine AEP
    • CAS-140-31-8
    • 1-Piperazine ethanamine
    • 1-(beta-Aminoethyl)piperazine
    • UNII-I86052F9F6
    • 1Piperazineethanamine
    • 1Piperazineethylamine
    • MFCD00005971
    • 2-aminoethylpiperazine
    • monoaminoethylpiperazine
    • N-2-aminoethylpiperazine
    • N(2Aminoethyl)piperazine
    • 1(2Aminoethyl)piperazine
    • 1-MAEP
    • N(betaAminoethyl)piperazine
    • Piperazine, 1(2aminoethyl)
    • 2-piperazin-1-yl-ethylamine
    • SCHEMBL17210
    • N-(2-amino ethyl)piperazine
    • N-(2-aminoethyl)-piperazine
    • piperazine, N-2-aminoethyl-
    • WLN: T6M DNTJ D2Z
    • 1-(2-aminoethyl) piperazine
    • 1-(2-aminoethyl)-piperazine
    • N-(beta-aminoethyl)-piperazine
    • 1-(2-aminoethyl)- piperazine
    • CHEMBL209790
    • D.E.H. 39 (Salt/Mix)
    • 2-(1-Piperazinyl)ethanamine #
    • 1-(2-Aminoethyl)piperazine, 99%
    • ALBB-021351
    • NSC38968
    • Tox21_202230
    • Tox21_302922
    • BBL011596
    • STL163329
    • AKOS000118842
    • FA75429
    • LF-0556
    • UN 2815
    • NCGC00249192-01
    • NCGC00256327-01
    • NCGC00259779-01
    • SMR000393948
    • DB-016170
    • A0304
    • NS00004675
    • EN300-17952
    • N-Aminoethylpiperazine [UN2815] [Corrosive]
    • Q3887815
    • Z57127897
    • F2191-0297
    • 205-411-0

  • Applications

    N-Aminoethylpiperazine (CAS 140-31-8) is widely used as a chemical intermediate in organic synthesis. It serves as a building block for polymers and coatings, particularly as a diamine hardener or chain extender in polyurethane and epoxy resin formulations; it also acts as a reactive intermediate for the manufacture of specialty surfactants and cleaners. In addition, it functions as a ligand or chelating agent for metal ion coordination in various formulations and as a precursor to pharmaceutical and agrochemical intermediates. These uses reflect applications across polymer chemistry, coatings/inks, adhesives, cleaners, and related industrial sectors, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 110.05
    methanol 371.09
    isopropanol 26.34
    water 762.56
    ethyl acetate 25.14
    n-propanol 71.61
    acetone 10.53
    n-butanol 42.5
    acetonitrile 25.67
    DMF 114.06
    toluene 3.4
    isobutanol 29.09
    1,4-dioxane 42.65
    methyl acetate 22.24
    THF 47.91
    2-butanone 11.24
    n-pentanol 17.88
    sec-butanol 21.3
    n-hexane 0.47
    ethylene glycol 366.25
    NMP 241.74
    cyclohexane 2.35
    DMSO 186.95
    n-butyl acetate 17.49
    n-octanol 7.84
    chloroform 76.82
    n-propyl acetate 9.48
    acetic acid 637.36
    dichloromethane 80.9
    cyclohexanone 38.92
    propylene glycol 166.0
    isopropyl acetate 7.53
    DMAc 78.69
    2-ethoxyethanol 70.06
    isopentanol 14.75
    n-heptane 2.11
    ethyl formate 64.53
    1,2-dichloroethane 27.43
    n-hexanol 25.99
    2-methoxyethanol 212.39
    isobutyl acetate 4.35
    tetrachloromethane 25.69
    n-pentyl acetate 8.96
    transcutol 67.57
    n-heptanol 14.66
    ethylbenzene 1.19
    MIBK 2.77
    2-propoxyethanol 86.9
    tert-butanol 13.09
    MTBE 3.07
    2-butoxyethanol 46.21
    propionic acid 229.63
    o-xylene 3.6
    formic acid 1461.23
    diethyl ether 6.13
    m-xylene 2.69
    p-xylene 1.73
    chlorobenzene 13.35
    dimethyl carbonate 12.14
    n-octane 0.67
    formamide 629.09
    cyclopentanone 58.2
    2-pentanone 7.13
    anisole 4.24
    cyclopentyl methyl ether 17.15
    gamma-butyrolactone 185.3
    1-methoxy-2-propanol 69.41
    pyridine 46.3
    3-pentanone 7.95
    furfural 241.84
    n-dodecane 0.45
    diethylene glycol 158.26
    diisopropyl ether 1.26
    tert-amyl alcohol 13.96
    acetylacetone 11.84
    n-hexadecane 0.49
    acetophenone 8.31
    methyl propionate 25.77
    isopentyl acetate 9.8
    trichloroethylene 62.59
    n-nonanol 6.79
    cyclohexanol 33.23
    benzyl alcohol 19.27
    2-ethylhexanol 10.91
    isooctanol 8.45
    dipropyl ether 7.67
    1,2-dichlorobenzene 17.88
    ethyl lactate 22.15
    propylene carbonate 92.32
    n-methylformamide 222.79
    2-pentanol 10.43
    n-pentane 0.99
    1-propoxy-2-propanol 43.31
    1-methoxy-2-propyl acetate 23.39
    2-(2-methoxypropoxy) propanol 19.39
    mesitylene 1.78
    ε-caprolactone 70.69
    p-cymene 4.2
    epichlorohydrin 72.86
    1,1,1-trichloroethane 17.25
    2-aminoethanol 307.86
    morpholine-4-carbaldehyde 162.86
    sulfolane 246.17
    2,2,4-trimethylpentane 0.64
    2-methyltetrahydrofuran 27.13
    n-hexyl acetate 9.27
    isooctane 0.28
    2-(2-butoxyethoxy)ethanol 30.18
    sec-butyl acetate 3.88
    tert-butyl acetate 5.0
    decalin 0.73
    glycerin 381.79
    diglyme 51.96
    acrylic acid 336.42
    isopropyl myristate 2.74
    n-butyric acid 181.13
    acetyl acetate 23.56
    di(2-ethylhexyl) phthalate 9.78
    ethyl propionate 8.68
    nitromethane 277.74
    1,2-diethoxyethane 9.0
    benzonitrile 21.06
    trioctyl phosphate 7.57
    1-bromopropane 8.31
    gamma-valerolactone 133.56
    n-decanol 4.64
    triethyl phosphate 12.22
    4-methyl-2-pentanol 3.67
    propionitrile 24.21
    vinylene carbonate 110.1
    1,1,2-trichlorotrifluoroethane 260.27
    DMS 14.08
    cumene 1.29
    2-octanol 4.93
    2-hexanone 3.94
    octyl acetate 5.52
    limonene 6.16
    1,2-dimethoxyethane 25.96
    ethyl orthosilicate 10.47
    tributyl phosphate 8.51
    diacetone alcohol 13.18
    N,N-dimethylaniline 4.19
    acrylonitrile 47.91
    aniline 24.59
    1,3-propanediol 195.59
    bromobenzene 9.15
    dibromomethane 33.91
    1,1,2,2-tetrachloroethane 53.63
    2-methyl-cyclohexyl acetate 10.36
    tetrabutyl urea 9.89
    diisobutyl methanol 3.89
    2-phenylethanol 22.78
    styrene 1.74
    dioctyl adipate 7.0
    dimethyl sulfate 38.0
    ethyl butyrate 12.53
    methyl lactate 54.04
    butyl lactate 20.28
    diethyl carbonate 9.94
    propanediol butyl ether 36.2
    triethyl orthoformate 11.77
    p-tert-butyltoluene 4.07
    methyl 4-tert-butylbenzoate 14.82
    morpholine 69.98
    tert-butylamine 6.07
    n-dodecanol 3.49
    dimethoxymethane 25.53
    ethylene carbonate 73.74
    cyrene 42.93
    2-ethoxyethyl acetate 15.32
    2-ethylhexyl acetate 8.52
    1,2,4-trichlorobenzene 25.01
    4-methylpyridine 23.26
    dibutyl ether 3.19
    2,6-dimethyl-4-heptanol 3.89
    DEF 32.85
    dimethyl isosorbide 40.17
    tetrachloroethylene 63.58
    eugenol 22.56
    triacetin 17.53
    span 80 28.48
    1,4-butanediol 73.87
    1,1-dichloroethane 14.02
    2-methyl-1-pentanol 8.6
    methyl formate 113.81
    2-methyl-1-butanol 21.09
    n-decane 0.71
    butyronitrile 19.73
    3,7-dimethyl-1-octanol 5.2
    1-chlorooctane 2.49
    1-chlorotetradecane 1.16
    n-nonane 0.69
    undecane 0.54
    tert-butylcyclohexane 0.54
    cyclooctane 0.94
    cyclopentanol 63.8
    tetrahydropyran 20.46
    tert-amyl methyl ether 3.84
    2,5,8-trioxanonane 36.02
    1-hexene 1.24
    2-isopropoxyethanol 25.66
    2,2,2-trifluoroethanol 362.14
    methyl butyrate 12.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction