N-Acetyl-L-Lysine

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  • Identifiers

    CAS number
    1946-82-3

    Molecular formula
    C8H16N2O3

    SMILES
    CC(=O)N[C@@H](CCCCN)C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 61.01%
    Savory 41.42%
    Meaty 36.62%
    Fishy 36.32%
    Cooling 25.45%
    Sweet 21.43%
    Cheesy 21.35%
    Cooked 19.7%
    Animal 17.91%
    Milky 17.52%

     

    Flavor
    Odorless 62.19%
    Mild 35.87%
    Bland 29.48%
    Faint 22.66%
    Sweet-like 21.62%
    Sulfury 20.64%
    Yeast 20.63%
    Nitrile 19.47%
    Acrid 19.44%
    Bouillon 19.38%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.4

    pKa est.
    6.97 (neutral)

    Molecular weight
    188.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    369°C

    Melting point expt.

    • 256 - 258 °C

    Flash point

    • 188.86 ˚C est.

  • Synonyms

    • 1946-82-3
    • N-ACETYL-L-LYSINE
    • N2-Acetyl-L-lysine
    • N(alpha)-Acetyllysine
    • (2S)-2-acetamido-6-aminohexanoic acid
    • 7D44E6BN1B
    • DTXSID501036027
    • NSC-353625
    • (2S)-2-acetamido-6-ammoniohexanoate
    • RefChem:828915
    • DTXCID101837813
    • 217-747-5
    • N-alpha-acetyllysine
    • Ac-Lys-OH
    • Nalpha-Acetyl-L-lysine
    • N-alpha-Acetyl-L-lysine
    • acetyl-l-lysine
    • n-acetyllysine
    • N|A-Acetyl-L-lysine
    • MFCD00008233
    • L-Lysine, N2-acetyl-
    • N(alpha)-acetyl-L-lysine
    • N(2)-acetyl-L-lysine
    • (2S)-2-(acetylamino)-6-aminohexanoic acid
    • 6-Amino-L-2-acetamidohexanoic acid
    • Na-Acetyl-L-Lysine
    • N2-acetyllysine
    • CHEBI:35704
    • (2S)-6-amino-2-acetamidohexanoic acid
    • N?-Acetyl-L-lysine
    • ac-lysine
    • N.alpha.-Acetyllysine
    • .alpha.-Acetyl-L-lysine
    • N.alpha.-Acetyl-L-lysine
    • Ac-L-Lys-OH
    • Lysine, N2-acetyl-, L-
    • UNII-7D44E6BN1B
    • acetyl-lysine
    • N-a-Acetyllysine
    • 6-Amino-L-2-acetamidohexanoic Acid; N2-Acetyl-L-lysine; N2-Acetyllysine; N-Acetyl-L-lysine; Na-Acetyllysine
    • EINECS 217-747-5
    • Lysine Impurity 20
    • Lysine Impurity 52
    • N-a-Acetyl-L-lysine
    • N??-Acetyl-L-lysine
    • (2S)-2-acetamido-6-amino-hexanoic acid
    • lysine, alpha-N-acetyl-
    • bmse000830
    • Epitope ID:143648
    • SCHEMBL20529
    • N(.alpha.)-Acetyl-l-lysine
    • 6-amino-l-2-acetamidohexanoate
    • orb1302508
    • CHEMBL1241437
    • MSK2861
    • s3345
    • SBB067149
    • AKOS015837751
    • EBC-153129
    • FA47436
    • HY-W048838
    • NSC 353625
    • AS-46851
    • N-alpha-Acetyl-L-lysine (Ac-L-Lys-OH)
    • SY051389
    • A2171
    • CS-0101238
    • NS00046545
    • F10720
    • EN300-1699962
    • 946A823
    • F463049
    • Q27104319
    • Z1255438452
    • 1946-82-3

  • Applications

    N-Acetyl-L-Lysine (CAS 1946-82-3) is primarily used as a chemical building block and protecting-group derivative in peptide synthesis and related biotech workflows, enabling the incorporation of acetylated lysine residues in complex peptide sequences. It also serves in cosmetics and personal care formulations as a conditioning and stabilizing ingredient and as a source of amino-acid–type functionality in advanced formulations. In pharmaceutical manufacturing, it functions as an intermediate for the synthesis of peptide-based APIs or related excipients. In polymers and plastics, it may be employed as a functionalized amino-acid derivative to modify polymer properties or to introduce biocompatible, hydrophilic functionality. Usage is subject to formulation specifics and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.27
    methanol 52.2
    isopropanol 2.46
    water 318.82
    ethyl acetate 1.33
    n-propanol 4.3
    acetone 1.78
    n-butanol 2.36
    acetonitrile 1.05
    DMF 92.96
    toluene 0.6
    isobutanol 3.49
    1,4-dioxane 3.25
    methyl acetate 1.06
    THF 11.15
    2-butanone 1.19
    n-pentanol 2.46
    sec-butanol 2.49
    n-hexane 0.18
    ethylene glycol 91.24
    NMP 145.89
    cyclohexane 0.21
    DMSO 203.33
    n-butyl acetate 2.3
    n-octanol 0.98
    chloroform 1.08
    n-propyl acetate 1.26
    acetic acid 107.85
    dichloromethane 1.12
    cyclohexanone 9.82
    propylene glycol 66.47
    isopropyl acetate 1.44
    DMAc 95.76
    2-ethoxyethanol 23.96
    isopentanol 3.48
    n-heptane 0.12
    ethyl formate 10.96
    1,2-dichloroethane 1.05
    n-hexanol 3.26
    2-methoxyethanol 60.81
    isobutyl acetate 1.06
    tetrachloromethane 0.83
    n-pentyl acetate 1.21
    transcutol 24.17
    n-heptanol 1.63
    ethylbenzene 0.62
    MIBK 1.83
    2-propoxyethanol 17.25
    tert-butanol 6.31
    MTBE 1.1
    2-butoxyethanol 8.29
    propionic acid 21.98
    o-xylene 1.28
    formic acid 405.91
    diethyl ether 0.3
    m-xylene 1.06
    p-xylene 0.93
    chlorobenzene 0.87
    dimethyl carbonate 3.43
    n-octane 0.07
    formamide 187.76
    cyclopentanone 15.23
    2-pentanone 1.2
    anisole 1.66
    cyclopentyl methyl ether 2.96
    gamma-butyrolactone 33.11
    1-methoxy-2-propanol 19.09
    pyridine 3.16
    3-pentanone 1.1
    furfural 62.39
    n-dodecane 0.05
    diethylene glycol 55.35
    diisopropyl ether 0.3
    tert-amyl alcohol 6.23
    acetylacetone 5.55
    n-hexadecane 0.06
    acetophenone 4.0
    methyl propionate 2.05
    isopentyl acetate 3.21
    trichloroethylene 2.37
    n-nonanol 0.99
    cyclohexanol 4.71
    benzyl alcohol 6.26
    2-ethylhexanol 1.8
    isooctanol 1.54
    dipropyl ether 0.65
    1,2-dichlorobenzene 1.43
    ethyl lactate 6.42
    propylene carbonate 21.73
    n-methylformamide 48.16
    2-pentanol 1.14
    n-pentane 0.1
    1-propoxy-2-propanol 8.27
    1-methoxy-2-propyl acetate 6.19
    2-(2-methoxypropoxy) propanol 12.16
    mesitylene 0.88
    ε-caprolactone 14.39
    p-cymene 0.93
    epichlorohydrin 8.63
    1,1,1-trichloroethane 0.78
    2-aminoethanol 83.34
    morpholine-4-carbaldehyde 71.52
    sulfolane 103.14
    2,2,4-trimethylpentane 0.15
    2-methyltetrahydrofuran 4.0
    n-hexyl acetate 1.65
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 13.45
    sec-butyl acetate 0.99
    tert-butyl acetate 2.54
    decalin 0.21
    glycerin 174.57
    diglyme 19.52
    acrylic acid 37.64
    isopropyl myristate 0.75
    n-butyric acid 19.86
    acetyl acetate 2.94
    di(2-ethylhexyl) phthalate 4.11
    ethyl propionate 1.4
    nitromethane 44.2
    1,2-diethoxyethane 1.5
    benzonitrile 3.38
    trioctyl phosphate 2.26
    1-bromopropane 0.33
    gamma-valerolactone 50.25
    n-decanol 0.77
    triethyl phosphate 3.02
    4-methyl-2-pentanol 1.48
    propionitrile 1.1
    vinylene carbonate 18.65
    1,1,2-trichlorotrifluoroethane 52.11
    DMS 3.29
    cumene 0.76
    2-octanol 0.8
    2-hexanone 1.18
    octyl acetate 1.12
    limonene 1.01
    1,2-dimethoxyethane 17.62
    ethyl orthosilicate 2.49
    tributyl phosphate 2.55
    diacetone alcohol 11.74
    N,N-dimethylaniline 2.63
    acrylonitrile 3.13
    aniline 2.56
    1,3-propanediol 50.21
    bromobenzene 0.67
    dibromomethane 0.72
    1,1,2,2-tetrachloroethane 2.79
    2-methyl-cyclohexyl acetate 3.42
    tetrabutyl urea 4.26
    diisobutyl methanol 1.3
    2-phenylethanol 4.94
    styrene 0.56
    dioctyl adipate 2.17
    dimethyl sulfate 17.75
    ethyl butyrate 1.93
    methyl lactate 15.8
    butyl lactate 5.41
    diethyl carbonate 1.95
    propanediol butyl ether 14.04
    triethyl orthoformate 2.33
    p-tert-butyltoluene 0.88
    methyl 4-tert-butylbenzoate 7.08
    morpholine 5.97
    tert-butylamine 1.9
    n-dodecanol 0.6
    dimethoxymethane 7.52
    ethylene carbonate 12.38
    cyrene 28.98
    2-ethoxyethyl acetate 2.5
    2-ethylhexyl acetate 2.02
    1,2,4-trichlorobenzene 2.0
    4-methylpyridine 3.43
    dibutyl ether 0.41
    2,6-dimethyl-4-heptanol 1.3
    DEF 7.62
    dimethyl isosorbide 24.26
    tetrachloroethylene 3.31
    eugenol 9.95
    triacetin 4.28
    span 80 10.85
    1,4-butanediol 24.41
    1,1-dichloroethane 0.44
    2-methyl-1-pentanol 3.71
    methyl formate 37.23
    2-methyl-1-butanol 3.79
    n-decane 0.08
    butyronitrile 1.31
    3,7-dimethyl-1-octanol 1.41
    1-chlorooctane 0.23
    1-chlorotetradecane 0.14
    n-nonane 0.07
    undecane 0.06
    tert-butylcyclohexane 0.19
    cyclooctane 0.13
    cyclopentanol 9.73
    tetrahydropyran 1.27
    tert-amyl methyl ether 1.42
    2,5,8-trioxanonane 19.45
    1-hexene 0.36
    2-isopropoxyethanol 9.3
    2,2,2-trifluoroethanol 50.76
    methyl butyrate 3.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction