N-Acetyl-L-arginine

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  • Identifiers

    CAS number
    155-84-0

    Molecular formula
    C8H16N4O3

    SMILES
    CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 63.67%
    Savory 39.8%
    Meaty 36.41%
    Fishy 29.71%
    Cooling 25.44%
    Cooked 22.02%
    Sweet 20.04%
    Roasted 18.37%
    Cheesy 18.03%
    Pungent 17.04%

     

    Flavor
    Odorless 56.81%
    Bitter 32.4%
    Mild 32.36%
    Bland 28.58%
    Roasted 22.11%
    Cooked 22.0%
    Faint 21.93%
    Sweet-like 21.2%
    Yeast 21.15%
    Very mild 20.54%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.7

    pKa est.
    8.11 (weak base)

    Molecular weight
    216.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    414°C

    Flash point

    • 207.62 ˚C est.

  • Synonyms

    • N-Acetyl-L-arginine
    • 155-84-0
    • N-ALPHA-L-ACETYL-ARGININE
    • N-Ac-L-Arg-OH
    • TQ7DL04CAE
    • (2S)-5-carbamimidamido-2-acetamidopentanoic acid
    • DTXSID80883338
    • N-acetyl-(L)-arginine
    • (2S)-2-acetamido-5-(diaminomethylideneamino)pentanoic acid
    • n-alpha-acetylarginine
    • RefChem:828878
    • DTXCID901022876
    • (2S)-2-acetamido-5-(diaminomethylideneazaniumyl)pentanoate
    • Ac-Arg-OH
    • L-Arginine, N2-acetyl-
    • N2-Acetyl-L-arginine
    • acetyl arginine
    • n-acetylarginine
    • N-ALPHA-ACETYL-L-ARGININE
    • MFCD00019733
    • C8H16N4O3
    • N-Alpha-Acetyl-L-Arginine Dihydrate
    • N~2~-acetyl-L-arginine
    • N.alpha.-Acetyl-l-arginine
    • Arginine, N2-acetyl-
    • (S)-2-Acetamido-5-guanidinopentanoic acid
    • N|A-Acetyl-L-arginine
    • UNII-TQ7DL04CAE
    • EINECS 205-846-6
    • N-a-Acetyl-L-arginine
    • Maybridge1_002433
    • N(2)-acetyl-L-arginine
    • N(alpha)-acetyl-L-arginine
    • DivK1c_001185
    • SCHEMBL446929
    • N.ALPHA.-ACETYLARGININE
    • orb1299263
    • SCHEMBL29521677
    • CHEBI:40521
    • ARGININE, N2-ACETYL-, L-
    • .ALPHA.-N-ACETYL-L-ARGININE
    • EBC-47439
    • s6354
    • AKOS015901411
    • CS-W014846
    • DB01985
    • HY-W014130
    • CDS1_000145
    • s12016
    • AS-57712
    • FA111812
    • L-ARGININE, N2-ACETYL-, DIHYDRATE
    • NS00068749
    • (2S)-2-acetamido-5-guanidino-pentanoic acid
    • A-0430
    • EN300-7403858
    • F813765
    • Q27093079
    • Z1508915909
    • 155-84-0

  • Applications

    N-Acetyl-L-arginine (CAS 155-84-0) is primarily used as an intermediate in pharmaceutical and biochemical synthesis, serving as a protected amino acid derivative for the preparation of arginine-containing peptides and related acetylated derivatives. In industrial manufacturing, it can function as a precursor or building block for specialized arginine-containing compounds and derivatives. In chemical research and development, it is employed as a reagent and reference standard in organic synthesis and analyses of amino acid derivatives. In cosmetics and personal care, it is evaluated as a potential conditioning ingredient or as a source of arginine functionality in selected formulations, subject to regulatory and formulation limits. In laboratory settings, it can be used as a reference material or analytical standard for quantifying arginine-derived compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.32
    methanol 1.06
    isopropanol 0.12
    water 30.35
    ethyl acetate 0.06
    n-propanol 0.18
    acetone 0.06
    n-butanol 0.12
    acetonitrile 0.07
    DMF 5.53
    toluene 0.06
    isobutanol 0.12
    1,4-dioxane 0.14
    methyl acetate 0.07
    THF 0.43
    2-butanone 0.1
    n-pentanol 0.12
    sec-butanol 0.13
    n-hexane 0.06
    ethylene glycol 2.36
    NMP 10.11
    cyclohexane 0.02
    DMSO 14.93
    n-butyl acetate 0.08
    n-octanol 0.06
    chloroform 0.15
    n-propyl acetate 0.07
    acetic acid 2.02
    dichloromethane 0.21
    cyclohexanone 0.4
    propylene glycol 1.84
    isopropyl acetate 0.05
    DMAc 7.64
    2-ethoxyethanol 1.18
    isopentanol 0.12
    n-heptane 0.03
    ethyl formate 0.38
    1,2-dichloroethane 0.12
    n-hexanol 0.13
    2-methoxyethanol 2.64
    isobutyl acetate 0.04
    tetrachloromethane 0.08
    n-pentyl acetate 0.06
    transcutol 1.06
    n-heptanol 0.1
    ethylbenzene 0.07
    MIBK 0.08
    2-propoxyethanol 0.96
    tert-butanol 0.15
    MTBE 0.04
    2-butoxyethanol 0.55
    propionic acid 0.47
    o-xylene 0.1
    formic acid 23.13
    diethyl ether 0.05
    m-xylene 0.07
    p-xylene 0.1
    chlorobenzene 0.04
    dimethyl carbonate 0.2
    n-octane 0.02
    formamide 9.64
    cyclopentanone 0.6
    2-pentanone 0.08
    anisole 0.09
    cyclopentyl methyl ether 0.2
    gamma-butyrolactone 1.14
    1-methoxy-2-propanol 1.14
    pyridine 0.28
    3-pentanone 0.1
    furfural 3.53
    n-dodecane 0.01
    diethylene glycol 2.89
    diisopropyl ether 0.02
    tert-amyl alcohol 0.19
    acetylacetone 0.18
    n-hexadecane 0.01
    acetophenone 0.22
    methyl propionate 0.15
    isopentyl acetate 0.1
    trichloroethylene 0.22
    n-nonanol 0.07
    cyclohexanol 0.17
    benzyl alcohol 0.27
    2-ethylhexanol 0.09
    isooctanol 0.08
    dipropyl ether 0.09
    1,2-dichlorobenzene 0.08
    ethyl lactate 0.39
    propylene carbonate 0.73
    n-methylformamide 2.48
    2-pentanol 0.07
    n-pentane 0.02
    1-propoxy-2-propanol 0.51
    1-methoxy-2-propyl acetate 0.25
    2-(2-methoxypropoxy) propanol 0.93
    mesitylene 0.05
    ε-caprolactone 0.53
    p-cymene 0.06
    epichlorohydrin 0.51
    1,1,1-trichloroethane 0.06
    2-aminoethanol 2.26
    morpholine-4-carbaldehyde 5.05
    sulfolane 6.39
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.16
    n-hexyl acetate 0.08
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 0.87
    sec-butyl acetate 0.04
    tert-butyl acetate 0.08
    decalin 0.02
    glycerin 9.81
    diglyme 1.32
    acrylic acid 1.05
    isopropyl myristate 0.04
    n-butyric acid 0.48
    acetyl acetate 0.08
    di(2-ethylhexyl) phthalate 0.2
    ethyl propionate 0.09
    nitromethane 1.31
    1,2-diethoxyethane 0.1
    benzonitrile 0.17
    trioctyl phosphate 0.11
    1-bromopropane 0.07
    gamma-valerolactone 2.46
    n-decanol 0.06
    triethyl phosphate 0.21
    4-methyl-2-pentanol 0.06
    propionitrile 0.08
    vinylene carbonate 0.82
    1,1,2-trichlorotrifluoroethane 3.84
    DMS 0.14
    cumene 0.07
    2-octanol 0.06
    2-hexanone 0.09
    octyl acetate 0.05
    limonene 0.06
    1,2-dimethoxyethane 1.17
    ethyl orthosilicate 0.19
    tributyl phosphate 0.14
    diacetone alcohol 0.44
    N,N-dimethylaniline 0.22
    acrylonitrile 0.2
    aniline 0.16
    1,3-propanediol 1.31
    bromobenzene 0.04
    dibromomethane 0.13
    1,1,2,2-tetrachloroethane 0.26
    2-methyl-cyclohexyl acetate 0.15
    tetrabutyl urea 0.3
    diisobutyl methanol 0.06
    2-phenylethanol 0.2
    styrene 0.05
    dioctyl adipate 0.09
    dimethyl sulfate 1.22
    ethyl butyrate 0.11
    methyl lactate 1.08
    butyl lactate 0.33
    diethyl carbonate 0.09
    propanediol butyl ether 0.79
    triethyl orthoformate 0.17
    p-tert-butyltoluene 0.05
    methyl 4-tert-butylbenzoate 0.47
    morpholine 0.3
    tert-butylamine 0.07
    n-dodecanol 0.04
    dimethoxymethane 0.66
    ethylene carbonate 0.42
    cyrene 2.29
    2-ethoxyethyl acetate 0.1
    2-ethylhexyl acetate 0.08
    1,2,4-trichlorobenzene 0.1
    4-methylpyridine 0.26
    dibutyl ether 0.05
    2,6-dimethyl-4-heptanol 0.06
    DEF 0.53
    dimethyl isosorbide 1.66
    tetrachloroethylene 0.26
    eugenol 0.71
    triacetin 0.2
    span 80 0.6
    1,4-butanediol 0.72
    1,1-dichloroethane 0.05
    2-methyl-1-pentanol 0.13
    methyl formate 1.72
    2-methyl-1-butanol 0.14
    n-decane 0.01
    butyronitrile 0.09
    3,7-dimethyl-1-octanol 0.06
    1-chlorooctane 0.03
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 0.27
    tetrahydropyran 0.08
    tert-amyl methyl ether 0.08
    2,5,8-trioxanonane 1.38
    1-hexene 0.1
    2-isopropoxyethanol 0.4
    2,2,2-trifluoroethanol 1.93
    methyl butyrate 0.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction