N-Acetyl-DL-methionine

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  • Identifiers

    CAS number
    1115-47-5

    Molecular formula
    C7H13NO3S

    SMILES
    CC(=O)NC(CCSC)C(=O)O

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Meaty 69.03%
    Savory 52.78%
    Sulfurous 47.54%
    Roasted 46.36%
    Sweet 36.09%
    Cooked 36.08%
    Onion 29.16%
    Beefy 27.03%
    Cheesy 25.91%
    Nutty 23.3%

     

    Flavor
    Odorless 42.51%
    Sulfury 31.49%
    Cooked 30.04%
    Roasted 29.93%
    Mild 29.67%
    Sulfurous 28.33%
    Bland 23.58%
    Cabbage 22.41%
    Acrid 20.83%
    Taco 20.43%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    7.14 (neutral)

    Molecular weight
    191.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    368°C

    Flash point

    • 173.39 ˚C est.

  • Synonyms

    • N-Acetyl-DL-methionine
    • METHIONINE, N-ACETYL-
    • RefChem:828872
    • 1115-47-5
    • Ac-DL-Met-OH
    • Acetyl-DL-methionine
    • DL-Methionine, N-acetyl-
    • DL-N-Acetylmethionine
    • Methionine, N-acetyl-, DL-
    • 2-Acetamido-4-(methylthio)butanoic acid
    • N-acetyl-D,L-methionine
    • N-Acetylmethionine, DL-
    • 2-acetamido-4-methylsulfanylbutanoic acid
    • dl-Acetylmethionine
    • MFCD00008681
    • N-ACETYL-METHIONINE
    • 2-acetamido-4-methylsulfanyl-butanoic acid
    • 2-acetamido-4-(methylsulfanyl)butanoic acid
    • 383941IGXN
    • NSC-7633
    • (2RS)-2-(Acetylamino)-4-(methylsulfanyl)butanoic Acid (N-Acetyl-DL-methionine)
    • N-Acetyl(methyl)homocysteine
    • 4-04-00-03205 (Beilstein Handbook Reference)
    • NSC 7633
    • EINECS 214-224-3
    • Methionine EP Impurity C
    • N-Acetyl(methyl)homocysteine #
    • BRN 1725554
    • UNII-383941IGXN
    • Ac-Met
    • Ac-DL-Met
    • 2-Acetylamino-4-methylsulfanyl-butyric acid
    • WLN: 1VMYVQ2S1
    • CHEMBL45002
    • SCHEMBL109680
    • orb1302458
    • DTXSID5037022
    • XUYPXLNMDZIRQH-UHFFFAOYSA-
    • N-ACETYLMETHIONINE DL-FORM
    • NSC7633
    • CHEBI:132958
    • HMS3604I21
    • N-Acetyl-DL-methionine (Standard)
    • ALBB-023615
    • HY-W019704R
    • EBC-47275
    • NSC118514
    • s3087
    • STK387102
    • AKOS000133585
    • AKOS016843017
    • FA10863
    • FS-3977
    • HY-W019704
    • N-ACETYLMETHIONINE DL-FORM [MI]
    • AC-15650
    • N-ACETYL-D,L-METHIONINE [USP-RS]
    • 2-(acetylamino)-4-methylthiobutanoic acid
    • DB-043072
    • DB-054845
    • METHIONINE IMPURITY C [EP IMPURITY]
    • 2-(Acetylamino)-4-(methylthio)butanoic acid
    • A0100
    • CS-0031301
    • ST45022125
    • EN300-302497
    • F93018
    • M06033
    • N-ACETYL-D,L-METHIONINE [USP IMPURITY]
    • N-Acetyl-DL-methionine, ReagentPlus(R), 99%
    • W-108672
    • Q27256733
    • Z85883131
    • 2-(ACETYLAMINO)-4-(METHYLSULFANYL)BUTANOIC ACID
    • F2191-0246
    • N-Acetyl-DL-methionine, Vetec(TM) reagent grade, 98%
    • N-Acetyl-D,L-Methionine, United States Pharmacopeia (USP) Reference Standard
    • InChI=1/C7H13NO3S/c1-5(9)8-6(7(10)11)3-4-12-2/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)
    • 1115-47-5

  • Applications

    N-Acetyl-DL-methionine (CAS 1115-47-5) is primarily used as a protected methionine building block in organic synthesis and pharmaceutical development, serving as a stable precursor for methionine-containing compounds and related derivatives. It is commonly employed as an N-acetyl protecting group in peptide synthesis, enabling controlled assembly of sequences and selective deprotection. In chemistry and drug research, it also functions as a starting material for preparing methionine derivatives and sulfur-containing heterocycles. The compound may be considered as a methionine source in specialized animal nutrition or dietary-supplement formulations, subject to regulatory approvals and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 176.13
    methanol 431.05
    isopropanol 88.38
    water 148.63
    ethyl acetate 9.69
    n-propanol 106.14
    acetone 66.87
    n-butanol 70.21
    acetonitrile 15.66
    DMF 573.45
    toluene 4.94
    isobutanol 61.61
    1,4-dioxane 81.31
    methyl acetate 14.03
    THF 140.12
    2-butanone 25.59
    n-pentanol 45.67
    sec-butanol 60.31
    n-hexane 1.13
    ethylene glycol 219.51
    NMP 328.73
    cyclohexane 2.32
    DMSO 620.45
    n-butyl acetate 15.19
    n-octanol 11.31
    chloroform 3.98
    n-propyl acetate 11.1
    acetic acid 205.13
    dichloromethane 3.1
    cyclohexanone 75.94
    propylene glycol 164.14
    isopropyl acetate 10.15
    DMAc 331.93
    2-ethoxyethanol 155.75
    isopentanol 53.13
    n-heptane 0.95
    ethyl formate 44.57
    1,2-dichloroethane 6.33
    n-hexanol 31.77
    2-methoxyethanol 361.63
    isobutyl acetate 8.22
    tetrachloromethane 2.68
    n-pentyl acetate 10.3
    transcutol 138.96
    n-heptanol 14.35
    ethylbenzene 4.69
    MIBK 17.72
    2-propoxyethanol 88.12
    tert-butanol 101.3
    MTBE 17.58
    2-butoxyethanol 45.24
    propionic acid 74.48
    o-xylene 8.01
    formic acid 394.34
    diethyl ether 8.05
    m-xylene 6.8
    p-xylene 6.76
    chlorobenzene 5.31
    dimethyl carbonate 13.17
    n-octane 0.5
    formamide 318.63
    cyclopentanone 102.63
    2-pentanone 21.37
    anisole 15.27
    cyclopentyl methyl ether 28.61
    gamma-butyrolactone 113.04
    1-methoxy-2-propanol 134.68
    pyridine 28.71
    3-pentanone 11.81
    furfural 140.47
    n-dodecane 0.48
    diethylene glycol 149.26
    diisopropyl ether 3.38
    tert-amyl alcohol 70.21
    acetylacetone 36.16
    n-hexadecane 0.53
    acetophenone 25.86
    methyl propionate 13.34
    isopentyl acetate 18.02
    trichloroethylene 11.05
    n-nonanol 10.1
    cyclohexanol 47.23
    benzyl alcohol 36.37
    2-ethylhexanol 14.14
    isooctanol 11.24
    dipropyl ether 6.21
    1,2-dichlorobenzene 7.11
    ethyl lactate 20.85
    propylene carbonate 57.51
    n-methylformamide 218.05
    2-pentanol 26.0
    n-pentane 1.12
    1-propoxy-2-propanol 44.27
    1-methoxy-2-propyl acetate 25.43
    2-(2-methoxypropoxy) propanol 48.18
    mesitylene 5.41
    ε-caprolactone 66.06
    p-cymene 5.35
    epichlorohydrin 63.36
    1,1,1-trichloroethane 4.97
    2-aminoethanol 279.4
    morpholine-4-carbaldehyde 231.51
    sulfolane 216.38
    2,2,4-trimethylpentane 0.94
    2-methyltetrahydrofuran 58.91
    n-hexyl acetate 14.34
    isooctane 0.69
    2-(2-butoxyethoxy)ethanol 61.52
    sec-butyl acetate 7.69
    tert-butyl acetate 16.62
    decalin 1.54
    glycerin 283.25
    diglyme 98.45
    acrylic acid 87.87
    isopropyl myristate 6.37
    n-butyric acid 64.55
    acetyl acetate 11.85
    di(2-ethylhexyl) phthalate 16.43
    ethyl propionate 8.9
    nitromethane 140.07
    1,2-diethoxyethane 16.17
    benzonitrile 20.02
    trioctyl phosphate 11.01
    1-bromopropane 2.97
    gamma-valerolactone 180.97
    n-decanol 7.53
    triethyl phosphate 11.98
    4-methyl-2-pentanol 15.16
    propionitrile 13.5
    vinylene carbonate 50.57
    1,1,2-trichlorotrifluoroethane 108.64
    DMS 15.35
    cumene 4.64
    2-octanol 7.94
    2-hexanone 16.49
    octyl acetate 9.02
    limonene 6.89
    1,2-dimethoxyethane 147.99
    ethyl orthosilicate 10.62
    tributyl phosphate 11.75
    diacetone alcohol 51.89
    N,N-dimethylaniline 19.44
    acrylonitrile 23.94
    aniline 18.03
    1,3-propanediol 242.62
    bromobenzene 3.56
    dibromomethane 2.75
    1,1,2,2-tetrachloroethane 13.68
    2-methyl-cyclohexyl acetate 18.07
    tetrabutyl urea 21.19
    diisobutyl methanol 8.53
    2-phenylethanol 26.31
    styrene 4.58
    dioctyl adipate 14.32
    dimethyl sulfate 45.97
    ethyl butyrate 11.82
    methyl lactate 39.22
    butyl lactate 23.11
    diethyl carbonate 9.91
    propanediol butyl ether 58.99
    triethyl orthoformate 11.66
    p-tert-butyltoluene 5.29
    methyl 4-tert-butylbenzoate 29.35
    morpholine 129.99
    tert-butylamine 31.55
    n-dodecanol 5.63
    dimethoxymethane 78.75
    ethylene carbonate 40.29
    cyrene 73.76
    2-ethoxyethyl acetate 17.14
    2-ethylhexyl acetate 12.28
    1,2,4-trichlorobenzene 10.41
    4-methylpyridine 29.15
    dibutyl ether 5.25
    2,6-dimethyl-4-heptanol 8.53
    DEF 52.63
    dimethyl isosorbide 77.54
    tetrachloroethylene 12.68
    eugenol 37.75
    triacetin 21.0
    span 80 39.38
    1,4-butanediol 107.45
    1,1-dichloroethane 3.44
    2-methyl-1-pentanol 38.41
    methyl formate 126.13
    2-methyl-1-butanol 50.87
    n-decane 0.68
    butyronitrile 17.6
    3,7-dimethyl-1-octanol 11.95
    1-chlorooctane 2.69
    1-chlorotetradecane 1.37
    n-nonane 0.61
    undecane 0.55
    tert-butylcyclohexane 1.25
    cyclooctane 0.93
    cyclopentanol 84.4
    tetrahydropyran 36.5
    tert-amyl methyl ether 14.84
    2,5,8-trioxanonane 78.58
    1-hexene 3.77
    2-isopropoxyethanol 64.35
    2,2,2-trifluoroethanol 71.96
    methyl butyrate 19.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction