N-(2-Hydroxyethyl)hexonamide

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  • Identifiers

    CAS number
    686298-93-1

    Molecular formula
    C8H17NO7

    SMILES
    C(CO)NC(=O)C(C(C(C(CO)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 65.3%
    Sweet 52.31%
    Savory 23.6%
    Fishy 21.63%
    Alcoholic 20.49%
    Cooling 19.08%
    Buttery 17.49%
    Milky 16.2%
    Bitter 16.02%
    Caramellic 16.0%

     

    Flavor
    Odorless 72.46%
    Sweet 38.86%
    Sweet-like 32.79%
    Very mild 28.8%
    Bland 25.47%
    Mild 21.69%
    Very slight 20.87%
    Bitter 20.62%
    Yeast 20.08%
    Cauliflower 18.57%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.3

    pKa est.
    5.09 (weak acid)

    Molecular weight
    239.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1613°C

    Flash point

    • 275.52 ˚C est.

    Solubility expt.

    • Very soluble in water; insoluble in pentane
    • Slightly soluble (in ethanol)

  • Synonyms

    • N-(2-Hydroxyethyl)hexonamide
    • DTXSID80863539
    • RefChem:825489
    • DTXCID90812139
    • Gluconic acid ethanolamine
    • N-(2-Hydroxyethyl) Hexonamide
    • SCHEMBL4949039
    • N-(2-Hydroxyethyl) gluconamide
    • CHEBI:166480
    • 686298-93-1
    • NS00121144
    • 686298-93-1

  • Applications

    N-(2-Hydroxyethyl)hexonamide (CAS 686298-93-1) is commonly used as an intermediate and processing additive in specialty formulations. Its amphiphilic structure enables applications as a nonionic surfactant and emulsifier in cosmetics, personal care, and household cleaning products, while its hydroxyethyl functionality supports use as a humectant or moisture-retaining component in skin- and hair-care formulations. It also serves as a processing aid and wetting/leveling agent in coatings, paints, and ink formulations. In polymer and plastics contexts, it can be employed as a building block for specialty surfactants or as a compatibility modifier in polymer blends. Additionally, it may be used as an intermediate in the synthesis of pharmaceutical or agrochemical intermediates, where further functionalization of the hydroxyethyl group is pursued.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.07
    methanol 11.32
    isopropanol 0.49
    water 1560.27
    ethyl acetate 0.21
    n-propanol 0.83
    acetone 0.47
    n-butanol 0.5
    acetonitrile 0.34
    DMF 163.3
    toluene 0.14
    isobutanol 0.43
    1,4-dioxane 2.07
    methyl acetate 0.26
    THF 0.98
    2-butanone 0.36
    n-pentanol 0.24
    sec-butanol 0.6
    n-hexane 0.05
    ethylene glycol 142.9
    NMP 124.45
    cyclohexane 0.47
    DMSO 402.62
    n-butyl acetate 0.19
    n-octanol 0.32
    chloroform 0.06
    n-propyl acetate 0.12
    acetic acid 12.58
    dichloromethane 0.09
    cyclohexanone 1.63
    propylene glycol 38.21
    isopropyl acetate 0.16
    DMAc 65.25
    2-ethoxyethanol 7.36
    isopentanol 0.37
    n-heptane 0.25
    ethyl formate 0.46
    1,2-dichloroethane 0.2
    n-hexanol 0.59
    2-methoxyethanol 30.11
    isobutyl acetate 0.06
    tetrachloromethane 0.08
    n-pentyl acetate 0.17
    transcutol 7.31
    n-heptanol 0.56
    ethylbenzene 0.09
    MIBK 0.23
    2-propoxyethanol 4.37
    tert-butanol 1.0
    MTBE 0.2
    2-butoxyethanol 2.45
    propionic acid 3.38
    o-xylene 0.33
    formic acid 413.49
    diethyl ether 0.17
    m-xylene 0.19
    p-xylene 0.11
    chlorobenzene 0.04
    dimethyl carbonate 2.21
    n-octane 0.1
    formamide 224.43
    cyclopentanone 1.89
    2-pentanone 0.3
    anisole 0.21
    cyclopentyl methyl ether 0.93
    gamma-butyrolactone 3.05
    1-methoxy-2-propanol 11.98
    pyridine 0.82
    3-pentanone 0.5
    furfural 5.91
    n-dodecane 0.04
    diethylene glycol 27.37
    diisopropyl ether 0.1
    tert-amyl alcohol 1.07
    acetylacetone 0.97
    n-hexadecane 0.04
    acetophenone 0.51
    methyl propionate 0.91
    isopentyl acetate 0.15
    trichloroethylene 0.22
    n-nonanol 0.31
    cyclohexanol 1.87
    benzyl alcohol 0.77
    2-ethylhexanol 0.36
    isooctanol 0.37
    dipropyl ether 0.39
    1,2-dichlorobenzene 0.08
    ethyl lactate 1.47
    propylene carbonate 1.05
    n-methylformamide 35.21
    2-pentanol 0.34
    n-pentane 0.08
    1-propoxy-2-propanol 2.46
    1-methoxy-2-propyl acetate 1.04
    2-(2-methoxypropoxy) propanol 2.89
    mesitylene 0.2
    ε-caprolactone 1.77
    p-cymene 0.2
    epichlorohydrin 0.84
    1,1,1-trichloroethane 0.05
    2-aminoethanol 49.5
    morpholine-4-carbaldehyde 58.0
    sulfolane 40.89
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 0.55
    n-hexyl acetate 0.21
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 3.59
    sec-butyl acetate 0.08
    tert-butyl acetate 0.3
    decalin 0.08
    glycerin 242.72
    diglyme 6.82
    acrylic acid 9.42
    isopropyl myristate 0.11
    n-butyric acid 1.45
    acetyl acetate 0.28
    di(2-ethylhexyl) phthalate 0.28
    ethyl propionate 0.21
    nitromethane 10.77
    1,2-diethoxyethane 0.43
    benzonitrile 0.21
    trioctyl phosphate 0.28
    1-bromopropane 0.06
    gamma-valerolactone 8.34
    n-decanol 0.25
    triethyl phosphate 0.5
    4-methyl-2-pentanol 0.23
    propionitrile 0.24
    vinylene carbonate 1.21
    1,1,2-trichlorotrifluoroethane 16.51
    DMS 0.55
    cumene 0.09
    2-octanol 0.27
    2-hexanone 0.14
    octyl acetate 0.17
    limonene 0.38
    1,2-dimethoxyethane 3.18
    ethyl orthosilicate 0.43
    tributyl phosphate 0.23
    diacetone alcohol 2.59
    N,N-dimethylaniline 0.58
    acrylonitrile 0.73
    aniline 0.6
    1,3-propanediol 19.09
    bromobenzene 0.03
    dibromomethane 0.06
    1,1,2,2-tetrachloroethane 0.35
    2-methyl-cyclohexyl acetate 0.29
    tetrabutyl urea 0.68
    diisobutyl methanol 0.29
    2-phenylethanol 0.65
    styrene 0.07
    dioctyl adipate 0.24
    dimethyl sulfate 12.26
    ethyl butyrate 0.26
    methyl lactate 10.5
    butyl lactate 0.81
    diethyl carbonate 0.19
    propanediol butyl ether 4.02
    triethyl orthoformate 0.43
    p-tert-butyltoluene 0.23
    methyl 4-tert-butylbenzoate 1.17
    morpholine 4.08
    tert-butylamine 0.36
    n-dodecanol 0.21
    dimethoxymethane 7.9
    ethylene carbonate 0.8
    cyrene 10.41
    2-ethoxyethyl acetate 0.34
    2-ethylhexyl acetate 0.13
    1,2,4-trichlorobenzene 0.14
    4-methylpyridine 0.45
    dibutyl ether 0.15
    2,6-dimethyl-4-heptanol 0.29
    DEF 4.84
    dimethyl isosorbide 4.21
    tetrachloroethylene 0.45
    eugenol 1.57
    triacetin 0.69
    span 80 2.82
    1,4-butanediol 6.75
    1,1-dichloroethane 0.04
    2-methyl-1-pentanol 0.22
    methyl formate 10.83
    2-methyl-1-butanol 0.49
    n-decane 0.07
    butyronitrile 0.13
    3,7-dimethyl-1-octanol 0.22
    1-chlorooctane 0.09
    1-chlorotetradecane 0.05
    n-nonane 0.08
    undecane 0.05
    tert-butylcyclohexane 0.04
    cyclooctane 0.27
    cyclopentanol 1.85
    tetrahydropyran 0.6
    tert-amyl methyl ether 0.39
    2,5,8-trioxanonane 6.67
    1-hexene 0.05
    2-isopropoxyethanol 2.05
    2,2,2-trifluoroethanol 22.04
    methyl butyrate 0.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction