N-[2-(1H-indol-3-yl)ethyl]tetracosanamide

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  • Identifiers

    CAS number
    152766-94-4

    Molecular formula
    C34H58N2O

    SMILES
    CCCCCCCCCCCCCCCCCCCCCCCC(=O)NCCC1=CNC2=CC=CC=C21

  • Odor profile

    Fragrance
    Waxy 53.54%
    Fatty 39.05%
    Meaty 31.55%
    Odorless 31.16%
    Animal 30.22%
    Savory 29.69%
    Fishy 28.06%
    Oily 25.77%
    Burnt 22.62%
    Cheesy 18.47%

     

    Flavor
    Bland 34.03%
    Mild 29.63%
    Odorless 27.11%
    Faint 24.3%
    Waxy 23.43%
    Slightly waxy 21.53%
    Delicate 20.61%
    Fatty 20.38%
    Bay oil 19.66%
    Diterpene 19.31%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    13.5

    pKa est.
    -260.64 (strong acid)

    Molecular weight
    510.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    878°C

    Melting point expt.

    • 120 - 123 °C

    Flash point

    • -972.98 ˚C est.

  • Synonyms

    • N-Lignoceroyltryptamine
    • N-[2-(1H-indol-3-yl)ethyl]tetracosanamide
    • Nb-Lignoceroyltryptamine
    • 152766-94-4
    • Nb-Tetracosanoyltryptamine
    • CHEMBL492171
    • SCHEMBL17868350
    • CHEBI:166547

  • Applications

    N-[2-(1H-indol-3-yl)ethyl]tetracosanamide (CAS 152766-94-4) is a long-chain amide that can be used as a synthetic intermediate and specialized additive for polymers and cosmetic formulations. Real-world applications may include: serving as a synthetic building block for complex organic molecules in pharmaceuticals, agrochemicals, and materials; acting as a lipid-like additive and surfactant/emulsifier in cosmetics and personal care formulations; functioning as a lubricant or viscosity-modifying additive in polymers, plastics, and coatings; acting as a fragrance component or fixative in perfumery due to the indole moiety; and as a cleaning formulation ingredient to aid wetting and solubilization in specialty cleaners. Use is typically target-specific and subject to local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.92
    methanol 13.12
    isopropanol 5.45
    water 0.59
    ethyl acetate 27.25
    n-propanol 9.87
    acetone 29.2
    n-butanol 10.66
    acetonitrile 5.69
    DMF 42.17
    toluene 9.95
    isobutanol 8.06
    1,4-dioxane 30.23
    methyl acetate 24.33
    THF 85.98
    2-butanone 38.68
    n-pentanol 11.3
    sec-butanol 9.7
    n-hexane 3.17
    ethylene glycol 1.18
    NMP 124.45
    cyclohexane 4.59
    DMSO 44.41
    n-butyl acetate 31.73
    n-octanol 10.56
    chloroform 122.18
    n-propyl acetate 37.39
    acetic acid 23.0
    dichloromethane 115.31
    cyclohexanone 92.76
    propylene glycol 2.54
    isopropyl acetate 23.67
    DMAc 126.6
    2-ethoxyethanol 26.4
    isopentanol 10.84
    n-heptane 2.59
    ethyl formate 20.74
    1,2-dichloroethane 57.9
    n-hexanol 7.98
    2-methoxyethanol 21.84
    isobutyl acetate 26.42
    tetrachloromethane 27.1
    n-pentyl acetate 56.56
    transcutol 86.85
    n-heptanol 12.01
    ethylbenzene 8.89
    MIBK 22.55
    2-propoxyethanol 23.8
    tert-butanol 6.8
    MTBE 16.2
    2-butoxyethanol 35.17
    propionic acid 17.65
    o-xylene 8.67
    formic acid 10.18
    diethyl ether 14.32
    m-xylene 6.9
    p-xylene 13.67
    chlorobenzene 24.52
    dimethyl carbonate 16.18
    n-octane 1.91
    formamide 16.57
    cyclopentanone 99.71
    2-pentanone 31.81
    anisole 19.46
    cyclopentyl methyl ether 35.49
    gamma-butyrolactone 102.47
    1-methoxy-2-propanol 19.23
    pyridine 37.97
    3-pentanone 33.04
    furfural 72.73
    n-dodecane 0.97
    diethylene glycol 9.26
    diisopropyl ether 5.99
    tert-amyl alcohol 12.83
    acetylacetone 42.79
    n-hexadecane 1.11
    acetophenone 34.09
    methyl propionate 27.62
    isopentyl acetate 32.53
    trichloroethylene 110.91
    n-nonanol 12.0
    cyclohexanol 15.09
    benzyl alcohol 14.47
    2-ethylhexanol 9.12
    isooctanol 12.0
    dipropyl ether 16.65
    1,2-dichlorobenzene 29.29
    ethyl lactate 18.04
    propylene carbonate 65.97
    n-methylformamide 19.04
    2-pentanol 7.87
    n-pentane 2.11
    1-propoxy-2-propanol 21.79
    1-methoxy-2-propyl acetate 33.69
    2-(2-methoxypropoxy) propanol 30.42
    mesitylene 4.6
    ε-caprolactone 96.91
    p-cymene 6.88
    epichlorohydrin 89.16
    1,1,1-trichloroethane 55.11
    2-aminoethanol 4.18
    morpholine-4-carbaldehyde 67.13
    sulfolane 147.48
    2,2,4-trimethylpentane 2.21
    2-methyltetrahydrofuran 55.59
    n-hexyl acetate 43.96
    isooctane 0.82
    2-(2-butoxyethoxy)ethanol 36.97
    sec-butyl acetate 29.31
    tert-butyl acetate 29.57
    decalin 2.87
    glycerin 5.08
    diglyme 84.0
    acrylic acid 14.79
    isopropyl myristate 13.69
    n-butyric acid 34.84
    acetyl acetate 19.97
    di(2-ethylhexyl) phthalate 17.49
    ethyl propionate 32.8
    nitromethane 41.3
    1,2-diethoxyethane 40.91
    benzonitrile 14.28
    trioctyl phosphate 12.37
    1-bromopropane 29.73
    gamma-valerolactone 134.32
    n-decanol 7.4
    triethyl phosphate 25.12
    4-methyl-2-pentanol 6.12
    propionitrile 7.93
    vinylene carbonate 53.13
    1,1,2-trichlorotrifluoroethane 74.47
    DMS 30.63
    cumene 7.13
    2-octanol 10.76
    2-hexanone 37.75
    octyl acetate 18.31
    limonene 10.46
    1,2-dimethoxyethane 52.57
    ethyl orthosilicate 25.66
    tributyl phosphate 17.39
    diacetone alcohol 27.72
    N,N-dimethylaniline 15.63
    acrylonitrile 8.43
    aniline 12.01
    1,3-propanediol 8.37
    bromobenzene 23.89
    dibromomethane 63.33
    1,1,2,2-tetrachloroethane 100.98
    2-methyl-cyclohexyl acetate 33.6
    tetrabutyl urea 25.59
    diisobutyl methanol 5.95
    2-phenylethanol 13.09
    styrene 9.83
    dioctyl adipate 26.7
    dimethyl sulfate 40.66
    ethyl butyrate 33.77
    methyl lactate 14.8
    butyl lactate 40.32
    diethyl carbonate 22.29
    propanediol butyl ether 23.0
    triethyl orthoformate 32.68
    p-tert-butyltoluene 5.9
    methyl 4-tert-butylbenzoate 41.5
    morpholine 36.13
    tert-butylamine 4.61
    n-dodecanol 4.95
    dimethoxymethane 29.74
    ethylene carbonate 45.24
    cyrene 38.96
    2-ethoxyethyl acetate 66.75
    2-ethylhexyl acetate 30.72
    1,2,4-trichlorobenzene 37.95
    4-methylpyridine 33.17
    dibutyl ether 20.24
    2,6-dimethyl-4-heptanol 5.95
    DEF 42.72
    dimethyl isosorbide 62.65
    tetrachloroethylene 73.17
    eugenol 39.15
    triacetin 56.33
    span 80 26.52
    1,4-butanediol 5.03
    1,1-dichloroethane 41.48
    2-methyl-1-pentanol 13.68
    methyl formate 17.38
    2-methyl-1-butanol 12.4
    n-decane 2.29
    butyronitrile 9.94
    3,7-dimethyl-1-octanol 9.44
    1-chlorooctane 10.48
    1-chlorotetradecane 3.02
    n-nonane 2.16
    undecane 1.38
    tert-butylcyclohexane 2.24
    cyclooctane 1.6
    cyclopentanol 17.39
    tetrahydropyran 36.34
    tert-amyl methyl ether 18.48
    2,5,8-trioxanonane 47.26
    1-hexene 8.99
    2-isopropoxyethanol 21.01
    2,2,2-trifluoroethanol 18.39
    methyl butyrate 48.08

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction