Myristyl Betaine

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  • Identifiers

    CAS number
    2601-33-4

    Molecular formula
    C18H37NO2

    SMILES
    CCCCCCCCCCCCCC[N+](C)(C)CC(=O)[O-]

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Waxy 67.99%
    Fatty 56.48%
    Oily 34.88%
    Woody 28.0%
    Odorless 25.62%
    Creamy 25.57%
    Floral 24.91%
    Sweet 24.53%
    Animal 24.11%
    Milky 23.75%

     

    Flavor
    Bland 36.03%
    Mild 31.51%
    Odorless 23.17%
    Faint 22.99%
    Waxy 22.3%
    Slightly waxy 22.09%
    Delicate 22.04%
    Bay oil 20.57%
    Beer 19.75%
    Diterpene 19.7%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.2

    pKa est.
    4.26 (weak acid)

    Molecular weight
    299.5 g/mol

    Flash point

    • -59.81 ˚C est.

  • Synonyms

    • 2601-33-4
    • Myristyl betaine
    • 1-Tetradecanaminium, N-(carboxymethyl)-N,N-dimethyl-, inner salt
    • Myristyl dimethyl glycine
    • Myristyl dimethyl betaine
    • (Carboxylatomethyl)dimethyltetradecylammonium
    • 95C19D1X0B
    • EINECS 220-006-9
    • N-TETRADECYL BETAINE
    • 1-Tetradecanaminium, N-(carboxymethyl)-N,N-dimethyl-, hydroxide, inner salt
    • Ammonium, (carboxymethyl)dimethyltetradecyl-, hydroxide, inner salt
    • N-(Carboxymethyl)-N,N-dimethyl-1-tetradecanaminium hydroxide, inner salt
    • RefChem:819753
    • MYRISTYL BETAINE [INCI]
    • N-TETRADECYL-N,N-DIMETHYLGLYCINE
    • 2-[dimethyl(tetradecyl)azaniumyl]acetate
    • (N,N-Dimethylmyristylammonio)acetate
    • 2-(dimethyl(tetradecyl)ammonio)acetate
    • 2-[dimethyl(tetradecyl)ammonio]acetate
    • UNII-95C19D1X0B
    • myristyldimethyl betaine
    • SCHEMBL353921
    • orb2939418
    • DTXSID4041288
    • [Dimethyl(tetradecyl)azaniumyl]acetate
    • HY-W250190
    • MSK162622-100A
    • CS-0310490
    • NS00013877
    • G79000
    • Q27271781
    • (N,N-Dimethylmyristylammonio)acetate, >=97.0% (HPLC)
    • Myristyldimethylglycine Solution in Acetonitrile, 100ug/mL
    • Alkyl carboxymethyl dimethyl ammonium compound C14 (AcMDMAC C14)
    • N-(Carboxymethyl)-N,N-dimethyl-1-tetradecanaminium hydroxide inner salt
    • 2601-33-4

  • Applications

    Myristyl Betaine (CAS 2601-33-4) is a zwitterionic surfactant derived from the myristyl chain. It is commonly used in cosmetics and personal care as a surfactant to boost foaming, cleansing performance, and softness in formulations such as cleansers, shampoos, and skin-care products, often serving as a co-surfactant or stabilizer for emulsions. It is also employed in household and industrial cleaning products as a surface-active agent, emulsifier, and dispersant to enhance cleaning efficiency and formulation stability. In coatings and inks, it can act as a dispersant and emulsifier to improve pigment dispersion and film formation. In pharmaceutical and cosmetic formulations, it may be evaluated as a surface-active excipient or processing aid, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 234.4
    methanol 377.24
    isopropanol 149.8
    water 1.01
    ethyl acetate 127.61
    n-propanol 204.44
    acetone 136.65
    n-butanol 162.17
    acetonitrile 56.36
    DMF 203.68
    toluene 57.43
    isobutanol 142.99
    1,4-dioxane 216.14
    methyl acetate 108.02
    THF 397.6
    2-butanone 125.79
    n-pentanol 101.91
    sec-butanol 130.31
    n-hexane 15.26
    ethylene glycol 51.1
    NMP 455.38
    cyclohexane 54.57
    DMSO 311.22
    n-butyl acetate 154.59
    n-octanol 66.37
    chloroform 576.33
    n-propyl acetate 151.57
    acetic acid 375.0
    dichloromethane 471.85
    cyclohexanone 438.68
    propylene glycol 99.32
    isopropyl acetate 108.16
    DMAc 235.96
    2-ethoxyethanol 189.66
    isopentanol 130.96
    n-heptane 13.45
    ethyl formate 125.83
    1,2-dichloroethane 341.87
    n-hexanol 103.63
    2-methoxyethanol 297.01
    isobutyl acetate 112.17
    tetrachloromethane 130.64
    n-pentyl acetate 187.45
    transcutol 552.49
    n-heptanol 85.64
    ethylbenzene 44.36
    MIBK 97.31
    2-propoxyethanol 203.65
    tert-butanol 165.09
    MTBE 85.42
    2-butoxyethanol 201.45
    propionic acid 213.67
    o-xylene 69.37
    formic acid 173.03
    diethyl ether 71.03
    m-xylene 59.67
    p-xylene 63.37
    chlorobenzene 136.19
    dimethyl carbonate 47.96
    n-octane 7.57
    formamide 186.42
    cyclopentanone 397.69
    2-pentanone 118.92
    anisole 78.73
    cyclopentyl methyl ether 193.65
    gamma-butyrolactone 489.6
    1-methoxy-2-propanol 211.72
    pyridine 194.01
    3-pentanone 98.42
    furfural 376.34
    n-dodecane 4.47
    diethylene glycol 150.2
    diisopropyl ether 32.21
    tert-amyl alcohol 146.68
    acetylacetone 153.81
    n-hexadecane 5.24
    acetophenone 128.45
    methyl propionate 116.35
    isopentyl acetate 142.17
    trichloroethylene 609.66
    n-nonanol 64.02
    cyclohexanol 244.61
    benzyl alcohol 101.13
    2-ethylhexanol 78.13
    isooctanol 78.57
    dipropyl ether 71.42
    1,2-dichlorobenzene 167.56
    ethyl lactate 106.48
    propylene carbonate 287.99
    n-methylformamide 175.48
    2-pentanol 90.44
    n-pentane 13.15
    1-propoxy-2-propanol 170.38
    1-methoxy-2-propyl acetate 156.58
    2-(2-methoxypropoxy) propanol 145.24
    mesitylene 48.17
    ε-caprolactone 409.06
    p-cymene 48.29
    epichlorohydrin 446.6
    1,1,1-trichloroethane 294.98
    2-aminoethanol 143.84
    morpholine-4-carbaldehyde 315.05
    sulfolane 747.61
    2,2,4-trimethylpentane 13.11
    2-methyltetrahydrofuran 270.05
    n-hexyl acetate 180.11
    isooctane 7.68
    2-(2-butoxyethoxy)ethanol 212.82
    sec-butyl acetate 103.38
    tert-butyl acetate 134.17
    decalin 21.19
    glycerin 147.09
    diglyme 346.52
    acrylic acid 181.54
    isopropyl myristate 54.82
    n-butyric acid 317.91
    acetyl acetate 107.24
    di(2-ethylhexyl) phthalate 73.36
    ethyl propionate 108.99
    nitromethane 299.8
    1,2-diethoxyethane 135.65
    benzonitrile 112.29
    trioctyl phosphate 57.45
    1-bromopropane 146.45
    gamma-valerolactone 553.63
    n-decanol 43.48
    triethyl phosphate 80.46
    4-methyl-2-pentanol 62.02
    propionitrile 73.62
    vinylene carbonate 242.67
    1,1,2-trichlorotrifluoroethane 480.31
    DMS 123.5
    cumene 43.04
    2-octanol 59.0
    2-hexanone 110.8
    octyl acetate 78.04
    limonene 75.84
    1,2-dimethoxyethane 220.79
    ethyl orthosilicate 81.59
    tributyl phosphate 68.98
    diacetone alcohol 175.74
    N,N-dimethylaniline 68.11
    acrylonitrile 91.79
    aniline 103.37
    1,3-propanediol 192.57
    bromobenzene 126.84
    dibromomethane 316.58
    1,1,2,2-tetrachloroethane 608.6
    2-methyl-cyclohexyl acetate 145.18
    tetrabutyl urea 87.31
    diisobutyl methanol 47.99
    2-phenylethanol 105.68
    styrene 46.97
    dioctyl adipate 100.25
    dimethyl sulfate 113.21
    ethyl butyrate 122.38
    methyl lactate 100.62
    butyl lactate 178.8
    diethyl carbonate 81.84
    propanediol butyl ether 177.68
    triethyl orthoformate 108.09
    p-tert-butyltoluene 45.7
    methyl 4-tert-butylbenzoate 159.07
    morpholine 325.05
    tert-butylamine 96.69
    n-dodecanol 30.1
    dimethoxymethane 123.02
    ethylene carbonate 215.2
    cyrene 173.17
    2-ethoxyethyl acetate 206.13
    2-ethylhexyl acetate 126.21
    1,2,4-trichlorobenzene 213.42
    4-methylpyridine 151.06
    dibutyl ether 64.78
    2,6-dimethyl-4-heptanol 47.99
    DEF 155.68
    dimethyl isosorbide 265.24
    tetrachloroethylene 463.47
    eugenol 146.12
    triacetin 214.77
    span 80 163.89
    1,4-butanediol 76.46
    1,1-dichloroethane 254.95
    2-methyl-1-pentanol 89.32
    methyl formate 117.67
    2-methyl-1-butanol 128.17
    n-decane 9.32
    butyronitrile 87.06
    3,7-dimethyl-1-octanol 65.89
    1-chlorooctane 49.53
    1-chlorotetradecane 15.78
    n-nonane 8.81
    undecane 6.2
    tert-butylcyclohexane 17.11
    cyclooctane 15.12
    cyclopentanol 248.81
    tetrahydropyran 249.7
    tert-amyl methyl ether 82.32
    2,5,8-trioxanonane 224.7
    1-hexene 42.66
    2-isopropoxyethanol 138.28
    2,2,2-trifluoroethanol 175.08
    methyl butyrate 161.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction