Monobenzone

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  • Identifiers

    CAS number
    103-16-2

    Molecular formula
    C13H12O2

    SMILES
    C1=CC=C(C=C1)COC2=CC=C(C=C2)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 70.79%
    Phenolic 63.37%
    Floral 58.82%
    Balsamic 44.75%
    Spicy 41.55%
    Aromatic 39.93%
    Fruity 38.61%
    Anisic 37.71%
    Medicinal 37.52%
    Vanilla 37.16%

     

    Flavor
    Sweet 71.61%
    Phenolic 53.03%
    Bitter 52.23%
    Floral 44.17%
    Balsam 43.52%
    Powdery 41.71%
    Fruity 37.8%
    Anise 37.42%
    Vanilla 37.27%
    Almond 35.72%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    9.59 (weak base)

    Molecular weight
    200.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    341°C

    Melting point expt.

    • 122 °C
    • 122.5 °C
    • 110 - 118 °C

    Flash point

    • 158.93 ˚C est.

    Solubility expt.

    • 251 mg/L
    • SOLUBILITY IN BOILNG WATER ABOUT 1.0 G/100 ML; SOL IN ALC, ETHER, BENZENE
    • INSOL IN WATER
    • FREELY SOL IN ACETONE
    • Practically insoluble in petroleum hydrocarbons, very soluble in benzene and alkalies.
    • 3.92e-02 g/L

  • Synonyms

    • Monobenzone
    • 4-Benzyloxyphenol
    • 103-16-2
    • 4-(Benzyloxy)phenol
    • Hydroquinone monobenzyl ether
    • Benoquin
    • P-(BENZYLOXY)PHENOL
    • Benzoquin
    • Monobenzyl hydroquinone
    • Hydroquinone benzyl ether
    • Leucodinine
    • Monobenzon
    • Superlite
    • Agerite alba
    • 4-(Phenylmethoxy)phenol
    • p-Hydroxyphenyl benzyl ether
    • Dermochinona
    • Carmifal
    • Depigman
    • Pigmex
    • Benzyl p-hydroxyphenyl ether
    • Monobenzyl ether hydroquinone
    • Alba-Dome
    • Monobenzona
    • 4-(Benzyloxyl)phenol
    • Agerite
    • Benzyl hydroquinone
    • Phenol, 4-(phenylmethoxy)-
    • Monobenzonum
    • Monobenzone [INN]
    • 4-phenylmethoxyphenol
    • Monobenzonum [INN-Latin]
    • Monobenzona [INN-Spanish]
    • Superlite (antioxidant)
    • P-BENZYLOXYPHENOL
    • Monobenzyl Ether of Hydroquinone
    • Alba
    • Hydrochinon monobenzylether [Czech]
    • Phenol, p-(benzyloxy)-
    • Hydrochinon monobenzylether
    • 4-Benzyloxy-phenol
    • 4-phenylmethoxy-phenol
    • MFCD00002333
    • NSC 2132
    • NSC-2132
    • 9L2KA76MG5
    • CHEBI:34380
    • Monobenzone (Benoquin)
    • 4-benzyloxy phenol
    • PBP
    • DTXSID2020717
    • NSC33918
    • NCGC00016360-01
    • CAS-103-16-2
    • WLN: QR DO1R
    • MONOBENZONE (MART.)
    • MONOBENZONE [MART.]
    • MONOBENZONE (USP-RS)
    • MONOBENZONE [USP-RS]
    • DTXCID00717
    • MONOBENZONE (USP MONOGRAPH)
    • MONOBENZONE [USP MONOGRAPH]
    • Benoquin (TN)
    • HSDB 4019
    • SR-05000001819
    • Monobenzone (USP/INN)
    • Monobenzone [USP:INN]
    • EINECS 203-083-3
    • BRN 1958305
    • UNII-9L2KA76MG5
    • 4-benzoxyphenol
    • AI3-14325
    • Hydroquinone Monobenzylether; 4-Benzyloxyphenol; 4-(Benzyloxy)phenol
    • 4-benzyloxylphenol
    • p-benzyloxy phenol
    • p-benzyloxy-phenol
    • Monobenzone, USP
    • 4(benzyloxy)phenol
    • (p)-Benzyloxyphenol
    • MBEH
    • 4-(benzyloxy)-phenol
    • para-(Benzyloxy)phenol
    • Monobenzone (Standard)
    • MONOBENZONE [MI]
    • Prestwick0_000912
    • Prestwick1_000912
    • Prestwick2_000912
    • Prestwick3_000912
    • MONOBENZONE [HSDB]
    • MONOBENZONE [VANDF]
    • CHEMBL1388
    • Oprea1_698781
    • SCHEMBL35631
    • BSPBio_000784
    • MONOBENZONE [WHO-DD]
    • Monobenzone;4-Benzyloxyphenol
    • 4-(Benzyloxy)phenol, 98%
    • 4-06-00-05728 (Beilstein Handbook Reference)
    • BIDD:ER0003
    • SPBio_002973
    • BPBio1_000864
    • GTPL6830
    • 4-(Benzyloxy)phenol, >=99%
    • D11AX13
    • MONOBENZONE [ORANGE BOOK]
    • NSC2132
    • HMS1570H06
    • HMS1580P12
    • HMS2097H06
    • HMS3655K15
    • HMS3714H06
    • Pharmakon1600-01503031
    • 4-(Benzyloxy)phenol (Monobenzone)
    • BCP09974
    • CS-B0870
    • Tox21_110396
    • Tox21_201147
    • 4-(Benzyloxy)phenol; Hydroquinone monobenzyl ether; PBP; Monobenzone
    • BDBM50410520
    • HY-30272R
    • NSC-33918
    • NSC758211
    • s1652
    • STL283939
    • AKOS000119555
    • Tox21_110396_1
    • AC-2492
    • CCG-213094

  • Applications

    Monobenzone (CAS 103-16-2) is primarily used as a topical depigmenting agent in dermatology, providing an irreversible reduction of melanin synthesis for vitiligo patients and formulated in prescription creams under medical supervision. In cosmetics and personal care, it may appear in controlled skin-lightening formulations, subject to strict regulatory and safety requirements. In research and development, monobenzone is evaluated to understand pigment biosynthesis and tyrosinase inhibition mechanisms, supporting the development of assessment methods and safety evaluations for depigmenting actives. In the chemical industry, it may be used as a precursor or intermediate in specialized dye- and pigment-related syntheses, depending on application scope and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 267.7
    methanol 360.18
    isopropanol 124.32
    water 0.1
    ethyl acetate 768.04
    n-propanol 165.82
    acetone 0.14
    n-butanol 102.96
    acetonitrile 279.74
    DMF 0.29
    toluene 25.29
    isobutanol 43.6
    1,4-dioxane 536.57
    methyl acetate 101.33
    THF 73.46
    2-butanone 12.93
    n-pentanol 91.49
    sec-butanol 120.71
    n-hexane 2.18
    ethylene glycol 41.91
    NMP 0.29
    cyclohexane 4.82
    DMSO 22.13
    n-butyl acetate 72.14
    n-octanol 19.12
    chloroform 168.71
    n-propyl acetate 76.63
    acetic acid 76.63
    dichloromethane 150.97
    cyclohexanone 5.93
    propylene glycol 83.37
    isopropyl acetate 129.76
    DMAc 5.13
    2-ethoxyethanol 297.76
    isopentanol 59.77
    n-heptane 5.26
    ethyl formate 42.74
    1,2-dichloroethane 87.48
    n-hexanol 60.02
    2-methoxyethanol 248.05
    isobutyl acetate 34.55
    tetrachloromethane 8.14
    n-pentyl acetate 25.53
    transcutol 1074.9
    n-heptanol 21.16
    ethylbenzene 23.76
    MIBK 20.96
    2-propoxyethanol 163.86
    tert-butanol 83.65
    MTBE 77.87
    2-butoxyethanol 63.78
    propionic acid 76.35
    o-xylene 15.66
    formic acid 42.38
    diethyl ether 307.41
    m-xylene 15.81
    p-xylene 13.46
    chlorobenzene 14.87
    dimethyl carbonate 18.8
    n-octane 2.3
    formamide 82.66
    cyclopentanone 2.58
    2-pentanone 10.35
    anisole 91.5
    cyclopentyl methyl ether 20.63
    gamma-butyrolactone 10.3
    1-methoxy-2-propanol 171.53
    pyridine 87.53
    3-pentanone 16.13
    furfural 29.76
    n-dodecane 2.47
    diethylene glycol 148.92
    diisopropyl ether 40.09
    tert-amyl alcohol 90.16
    acetylacetone 23.48
    n-hexadecane 2.69
    acetophenone 31.92
    methyl propionate 86.92
    isopentyl acetate 62.03
    trichloroethylene 110.26
    n-nonanol 20.96
    cyclohexanol 27.26
    benzyl alcohol 42.77
    2-ethylhexanol 33.59
    isooctanol 18.33
    dipropyl ether 78.51
    1,2-dichlorobenzene 19.15
    ethyl lactate 35.55
    propylene carbonate 18.88
    n-methylformamide 5.75
    2-pentanol 77.84
    n-pentane 2.54
    1-propoxy-2-propanol 104.36
    1-methoxy-2-propyl acetate 111.12
    2-(2-methoxypropoxy) propanol 120.36
    mesitylene 10.36
    ε-caprolactone 23.72
    p-cymene 15.26
    epichlorohydrin 88.96
    1,1,1-trichloroethane 42.02
    2-aminoethanol 124.2
    morpholine-4-carbaldehyde 18.59
    sulfolane 6.69
    2,2,4-trimethylpentane 3.56
    2-methyltetrahydrofuran 46.15
    n-hexyl acetate 37.41
    isooctane 2.9
    2-(2-butoxyethoxy)ethanol 179.09
    sec-butyl acetate 71.99
    tert-butyl acetate 90.42
    decalin 4.47
    glycerin 86.34
    diglyme 329.39
    acrylic acid 41.85
    isopropyl myristate 26.51
    n-butyric acid 109.96
    acetyl acetate 157.76
    di(2-ethylhexyl) phthalate 20.99
    ethyl propionate 112.02
    nitromethane 47.7
    1,2-diethoxyethane 339.53
    benzonitrile 31.72
    trioctyl phosphate 11.46
    1-bromopropane 55.96
    gamma-valerolactone 15.52
    n-decanol 16.72
    triethyl phosphate 34.04
    4-methyl-2-pentanol 40.29
    propionitrile 163.53
    vinylene carbonate 25.09
    1,1,2-trichlorotrifluoroethane 75.08
    DMS 49.64
    cumene 15.25
    2-octanol 12.97
    2-hexanone 22.38
    octyl acetate 24.98
    limonene 15.91
    1,2-dimethoxyethane 218.14
    ethyl orthosilicate 39.59
    tributyl phosphate 18.47
    diacetone alcohol 64.95
    N,N-dimethylaniline 29.96
    acrylonitrile 111.87
    aniline 31.3
    1,3-propanediol 150.96
    bromobenzene 17.16
    dibromomethane 85.67
    1,1,2,2-tetrachloroethane 100.42
    2-methyl-cyclohexyl acetate 40.33
    tetrabutyl urea 16.85
    diisobutyl methanol 30.52
    2-phenylethanol 47.87
    styrene 26.66
    dioctyl adipate 46.39
    dimethyl sulfate 10.53
    ethyl butyrate 88.07
    methyl lactate 37.37
    butyl lactate 24.16
    diethyl carbonate 65.97
    propanediol butyl ether 56.09
    triethyl orthoformate 61.63
    p-tert-butyltoluene 15.32
    methyl 4-tert-butylbenzoate 46.91
    morpholine 345.45
    tert-butylamine 46.52
    n-dodecanol 14.23
    dimethoxymethane 31.9
    ethylene carbonate 26.22
    cyrene 33.41
    2-ethoxyethyl acetate 89.03
    2-ethylhexyl acetate 45.14
    1,2,4-trichlorobenzene 22.66
    4-methylpyridine 17.83
    dibutyl ether 55.42
    2,6-dimethyl-4-heptanol 30.52
    DEF 13.35
    dimethyl isosorbide 143.62
    tetrachloroethylene 58.59
    eugenol 51.09
    triacetin 68.24
    span 80 60.12
    1,4-butanediol 50.37
    1,1-dichloroethane 36.42
    2-methyl-1-pentanol 67.91
    methyl formate 3.54
    2-methyl-1-butanol 55.36
    n-decane 3.73
    butyronitrile 91.8
    3,7-dimethyl-1-octanol 32.37
    1-chlorooctane 13.41
    1-chlorotetradecane 7.34
    n-nonane 3.12
    undecane 2.86
    tert-butylcyclohexane 4.95
    cyclooctane 2.24
    cyclopentanol 10.83
    tetrahydropyran 136.02
    tert-amyl methyl ether 77.86
    2,5,8-trioxanonane 257.5
    1-hexene 15.19
    2-isopropoxyethanol 143.93
    2,2,2-trifluoroethanol 17.06
    methyl butyrate 58.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction