Methylglucamine hydrochloride

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  • Identifiers

    CAS number
    35564-86-4

    Molecular formula
    C7H18ClNO5

    SMILES
    CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.Cl

    Safety labels

  • Odor profile

    Fragrance
    Odorless 68.75%
    Sweet 39.83%
    Fishy 30.97%
    Alcoholic 22.89%
    Savory 20.08%
    Cooling 18.51%
    Oily 15.66%
    Bitter 15.62%
    Buttery 13.71%
    Ripe 13.25%

     

    Flavor
    Odorless 71.34%
    Sweet 53.3%
    Sweet-like 32.75%
    Bland 22.95%
    Mild 22.87%
    Very slight 22.02%
    Very mild 21.49%
    Bitter 19.63%
    Cauliflower 19.3%
    Soup 19.16%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.14 (neutral)

    Molecular weight
    231.67 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    640°C

    Flash point

    • 221.13 ˚C est.

  • Synonyms

    • N-Methyl-D-glucamine Hydrochloride
    • 35564-86-4
    • meglumine hydrochloride
    • Methylglucamine hydrochloride
    • Methylglucamine HCl
    • Methylglucamine chloride
    • n-methylglucamine hydrochloride
    • N-Methyl glucamine hydrochloride
    • D-(-)-N-Methylglucaminium chloride
    • 2IG86HL9XM
    • Methylglucamine HCl [INCI]
    • D-Glucitol, 1-deoxy-1-(methylamino)-, hydrochloride
    • D-Glucitol, 1-deoxy-1-(methylamino)-, hydrochloride (1:1)
    • RefChem:818611
    • 927-938-1
    • N-Methyl-d-glucamine HCl
    • MFCD00060164
    • N-Methyl-D-glucamine Hydrochloride [for Buffer]
    • (2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol hydrochloride
    • (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol;hydrochloride
    • C7H18ClNO5
    • N-Methyl-D-glucamine HCI
    • UNII-2IG86HL9XM
    • SCHEMBL437869
    • (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol hydrochloride
    • PKPZZAVJXDZHDW-LJTMIZJLSA-N
    • N-methyl d-glucamine hydrochloride
    • AKOS027321018
    • MM07028
    • AS-49765
    • SY110501
    • DB-244492
    • CS-0151044
    • M0713
    • N10394
    • F046848
    • Q27254785
    • D-Glucitol,1-deoxy-1-(methylamino)-, hydrochloride (9CI)
    • 1-Deoxy-1-(methylamino)-D-glucitol hydrochloride, AldrichCPR
    • 35564-86-4

  • Applications

    Methylglucamine hydrochloride (CAS 35564-86-4) is used in pharmaceutical formulations as a buffering agent and solubilizer by forming meglumine salts to enhance the water solubility and stability of acidic active ingredients. It also serves as the meglumine salt used to prepare iodinated meglumine salts for contrast agents in diagnostic imaging. In cosmetics and personal care, it can function as a buffering or stabilizing excipient in formulations. In industrial manufacturing, it can act as an intermediate or precursor for synthesizing other meglumine salts and related compounds. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.57
    methanol 7.23
    isopropanol 0.19
    water 1656.89
    ethyl acetate 0.19
    n-propanol 0.52
    acetone 0.1
    n-butanol 0.3
    acetonitrile 0.16
    DMF 30.62
    toluene 0.05
    isobutanol 0.29
    1,4-dioxane 0.86
    methyl acetate 0.15
    THF 0.5
    2-butanone 0.14
    n-pentanol 0.13
    sec-butanol 0.33
    n-hexane 0.03
    ethylene glycol 117.74
    NMP 68.99
    cyclohexane 0.21
    DMSO 77.62
    n-butyl acetate 0.17
    n-octanol 0.28
    chloroform 0.08
    n-propyl acetate 0.1
    acetic acid 13.21
    dichloromethane 0.09
    cyclohexanone 1.01
    propylene glycol 29.28
    isopropyl acetate 0.14
    DMAc 21.98
    2-ethoxyethanol 3.58
    isopentanol 0.21
    n-heptane 0.14
    ethyl formate 0.35
    1,2-dichloroethane 0.12
    n-hexanol 0.44
    2-methoxyethanol 13.62
    isobutyl acetate 0.06
    tetrachloromethane 0.12
    n-pentyl acetate 0.15
    transcutol 5.36
    n-heptanol 0.48
    ethylbenzene 0.05
    MIBK 0.13
    2-propoxyethanol 3.36
    tert-butanol 0.38
    MTBE 0.09
    2-butoxyethanol 2.14
    propionic acid 3.52
    o-xylene 0.15
    formic acid 484.18
    diethyl ether 0.08
    m-xylene 0.1
    p-xylene 0.06
    chlorobenzene 0.04
    dimethyl carbonate 1.11
    n-octane 0.06
    formamide 143.29
    cyclopentanone 1.12
    2-pentanone 0.13
    anisole 0.11
    cyclopentyl methyl ether 0.56
    gamma-butyrolactone 2.8
    1-methoxy-2-propanol 5.37
    pyridine 0.37
    3-pentanone 0.26
    furfural 5.16
    n-dodecane 0.03
    diethylene glycol 23.68
    diisopropyl ether 0.06
    tert-amyl alcohol 0.59
    acetylacetone 0.48
    n-hexadecane 0.03
    acetophenone 0.33
    methyl propionate 0.65
    isopentyl acetate 0.16
    trichloroethylene 0.18
    n-nonanol 0.27
    cyclohexanol 1.27
    benzyl alcohol 0.49
    2-ethylhexanol 0.34
    isooctanol 0.37
    dipropyl ether 0.23
    1,2-dichlorobenzene 0.09
    ethyl lactate 1.48
    propylene carbonate 1.32
    n-methylformamide 13.61
    2-pentanol 0.2
    n-pentane 0.04
    1-propoxy-2-propanol 2.07
    1-methoxy-2-propyl acetate 0.89
    2-(2-methoxypropoxy) propanol 2.31
    mesitylene 0.13
    ε-caprolactone 1.68
    p-cymene 0.19
    epichlorohydrin 0.56
    1,1,1-trichloroethane 0.04
    2-aminoethanol 36.54
    morpholine-4-carbaldehyde 29.37
    sulfolane 32.29
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 0.35
    n-hexyl acetate 0.2
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 2.91
    sec-butyl acetate 0.08
    tert-butyl acetate 0.24
    decalin 0.06
    glycerin 210.95
    diglyme 4.53
    acrylic acid 9.95
    isopropyl myristate 0.1
    n-butyric acid 1.67
    acetyl acetate 0.27
    di(2-ethylhexyl) phthalate 0.38
    ethyl propionate 0.18
    nitromethane 5.73
    1,2-diethoxyethane 0.22
    benzonitrile 0.16
    trioctyl phosphate 0.34
    1-bromopropane 0.04
    gamma-valerolactone 5.04
    n-decanol 0.21
    triethyl phosphate 0.55
    4-methyl-2-pentanol 0.16
    propionitrile 0.14
    vinylene carbonate 1.28
    1,1,2-trichlorotrifluoroethane 16.49
    DMS 0.5
    cumene 0.07
    2-octanol 0.23
    2-hexanone 0.08
    octyl acetate 0.15
    limonene 0.3
    1,2-dimethoxyethane 1.22
    ethyl orthosilicate 0.47
    tributyl phosphate 0.3
    diacetone alcohol 1.73
    N,N-dimethylaniline 0.32
    acrylonitrile 0.42
    aniline 0.26
    1,3-propanediol 12.58
    bromobenzene 0.03
    dibromomethane 0.06
    1,1,2,2-tetrachloroethane 0.31
    2-methyl-cyclohexyl acetate 0.32
    tetrabutyl urea 0.58
    diisobutyl methanol 0.3
    2-phenylethanol 0.58
    styrene 0.04
    dioctyl adipate 0.24
    dimethyl sulfate 6.83
    ethyl butyrate 0.23
    methyl lactate 7.43
    butyl lactate 0.93
    diethyl carbonate 0.19
    propanediol butyl ether 3.85
    triethyl orthoformate 0.4
    p-tert-butyltoluene 0.21
    methyl 4-tert-butylbenzoate 1.14
    morpholine 1.75
    tert-butylamine 0.15
    n-dodecanol 0.16
    dimethoxymethane 1.98
    ethylene carbonate 0.86
    cyrene 10.49
    2-ethoxyethyl acetate 0.29
    2-ethylhexyl acetate 0.15
    1,2,4-trichlorobenzene 0.15
    4-methylpyridine 0.18
    dibutyl ether 0.09
    2,6-dimethyl-4-heptanol 0.3
    DEF 2.28
    dimethyl isosorbide 4.41
    tetrachloroethylene 0.52
    eugenol 1.69
    triacetin 0.74
    span 80 3.16
    1,4-butanediol 4.74
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 0.15
    methyl formate 4.32
    2-methyl-1-butanol 0.34
    n-decane 0.05
    butyronitrile 0.08
    3,7-dimethyl-1-octanol 0.22
    1-chlorooctane 0.07
    1-chlorotetradecane 0.04
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.03
    cyclooctane 0.14
    cyclopentanol 1.53
    tetrahydropyran 0.28
    tert-amyl methyl ether 0.21
    2,5,8-trioxanonane 4.69
    1-hexene 0.03
    2-isopropoxyethanol 1.21
    2,2,2-trifluoroethanol 25.87
    methyl butyrate 0.25

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction