Methylene chloride-d2

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  • Identifiers

    CAS number
    1665-00-5

    Molecular formula
    CH2Cl2

    SMILES
    [2H]C([2H])(Cl)Cl

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 44.62%
    Sweet 28.75%
    Floral 26.34%
    Fishy 22.28%
    Balsamic 21.92%
    Woody 21.52%
    Fresh 18.93%
    Animal 17.94%
    Clean 17.76%
    Citrus 17.4%

     

    Flavor
    Odorless 40.28%
    Sulfurous 21.18%
    Sulfury 20.3%
    Meaty 18.85%
    Bloody 18.45%
    Rotten 18.43%
    Glue 18.43%
    Mild 18.26%
    Mousy 18.06%
    Sweet-like 17.94%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    17.92 (strong base)

    Molecular weight
    86.94 g/mol

    Flash point

    • -7.57 ˚C est.

  • Synonyms

    • Dichloromethane-d2
    • 1665-00-5
    • Methylene chloride-D2
    • dichloro(dideuterio)methane
    • Dichloro(2H2)methane
    • Methane-d2, dichloro- (6CI,7CI,8CI,9CI)
    • Methane-d2, dichloro-
    • Dideuteromethylenechloride
    • Deuterated dichloromethane
    • methylene-d2 chloride
    • CD2Cl2
    • EINECS 216-776-0
    • MFCD00000882
    • Dichloromethane-d2 100 |Ig/mL in methanol
    • Dideuteromethylene Chloride
    • Dichloromethane-d2, 99.9 atom % D
    • Dichloromethane-d2, "100%", 99.96 atom % D
    • Dichloromethane, deuterated
    • Solaesthind2
    • Solmethined2
    • Narkotild2
    • Dichloromethaned2
    • Aerothene MMd2
    • Methane dichlorided2
    • Methaned2, dichloro
    • DCMd2
    • Freon 30d2
    • Methylene bichlorided2
    • Methylene dichlorided2
    • Dichlorodideuteriomethane
    • Methane-D2-, dichloro-
    • Methane-d2, dichloro-(6CI,7CI,8CI,9CI)
    • CD2C12
    • HY-E0080A
    • DTXSID80937204
    • CHEBI:193042
    • Methylene Chloride D2 >99.6%
    • AKOS015904236
    • Dichloromethane-d2, 99.5 atom % D
    • Dichloromethane-d2, 100.0 atom % D
    • AS-75499
    • FD167523
    • DB-320118
    • CS-0850475
    • D3529
    • D3569
    • Dichloromethane-d2, cont. 0,03 v/v% TMS
    • Dichloromethane D2 100 microg/mL in Methanol
    • D90197
    • Methylene chloride-D2 (D, 99.8%) reagent grade
    • Q1101325
    • Dichloromethane-d2, 99.5 atom % D, contains 1 % (v/v) TMS
    • Dichloromethane-d2, 99.9 atom % D, contains 0.1 % (v/v) TMS
    • Dichloromethane-d2, >=99.5 atom % D, contains 0.03 % (v/v) TMS
    • 216-776-0

  • Applications

    Methylene chloride-d2, CAS 1665-00-5, is primarily used as a deuterated solvent for nuclear magnetic resonance (NMR) spectroscopy in research and development, providing clear spectral data for organic compounds. It is also employed as a solvent for analytical sample preparation and as a reaction medium in small-scale organic synthesis in laboratory settings. Its deuterium content makes it useful in isotopic labeling and mechanistic studies in chemical research. It can also serve as an inert solvent in certain laboratory workflows, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 147.04
    methanol 144.47
    isopropanol 115.65
    water 10.91
    ethyl acetate 103.38
    n-propanol 113.37
    acetone 244.66
    n-butanol 117.58
    acetonitrile 178.26
    DMF 324.56
    toluene 87.64
    isobutanol 87.93
    1,4-dioxane 222.03
    methyl acetate 131.87
    THF 278.69
    2-butanone 162.09
    n-pentanol 84.59
    sec-butanol 112.48
    n-hexane 43.96
    ethylene glycol 60.27
    NMP 346.8
    cyclohexane 97.32
    DMSO 367.49
    n-butyl acetate 114.62
    n-octanol 77.7
    chloroform 329.06
    n-propyl acetate 98.79
    acetic acid 201.82
    dichloromethane 291.8
    cyclohexanone 244.33
    propylene glycol 47.35
    isopropyl acetate 73.24
    DMAc 272.21
    2-ethoxyethanol 132.5
    isopentanol 95.03
    n-heptane 68.9
    ethyl formate 88.1
    1,2-dichloroethane 194.54
    n-hexanol 89.13
    2-methoxyethanol 190.14
    isobutyl acetate 64.77
    tetrachloromethane 111.87
    n-pentyl acetate 87.02
    transcutol 343.15
    n-heptanol 67.02
    ethylbenzene 56.17
    MIBK 80.45
    2-propoxyethanol 129.76
    tert-butanol 136.91
    MTBE 123.58
    2-butoxyethanol 103.43
    propionic acid 100.81
    o-xylene 89.95
    formic acid 92.26
    diethyl ether 145.75
    m-xylene 67.31
    p-xylene 84.02
    chlorobenzene 108.56
    dimethyl carbonate 55.21
    n-octane 26.35
    formamide 138.73
    cyclopentanone 247.25
    2-pentanone 134.22
    anisole 106.11
    cyclopentyl methyl ether 160.98
    gamma-butyrolactone 211.96
    1-methoxy-2-propanol 135.38
    pyridine 212.74
    3-pentanone 121.02
    furfural 220.68
    n-dodecane 17.3
    diethylene glycol 115.56
    diisopropyl ether 57.22
    tert-amyl alcohol 121.82
    acetylacetone 134.17
    n-hexadecane 19.01
    acetophenone 119.67
    methyl propionate 99.66
    isopentyl acetate 96.62
    trichloroethylene 326.75
    n-nonanol 67.66
    cyclohexanol 159.48
    benzyl alcohol 91.53
    2-ethylhexanol 76.91
    isooctanol 56.88
    dipropyl ether 122.17
    1,2-dichlorobenzene 112.59
    ethyl lactate 53.56
    propylene carbonate 114.57
    n-methylformamide 139.62
    2-pentanol 94.86
    n-pentane 57.88
    1-propoxy-2-propanol 118.72
    1-methoxy-2-propyl acetate 94.14
    2-(2-methoxypropoxy) propanol 107.53
    mesitylene 50.9
    ε-caprolactone 178.06
    p-cymene 67.01
    epichlorohydrin 203.04
    1,1,1-trichloroethane 208.09
    2-aminoethanol 79.13
    morpholine-4-carbaldehyde 276.63
    sulfolane 280.06
    2,2,4-trimethylpentane 28.18
    2-methyltetrahydrofuran 219.49
    n-hexyl acetate 102.16
    isooctane 18.09
    2-(2-butoxyethoxy)ethanol 133.75
    sec-butyl acetate 65.65
    tert-butyl acetate 86.58
    decalin 34.96
    glycerin 75.49
    diglyme 266.72
    acrylic acid 103.35
    isopropyl myristate 54.64
    n-butyric acid 119.65
    acetyl acetate 74.61
    di(2-ethylhexyl) phthalate 50.36
    ethyl propionate 75.59
    nitromethane 252.27
    1,2-diethoxyethane 155.47
    benzonitrile 118.39
    trioctyl phosphate 41.81
    1-bromopropane 143.55
    gamma-valerolactone 238.7
    n-decanol 53.07
    triethyl phosphate 59.74
    4-methyl-2-pentanol 54.0
    propionitrile 113.24
    vinylene carbonate 107.31
    1,1,2-trichlorotrifluoroethane 195.53
    DMS 74.43
    cumene 47.94
    2-octanol 56.97
    2-hexanone 113.98
    octyl acetate 64.8
    limonene 103.66
    1,2-dimethoxyethane 227.88
    ethyl orthosilicate 62.57
    tributyl phosphate 49.06
    diacetone alcohol 106.55
    N,N-dimethylaniline 104.81
    acrylonitrile 134.4
    aniline 107.42
    1,3-propanediol 103.38
    bromobenzene 102.82
    dibromomethane 237.17
    1,1,2,2-tetrachloroethane 266.8
    2-methyl-cyclohexyl acetate 83.19
    tetrabutyl urea 77.4
    diisobutyl methanol 61.67
    2-phenylethanol 88.72
    styrene 71.59
    dioctyl adipate 76.83
    dimethyl sulfate 98.38
    ethyl butyrate 102.15
    methyl lactate 63.99
    butyl lactate 70.51
    diethyl carbonate 68.89
    propanediol butyl ether 97.11
    triethyl orthoformate 84.08
    p-tert-butyltoluene 63.95
    methyl 4-tert-butylbenzoate 109.46
    morpholine 244.07
    tert-butylamine 106.89
    n-dodecanol 45.26
    dimethoxymethane 158.54
    ethylene carbonate 91.23
    cyrene 117.03
    2-ethoxyethyl acetate 98.06
    2-ethylhexyl acetate 89.34
    1,2,4-trichlorobenzene 133.54
    4-methylpyridine 193.69
    dibutyl ether 98.1
    2,6-dimethyl-4-heptanol 61.67
    DEF 192.47
    dimethyl isosorbide 164.04
    tetrachloroethylene 231.28
    eugenol 105.64
    triacetin 103.54
    span 80 100.29
    1,4-butanediol 53.13
    1,1-dichloroethane 182.14
    2-methyl-1-pentanol 76.39
    methyl formate 108.99
    2-methyl-1-butanol 94.5
    n-decane 27.65
    butyronitrile 111.23
    3,7-dimethyl-1-octanol 70.34
    1-chlorooctane 67.88
    1-chlorotetradecane 33.48
    n-nonane 29.97
    undecane 20.65
    tert-butylcyclohexane 30.68
    cyclooctane 37.68
    cyclopentanol 149.73
    tetrahydropyran 221.16
    tert-amyl methyl ether 116.72
    2,5,8-trioxanonane 191.08
    1-hexene 80.58
    2-isopropoxyethanol 103.23
    2,2,2-trifluoroethanol 98.16
    methyl butyrate 104.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Carob bean extract 1 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.01%