methyl (S)-lactate

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  • Identifiers

    CAS number
    27871-49-4

    Molecular formula
    C4H8O3

    SMILES
    C[C@@H](C(=O)OC)O

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Caramellic 75.01%
    Buttery 59.44%
    Ethereal 55.55%
    Sweet 49.8%
    Fruity 46.28%
    Milky 41.74%
    Rummy 41.64%
    Winey 39.86%
    Burnt 36.88%
    Creamy 36.38%

     

    Flavor
    Fruity 83.71%
    Creamy 53.14%
    Sweet 46.3%
    Buttery 45.3%
    Butter 37.49%
    Fruit 33.04%
    Grape 32.44%
    Fatty 30.57%
    Tropical 30.19%
    Berry 29.63%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -0.1

    pKa est.
    6.59 (neutral)

    Molecular weight
    104.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    144°C

    Flash point

    • 49.42 ˚C est.

  • Synonyms

    • 27871-49-4
    • Methyl (S)-(-)-lactate
    • Methyl L-lactate
    • (S)-Methyl lactate
    • (-)-Methyl L-lactate
    • Methyl (S)-2-hydroxypropionate
    • (-)-Methyl lactate
    • methyl (2S)-2-hydroxypropanoate
    • (S)-Lactic acid methyl ester
    • L-Methyl Lactate
    • Methyl L-(-)-Lactate
    • (S)-methyl 2-hydroxypropanoate
    • methyl (S)-lactate
    • Methyl lactate, L-
    • Propanoic acid, 2-hydroxy-, methyl ester, (2S)-
    • (-)-Lactic acid methyl ester
    • Methyl (S)-2-hydroxypropanoate
    • (S)-(-)-methyl lactate
    • methyl (2S)-lactate
    • (-)-2-Hydroxypropionic acid methyl ester
    • Lactic acid, methyl ester, L-
    • L-lactate methyl ester
    • (S)-(-)-Lactic acid methyl ester
    • EINECS 248-704-9
    • L-lactic acid methyl ester
    • methyl (-)-(s)-lactate
    • Propanoic acid, 2-hydroxy-, methyl ester, (S)-
    • DTXSID9074359
    • METHYL LACTATE, (-)-
    • CHEBI:83222
    • methyl (2S)-2-hydroxypropionate
    • EC 248-704-9
    • MFCD00064265
    • 0379G9C44S
    • (-)-2-hydroxypropanoic acid methyl ester
    • UNII-0379G9C44S
    • (-)-methyl-l-lactate
    • methyl(-)-(S)-lactate
    • Methyl(S)-(-)-lactate
    • methyl-(S)-(-)-lactate
    • SCHEMBL65010
    • (S)-methyl2-hydroxypropanoate
    • (S)-lactic acid, methyl ester
    • CS-WAA0219
    • DTXCID4037740
    • L-(-)-Lactic Acid Methyl Ester
    • (S)-(+)-lactic acid methyl ester
    • (S)-(+)- lactic acid methyl ester
    • AKOS024437765
    • FM14250
    • AS-10665
    • (2S)-2-Hydroxypropionic acid methyl ester
    • DB-003713
    • L0163
    • EN300-153431
    • (-)-Methyl L-lactate, analytical reference material
    • Q27156697
    • Methyl (S)-(-)-lactate;L-(-)-Lactic Acid Methyl Ester
    • (-)-Methyl L-lactate, 98%, optical purity ee: 97% (GLC)

  • Applications

    Methyl (S)-lactate, CAS 27871-49-4, is used as a renewable solvent in industrial manufacturing, including coatings, inks, adhesives, and cleaning formulations. It also serves as an enantioenriched intermediate or building block in the synthesis of pharmaceutical compounds. In perfumery and flavor applications, it functions as a solvent and carrier for fragrance and flavor ingredients. In cosmetics and personal care, it provides a solvent base and formulation aid. As a processing aid for biodegradable polymers such as polylactic acid, it can act as a plasticizer or co-solvent to improve flexibility and processability. It is also considered for sustainable processing and formulation in electronics cleaning and related industries.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 773.17
    methanol 1743.1
    isopropanol 427.36
    water 599.29
    ethyl acetate 153.7
    n-propanol 471.77
    acetone 407.66
    n-butanol 372.18
    acetonitrile 368.67
    DMF 855.36
    toluene 25.5
    isobutanol 301.07
    1,4-dioxane 440.77
    methyl acetate 192.67
    THF 394.95
    2-butanone 209.16
    n-pentanol 253.42
    sec-butanol 321.1
    n-hexane 17.01
    ethylene glycol 573.12
    NMP 474.74
    cyclohexane 24.33
    DMSO 1204.33
    n-butyl acetate 66.39
    n-octanol 78.03
    chloroform 154.89
    n-propyl acetate 85.07
    acetic acid 1184.03
    dichloromethane 270.95
    cyclohexanone 219.23
    propylene glycol 313.47
    isopropyl acetate 74.81
    DMAc 458.55
    2-ethoxyethanol 688.15
    isopentanol 269.2
    n-heptane 15.12
    ethyl formate 247.74
    1,2-dichloroethane 183.47
    n-hexanol 121.65
    2-methoxyethanol 1042.0
    isobutyl acetate 37.45
    tetrachloromethane 42.56
    n-pentyl acetate 61.45
    transcutol 638.25
    n-heptanol 72.24
    ethylbenzene 23.52
    MIBK 100.41
    2-propoxyethanol 267.85
    tert-butanol 541.31
    MTBE 212.61
    2-butoxyethanol 159.81
    propionic acid 342.39
    o-xylene 34.53
    formic acid 2012.99
    diethyl ether 188.12
    m-xylene 26.3
    p-xylene 32.83
    chlorobenzene 48.19
    dimethyl carbonate 64.75
    n-octane 8.04
    formamide 1776.57
    cyclopentanone 270.77
    2-pentanone 165.23
    anisole 86.26
    cyclopentyl methyl ether 149.79
    gamma-butyrolactone 349.16
    1-methoxy-2-propanol 439.66
    pyridine 177.56
    3-pentanone 110.21
    furfural 416.02
    n-dodecane 6.2
    diethylene glycol 376.04
    diisopropyl ether 45.9
    tert-amyl alcohol 389.39
    acetylacetone 168.38
    n-hexadecane 6.45
    acetophenone 92.23
    methyl propionate 131.85
    isopentyl acetate 61.9
    trichloroethylene 241.16
    n-nonanol 64.14
    cyclohexanol 203.77
    benzyl alcohol 129.5
    2-ethylhexanol 64.98
    isooctanol 58.35
    dipropyl ether 62.54
    1,2-dichlorobenzene 56.75
    ethyl lactate 70.15
    propylene carbonate 138.89
    n-methylformamide 713.2
    2-pentanol 194.49
    n-pentane 24.58
    1-propoxy-2-propanol 139.72
    1-methoxy-2-propyl acetate 79.21
    2-(2-methoxypropoxy) propanol 134.29
    mesitylene 22.24
    ε-caprolactone 195.13
    p-cymene 23.87
    epichlorohydrin 369.23
    1,1,1-trichloroethane 78.84
    2-aminoethanol 655.3
    morpholine-4-carbaldehyde 522.0
    sulfolane 453.35
    2,2,4-trimethylpentane 17.29
    2-methyltetrahydrofuran 274.88
    n-hexyl acetate 82.72
    isooctane 9.97
    2-(2-butoxyethoxy)ethanol 194.19
    sec-butyl acetate 42.91
    tert-butyl acetate 97.5
    decalin 11.88
    glycerin 516.5
    diglyme 366.79
    acrylic acid 396.53
    isopropyl myristate 33.39
    n-butyric acid 324.93
    acetyl acetate 80.81
    di(2-ethylhexyl) phthalate 45.15
    ethyl propionate 68.99
    nitromethane 1075.39
    1,2-diethoxyethane 148.71
    benzonitrile 98.3
    trioctyl phosphate 35.63
    1-bromopropane 81.27
    gamma-valerolactone 438.28
    n-decanol 46.85
    triethyl phosphate 38.57
    4-methyl-2-pentanol 106.73
    propionitrile 174.74
    vinylene carbonate 151.25
    1,1,2-trichlorotrifluoroethane 341.2
    DMS 63.79
    cumene 23.7
    2-octanol 51.83
    2-hexanone 101.83
    octyl acetate 45.55
    limonene 38.27
    1,2-dimethoxyethane 588.37
    ethyl orthosilicate 38.18
    tributyl phosphate 41.66
    diacetone alcohol 204.7
    N,N-dimethylaniline 77.83
    acrylonitrile 240.74
    aniline 100.05
    1,3-propanediol 707.16
    bromobenzene 34.12
    dibromomethane 144.16
    1,1,2,2-tetrachloroethane 175.6
    2-methyl-cyclohexyl acetate 56.62
    tetrabutyl urea 61.67
    diisobutyl methanol 45.93
    2-phenylethanol 75.66
    styrene 29.38
    dioctyl adipate 56.19
    dimethyl sulfate 125.74
    ethyl butyrate 61.8
    methyl lactate 112.61
    butyl lactate 68.27
    diethyl carbonate 41.0
    propanediol butyl ether 155.06
    triethyl orthoformate 48.88
    p-tert-butyltoluene 23.31
    methyl 4-tert-butylbenzoate 91.68
    morpholine 487.72
    tert-butylamine 272.23
    n-dodecanol 36.45
    dimethoxymethane 372.78
    ethylene carbonate 113.88
    cyrene 159.71
    2-ethoxyethyl acetate 99.8
    2-ethylhexyl acetate 43.16
    1,2,4-trichlorobenzene 66.0
    4-methylpyridine 147.09
    dibutyl ether 56.59
    2,6-dimethyl-4-heptanol 45.93
    DEF 255.21
    dimethyl isosorbide 183.22
    tetrachloroethylene 165.15
    eugenol 107.87
    triacetin 85.85
    span 80 106.19
    1,4-butanediol 378.86
    1,1-dichloroethane 102.36
    2-methyl-1-pentanol 192.19
    methyl formate 516.34
    2-methyl-1-butanol 263.79
    n-decane 9.85
    butyronitrile 184.74
    3,7-dimethyl-1-octanol 69.99
    1-chlorooctane 31.17
    1-chlorotetradecane 13.63
    n-nonane 9.78
    undecane 7.55
    tert-butylcyclohexane 11.98
    cyclooctane 9.54
    cyclopentanol 258.67
    tetrahydropyran 230.55
    tert-amyl methyl ether 174.83
    2,5,8-trioxanonane 247.83
    1-hexene 44.82
    2-isopropoxyethanol 308.09
    2,2,2-trifluoroethanol 422.97
    methyl butyrate 122.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction