Methyl Parathion

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  • Identifiers

    CAS number
    298-00-0

    Molecular formula
    C8H10NO5PS

    SMILES
    COP(=S)(OC)OC1=CC=C(C=C1)[N+](=O)[O-]

    Safety labels

    Flammable
    Flammable

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 59.7%
    Roasted 23.2%
    Sulfurous 22.45%
    Savory 20.38%
    Cooked 20.34%
    Meaty 19.52%
    Grape 18.98%
    Burnt 18.41%
    Sour 18.04%
    Milky 18.0%

     

    Flavor
    Odorless 41.32%
    Bitter 39.65%
    Fruity 36.61%
    Mild 30.14%
    Very mild 24.09%
    Bland 23.86%
    Grape 22.05%
    Orange flower 20.52%
    Yeast 19.66%
    Orange blossom 19.58%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 0.0012 [mmHg]. Odor threshold from AIHA
    • 0.1328 mg/cu m odor low and high.
    • 1.23X10-2 ppm (detection in water; purity not specified)

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    7.91 (neutral)

    Molecular weight
    263.21 g/mol

    Melting point expt.

    • 99 to 100 °F (EPA, 1998)
    • 35.8 °C
    • MP: 37-38 °C
    • 35-38 °C
    • 99 °F

    Boiling point

    • 246 °F at 0.13 mmHg (NTP, 1992)
    • 154 °C at 136 Pa
    • 289 °F

    Flash point

    • 133.03 ˚C est.
    • commercial product, containing xylene, has flashpoint of 115F (EPA, 1998)
    • 42 °C (Closed cup)

    Solubility expt.

    • less than 1 mg/mL at 73 °F (NTP, 1992)
    • In water, 37.7 mg/L at 20 °C
    • Soluble in organic solvents
    • Readily soluble in common organic solvents, e.g. dichloromethane, toluene >200, hexane 10 to 20 (all in g/L at 20 °C). Sparingly soluble in petroleum ether and some types of mineral oil.
    • Readily soluble in 2-propanol. Hardly soluble in n-hexane
    • Solubility in water, g/100ml: 0.006
    • (77 °F): 0.006%

  • Synonyms

    • Parathion-methyl
    • METHYL PARATHION
    • 298-00-0
    • Methylparathion
    • Dimethyl parathion
    • Metacide
    • Metaphos
    • Metafos
    • Metron
    • Vofatox
    • Wofatox
    • Parathion methyl
    • Folidol M
    • Cekumethion
    • Methylthiophos
    • Oleovofotox
    • Thiophenit
    • Azophos
    • Devithion
    • Paratox
    • Paratuf
    • Quinophos
    • Tekwaisa
    • Azofos
    • Meptox
    • Yphos
    • Metacid 50
    • Dalf
    • M-Parathion
    • Partron M
    • Penncap MLS
    • metacid
    • Metron (pesticide)
    • Mepaton
    • Kilex parathion
    • Methyl fosferno
    • Nitrox 80
    • Folidol 600
    • Folidol M-40
    • Me-parathion
    • Methyl niran
    • Sinafid M-48
    • O,O-Dimethyl O-(4-nitrophenyl) phosphorothioate
    • methyl parathione
    • Penncap-M
    • Bladan-M
    • Parton-M
    • Methyl-E 605
    • Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester
    • Parathion methyl homolog
    • Demethylfenitrothion
    • Dimethyl p-nitrophenyl thiophosphate
    • Folidol-80
    • Wofatox 80
    • Fosferno M 50
    • Metafos (pesticide)
    • Parapest M-50
    • Metyloparation
    • Metylparation
    • Folidol M 50
    • Thylpar M-50
    • Wofatox 50 EC
    • Caswell No. 372
    • Metylparation [Czech]
    • Metacide (insecticide)
    • Parathion-metile
    • Methyl 1605
    • O,O-Dimethyl O-(p-nitrophenyl) thionophosphate
    • Metyloparation [Polish]
    • A-GRO
    • Bladan M
    • Metilparation (Hungarian)
    • RCRA waste number P071
    • Dimethyl 4-nitrophenyl phosphorothionate
    • Drexel methyl parathion 4E
    • Parathion-metile [Italian]
    • Me 605SP
    • CCRIS 405
    • Parathion-methyl [BSI:ISO]
    • 8056HC
    • BAY 11405
    • Parataf
    • Wofotox
    • Dimethyl p-nitrophenyl phosphorothionate
    • Methyl-bladan
    • Parathion-methyl [ISO]
    • BAY E-601
    • HSDB 1168
    • EPA Shaughnessy Code: 053501
    • NCI-C02971
    • Penncap M
    • p-Nitrophenyldimethylthionophosphate
    • Dimethyl-p-nitrophenyl thionphosphate
    • EINECS 206-050-1
    • ME 605
    • ENT 17,292
    • EPA Pesticide Chemical Code 053501
    • Dimethyl p-nitrophenyl monothiophosphate
    • O,O-Dimethyl O-(p-nitrophenyl) phosphorothioate
    • BRN 1914724
    • 41BCL2O91D
    • DTXSID1020855
    • CHEBI:38746
    • AI3-17292
    • O,O-Dimethyl O-p-nitrophenyl thiophosphate
    • E 601
    • o,o-Dimethyl o-(4-nitrophenyl) thiophosphate
    • O,O-Dimethyl-O-p-nitrofenylthiofosfat [Czech]
    • dimethyl p-nitrophenyl thionophosphate
    • O,O-Dimethyl-O-(4-nitrophenyl) phosphorothioate
    • O,O-Dimethyl-O-p-nitrofenylthiofosfat
    • M40 & 80
    • DTXCID30855
    • METHYL PARATHION [MI]
    • O,O-Dimethyl-O-(4-nitro-fenyl)-monothiofosfaat [Dutch]
    • O,O-Dimethyl-O-(4-nitrophenyl)-thionophosphat [German]
    • O,O-Dimethyl-O-(p-nitrophenyl)-thionophosphat [German]
    • O,O-Dimetil-O-(4-nitro-fenil)-monotiofosfato [Italian]
    • Phosphorothioic acid, o,o-dimethyl-o-p-nitrophenyl ester
    • METHYL PARATHION [IARC]
    • PARATHION-METHYL [HSDB]
    • O,O-Dimethyl-O-(4-nitro-phenyl)-monothiophosphat [German]
    • Phenol, p-nitro-, O-ester with O,O-dimethylphosphorothioate
    • Phosphorothioic acid, O,O-dimethyl O-(p-nitrophenyl) ester
    • BAY E 601
    • Phenol, p-nitro-, O-ester with O,O-dimethyl phosphorothioate
    • O,O-Dimethyl-O-(4-nitrophenyl)-thionophosphat
    • O,O-Dimethyl-O-(p-nitrophenyl)-thionophosphat

  • Applications

    Methyl Parathion (CAS 298-00-0) is an organophosphate insecticide primarily used in agriculture for pest control on crops such as fruits, vegetables, and cotton, applied as foliar sprays or soil treatments where permitted; it has also been used for stored-product pest control in some jurisdictions. It may also serve as an intermediate in the chemical manufacturing of other organophosphate pesticides, and in some laboratories may be used as a reference compound for pesticide-residue analysis and toxicology research, all subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 30.41
    methanol 43.74
    isopropanol 26.84
    water 3.95
    ethyl acetate 49.18
    n-propanol 24.76
    acetone 124.42
    n-butanol 21.2
    acetonitrile 67.61
    DMF 344.26
    toluene 15.22
    isobutanol 17.43
    1,4-dioxane 77.35
    methyl acetate 70.3
    THF 115.46
    2-butanone 88.82
    n-pentanol 23.73
    sec-butanol 29.32
    n-hexane 0.48
    ethylene glycol 26.04
    NMP 217.51
    cyclohexane 1.53
    DMSO 266.19
    n-butyl acetate 32.86
    n-octanol 23.54
    chloroform 59.74
    n-propyl acetate 46.14
    acetic acid 46.34
    dichloromethane 67.87
    cyclohexanone 97.25
    propylene glycol 25.83
    isopropyl acetate 32.68
    DMAc 307.62
    2-ethoxyethanol 103.93
    isopentanol 19.13
    n-heptane 1.83
    ethyl formate 56.55
    1,2-dichloroethane 52.13
    n-hexanol 20.45
    2-methoxyethanol 128.83
    isobutyl acetate 25.22
    tetrachloromethane 4.09
    n-pentyl acetate 38.23
    transcutol 107.35
    n-heptanol 19.62
    ethylbenzene 10.92
    MIBK 38.09
    2-propoxyethanol 72.11
    tert-butanol 40.38
    MTBE 27.83
    2-butoxyethanol 51.21
    propionic acid 33.59
    o-xylene 15.78
    formic acid 64.97
    diethyl ether 26.69
    m-xylene 12.8
    p-xylene 15.62
    chlorobenzene 25.05
    dimethyl carbonate 54.95
    n-octane 1.83
    formamide 139.57
    cyclopentanone 120.27
    2-pentanone 60.68
    anisole 47.46
    cyclopentyl methyl ether 35.83
    gamma-butyrolactone 129.97
    1-methoxy-2-propanol 96.48
    pyridine 67.22
    3-pentanone 51.64
    furfural 150.63
    n-dodecane 2.16
    diethylene glycol 77.37
    diisopropyl ether 7.91
    tert-amyl alcohol 38.55
    acetylacetone 91.86
    n-hexadecane 2.44
    acetophenone 71.7
    methyl propionate 59.58
    isopentyl acetate 27.21
    trichloroethylene 97.46
    n-nonanol 23.74
    cyclohexanol 26.27
    benzyl alcohol 49.57
    2-ethylhexanol 15.14
    isooctanol 16.5
    dipropyl ether 19.36
    1,2-dichlorobenzene 30.97
    ethyl lactate 45.51
    propylene carbonate 68.35
    n-methylformamide 132.19
    2-pentanol 18.55
    n-pentane 0.7
    1-propoxy-2-propanol 55.22
    1-methoxy-2-propyl acetate 50.83
    2-(2-methoxypropoxy) propanol 61.14
    mesitylene 8.81
    ε-caprolactone 76.59
    p-cymene 12.19
    epichlorohydrin 116.8
    1,1,1-trichloroethane 25.71
    2-aminoethanol 33.16
    morpholine-4-carbaldehyde 201.6
    sulfolane 169.21
    2,2,4-trimethylpentane 0.84
    2-methyltetrahydrofuran 54.27
    n-hexyl acetate 39.68
    isooctane 0.58
    2-(2-butoxyethoxy)ethanol 65.56
    sec-butyl acetate 27.44
    tert-butyl acetate 38.19
    decalin 1.28
    glycerin 54.9
    diglyme 114.49
    acrylic acid 39.93
    isopropyl myristate 20.76
    n-butyric acid 37.91
    acetyl acetate 34.48
    di(2-ethylhexyl) phthalate 25.87
    ethyl propionate 38.32
    nitromethane 185.77
    1,2-diethoxyethane 50.51
    benzonitrile 52.67
    trioctyl phosphate 19.01
    1-bromopropane 15.39
    gamma-valerolactone 190.59
    n-decanol 19.42
    triethyl phosphate 25.22
    4-methyl-2-pentanol 12.23
    propionitrile 43.4
    vinylene carbonate 74.07
    1,1,2-trichlorotrifluoroethane 100.29
    DMS 41.77
    cumene 8.55
    2-octanol 18.87
    2-hexanone 52.38
    octyl acetate 28.09
    limonene 15.79
    1,2-dimethoxyethane 154.84
    ethyl orthosilicate 22.65
    tributyl phosphate 21.26
    diacetone alcohol 64.97
    N,N-dimethylaniline 42.05
    acrylonitrile 73.77
    aniline 31.79
    1,3-propanediol 46.39
    bromobenzene 19.94
    dibromomethane 33.08
    1,1,2,2-tetrachloroethane 84.13
    2-methyl-cyclohexyl acetate 34.84
    tetrabutyl urea 39.09
    diisobutyl methanol 12.18
    2-phenylethanol 39.91
    styrene 13.6
    dioctyl adipate 34.03
    dimethyl sulfate 99.7
    ethyl butyrate 34.12
    methyl lactate 67.81
    butyl lactate 37.73
    diethyl carbonate 25.87
    propanediol butyl ether 47.86
    triethyl orthoformate 28.13
    p-tert-butyltoluene 11.96
    methyl 4-tert-butylbenzoate 59.26
    morpholine 84.55
    tert-butylamine 17.5
    n-dodecanol 15.41
    dimethoxymethane 144.46
    ethylene carbonate 56.14
    cyrene 88.34
    2-ethoxyethyl acetate 57.66
    2-ethylhexyl acetate 21.74
    1,2,4-trichlorobenzene 38.65
    4-methylpyridine 71.59
    dibutyl ether 20.96
    2,6-dimethyl-4-heptanol 12.18
    DEF 96.42
    dimethyl isosorbide 98.68
    tetrachloroethylene 40.19
    eugenol 66.73
    triacetin 58.68
    span 80 43.49
    1,4-butanediol 34.52
    1,1-dichloroethane 32.96
    2-methyl-1-pentanol 21.93
    methyl formate 121.67
    2-methyl-1-butanol 18.81
    n-decane 3.17
    butyronitrile 38.57
    3,7-dimethyl-1-octanol 20.09
    1-chlorooctane 12.5
    1-chlorotetradecane 6.61
    n-nonane 2.63
    undecane 2.58
    tert-butylcyclohexane 1.07
    cyclooctane 0.9
    cyclopentanol 32.38
    tetrahydropyran 41.56
    tert-amyl methyl ether 28.54
    2,5,8-trioxanonane 98.81
    1-hexene 3.2
    2-isopropoxyethanol 68.86
    2,2,2-trifluoroethanol 46.89
    methyl butyrate 54.37

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction