Methyl iodide

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  • Identifiers

    CAS number
    74-88-4

    Molecular formula
    CH3I

    SMILES
    CI

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Ethereal 51.55%
    Alcoholic 51.48%
    Solvent 42.3%
    Fermented 41.74%
    Sweet 36.15%
    Fishy 34.99%
    Gassy 34.48%
    Musty 32.64%
    Oily 31.04%
    Pungent 30.45%

     

    Flavor
    Sulfur 36.19%
    Gasoline 35.06%
    Egg 34.81%
    Garlic 33.33%
    Fishy 32.53%
    Rotten 29.06%
    Decomposing cabbage 27.98%
    Fruity 23.9%
    Pungent 23.32%
    Sulfurous 22.95%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    4.29 (weak acid)

    Molecular weight
    141.939 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -87.6 °F (NTP, 1992)
    • -66.5 °C
    • -88 °F

    Boiling point

    • 108.3 °F at 760 mmHg (NTP, 1992)
    • 42.5 °C
    • 109 °F

    Flash point

    • 3.2 ˚C est.

    Solubility expt.

    • 10 to 50 mg/mL at 64 °F (NTP, 1992)
    • Miscible with alcohol, ether.
    • Sol in acetone
    • SOL IN CARBON TETRACHLORIDE
    • 1.39X10+4 mg/l at 20 °C in water
    • Solubility in water, g/100ml at 20 °C: 1.4
    • 1%

  • Synonyms

    • IODOMETHANE
    • Methyl iodide
    • 74-88-4
    • Monoiodomethane
    • Methane, iodo-
    • Methyljodid
    • Jod-methan
    • Methyliodide
    • Iodometano
    • Joodmethaan
    • Methyljodide
    • Methyl iodine
    • Metylu jodek
    • Iodure de methyle
    • Methyliodid
    • Monoioduro di metile
    • Halon 10001
    • CH3I
    • Joodmethaan [Dutch]
    • Monoiodmethan
    • Iodmethan
    • RCRA waste number U138
    • iodo-methane
    • Iodometano [Italian]
    • Jod-methan [German]
    • Methyljodid [German]
    • Methyljodide [Dutch]
    • Metylu jodek [Polish]
    • Iodure de methyle [French]
    • NSC 9366
    • CCRIS 395
    • Monoioduro di metile [Italian]
    • iodo methane
    • HSDB 1336
    • DAT010ZJSR
    • EINECS 200-819-5
    • CHEBI:39282
    • NSC-9366
    • MFCD00001073
    • METHYL IODIDE [MI]
    • IODOMETHANE-13C-D3
    • METHYL IODIDE [HSDB]
    • METHYL IODIDE [IARC]
    • DTXSID0024187
    • EC 200-819-5
    • JOODMETHAAN (DUTCH)
    • IODOMETANO (ITALIAN)
    • JOD-METHAN (GERMAN)
    • METHYLJODID (GERMAN)
    • METHYLJODIDE (DUTCH)
    • METHYL IODIDE (IARC)
    • MEI
    • METYLU JODEK (POLISH)
    • IODURE DE METHYLE (FRENCH)
    • MONOIODURO DI METILE (ITALIAN)
    • UNII-DAT010ZJSR
    • UN2644
    • RCRA waste no. U138
    • iodmethane
    • iodometane
    • iodomethan
    • iodornethane
    • methiodide
    • methyliodine
    • carbon-iodine
    • mehyl iodide
    • methy iodide
    • metyl iodide
    • Methyl-iodide
    • meth-yl iodide
    • 1-iodomethane
    • methane, iodo
    • ICH3
    • WLN: I1
    • METHYL IODIDE (CH3I)
    • Methyl iodide (ACGIH:OSHA)
    • CHEMBL115849
    • DTXCID804187
    • Iodomethane, ampule of 100 mg
    • NSC9366
    • BCP26570
    • BBL034228
    • Iodomethane, for synthesis, 99.0%
    • STL281179
    • AKOS009031541
    • Methyl iodide [UN2644] [Poison]
    • UN 2644
    • Iodomethane, purum, >=99.0% (GC)
    • Iodomethane contains copper as stabilizer
    • BP-11384
    • Iodomethane, SAJ first grade, >=93.0%
    • Iodomethane, SAJ special grade, >=99.5%
    • I0060
    • NS00001340
    • C18448
    • Iodomethane, puriss., redist., >=99.5% (GC)
    • Q421729
    • F2190-0170
    • Iodomethane, contains copper as stabilizer, ReagentPlus(R), 99%
    • Iodomethane, contains copper as stabilizer, ReagentPlus(R), 99.5%
    • Iodomethane, 2000 mug/mL in methanol: water (4:1), analytical standard
    • Iodomethane, 2M soln. in tert-butyl methyl ether (stabilized with Cu)
    • 200-819-5

  • Applications

    Methyl iodide is widely used as a methylating reagent in organic synthesis, enabling the introduction of methyl groups into nucleophiles such as amines and phenols to give methylated products including methylated amines and methyl ethers. It serves as a key building block in the manufacture of pharmaceutical and agrochemical active ingredients and can be used to prepare quaternary ammonium salts that function as specialty surfactants and phase-transfer catalysts. It is also employed as a derivatization reagent in analytical chemistry to improve volatility or detectability of certain compounds in GC/MS analyses. Historically, methyl iodide has been used as a soil fumigant for pest control, but its use is now heavily regulated and restricted in many regions. It may also appear as a synthetic intermediate in polymer and coating formulations where methylation of functional groups is required.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 140.69
    methanol 122.97
    isopropanol 112.56
    water 2.11
    ethyl acetate 139.11
    n-propanol 122.42
    acetone 269.49
    n-butanol 127.81
    acetonitrile 127.66
    DMF 283.72
    toluene 158.52
    isobutanol 91.65
    1,4-dioxane 349.38
    methyl acetate 134.15
    THF 563.58
    2-butanone 190.35
    n-pentanol 100.95
    sec-butanol 102.82
    n-hexane 63.86
    ethylene glycol 51.82
    NMP 407.82
    cyclohexane 138.52
    DMSO 386.74
    n-butyl acetate 206.24
    n-octanol 112.64
    chloroform 464.9
    n-propyl acetate 138.39
    acetic acid 222.0
    dichloromethane 352.34
    cyclohexanone 404.81
    propylene glycol 55.16
    isopropyl acetate 103.19
    DMAc 201.29
    2-ethoxyethanol 138.94
    isopentanol 102.22
    n-heptane 115.55
    ethyl formate 109.06
    1,2-dichloroethane 242.04
    n-hexanol 147.03
    2-methoxyethanol 197.25
    isobutyl acetate 104.08
    tetrachloromethane 155.5
    n-pentyl acetate 163.42
    transcutol 425.06
    n-heptanol 115.32
    ethylbenzene 85.14
    MIBK 122.63
    2-propoxyethanol 201.97
    tert-butanol 134.9
    MTBE 120.81
    2-butoxyethanol 164.25
    propionic acid 134.01
    o-xylene 108.4
    formic acid 65.39
    diethyl ether 163.95
    m-xylene 112.12
    p-xylene 109.83
    chlorobenzene 206.77
    dimethyl carbonate 71.21
    n-octane 47.94
    formamide 91.12
    cyclopentanone 468.04
    2-pentanone 195.02
    anisole 149.62
    cyclopentyl methyl ether 279.16
    gamma-butyrolactone 405.16
    1-methoxy-2-propanol 158.97
    pyridine 341.74
    3-pentanone 155.83
    furfural 390.15
    n-dodecane 33.16
    diethylene glycol 160.99
    diisopropyl ether 77.67
    tert-amyl alcohol 108.91
    acetylacetone 205.48
    n-hexadecane 37.07
    acetophenone 158.4
    methyl propionate 125.72
    isopentyl acetate 162.31
    trichloroethylene 421.9
    n-nonanol 99.24
    cyclohexanol 188.4
    benzyl alcohol 124.49
    2-ethylhexanol 121.71
    isooctanol 99.13
    dipropyl ether 199.43
    1,2-dichlorobenzene 185.21
    ethyl lactate 71.32
    propylene carbonate 225.56
    n-methylformamide 127.26
    2-pentanol 100.58
    n-pentane 68.92
    1-propoxy-2-propanol 189.37
    1-methoxy-2-propyl acetate 162.21
    2-(2-methoxypropoxy) propanol 141.22
    mesitylene 85.66
    ε-caprolactone 291.21
    p-cymene 101.76
    epichlorohydrin 326.05
    1,1,1-trichloroethane 269.1
    2-aminoethanol 78.14
    morpholine-4-carbaldehyde 332.68
    sulfolane 518.67
    2,2,4-trimethylpentane 35.91
    2-methyltetrahydrofuran 365.67
    n-hexyl acetate 173.99
    isooctane 32.12
    2-(2-butoxyethoxy)ethanol 197.11
    sec-butyl acetate 94.07
    tert-butyl acetate 131.22
    decalin 54.31
    glycerin 82.68
    diglyme 342.67
    acrylic acid 135.46
    isopropyl myristate 95.4
    n-butyric acid 173.24
    acetyl acetate 115.34
    di(2-ethylhexyl) phthalate 86.17
    ethyl propionate 105.39
    nitromethane 232.09
    1,2-diethoxyethane 216.16
    benzonitrile 182.67
    trioctyl phosphate 73.46
    1-bromopropane 183.57
    gamma-valerolactone 432.28
    n-decanol 81.54
    triethyl phosphate 84.68
    4-methyl-2-pentanol 70.87
    propionitrile 115.13
    vinylene carbonate 207.29
    1,1,2-trichlorotrifluoroethane 255.52
    DMS 117.74
    cumene 70.53
    2-octanol 94.53
    2-hexanone 158.62
    octyl acetate 109.48
    limonene 150.32
    1,2-dimethoxyethane 230.59
    ethyl orthosilicate 87.76
    tributyl phosphate 84.29
    diacetone alcohol 144.38
    N,N-dimethylaniline 126.09
    acrylonitrile 140.1
    aniline 162.43
    1,3-propanediol 109.84
    bromobenzene 210.97
    dibromomethane 308.46
    1,1,2,2-tetrachloroethane 358.43
    2-methyl-cyclohexyl acetate 128.11
    tetrabutyl urea 117.95
    diisobutyl methanol 101.71
    2-phenylethanol 140.89
    styrene 113.1
    dioctyl adipate 120.28
    dimethyl sulfate 126.92
    ethyl butyrate 150.43
    methyl lactate 79.19
    butyl lactate 120.02
    diethyl carbonate 96.35
    propanediol butyl ether 143.14
    triethyl orthoformate 118.4
    p-tert-butyltoluene 100.25
    methyl 4-tert-butylbenzoate 156.53
    morpholine 334.35
    tert-butylamine 103.33
    n-dodecanol 72.07
    dimethoxymethane 184.84
    ethylene carbonate 170.41
    cyrene 162.33
    2-ethoxyethyl acetate 169.57
    2-ethylhexyl acetate 155.74
    1,2,4-trichlorobenzene 207.64
    4-methylpyridine 279.68
    dibutyl ether 148.84
    2,6-dimethyl-4-heptanol 101.71
    DEF 185.95
    dimethyl isosorbide 250.18
    tetrachloroethylene 294.32
    eugenol 153.6
    triacetin 154.14
    span 80 166.44
    1,4-butanediol 58.21
    1,1-dichloroethane 219.59
    2-methyl-1-pentanol 89.81
    methyl formate 112.33
    2-methyl-1-butanol 93.93
    n-decane 49.49
    butyronitrile 137.35
    3,7-dimethyl-1-octanol 99.58
    1-chlorooctane 110.19
    1-chlorotetradecane 58.33
    n-nonane 53.29
    undecane 38.79
    tert-butylcyclohexane 49.22
    cyclooctane 60.58
    cyclopentanol 208.7
    tetrahydropyran 371.16
    tert-amyl methyl ether 111.27
    2,5,8-trioxanonane 256.61
    1-hexene 111.75
    2-isopropoxyethanol 113.95
    2,2,2-trifluoroethanol 89.97
    methyl butyrate 139.72

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction